Kappa-type opioid receptor - Rattus norvegicus (Rat)

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P34975 (OPRK_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 105. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Kappa-type opioid receptor
Short name=K-OR-1
Short name=KOR-1

Gene names

Name:	Oprk1
Synonyms:	Ror-d

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
Subunit structure	Interacts with SLC9A3R1. Interacts with GABARAPL1 By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to virus Inferred from electronic annotation. Source: Compara immune response Inferred from electronic annotation. Source: Compara phospholipase C-activating G-protein coupled receptor signaling pathway Inferred from direct assay PubMed 9572309. Source: UniProtKB
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	dynorphin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 380

380

Kappa-type opioid receptor

PRO_0000069969

Regions

Topological domain

1 – 58

Extracellular Potential

Transmembrane

59 – 85

Helical; Name=1; Potential

Topological domain

86 – 95

Cytoplasmic Potential

Transmembrane

96 – 117

Helical; Name=2; Potential

Topological domain

118 – 132

Extracellular Potential

Transmembrane

133 – 154

Helical; Name=3; Potential

Topological domain

155 – 173

Cytoplasmic Potential

Transmembrane

174 – 196

Helical; Name=4; Potential

Topological domain

197 – 222

Extracellular Potential

Transmembrane

223 – 247

Helical; Name=5; Potential

Topological domain

248 – 275

Cytoplasmic Potential

Transmembrane

276 – 299

Helical; Name=6; Potential

Topological domain

300 – 311

Extracellular Potential

Transmembrane

312 – 333

Helical; Name=7; Potential

Topological domain

334 – 380

Cytoplasmic Potential

Amino acid modifications

Lipidation

345

S-palmitoyl cysteine Potential

Glycosylation

N-linked (GlcNAc...) By similarity

Glycosylation

N-linked (GlcNAc...) By similarity

Disulfide bond

131 ↔ 210

By similarity

Experimental info

Sequence conflict

V → L in BAA04109. Ref.2

Sequence conflict

345

C → Y in AAA41496. Ref.3

Sequences

Sequence

Length

Mass (Da)

Tools

P34975 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 107FEEDB09886F92
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FASTA

380

42,688

        10         20         30         40         50         60 
MESPIQIFRG EPGPTCAPSA CLLPNSSSWF PNWAESDSNG SVGSEDQQLE PAHISPAIPV 

        70         80         90        100        110        120 
IITAVYSVVF VVGLVGNSLV MFVIIRYTKM KTATNIYIFN LALADALVTT TMPFQSAVYL 

       130        140        150        160        170        180 
MNSWPFGDVL CKIVISIDYY NMFTSIFTLT MMSVDRYIAV CHPVKALDFR TPLKAKIINI 

       190        200        210        220        230        240 
CIWLLASSVG ISAIVLGGTK VREDVDVIEC SLQFPDDEYS WWDLFMKICV FVFAFVIPVL 

       250        260        270        280        290        300 
IIIVCYTLMI LRLKSVRLLS GSREKDRNLR RITKLVLVVV AVFIICWTPI HIFILVEALG 

       310        320        330        340        350        360 
STSHSTAVLS SYYFCIALGY TNSSLNPVLY AFLDENFKRC FRDFCFPIKM RMERQSTNRV 

       370        380 
RNTVQDPASM RDVGGMNKPV

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References

[1]	"Molecular cloning of a rat kappa opioid receptor reveals sequence similarities to the mu and delta opioid receptors." Chen Y., Mestek A., Liu J., Yu L. Biochem. J. 295:625-628(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Cloning and expression of a cDNA for the rat kappa-opioid receptor." Minami M., Toya T., Katao Y., Maekawa K., Nakamura S., Onogi T., Kaneko S., Satoh M. FEBS Lett. 329:291-295(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Molecular cloning and expression of a rat kappa opioid receptor." Li S., Zhu J., Chen C., Chen Y.-W., Deriel J.K., Ashby B., Liu-Chen L.-Y. Biochem. J. 295:629-633(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Brain.
[4]	"Cloning and pharmacological characterization of a rat kappa opioid receptor." Meng F., Xie G.-X., Thompson R.C., Mansour A., Goldstein A., Watson S.J., Akil H. Proc. Natl. Acad. Sci. U.S.A. 90:9954-9958(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Brain.
[5]	"cDNA cloning and pharmacological characterization of an opioid receptor with high affinities for kappa-subtype-selective ligands." Nishi M., Takeshima H., Fukuda K., Kato S., Mori K. FEBS Lett. 330:77-80(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Brain.
[6]	"Structure and expression of a rat kappa opioid receptor gene." Yakovlev A.G., Krueger K.E., Faden A.I. J. Biol. Chem. 270:6421-6424(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Sprague-Dawley.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L22001 mRNA. Translation: AAA41495.1. D16829 mRNA. Translation: BAA04109.1. L22536 mRNA. Translation: AAA41496.1. U00442 mRNA. Translation: AAA18261.1. D16534 mRNA. Translation: BAA03971.1. U17995, U17993, U17994 Genomic DNA. Translation: AAC53249.1.
IPI	IPI00199851.
PIR	S36143.
RefSeq	NP_058863.1. NM_017167.2.
UniGene	Rn.89571.
3D structure databases
ProteinModelPortal	P34975.
ModBase	Search...
Protein-protein interaction databases
IntAct	P34975. 1 interaction.
STRING	10116.ENSRNOP00000010255.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P34975.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000010254; ENSRNOP00000010255; ENSRNOG00000007647.
GeneID	29335.
KEGG	rno:29335.
UCSC	RGD:69426. rat.
Organism-specific databases
CTD	4986.
RGD	69426. Oprk1.
Phylogenomic databases
eggNOG	NOG317066.
GeneTree	ENSGT00630000089574.
HOGENOM	HOG000230486.
HOVERGEN	HBG106919.
InParanoid	P34975.
KO	K04214.
OMA	DVDVIEC.
OrthoDB	EOG4GMTXD.
Gene expression databases
Genevestigator	P34975.
GermOnline	ENSRNOG00000007647. Rattus norvegicus.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000452. Kappa_opi_rcpt. IPR001418. Opioid_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00532. KAPPAOPIOIDR. PR00384. OPIOIDR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P34975.
ChEMBL	CHEMBL3614.
NextBio	608812.

Entry information

Entry name

OPRK_RAT

Accession

Primary (citable) accession number: P34975

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	April 3, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents