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P34978 (TA2R_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thromboxane A2 receptor

Short name=TXA2-R
Alternative name(s):
Prostanoid TP receptor
TXR2
Gene names
Name:Tbxa2r
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length341 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C and adenylyl cyclase.

Subunit structure

Interacts with RPGRIP1L. Interacts with GNB2L1/RACK1; the interaction regulates TBXA2R cell surface expression By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

In the brain, expressed in all types of glial cells. In the kidney, expressed in the mesangial cells of the glomerulus, smooth muscle cells of the renal arterioles, and in transitional cell epithelium of renal pelvis.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processinflammatory response

Inferred from electronic annotation. Source: Ensembl

positive regulation of angiogenesis

Inferred from direct assay PubMed 16720756. Source: RGD

positive regulation of blood pressure

Inferred from mutant phenotype PubMed 16115588. Source: RGD

positive regulation of cytosolic calcium ion concentration

Inferred from direct assay Ref.1. Source: RGD

positive regulation of smooth muscle contraction

Inferred from electronic annotation. Source: Ensembl

positive regulation of vasoconstriction

Inferred from mutant phenotype PubMed 16905600. Source: RGD

response to drug

Inferred from expression pattern PubMed 11409645. Source: RGD

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

response to nutrient

Inferred from expression pattern PubMed 14621185. Source: RGD

second-messenger-mediated signaling

Inferred from electronic annotation. Source: Ensembl

water homeostasis

Traceable author statement PubMed 11777901. Source: RGD

   Cellular_componentacrosomal vesicle

Inferred from direct assay PubMed 7649122. Source: RGD

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionthromboxane receptor activity

Inferred from direct assay Ref.1. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 341341Thromboxane A2 receptor
PRO_0000070140

Regions

Topological domain1 – 2929Extracellular Potential
Transmembrane30 – 5223Helical; Name=1; Potential
Topological domain53 – 6513Cytoplasmic Potential
Transmembrane66 – 8621Helical; Name=2; Potential
Topological domain87 – 10519Extracellular Potential
Transmembrane106 – 12722Helical; Name=3; Potential
Topological domain128 – 14720Cytoplasmic Potential
Transmembrane148 – 17023Helical; Name=4; Potential
Topological domain171 – 19121Extracellular Potential
Transmembrane192 – 21726Helical; Name=5; Potential
Topological domain218 – 24427Cytoplasmic Potential
Transmembrane245 – 26824Helical; Name=6; Potential
Topological domain269 – 28719Extracellular Potential
Transmembrane288 – 30922Helical; Name=7; Potential
Topological domain310 – 34132Cytoplasmic Potential

Amino acid modifications

Glycosylation41N-linked (GlcNAc...) Potential
Glycosylation161N-linked (GlcNAc...) Potential
Disulfide bond104 ↔ 181 By similarity

Experimental info

Sequence conflict1881E → G in BAA06844. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P34978 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: E85843FE54C1CD94

FASTA34136,928
        10         20         30         40         50         60 
MWLNSTSLGA CFRPVNITLQ ERRAIASPWF AASFCALGLG SNLLALSVLA GARPGAGPRS 

        70         80         90        100        110        120 
SFLALLCGLV LTDFLGLLVT GAVVASQHAA LLDWRATDPG CRLCHFMGAA MVFFGLCPLL 

       130        140        150        160        170        180 
LGAAMAAERF VGITRPFSRP AATSRRAWAT VGLVWVGAGT LGLLPLLGLG RYSVQYPGSW 

       190        200        210        220        230        240 
CFLTLGAERG DVAFGLMFAL LGSVSVGLSL LLNTVSVATL CRVYHAREAT QRPRDCEVEM 

       250        260        270        280        290        300 
MVQLVGIMVV ATVCWMPLLV FILQTLLQTL PVMSPSGQLL RTTERQLLIY LRVATWNQIL 

       310        320        330        340 
DPWVYILFRR SVLRRLHPRF TSQLQAVSLH SPPTQAMLSG P 

« Hide

References

[1]"Rat kidney thromboxane receptor: molecular cloning, signal transduction, and intrarenal expression localization."
Abe T., Takeuchi K., Takahashi N., Tsutsumi E., Taniyama Y., Abe K.
J. Clin. Invest. 96:657-664(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Kidney.
[2]"cDNA cloning of a thromboxane A2 receptor from rat astrocytes."
Kitanaka J., Hashimoto H., Sugimoto Y., Sawada M., Negishi M., Suzumura A., Marunouchi T., Ichikawa A., Baba A.
Biochim. Biophys. Acta 1265:220-223(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.
[3]"Characterization of a rat kidney thromboxane A2 receptor: high affinity for the agonist ligand I-BOP."
D'Angelo D.D., Terasawa T., Carlisle S.J., Dorn G.W. II, Lynch K.R.
Prostaglandins 52:303-316(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D21158 mRNA. Translation: BAA04694.1.
D32080 mRNA. Translation: BAA06844.1.
PIRI55623.
RefSeqNP_058750.1. NM_017054.1.
XP_006240908.1. XM_006240846.1.
XP_006240909.1. XM_006240847.1.
UniGeneRn.44614.

3D structure databases

ProteinModelPortalP34978.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-60433N.
STRING10116.ENSRNOP00000027932.

Chemistry

BindingDBP34978.
ChEMBLCHEMBL3156.
GuidetoPHARMACOLOGY346.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP34978.

Proteomic databases

PaxDbP34978.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000027932; ENSRNOP00000027932; ENSRNOG00000020585.
GeneID24816.
KEGGrno:24816.
UCSCRGD:3825. rat.

Organism-specific databases

CTD6915.
RGD3825. Tbxa2r.

Phylogenomic databases

eggNOGNOG263172.
GeneTreeENSGT00690000102015.
HOGENOMHOG000015238.
HOVERGENHBG108543.
InParanoidP34978.
KOK04264.
OMAATLCRVY.
OrthoDBEOG7TBC2R.
PhylomeDBP34978.
TreeFamTF324982.

Gene expression databases

GenevestigatorP34978.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001105. Thbox_rcpt.
[Graphical view]
PANTHERPTHR11866. PTHR11866. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01788. PROSTANOIDR.
PR00429. THROMBOXANER.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio604510.
PROP34978.

Entry information

Entry nameTA2R_RAT
AccessionPrimary (citable) accession number: P34978
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries