P34974 (ACTHR_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adrenocorticotropic hormone receptor
Short name=ACTH receptor
Short name=ACTH-R

Alternative name(s):
Adrenocorticotropin receptor
Melanocortin receptor 2
Short name=MC2-R

Gene names

Name:

MC2R

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for ACTH. This receptor is mediated by G proteins which activate adenylate cyclase.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Melanocytes and corticoadrenal tissue.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	corticotropin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 297	297	Adrenocorticotropic hormone receptor		PRO_0000069052
Regions
	Topological domain	1 – 23	23	Extracellular By similarity
	Transmembrane	24 – 49	26	Helical; Name=1; By similarity
	Topological domain	50 – 58	9	Cytoplasmic By similarity
	Transmembrane	59 – 79	21	Helical; Name=2; By similarity
	Topological domain	80 – 104	25	Extracellular By similarity
	Transmembrane	105 – 126	22	Helical; Name=3; By similarity
	Topological domain	127 – 147	21	Cytoplasmic By similarity
	Transmembrane	148 – 168	21	Helical; Name=4; By similarity
	Topological domain	169 – 180	12	Extracellular By similarity
	Transmembrane	181 – 199	19	Helical; Name=5; By similarity
	Topological domain	200 – 217	18	Cytoplasmic By similarity
	Transmembrane	218 – 244	27	Helical; Name=6; By similarity
	Topological domain	245 – 256	12	Extracellular By similarity
	Transmembrane	257 – 278	22	Helical; Name=7; By similarity
	Topological domain	279 – 297	19	Cytoplasmic By similarity
Amino acid modifications
	Lipidation	293	1	S-palmitoyl cysteine Potential
	Glycosylation	12	1	N-linked (GlcNAc...) Potential
	Glycosylation	17	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	145 – 150	6	HRALVI → APCPRH in AAA30355. Ref.1
	Sequence conflict	278	1	F → L in CAA52610. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P34974 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 8B77A8C2E268BB1E	FASTA	297	33,293
	10 20 30 40 50 60 MKHILNLYEN INSTARNNSD CPAVILPEEI FFTVSIVGVL ENLMVLLAVA KNKSLQSPMY 70 80 90 100 110 120 FFICSLAISD MLGSLYKILE NVLIMFKNMG YLEPRGSFES TADDVVDSLF ILSLLGSICS 130 140 150 160 170 180 LSVIAADRYI TIFHALQYHR IMTPHRALVI LTVLWAGCTG SGITIVTFSH HVPTVIAFTA 190 200 210 220 230 240 LFPLMLAFIL CLYVHMFLLA RSHTRRTPSL PKANMRGAVT LTVLLGVFIF CWAPFVLHVL 250 260 270 280 290 LMTFCPADPY CACYMSLFQV NGVLIMCNAI IDPFIYAFRS PELRVAFKKM VICNCYQ

References

[1]	"Molecular genetics of the ACTH and melanocyte-stimulating hormone receptors." Cone R.D., Mountjoy K.G. Trends Endocrinol. Metab. 4:26-31(1993) Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"cDNA cloning and sequence analysis of the bovine adrenocorticotropic hormone (ACTH) receptor." Raikhinstein M., Zohar M., Hanukoglu I. Biochim. Biophys. Acta 1220:329-332(1994) [PubMed: 8305507] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Adrenal cortex.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L23149 mRNA. Translation: AAA30355.1. X74501 mRNA. Translation: CAA52610.1.
IPI	IPI00717263.
PIR	I45849. S42767.
RefSeq	NP_776534.1. NM_174109.2.
UniGene	Bt.3956.
3D structure databases
ProteinModelPortal	P34974.
ModBase	Search...
Protein-protein interaction databases
STRING	P34974.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	P34974.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000014661; ENSBTAP00000014661; ENSBTAG00000011038.
GeneID	281299.
KEGG	bta:281299.
Organism-specific databases
CTD	4158.
Phylogenomic databases
eggNOG	maNOG10653.
GeneTree	ENSGT00600000084156.
HOVERGEN	HBG108148.
InParanoid	P34974.
OMA	ARNNSDC.
OrthoDB	EOG4CNQRP.
PhylomeDB	P34974.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR001168. ACTH_rcpt. IPR017452. GPCR_Rhodpsn_supfam. IPR001671. Melcrt_ACTH_rcpt. [Graphical view]
KO	K04200.
PANTHER	PTHR22750:SF3. ACTH_rcpt. 1 hit.
Pfam	PF00001. 7tm_1. 2 hits. [Graphical view]
PRINTS	PR00520. ACTROPHINR. PR00237. GPCRRHODOPSN. PR00534. MCRFAMILY.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACTHR_BOVIN

Accession

Primary (citable) accession number: P34974

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	November 16, 2011
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program