Reviewed,
UniProtKB/Swiss-Prot P34972 (CNR2_HUMAN)
Last modified
November 4, 2008.
Version 76.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cannabinoid receptor 2 Short name=CB-2 Short name=CB2 Alternative name(s): CX5 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 360 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Involved in cannabinoid-induced CNS effects through G-protein mediated inhibition of adenylate cyclase. Could be a receptor for anandamide. |
| Subcellular location | |
| Tissue specificity | Not found in brain. Found in spleen. |
| Sequence similarities | Belongs to the G-protein coupled receptor 1 family. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Transmembrane |
| Molecular function | G-protein coupled receptor Receptor Transducer |
| PTM | Glycoprotein |
Gene Ontology (GO) | |
| Biological process | G-protein signaling, coupled to cyclic nucleotide second messenger Traceable author statement. Source: ProtInc behaviorTraceable author statement. Source: ProtInc immune responseTraceable author statement. Source: ProtInc |
| Cellular component | integral to plasma membrane Traceable author statement. Source: ProtInc |
| Molecular function | cannabinoid receptor activity Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 360 | 360 | Cannabinoid receptor 2 | PRO_0000069323 | |||||
Regions | |||||||||
| Topological domain | 1 – 33 | 33 | Extracellular Potential | ||||||
| Transmembrane | 34 – 59 | 26 | 1 Potential | ||||||
| Topological domain | 60 – 71 | 12 | Cytoplasmic Potential | ||||||
| Transmembrane | 72 – 92 | 21 | 2 Potential | ||||||
| Topological domain | 93 – 104 | 12 | Extracellular Potential | ||||||
| Transmembrane | 105 – 129 | 25 | 3 Potential | ||||||
| Topological domain | 130 – 149 | 20 | Cytoplasmic Potential | ||||||
| Transmembrane | 150 – 172 | 23 | 4 Potential | ||||||
| Topological domain | 173 – 188 | 16 | Extracellular Potential | ||||||
| Transmembrane | 189 – 214 | 26 | 5 Potential | ||||||
| Topological domain | 215 – 246 | 32 | Cytoplasmic Potential | ||||||
| Transmembrane | 247 – 267 | 21 | 6 Potential | ||||||
| Topological domain | 268 – 279 | 12 | Extracellular Potential | ||||||
| Transmembrane | 280 – 301 | 22 | 7 Potential | ||||||
| Topological domain | 302 – 360 | 59 | Cytoplasmic Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 11 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Natural variant | 316 | 1 | H → Y: dbSNP rs2229579. | VAR_029209 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular characterization of a peripheral receptor for cannabinoids." Munro S., Thomas K.L., Abu-Shaar M. Nature 365:61-65(1993) [PubMed: 7689702] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The mRNA encoding the human cannabinoid CB2 receptor is expressed in embryonic kidney HEK293 cells." Bruss M., Bonisch H. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Cannabinoid receptors and their genes." Bruss M., Bonisch H. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Blood. |
| [4] | "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Warren C.N., Aronstam R.S., Sharma S.V. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X74328 mRNA. Translation: CAA52376.1. AJ430063 mRNA. Translation: CAD22548.1. AJ430064 Genomic DNA. Translation: CAD22549.1. AY242132 Genomic DNA. Translation: AAO92299.1. | |
| PIR | S36750. |
| RefSeq | NP_001832.1. |
| UniGene | Hs.73037 |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| GPCRDB | Search... |
PTM databases | |
| PhosphoSite | P34972. |
Genome annotation databases | |
| Ensembl | ENSG00000188822. Homo sapiens. [Contig view] |
| GeneID | 1269. |
| KEGG | hsa:1269. |
Organism-specific databases | |
| H-InvDB | HIX0028631. |
| HGNC | HGNC:2160. CNR2. |
| HPA | CAB009719. |
| MIM | 605051. gene. |
| PharmGKB | PA26682. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | P34972. |
| HOVERGEN | P34972. |
Gene expression databases | |
| ArrayExpress | P34972. |
| CleanEx | HS_CNR2. |
| GermOnline | ENSG00000188822. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001551. Canbinoid_rcpt_2. IPR002230. Cnbnoid_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view] |
| PANTHER | PTHR22750:SF11. Canbinoid_rcpt_2. 1 hit. |
| Pfam | PF00001. 7tm_1. 1 hit. [Graphical view] |
| PRINTS | PR00523. CANABINOID2R. PR00362. CANNABINOIDR. PR00237. GPCRRHODOPSN. |
| PROSITE | PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| BindingDB | P34972. |
| DrugBank | DB00486. Nabilone. |
| NextBio | 5139. |
| SOURCE | Search... |
Entry information
| Entry name | CNR2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P34972 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| 7-transmembrane G-linked receptors List of 7-transmembrane G-linked receptor entries |
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


