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P34972 (CNR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cannabinoid receptor 2

Short name=CB-2
Short name=CB2
Short name=hCB2
Alternative name(s):
CX5
Gene names
Name:CNR2
Synonyms:CB2A, CB2B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. Ref.11 Ref.15 Ref.16 Ref.20

Subcellular location

Cell membrane; Multi-pass membrane protein. Cell projectiondendrite By similarity. Perikaryon By similarity. Note: Localizes to apical dendrite of pyramidal neurons By similarity. Ref.10 Ref.15

Tissue specificity

Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. Ref.18 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2Ais observed predominantly in testis with some expression in brain, while isoform CB2Bis predominant in spleen and leukocytes. Ref.2 Ref.9 Ref.13 Ref.17 Ref.18 Ref.19 Ref.20

Post-translational modification

Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor. Ref.10

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Biological processInflammatory response
   Cellular componentCell membrane
Cell projection
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
Phosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

Traceable author statement PubMed 8679694. Source: ProtInc

immune response

Traceable author statement Ref.9. Source: ProtInc

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of action potential

Inferred from electronic annotation. Source: Ensembl

negative regulation of inflammatory response

Inferred from electronic annotation. Source: Ensembl

negative regulation of mast cell activation

Inferred from electronic annotation. Source: Ensembl

negative regulation of nitric-oxide synthase activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of synaptic transmission, GABAergic

Inferred from electronic annotation. Source: Ensembl

response to amphetamine

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentdendrite

Inferred from electronic annotation. Source: UniProtKB-SubCell

extrinsic component of cytoplasmic side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Traceable author statement PubMed 8679694. Source: ProtInc

perikaryon

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functioncannabinoid receptor activity

Traceable author statement PubMed 8679694. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 360360Cannabinoid receptor 2
PRO_0000069323

Regions

Topological domain1 – 3333Extracellular Potential
Transmembrane34 – 5926Helical; Name=1; Potential
Topological domain60 – 7112Cytoplasmic Potential
Transmembrane72 – 9221Helical; Name=2; Potential
Topological domain93 – 10412Extracellular Potential
Transmembrane105 – 12925Helical; Name=3; Potential
Topological domain130 – 14920Cytoplasmic Potential
Transmembrane150 – 17223Helical; Name=4; Potential
Topological domain173 – 18816Extracellular Potential
Transmembrane189 – 21426Helical; Name=5; Potential
Topological domain215 – 24632Cytoplasmic Potential
Transmembrane247 – 26721Helical; Name=6; Potential
Topological domain268 – 27912Extracellular Potential
Transmembrane280 – 30122Helical; Name=7; Potential
Topological domain302 – 36059Cytoplasmic Potential

Amino acid modifications

Modified residue3351Phosphoserine By similarity
Modified residue3361Phosphoserine By similarity
Modified residue3381Phosphothreonine By similarity
Modified residue3521Phosphoserine Ref.10
Glycosylation111N-linked (GlcNAc...) Potential

Natural variations

Natural variant631Q → R High incidence in Japanese depressed subjects. Ref.8 Ref.22
Corresponds to variant rs2501432 [ dbSNP | Ensembl ].
VAR_054310
Natural variant3161H → Y. Ref.5 Ref.8 Ref.22
Corresponds to variant rs2229579 [ dbSNP | Ensembl ].
VAR_029209

Experimental info

Mutagenesis1091K → A: No effect on agonist binding. Affects cannabinoid agonist binding; when associated with G-112. Ref.11
Mutagenesis1091K → R: No effect on agonist binding. Ref.11
Mutagenesis1121S → G: Affects cannabinoid agonist binding; when associated with A-109. Ref.11
Mutagenesis1301D → A: Loss of ligand binding. Alters agonist-induced inhibitory effect on adenylate cyclase. Ref.15
Mutagenesis1311R → A: No effect on ligand binding. Alters agonist-induced inhibitory effect on adenylate cyclase. Ref.15
Mutagenesis2011L → P: Abolishes ligand binding and agonist-induced inhibitory effect on adenylate cyclase. Ref.14
Mutagenesis2071Y → A: Abolishes agonist-induced inhibitory effect on adenylate cyclase. No effect on ligand binding. Ref.14
Mutagenesis2441A → E: Loss of ligand binding. Alters agonist-induced inhibitory effect on adenylate cyclase. Ref.15
Sequence conflict1731T → A in AAH95545. Ref.8
Sequence conflict3071R → H in AAH69722. Ref.8

Secondary structure

........ 360
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P34972 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: A7ECF68C16E7514B

FASTA36039,681
        10         20         30         40         50         60 
MEECWVTEIA NGSKDGLDSN PMKDYMILSG PQKTAVAVLC TLLGLLSALE NVAVLYLILS 

        70         80         90        100        110        120 
SHQLRRKPSY LFIGSLAGAD FLASVVFACS FVNFHVFHGV DSKAVFLLKI GSVTMTFTAS 

       130        140        150        160        170        180 
VGSLLLTAID RYLCLRYPPS YKALLTRGRA LVTLGIMWVL SALVSYLPLM GWTCCPRPCS 

       190        200        210        220        230        240 
ELFPLIPNDY LLSWLLFIAF LFSGIIYTYG HVLWKAHQHV ASLSGHQDRQ VPGMARMRLD 

       250        260        270        280        290        300 
VRLAKTLGLV LAVLLICWFP VLALMAHSLA TTLSDQVKKA FAFCSMLCLI NSMVNPVIYA 

       310        320        330        340        350        360 
LRSGEIRSSA HHCLAHWKKC VRGLGSEAKE EAPRSSVTET EADGKITPWP DSRDLDLSDC 

« Hide

References

« Hide 'large scale' references
[1]"Molecular characterization of a peripheral receptor for cannabinoids."
Munro S., Thomas K.L., Abu-Shaar M.
Nature 365:61-65(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands."
Liu Q.-R., Pan C.H., Hishimoto A., Li C.Y., Xi Z.X., Llorente-Berzal A., Viveros M.P., Ishiguro H., Arinami T., Onaivi E.S., Uhl G.R.
Genes Brain Behav. 8:519-530(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Spleen.
[3]"Cannabinoid receptors and their genes."
Bruess M., Boenisch H.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Tissue: Blood.
[4]"Isolation of complete coding sequence for cannabinoid receptor 2 (CNR2)."
Warren C.N., Aronstam R.S., Sharma S.V.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Amplification and cloning of human cannabinoid receptor 2 gene from Asiatic origin."
Saravanan T., Chugh A., Kant R.
Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT TYR-316.
Tissue: Blood.
[6]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-63 AND TYR-316.
Tissue: Brain.
[9]"Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations."
Galiegue S., Mary S., Marchand J., Dussossoy D., Carriere D., Carayon P., Bouaboula M., Shire D., Le Fur G., Casellas P.
Eur. J. Biochem. 232:54-61(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[10]"Regulation of peripheral cannabinoid receptor CB2 phosphorylation by the inverse agonist SR 144528. Implications for receptor biological responses."
Bouaboula M., Dussossoy D., Casellas P.
J. Biol. Chem. 274:20397-20405(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT SER-352, SUBCELLULAR LOCATION.
[11]"Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity."
Tao Q., McAllister S.D., Andreassi J., Nowell K.W., Cabral G.A., Hurst D.P., Bachtel K., Ekman M.C., Reggio P.H., Abood M.E.
Mol. Pharmacol. 55:605-613(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, MUTAGENESIS OF LYS-109 AND SER-112.
[12]"Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells."
Sugiura T., Kondo S., Kishimoto S., Miyashita T., Nakane S., Kodaka T., Suhara Y., Takayama H., Waku K.
J. Biol. Chem. 275:605-612(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION OF 2-ARACHIDONOYLGLYCEROL AS AN ENDOGENOUS LIGAND.
[13]"Presence and regulation of the endocannabinoid system in human dendritic cells."
Matias I., Pochard P., Orlando P., Salzet M., Pestel J., Di Marzo V.
Eur. J. Biochem. 269:3771-3778(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[14]"Absence of a conserved proline and presence of a conserved tyrosine in the CB2 cannabinoid receptor are crucial for its function."
Song Z.H., Feng W.
FEBS Lett. 531:290-294(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: MUTAGENESIS OF LEU-201 AND TYR-207.
[15]"Effects of D3.49A, R3.50A, and A6.34E mutations on ligand binding and activation of the cannabinoid-2 (CB2) receptor."
Feng W., Song Z.H.
Biochem. Pharmacol. 65:1077-1085(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF ASP-130; ARG-131 AND ALA-244.
[16]"2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism."
Kishimoto S., Gokoh M., Oka S., Muramatsu M., Kajiwara T., Waku K., Sugiura T.
J. Biol. Chem. 278:24469-24475(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[17]"Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors."
Casanova M.L., Blazquez C., Martinez-Palacio J., Villanueva C., Fernandez-Acenero M.J., Huffman J.W., Jorcano J.L., Guzman M.
J. Clin. Invest. 111:43-50(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[18]"Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains."
Benito C., Nunez E., Tolon R.M., Carrier E.J., Rabano A., Hillard C.J., Romero J.
J. Neurosci. 23:11136-11141(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[19]"Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study."
Nunez E., Benito C., Pazos M.R., Barbachano A., Fajardo O., Gonzalez S., Tolon R.M., Romero J.
Synapse 53:208-213(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[20]"Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons."
Anand U., Otto W.R., Sanchez-Herrera D., Facer P., Yiangou Y., Korchev Y., Birch R., Benham C., Bountra C., Chessell I.P., Anand P.
Pain 138:667-680(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
[21]"Structural biology of human cannabinoid receptor-2 helix 6 in membrane-mimetic environments."
Tiburu E.K., Tyukhtenko S., Deshmukh L., Vinogradova O., Janero D.R., Makriyannis A.
Biochem. Biophys. Res. Commun. 384:243-248(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 240-272.
[22]"Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects."
Onaivi E.S., Ishiguro H., Gong J.-P., Patel S., Meozzi P.A., Myers L., Perchuk A., Mora Z., Tagliaferro P.A., Gardner E., Brusco A., Akinshola B.E., Hope B., Lujilde J., Inada T., Iwasaki S., Macharia D., Teasenfitz L., Arinami T., Uhl G.R.
PLoS ONE 3:E1640-E1640(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ARG-63 AND TYR-316.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X74328 mRNA. Translation: CAA52376.1.
EU517121 mRNA. Translation: ACD31539.1.
AJ430063 mRNA. Translation: CAD22548.1.
AJ430064 Genomic DNA. Translation: CAD22549.1.
AY242132 Genomic DNA. Translation: AAO92299.1.
AM156854 mRNA. Translation: CAJ42137.1.
AM156855 mRNA. Translation: CAJ42138.1.
AM156856 mRNA. Translation: CAJ42139.1.
AL590609 Genomic DNA. Translation: CAI14799.1.
CH471134 Genomic DNA. Translation: EAW95099.1.
BC069722 mRNA. Translation: AAH69722.1.
BC074767 mRNA. Translation: AAH74767.1.
BC095545 mRNA. Translation: AAH95545.1.
CCDSCCDS245.1.
PIRS36750.
RefSeqNP_001832.1. NM_001841.2.
XP_005245793.1. XM_005245736.2.
XP_005245794.1. XM_005245737.2.
XP_005245795.1. XM_005245738.2.
UniGeneHs.73037.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2KI9NMR-A240-272[»]
ProteinModelPortalP34972.
SMRP34972. Positions 28-317.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP34972. 2 interactions.
STRING9606.ENSP00000363596.

Chemistry

BindingDBP34972.
ChEMBLCHEMBL253.
DrugBankDB00486. Nabilone.
GuidetoPHARMACOLOGY57.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP34972.

Polymorphism databases

DMDM461697.

Proteomic databases

MaxQBP34972.
PaxDbP34972.
PRIDEP34972.

Protocols and materials databases

DNASU1269.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000374472; ENSP00000363596; ENSG00000188822.
ENST00000536471; ENSP00000442830; ENSG00000188822.
GeneID1269.
KEGGhsa:1269.
UCSCuc001bif.3. human.

Organism-specific databases

CTD1269.
GeneCardsGC01M024197.
H-InvDBHIX0160038.
HGNCHGNC:2160. CNR2.
HPACAB009719.
HPA028718.
MIM605051. gene.
neXtProtNX_P34972.
PharmGKBPA26682.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG276403.
HOGENOMHOG000049272.
HOVERGENHBG051045.
InParanoidP34972.
KOK04278.
OMAVNFHVFH.
OrthoDBEOG7CK36K.
PhylomeDBP34972.
TreeFamTF330052.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP34972.
BgeeP34972.
CleanExHS_CNR2.
GenevestigatorP34972.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR001551. Canbinoid_rcpt_2.
IPR002230. Cnbnoid_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR22750:SF11. PTHR22750:SF11. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00523. CANABINOID2R.
PR00362. CANNABINOIDR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP34972.
GeneWikiCannabinoid_receptor_type_2.
GenomeRNAi1269.
NextBio5139.
PROP34972.
SOURCESearch...

Entry information

Entry nameCNR2_HUMAN
AccessionPrimary (citable) accession number: P34972
Secondary accession number(s): C6ES44 expand/collapse secondary AC list , Q4VBK8, Q5JRH7, Q6B0G7, Q6NSY0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 9, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries