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Protein

Thromboxane A2 receptor

Gene

Tbxa2r

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C and adenylyl cyclase.

GO - Molecular functioni

  • thromboxane A2 receptor activity Source: GO_Central
  • thromboxane receptor activity Source: RGD

GO - Biological processi

  • cellular response to lipopolysaccharide Source: RGD
  • positive regulation of angiogenesis Source: RGD
  • positive regulation of blood coagulation Source: RGD
  • positive regulation of blood pressure Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of vasoconstriction Source: RGD
  • response to drug Source: RGD
  • response to ethanol Source: RGD
  • response to nutrient Source: RGD
  • response to testosterone Source: RGD
  • water homeostasis Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-391908. Prostanoid ligand receptors.
R-RNO-416476. G alpha (q) signalling events.
R-RNO-416482. G alpha (12/13) signalling events.
R-RNO-428930. Thromboxane signalling through TP receptor.

Names & Taxonomyi

Protein namesi
Recommended name:
Thromboxane A2 receptor
Short name:
TXA2-R
Alternative name(s):
Prostanoid TP receptor
TXR2
Gene namesi
Name:Tbxa2r
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi3825. Tbxa2r.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 52Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini53 – 65CytoplasmicSequence analysisAdd BLAST13
Transmembranei66 – 86Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini87 – 105ExtracellularSequence analysisAdd BLAST19
Transmembranei106 – 127Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini128 – 147CytoplasmicSequence analysisAdd BLAST20
Transmembranei148 – 170Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini171 – 191ExtracellularSequence analysisAdd BLAST21
Transmembranei192 – 217Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini218 – 244CytoplasmicSequence analysisAdd BLAST27
Transmembranei245 – 268Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini269 – 287ExtracellularSequence analysisAdd BLAST19
Transmembranei288 – 309Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini310 – 341CytoplasmicSequence analysisAdd BLAST32

GO - Cellular componenti

  • acrosomal vesicle Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • nuclear speck Source: Ensembl
  • plasma membrane Source: RGD

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3156.
GuidetoPHARMACOLOGYi346.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701401 – 341Thromboxane A2 receptorAdd BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi16N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi104 ↔ 181PROSITE-ProRule annotation
Modified residuei328PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP34978.

PTM databases

PhosphoSitePlusiP34978.

Expressioni

Tissue specificityi

In the brain, expressed in all types of glial cells. In the kidney, expressed in the mesangial cells of the glomerulus, smooth muscle cells of the renal arterioles, and in transitional cell epithelium of renal pelvis.

Gene expression databases

BgeeiENSRNOG00000020585.
GenevisibleiP34978. RN.

Interactioni

Subunit structurei

Interacts with RPGRIP1L. Interacts with RACK1; the interaction regulates TBXA2R cell surface expression (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-60433N.
STRINGi10116.ENSRNOP00000027932.

Chemistry databases

BindingDBiP34978.

Structurei

3D structure databases

ProteinModelPortaliP34978.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000015238.
HOVERGENiHBG108543.
InParanoidiP34978.
KOiK04264.
OMAiRVYHDRE.
OrthoDBiEOG091G0DNT.
PhylomeDBiP34978.
TreeFamiTF324982.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001105. Thbox_rcpt.
PANTHERiPTHR11866. PTHR11866. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR01788. PROSTANOIDR.
PR00429. THROMBOXANER.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P34978-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLNSTSLGA CFRPVNITLQ ERRAIASPWF AASFCALGLG SNLLALSVLA
60 70 80 90 100
GARPGAGPRS SFLALLCGLV LTDFLGLLVT GAVVASQHAA LLDWRATDPG
110 120 130 140 150
CRLCHFMGAA MVFFGLCPLL LGAAMAAERF VGITRPFSRP AATSRRAWAT
160 170 180 190 200
VGLVWVGAGT LGLLPLLGLG RYSVQYPGSW CFLTLGAERG DVAFGLMFAL
210 220 230 240 250
LGSVSVGLSL LLNTVSVATL CRVYHAREAT QRPRDCEVEM MVQLVGIMVV
260 270 280 290 300
ATVCWMPLLV FILQTLLQTL PVMSPSGQLL RTTERQLLIY LRVATWNQIL
310 320 330 340
DPWVYILFRR SVLRRLHPRF TSQLQAVSLH SPPTQAMLSG P
Length:341
Mass (Da):36,928
Last modified:February 1, 1994 - v1
Checksum:iE85843FE54C1CD94
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188E → G in BAA06844 (PubMed:7696353).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21158 mRNA. Translation: BAA04694.1.
D32080 mRNA. Translation: BAA06844.1.
PIRiI55623.
RefSeqiNP_058750.1. NM_017054.1.
XP_006240908.1. XM_006240846.2.
UniGeneiRn.44614.

Genome annotation databases

EnsembliENSRNOT00000027932; ENSRNOP00000027932; ENSRNOG00000020585.
GeneIDi24816.
KEGGirno:24816.
UCSCiRGD:3825. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTA2R_RAT
AccessioniPrimary (citable) accession number: P34978
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 7, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families