Reviewed, UniProtKB/Swiss-Prot P34972 (CNR2_HUMAN)

Names and origin

Protein names

Recommended name:
    Cannabinoid receptor 2
      Short name=CB-2
      Short name=CB2
Alternative name(s):
    CX5

Gene names

Name:

CNR2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in cannabinoid-induced CNS effects through G-protein mediated inhibition of adenylate cyclase. Could be a receptor for anandamide.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Not found in brain. Found in spleen.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	G-protein signaling, coupled to cyclic nucleotide second messenger Traceable author statement. Source: ProtInc behavior Traceable author statement. Source: ProtInc immune response Traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc
Molecular function	cannabinoid receptor activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 360	360	Cannabinoid receptor 2		PRO_0000069323
Regions
	Topological domain	1 – 33	33	Extracellular Potential
	Transmembrane	34 – 59	26	1 Potential
	Topological domain	60 – 71	12	Cytoplasmic Potential
	Transmembrane	72 – 92	21	2 Potential
	Topological domain	93 – 104	12	Extracellular Potential
	Transmembrane	105 – 129	25	3 Potential
	Topological domain	130 – 149	20	Cytoplasmic Potential
	Transmembrane	150 – 172	23	4 Potential
	Topological domain	173 – 188	16	Extracellular Potential
	Transmembrane	189 – 214	26	5 Potential
	Topological domain	215 – 246	32	Cytoplasmic Potential
	Transmembrane	247 – 267	21	6 Potential
	Topological domain	268 – 279	12	Extracellular Potential
	Transmembrane	280 – 301	22	7 Potential
	Topological domain	302 – 360	59	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	11	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	316	1	H → Y: dbSNP rs2229579.		VAR_029209

Sequences

	Sequence		Length	Mass (Da)
	P34972-1 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: A7ECF68C16E7514B	FASTA	360	39,681
	10 20 30 40 50 60 MEECWVTEIA NGSKDGLDSN PMKDYMILSG PQKTAVAVLC TLLGLLSALE NVAVLYLILS 70 80 90 100 110 120 SHQLRRKPSY LFIGSLAGAD FLASVVFACS FVNFHVFHGV DSKAVFLLKI GSVTMTFTAS 130 140 150 160 170 180 VGSLLLTAID RYLCLRYPPS YKALLTRGRA LVTLGIMWVL SALVSYLPLM GWTCCPRPCS 190 200 210 220 230 240 ELFPLIPNDY LLSWLLFIAF LFSGIIYTYG HVLWKAHQHV ASLSGHQDRQ VPGMARMRLD 250 260 270 280 290 300 VRLAKTLGLV LAVLLICWFP VLALMAHSLA TTLSDQVKKA FAFCSMLCLI NSMVNPVIYA 310 320 330 340 350 360 LRSGEIRSSA HHCLAHWKKC VRGLGSEAKE EAPRSSVTET EADGKITPWP DSRDLDLSDC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of a peripheral receptor for cannabinoids." Munro S., Thomas K.L., Abu-Shaar M. Nature 365:61-65(1993) [PubMed: 7689702] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The mRNA encoding the human cannabinoid CB2 receptor is expressed in embryonic kidney HEK293 cells." Bruss M., Bonisch H. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cannabinoid receptors and their genes." Bruss M., Bonisch H. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Blood.
[4]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Warren C.N., Aronstam R.S., Sharma S.V. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X74328 mRNA. Translation: CAA52376.1. AJ430063 mRNA. Translation: CAD22548.1. AJ430064 Genomic DNA. Translation: CAD22549.1. AY242132 Genomic DNA. Translation: AAO92299.1.
PIR	S36750.
RefSeq	NP_001832.1.
UniGene	Hs.73037
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P34972.
Genome annotation databases
Ensembl	ENSG00000188822. Homo sapiens. [Contig view]
GeneID	1269.
KEGG	hsa:1269.
Organism-specific databases
H-InvDB	HIX0028631.
HGNC	HGNC:2160. CNR2.
HPA	CAB009719.
MIM	605051. gene.
PharmGKB	PA26682.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P34972.
HOVERGEN	P34972.
Gene expression databases
ArrayExpress	P34972.
CleanEx	HS_CNR2.
GermOnline	ENSG00000188822. Homo sapiens.
Family and domain databases
InterPro	IPR001551. Canbinoid_rcpt_2. IPR002230. Cnbnoid_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
PANTHER	PTHR22750:SF11. Canbinoid_rcpt_2. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00523. CANABINOID2R. PR00362. CANNABINOIDR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
BindingDB	P34972.
DrugBank	DB00486. Nabilone.
NextBio	5139.
SOURCE	Search...

Entry information

Entry name

CNR2_HUMAN

Accession

Primary (citable) accession number: P34972

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	November 4, 2008
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)