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Protein

Adrenocorticotropic hormone receptor

Gene

MC2R

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for corticotropin (ACTH). This receptor is mediated by G proteins which activate adenylate cyclase (cAMP).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-375276 Peptide ligand-binding receptors
R-BTA-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Adrenocorticotropic hormone receptor
Short name:
ACTH receptor
Short name:
ACTH-R
Alternative name(s):
Adrenocorticotropin receptor
Melanocortin receptor 2
Short name:
MC2-R
Gene namesi
Name:MC2R
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 24

Organism-specific databases

VGNCiVGNC:31293 MC2R

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularBy similarityAdd BLAST23
Transmembranei24 – 49Helical; Name=1By similarityAdd BLAST26
Topological domaini50 – 58CytoplasmicBy similarity9
Transmembranei59 – 79Helical; Name=2By similarityAdd BLAST21
Topological domaini80 – 104ExtracellularBy similarityAdd BLAST25
Transmembranei105 – 126Helical; Name=3By similarityAdd BLAST22
Topological domaini127 – 147CytoplasmicBy similarityAdd BLAST21
Transmembranei148 – 168Helical; Name=4By similarityAdd BLAST21
Topological domaini169 – 180ExtracellularBy similarityAdd BLAST12
Transmembranei181 – 199Helical; Name=5By similarityAdd BLAST19
Topological domaini200 – 217CytoplasmicBy similarityAdd BLAST18
Transmembranei218 – 244Helical; Name=6By similarityAdd BLAST27
Topological domaini245 – 256ExtracellularBy similarityAdd BLAST12
Transmembranei257 – 278Helical; Name=7By similarityAdd BLAST22
Topological domaini279 – 297CytoplasmicBy similarityAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690521 – 297Adrenocorticotropic hormone receptorAdd BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi17N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi293S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP34974
PRIDEiP34974

Expressioni

Tissue specificityi

Melanocytes and corticoadrenal tissue.

Interactioni

Subunit structurei

Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH) (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014661

Structurei

3D structure databases

ProteinModelPortaliP34974
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00770000120529
HOGENOMiHOG000246927
HOVERGENiHBG108148
InParanoidiP34974
KOiK04200
OMAiFHALQYH
OrthoDBiEOG091G0BVW
TreeFamiTF332646

Family and domain databases

InterProiView protein in InterPro
IPR001168 ACTH_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001671 Melcrt_ACTH_rcpt
PANTHERiPTHR22750:SF3 PTHR22750:SF3, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00520 ACTROPHINR
PR00237 GPCRRHODOPSN
PR00534 MCRFAMILY
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P34974-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHILNLYEN INSTARNNSD CPAVILPEEI FFTVSIVGVL ENLMVLLAVA
60 70 80 90 100
KNKSLQSPMY FFICSLAISD MLGSLYKILE NVLIMFKNMG YLEPRGSFES
110 120 130 140 150
TADDVVDSLF ILSLLGSICS LSVIAADRYI TIFHALQYHR IMTPHRALVI
160 170 180 190 200
LTVLWAGCTG SGITIVTFSH HVPTVIAFTA LFPLMLAFIL CLYVHMFLLA
210 220 230 240 250
RSHTRRTPSL PKANMRGAVT LTVLLGVFIF CWAPFVLHVL LMTFCPADPY
260 270 280 290
CACYMSLFQV NGVLIMCNAI IDPFIYAFRS PELRVAFKKM VICNCYQ
Length:297
Mass (Da):33,293
Last modified:February 1, 1994 - v1
Checksum:i8B77A8C2E268BB1E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti145 – 150HRALVI → APCPRH in AAA30355 (Ref. 1) Curated6
Sequence conflicti278F → L in CAA52610 (PubMed:8305507).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23149 mRNA Translation: AAA30355.1
X74501 mRNA Translation: CAA52610.1
PIRiI45849
S42767
RefSeqiNP_776534.1, NM_174109.2
UniGeneiBt.3956

Genome annotation databases

EnsembliENSBTAT00000014661; ENSBTAP00000014661; ENSBTAG00000011038
GeneIDi281299
KEGGibta:281299

Similar proteinsi

Entry informationi

Entry nameiACTHR_BOVIN
AccessioniPrimary (citable) accession number: P34974
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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