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Protein

Adrenocorticotropic hormone receptor

Gene

MC2R

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for corticotropin (ACTH). This receptor is mediated by G proteins which activate adenylate cyclase (cAMP).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-375276. Peptide ligand-binding receptors.
R-BTA-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Adrenocorticotropic hormone receptor
Short name:
ACTH receptor
Short name:
ACTH-R
Alternative name(s):
Adrenocorticotropin receptor
Melanocortin receptor 2
Short name:
MC2-R
Gene namesi
Name:MC2R
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 24

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularBy similarityAdd
BLAST
Transmembranei24 – 4926Helical; Name=1By similarityAdd
BLAST
Topological domaini50 – 589CytoplasmicBy similarity
Transmembranei59 – 7921Helical; Name=2By similarityAdd
BLAST
Topological domaini80 – 10425ExtracellularBy similarityAdd
BLAST
Transmembranei105 – 12622Helical; Name=3By similarityAdd
BLAST
Topological domaini127 – 14721CytoplasmicBy similarityAdd
BLAST
Transmembranei148 – 16821Helical; Name=4By similarityAdd
BLAST
Topological domaini169 – 18012ExtracellularBy similarityAdd
BLAST
Transmembranei181 – 19919Helical; Name=5By similarityAdd
BLAST
Topological domaini200 – 21718CytoplasmicBy similarityAdd
BLAST
Transmembranei218 – 24427Helical; Name=6By similarityAdd
BLAST
Topological domaini245 – 25612ExtracellularBy similarityAdd
BLAST
Transmembranei257 – 27822Helical; Name=7By similarityAdd
BLAST
Topological domaini279 – 29719CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Adrenocorticotropic hormone receptorPRO_0000069052Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi12 – 121N-linked (GlcNAc...)Sequence analysis
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence analysis
Lipidationi293 – 2931S-palmitoyl cysteineSequence analysis

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP34974.
PRIDEiP34974.

Expressioni

Tissue specificityi

Melanocytes and corticoadrenal tissue.

Interactioni

Subunit structurei

Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH) (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014661.

Structurei

3D structure databases

ProteinModelPortaliP34974.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00770000120529.
HOGENOMiHOG000246927.
HOVERGENiHBG108148.
InParanoidiP34974.
KOiK04200.
OMAiAVIWTFC.
OrthoDBiEOG091G0BVW.
TreeFamiTF332646.

Family and domain databases

InterProiIPR001168. ACTH_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF3. PTHR22750:SF3. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00520. ACTROPHINR.
PR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34974-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHILNLYEN INSTARNNSD CPAVILPEEI FFTVSIVGVL ENLMVLLAVA
60 70 80 90 100
KNKSLQSPMY FFICSLAISD MLGSLYKILE NVLIMFKNMG YLEPRGSFES
110 120 130 140 150
TADDVVDSLF ILSLLGSICS LSVIAADRYI TIFHALQYHR IMTPHRALVI
160 170 180 190 200
LTVLWAGCTG SGITIVTFSH HVPTVIAFTA LFPLMLAFIL CLYVHMFLLA
210 220 230 240 250
RSHTRRTPSL PKANMRGAVT LTVLLGVFIF CWAPFVLHVL LMTFCPADPY
260 270 280 290
CACYMSLFQV NGVLIMCNAI IDPFIYAFRS PELRVAFKKM VICNCYQ
Length:297
Mass (Da):33,293
Last modified:February 1, 1994 - v1
Checksum:i8B77A8C2E268BB1E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti145 – 1506HRALVI → APCPRH in AAA30355 (Ref. 1) Curated
Sequence conflicti278 – 2781F → L in CAA52610 (PubMed:8305507).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23149 mRNA. Translation: AAA30355.1.
X74501 mRNA. Translation: CAA52610.1.
PIRiI45849.
S42767.
RefSeqiNP_776534.1. NM_174109.2.
UniGeneiBt.3956.

Genome annotation databases

EnsembliENSBTAT00000014661; ENSBTAP00000014661; ENSBTAG00000011038.
GeneIDi281299.
KEGGibta:281299.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23149 mRNA. Translation: AAA30355.1.
X74501 mRNA. Translation: CAA52610.1.
PIRiI45849.
S42767.
RefSeqiNP_776534.1. NM_174109.2.
UniGeneiBt.3956.

3D structure databases

ProteinModelPortaliP34974.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014661.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP34974.
PRIDEiP34974.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000014661; ENSBTAP00000014661; ENSBTAG00000011038.
GeneIDi281299.
KEGGibta:281299.

Organism-specific databases

CTDi4158.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00770000120529.
HOGENOMiHOG000246927.
HOVERGENiHBG108148.
InParanoidiP34974.
KOiK04200.
OMAiAVIWTFC.
OrthoDBiEOG091G0BVW.
TreeFamiTF332646.

Enzyme and pathway databases

ReactomeiR-BTA-375276. Peptide ligand-binding receptors.
R-BTA-418555. G alpha (s) signalling events.

Family and domain databases

InterProiIPR001168. ACTH_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF3. PTHR22750:SF3. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00520. ACTROPHINR.
PR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACTHR_BOVIN
AccessioniPrimary (citable) accession number: P34974
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.