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Protein

Thromboxane A2 receptor

Gene

Tbxa2r

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C and adenylyl cyclase.

GO - Molecular functioni

  1. thromboxane receptor activity Source: RGD

GO - Biological processi

  1. inflammatory response Source: Ensembl
  2. positive regulation of angiogenesis Source: RGD
  3. positive regulation of blood pressure Source: RGD
  4. positive regulation of cytosolic calcium ion concentration Source: RGD
  5. positive regulation of smooth muscle contraction Source: Ensembl
  6. positive regulation of vasoconstriction Source: RGD
  7. response to drug Source: RGD
  8. response to lipopolysaccharide Source: Ensembl
  9. response to nutrient Source: RGD
  10. second-messenger-mediated signaling Source: Ensembl
  11. water homeostasis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_241591. Thromboxane signalling through TP receptor.
REACT_245473. G alpha (12/13) signalling events.
REACT_254225. Prostanoid ligand receptors.
REACT_263374. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Thromboxane A2 receptor
Short name:
TXA2-R
Alternative name(s):
Prostanoid TP receptor
TXR2
Gene namesi
Name:Tbxa2r
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi3825. Tbxa2r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929ExtracellularSequence AnalysisAdd
BLAST
Transmembranei30 – 5223Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini53 – 6513CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei66 – 8621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini87 – 10519ExtracellularSequence AnalysisAdd
BLAST
Transmembranei106 – 12722Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini128 – 14720CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei148 – 17023Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini171 – 19121ExtracellularSequence AnalysisAdd
BLAST
Transmembranei192 – 21726Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini218 – 24427CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei245 – 26824Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini269 – 28719ExtracellularSequence AnalysisAdd
BLAST
Transmembranei288 – 30922Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini310 – 34132CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. acrosomal vesicle Source: RGD
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Thromboxane A2 receptorPRO_0000070140Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi104 ↔ 181PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP34978.

PTM databases

PhosphoSiteiP34978.

Expressioni

Tissue specificityi

In the brain, expressed in all types of glial cells. In the kidney, expressed in the mesangial cells of the glomerulus, smooth muscle cells of the renal arterioles, and in transitional cell epithelium of renal pelvis.

Gene expression databases

GenevestigatoriP34978.

Interactioni

Subunit structurei

Interacts with RPGRIP1L. Interacts with GNB2L1/RACK1; the interaction regulates TBXA2R cell surface expression (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-60433N.
STRINGi10116.ENSRNOP00000027932.

Structurei

3D structure databases

ProteinModelPortaliP34978.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG263172.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000015238.
HOVERGENiHBG108543.
InParanoidiP34978.
KOiK04264.
OMAiLCHFMGV.
OrthoDBiEOG7TBC2R.
PhylomeDBiP34978.
TreeFamiTF324982.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001105. Thbox_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01788. PROSTANOIDR.
PR00429. THROMBOXANER.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34978-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLNSTSLGA CFRPVNITLQ ERRAIASPWF AASFCALGLG SNLLALSVLA
60 70 80 90 100
GARPGAGPRS SFLALLCGLV LTDFLGLLVT GAVVASQHAA LLDWRATDPG
110 120 130 140 150
CRLCHFMGAA MVFFGLCPLL LGAAMAAERF VGITRPFSRP AATSRRAWAT
160 170 180 190 200
VGLVWVGAGT LGLLPLLGLG RYSVQYPGSW CFLTLGAERG DVAFGLMFAL
210 220 230 240 250
LGSVSVGLSL LLNTVSVATL CRVYHAREAT QRPRDCEVEM MVQLVGIMVV
260 270 280 290 300
ATVCWMPLLV FILQTLLQTL PVMSPSGQLL RTTERQLLIY LRVATWNQIL
310 320 330 340
DPWVYILFRR SVLRRLHPRF TSQLQAVSLH SPPTQAMLSG P
Length:341
Mass (Da):36,928
Last modified:February 1, 1994 - v1
Checksum:iE85843FE54C1CD94
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti188 – 1881E → G in BAA06844 (PubMed:7696353).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21158 mRNA. Translation: BAA04694.1.
D32080 mRNA. Translation: BAA06844.1.
PIRiI55623.
RefSeqiNP_058750.1. NM_017054.1.
XP_006240908.1. XM_006240846.1.
XP_006240909.1. XM_006240847.1.
UniGeneiRn.44614.

Genome annotation databases

EnsembliENSRNOT00000027932; ENSRNOP00000027932; ENSRNOG00000020585.
GeneIDi24816.
KEGGirno:24816.
UCSCiRGD:3825. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21158 mRNA. Translation: BAA04694.1.
D32080 mRNA. Translation: BAA06844.1.
PIRiI55623.
RefSeqiNP_058750.1. NM_017054.1.
XP_006240908.1. XM_006240846.1.
XP_006240909.1. XM_006240847.1.
UniGeneiRn.44614.

3D structure databases

ProteinModelPortaliP34978.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60433N.
STRINGi10116.ENSRNOP00000027932.

Chemistry

BindingDBiP34978.
ChEMBLiCHEMBL3156.
GuidetoPHARMACOLOGYi346.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP34978.

Proteomic databases

PaxDbiP34978.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027932; ENSRNOP00000027932; ENSRNOG00000020585.
GeneIDi24816.
KEGGirno:24816.
UCSCiRGD:3825. rat.

Organism-specific databases

CTDi6915.
RGDi3825. Tbxa2r.

Phylogenomic databases

eggNOGiNOG263172.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000015238.
HOVERGENiHBG108543.
InParanoidiP34978.
KOiK04264.
OMAiLCHFMGV.
OrthoDBiEOG7TBC2R.
PhylomeDBiP34978.
TreeFamiTF324982.

Enzyme and pathway databases

ReactomeiREACT_241591. Thromboxane signalling through TP receptor.
REACT_245473. G alpha (12/13) signalling events.
REACT_254225. Prostanoid ligand receptors.
REACT_263374. G alpha (q) signalling events.

Miscellaneous databases

NextBioi604510.
PROiP34978.

Gene expression databases

GenevestigatoriP34978.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001105. Thbox_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01788. PROSTANOIDR.
PR00429. THROMBOXANER.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rat kidney thromboxane receptor: molecular cloning, signal transduction, and intrarenal expression localization."
    Abe T., Takeuchi K., Takahashi N., Tsutsumi E., Taniyama Y., Abe K.
    J. Clin. Invest. 96:657-664(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Kidney.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  3. "Characterization of a rat kidney thromboxane A2 receptor: high affinity for the agonist ligand I-BOP."
    D'Angelo D.D., Terasawa T., Carlisle S.J., Dorn G.W. II, Lynch K.R.
    Prostaglandins 52:303-316(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Kidney.

Entry informationi

Entry nameiTA2R_RAT
AccessioniPrimary (citable) accession number: P34978
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: January 7, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.