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Protein

Kappa-type opioid receptor

Gene

Oprk1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.2 Publications

GO - Molecular functioni

GO - Biological processi

  • adenylate cyclase-inhibiting opioid receptor signaling pathway Source: UniProtKB
  • behavioral response to cocaine Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • chemical synaptic transmission Source: GO_Central
  • conditioned place preference Source: RGD
  • defense response to virus Source: Ensembl
  • eating behavior Source: RGD
  • estrous cycle Source: RGD
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
  • immune response Source: Ensembl
  • locomotory behavior Source: UniProtKB
  • maternal behavior Source: RGD
  • negative regulation of luteinizing hormone secretion Source: RGD
  • neuropeptide signaling pathway Source: GO_Central
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  • positive regulation of dopamine secretion Source: RGD
  • positive regulation of eating behavior Source: RGD
  • positive regulation of locomotion Source: RGD
  • positive regulation of p38MAPK cascade Source: RGD
  • positive regulation of potassium ion transmembrane transport Source: RGD
  • regulation of saliva secretion Source: UniProtKB
  • regulation of sensory perception of pain Source: RGD
  • response to acrylamide Source: RGD
  • response to cocaine Source: RGD
  • response to estrogen Source: RGD
  • response to ethanol Source: RGD
  • response to insulin Source: RGD
  • response to morphine Source: RGD
  • response to radiation Source: RGD
  • sensory perception of pain Source: UniProtKB
  • sensory perception of temperature stimulus Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processBehavior

Enzyme and pathway databases

ReactomeiR-RNO-375276 Peptide ligand-binding receptors
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-type opioid receptor
Short name:
K-OR-1
Short name:
KOR-1
Gene namesi
Name:Oprk1
Synonyms:Ror-d
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi69426 Oprk1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 57ExtracellularBy similarityAdd BLAST57
Transmembranei58 – 85Helical; Name=1By similarityAdd BLAST28
Topological domaini86 – 95CytoplasmicBy similarity10
Transmembranei96 – 119Helical; Name=2By similarityAdd BLAST24
Topological domaini120 – 132ExtracellularBy similarityAdd BLAST13
Transmembranei133 – 154Helical; Name=3By similarityAdd BLAST22
Topological domaini155 – 173CytoplasmicBy similarityAdd BLAST19
Transmembranei174 – 196Helical; Name=4By similarityAdd BLAST23
Topological domaini197 – 222ExtracellularBy similarityAdd BLAST26
Transmembranei223 – 247Helical; Name=5By similarityAdd BLAST25
Topological domaini248 – 274CytoplasmicBy similarityAdd BLAST27
Transmembranei275 – 296Helical; Name=6By similarityAdd BLAST22
Topological domaini297 – 311ExtracellularBy similarityAdd BLAST15
Transmembranei312 – 333Helical; Name=7By similarityAdd BLAST22
Topological domaini334 – 380CytoplasmicBy similarityAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3614
GuidetoPHARMACOLOGYi318

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699691 – 380Kappa-type opioid receptorAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi39N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi131 ↔ 210PROSITE-ProRule annotation
Lipidationi345S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP34975

PTM databases

iPTMnetiP34975
PhosphoSitePlusiP34975

Expressioni

Gene expression databases

BgeeiENSRNOG00000007647
GenevisibleiP34975 RN

Interactioni

Subunit structurei

Interacts with SLC9A3R1. Interacts with GABARAPL1 (By similarity).By similarity

Protein-protein interaction databases

IntActiP34975, 1 interactor
STRINGi10116.ENSRNOP00000010255

Chemistry databases

BindingDBiP34975

Structurei

3D structure databases

ProteinModelPortaliP34975
SMRiP34975
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118797
HOGENOMiHOG000230486
HOVERGENiHBG106919
InParanoidiP34975
KOiK04214
OMAiVRNTVQD
OrthoDBiEOG091G0HEN
PhylomeDBiP34975
TreeFamiTF315737

Family and domain databases

CDDicd15091 7tmA_Kappa_opioid_R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000452 Kappa_opi_rcpt
IPR001418 Opioid_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00532 KAPPAOPIOIDR
PR00384 OPIOIDR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P34975-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESPIQIFRG EPGPTCAPSA CLLPNSSSWF PNWAESDSNG SVGSEDQQLE
60 70 80 90 100
PAHISPAIPV IITAVYSVVF VVGLVGNSLV MFVIIRYTKM KTATNIYIFN
110 120 130 140 150
LALADALVTT TMPFQSAVYL MNSWPFGDVL CKIVISIDYY NMFTSIFTLT
160 170 180 190 200
MMSVDRYIAV CHPVKALDFR TPLKAKIINI CIWLLASSVG ISAIVLGGTK
210 220 230 240 250
VREDVDVIEC SLQFPDDEYS WWDLFMKICV FVFAFVIPVL IIIVCYTLMI
260 270 280 290 300
LRLKSVRLLS GSREKDRNLR RITKLVLVVV AVFIICWTPI HIFILVEALG
310 320 330 340 350
STSHSTAVLS SYYFCIALGY TNSSLNPVLY AFLDENFKRC FRDFCFPIKM
360 370 380
RMERQSTNRV RNTVQDPASM RDVGGMNKPV
Length:380
Mass (Da):42,688
Last modified:February 1, 1994 - v1
Checksum:i107FEEDB09886F92
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42V → L in BAA04109 (PubMed:8103466).Curated1
Sequence conflicti345C → Y in AAA41496 (PubMed:8240268).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22001 mRNA Translation: AAA41495.1
D16829 mRNA Translation: BAA04109.1
L22536 mRNA Translation: AAA41496.1
U00442 mRNA Translation: AAA18261.1
D16534 mRNA Translation: BAA03971.1
U17995, U17993, U17994 Genomic DNA Translation: AAC53249.1
PIRiS36143
RefSeqiNP_058863.1, NM_017167.3
UniGeneiRn.89571

Genome annotation databases

EnsembliENSRNOT00000010254; ENSRNOP00000010255; ENSRNOG00000007647
GeneIDi29335
KEGGirno:29335
UCSCiRGD:69426 rat

Entry informationi

Entry nameiOPRK_RAT
AccessioniPrimary (citable) accession number: P34975
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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