Thromboxane A2 receptor - Tbxa2r - Rattus norvegicus (Rat)

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P34978 (TA2R_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Thromboxane A2 receptor
Short name=TXA2-R

Alternative name(s):
Prostanoid TP receptor
TXR2

Gene names

Name:

Tbxa2r

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	341 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C and adenylyl cyclase.
Subunit structure	Interacts with RPGRIP1L. Interacts with GNB2L1/RACK1; the interaction regulates TBXA2R cell surface expression By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	In the brain, expressed in all types of glial cells. In the kidney, expressed in the mesangial cells of the glomerulus, smooth muscle cells of the renal arterioles, and in transitional cell epithelium of renal pelvis.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	inflammatory response Inferred from electronic annotation. Source: Ensembl positive regulation of angiogenesis Inferred from direct assay PubMed 16720756. Source: RGD positive regulation of blood pressure Inferred from mutant phenotype PubMed 16115588. Source: RGD positive regulation of cytosolic calcium ion concentration Inferred from direct assay Ref.1. Source: RGD positive regulation of smooth muscle contraction Inferred from electronic annotation. Source: Ensembl positive regulation of vasoconstriction Inferred from mutant phenotype PubMed 16905600. Source: RGD response to drug Inferred from expression pattern PubMed 11409645. Source: RGD response to lipopolysaccharide Inferred from electronic annotation. Source: Ensembl response to nutrient Inferred from expression pattern PubMed 14621185. Source: RGD second-messenger-mediated signaling Inferred from electronic annotation. Source: Ensembl water homeostasis Traceable author statement PubMed 11777901. Source: RGD
Cellular_component	acrosomal vesicle Inferred from direct assay PubMed 7649122. Source: RGD integral component of membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	thromboxane receptor activity Inferred from direct assay Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 341

341

Thromboxane A2 receptor

PRO_0000070140

Regions

Topological domain

1 – 29

Extracellular Potential

Transmembrane

30 – 52

Helical; Name=1; Potential

Topological domain

53 – 65

Cytoplasmic Potential

Transmembrane

66 – 86

Helical; Name=2; Potential

Topological domain

87 – 105

Extracellular Potential

Transmembrane

106 – 127

Helical; Name=3; Potential

Topological domain

128 – 147

Cytoplasmic Potential

Transmembrane

148 – 170

Helical; Name=4; Potential

Topological domain

171 – 191

Extracellular Potential

Transmembrane

192 – 217

Helical; Name=5; Potential

Topological domain

218 – 244

Cytoplasmic Potential

Transmembrane

245 – 268

Helical; Name=6; Potential

Topological domain

269 – 287

Extracellular Potential

Transmembrane

288 – 309

Helical; Name=7; Potential

Topological domain

310 – 341

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

104 ↔ 181

By similarity

Experimental info

Sequence conflict

188

E → G in BAA06844. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

P34978 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: E85843FE54C1CD94
Show »

FASTA

341

36,928

        10         20         30         40         50         60 
MWLNSTSLGA CFRPVNITLQ ERRAIASPWF AASFCALGLG SNLLALSVLA GARPGAGPRS 

        70         80         90        100        110        120 
SFLALLCGLV LTDFLGLLVT GAVVASQHAA LLDWRATDPG CRLCHFMGAA MVFFGLCPLL 

       130        140        150        160        170        180 
LGAAMAAERF VGITRPFSRP AATSRRAWAT VGLVWVGAGT LGLLPLLGLG RYSVQYPGSW 

       190        200        210        220        230        240 
CFLTLGAERG DVAFGLMFAL LGSVSVGLSL LLNTVSVATL CRVYHAREAT QRPRDCEVEM 

       250        260        270        280        290        300 
MVQLVGIMVV ATVCWMPLLV FILQTLLQTL PVMSPSGQLL RTTERQLLIY LRVATWNQIL 

       310        320        330        340 
DPWVYILFRR SVLRRLHPRF TSQLQAVSLH SPPTQAMLSG P

« Hide

References

[1]	"Rat kidney thromboxane receptor: molecular cloning, signal transduction, and intrarenal expression localization." Abe T., Takeuchi K., Takahashi N., Tsutsumi E., Taniyama Y., Abe K. J. Clin. Invest. 96:657-664(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Kidney.
[2]	"cDNA cloning of a thromboxane A2 receptor from rat astrocytes." Kitanaka J., Hashimoto H., Sugimoto Y., Sawada M., Negishi M., Suzumura A., Marunouchi T., Ichikawa A., Baba A. Biochim. Biophys. Acta 1265:220-223(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Brain.
[3]	"Characterization of a rat kidney thromboxane A2 receptor: high affinity for the agonist ligand I-BOP." D'Angelo D.D., Terasawa T., Carlisle S.J., Dorn G.W. II, Lynch K.R. Prostaglandins 52:303-316(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D21158 mRNA. Translation: BAA04694.1. D32080 mRNA. Translation: BAA06844.1.
PIR	I55623.
RefSeq	NP_058750.1. NM_017054.1. XP_006240908.1. XM_006240846.1. XP_006240909.1. XM_006240847.1.
UniGene	Rn.44614.
3D structure databases
ProteinModelPortal	P34978.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
DIP	DIP-60433N.
STRING	10116.ENSRNOP00000027932.
Chemistry
BindingDB	P34978.
ChEMBL	CHEMBL3156.
GuidetoPHARMACOLOGY	346.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P34978.
Proteomic databases
PaxDb	P34978.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000027932; ENSRNOP00000027932; ENSRNOG00000020585.
GeneID	24816.
KEGG	rno:24816.
UCSC	RGD:3825. rat.
Organism-specific databases
CTD	6915.
RGD	3825. Tbxa2r.
Phylogenomic databases
eggNOG	NOG263172.
GeneTree	ENSGT00690000102015.
HOGENOM	HOG000015238.
HOVERGEN	HBG108543.
InParanoid	P34978.
KO	K04264.
OMA	ATLCRVY.
OrthoDB	EOG7TBC2R.
PhylomeDB	P34978.
TreeFam	TF324982.
Gene expression databases
Genevestigator	P34978.
Family and domain databases
Gene3D	1.20.1070.10. 1 hit.
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR008365. Prostanoid_rcpt. IPR001105. Thbox_rcpt. [Graphical view]
PANTHER	PTHR11866. PTHR11866. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01788. PROSTANOIDR. PR00429. THROMBOXANER.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	604510.
PRO	P34978.

Entry information

Entry name

TA2R_RAT

Accession

Primary (citable) accession number: P34978

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents