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P34978

- TA2R_RAT

UniProt

P34978 - TA2R_RAT

Protein

Thromboxane A2 receptor

Gene

Tbxa2r

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C and adenylyl cyclase.

    GO - Molecular functioni

    1. thromboxane receptor activity Source: RGD

    GO - Biological processi

    1. inflammatory response Source: Ensembl
    2. positive regulation of angiogenesis Source: RGD
    3. positive regulation of blood pressure Source: RGD
    4. positive regulation of cytosolic calcium ion concentration Source: RGD
    5. positive regulation of smooth muscle contraction Source: Ensembl
    6. positive regulation of vasoconstriction Source: RGD
    7. response to drug Source: RGD
    8. response to lipopolysaccharide Source: Ensembl
    9. response to nutrient Source: RGD
    10. second-messenger-mediated signaling Source: Ensembl
    11. water homeostasis Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thromboxane A2 receptor
    Short name:
    TXA2-R
    Alternative name(s):
    Prostanoid TP receptor
    TXR2
    Gene namesi
    Name:Tbxa2r
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi3825. Tbxa2r.

    Subcellular locationi

    GO - Cellular componenti

    1. acrosomal vesicle Source: RGD
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 341341Thromboxane A2 receptorPRO_0000070140Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi104 ↔ 181PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP34978.

    PTM databases

    PhosphoSiteiP34978.

    Expressioni

    Tissue specificityi

    In the brain, expressed in all types of glial cells. In the kidney, expressed in the mesangial cells of the glomerulus, smooth muscle cells of the renal arterioles, and in transitional cell epithelium of renal pelvis.

    Gene expression databases

    GenevestigatoriP34978.

    Interactioni

    Subunit structurei

    Interacts with RPGRIP1L. Interacts with GNB2L1/RACK1; the interaction regulates TBXA2R cell surface expression By similarity.By similarity

    Protein-protein interaction databases

    DIPiDIP-60433N.
    STRINGi10116.ENSRNOP00000027932.

    Structurei

    3D structure databases

    ProteinModelPortaliP34978.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2929ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini53 – 6513CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini87 – 10519ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini128 – 14720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini171 – 19121ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 24427CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini269 – 28719ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini310 – 34132CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5223Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei66 – 8621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei106 – 12722Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei148 – 17023Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei192 – 21726Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei245 – 26824Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei288 – 30922Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG263172.
    GeneTreeiENSGT00690000102015.
    HOGENOMiHOG000015238.
    HOVERGENiHBG108543.
    InParanoidiP34978.
    KOiK04264.
    OMAiATLCRVY.
    OrthoDBiEOG7TBC2R.
    PhylomeDBiP34978.
    TreeFamiTF324982.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008365. Prostanoid_rcpt.
    IPR001105. Thbox_rcpt.
    [Graphical view]
    PANTHERiPTHR11866. PTHR11866. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01788. PROSTANOIDR.
    PR00429. THROMBOXANER.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P34978-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWLNSTSLGA CFRPVNITLQ ERRAIASPWF AASFCALGLG SNLLALSVLA    50
    GARPGAGPRS SFLALLCGLV LTDFLGLLVT GAVVASQHAA LLDWRATDPG 100
    CRLCHFMGAA MVFFGLCPLL LGAAMAAERF VGITRPFSRP AATSRRAWAT 150
    VGLVWVGAGT LGLLPLLGLG RYSVQYPGSW CFLTLGAERG DVAFGLMFAL 200
    LGSVSVGLSL LLNTVSVATL CRVYHAREAT QRPRDCEVEM MVQLVGIMVV 250
    ATVCWMPLLV FILQTLLQTL PVMSPSGQLL RTTERQLLIY LRVATWNQIL 300
    DPWVYILFRR SVLRRLHPRF TSQLQAVSLH SPPTQAMLSG P 341
    Length:341
    Mass (Da):36,928
    Last modified:February 1, 1994 - v1
    Checksum:iE85843FE54C1CD94
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti188 – 1881E → G in BAA06844. (PubMed:7696353)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D21158 mRNA. Translation: BAA04694.1.
    D32080 mRNA. Translation: BAA06844.1.
    PIRiI55623.
    RefSeqiNP_058750.1. NM_017054.1.
    XP_006240908.1. XM_006240846.1.
    XP_006240909.1. XM_006240847.1.
    UniGeneiRn.44614.

    Genome annotation databases

    EnsembliENSRNOT00000027932; ENSRNOP00000027932; ENSRNOG00000020585.
    GeneIDi24816.
    KEGGirno:24816.
    UCSCiRGD:3825. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D21158 mRNA. Translation: BAA04694.1 .
    D32080 mRNA. Translation: BAA06844.1 .
    PIRi I55623.
    RefSeqi NP_058750.1. NM_017054.1.
    XP_006240908.1. XM_006240846.1.
    XP_006240909.1. XM_006240847.1.
    UniGenei Rn.44614.

    3D structure databases

    ProteinModelPortali P34978.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60433N.
    STRINGi 10116.ENSRNOP00000027932.

    Chemistry

    BindingDBi P34978.
    ChEMBLi CHEMBL3156.
    GuidetoPHARMACOLOGYi 346.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P34978.

    Proteomic databases

    PaxDbi P34978.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000027932 ; ENSRNOP00000027932 ; ENSRNOG00000020585 .
    GeneIDi 24816.
    KEGGi rno:24816.
    UCSCi RGD:3825. rat.

    Organism-specific databases

    CTDi 6915.
    RGDi 3825. Tbxa2r.

    Phylogenomic databases

    eggNOGi NOG263172.
    GeneTreei ENSGT00690000102015.
    HOGENOMi HOG000015238.
    HOVERGENi HBG108543.
    InParanoidi P34978.
    KOi K04264.
    OMAi ATLCRVY.
    OrthoDBi EOG7TBC2R.
    PhylomeDBi P34978.
    TreeFami TF324982.

    Miscellaneous databases

    NextBioi 604510.
    PROi P34978.

    Gene expression databases

    Genevestigatori P34978.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008365. Prostanoid_rcpt.
    IPR001105. Thbox_rcpt.
    [Graphical view ]
    PANTHERi PTHR11866. PTHR11866. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01788. PROSTANOIDR.
    PR00429. THROMBOXANER.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rat kidney thromboxane receptor: molecular cloning, signal transduction, and intrarenal expression localization."
      Abe T., Takeuchi K., Takahashi N., Tsutsumi E., Taniyama Y., Abe K.
      J. Clin. Invest. 96:657-664(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Kidney.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.
    3. "Characterization of a rat kidney thromboxane A2 receptor: high affinity for the agonist ligand I-BOP."
      D'Angelo D.D., Terasawa T., Carlisle S.J., Dorn G.W. II, Lynch K.R.
      Prostaglandins 52:303-316(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Kidney.

    Entry informationi

    Entry nameiTA2R_RAT
    AccessioniPrimary (citable) accession number: P34978
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3