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P34972

- CNR2_HUMAN

UniProt

P34972 - CNR2_HUMAN

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Protein
Cannabinoid receptor 2
Gene
CNR2, CB2A, CB2B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.4 Publications

GO - Molecular functioni

  1. cannabinoid receptor activity Source: ProtInc

GO - Biological processi

  1. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  2. immune response Source: ProtInc
  3. inflammatory response Source: UniProtKB-KW
  4. negative regulation of action potential Source: Ensembl
  5. negative regulation of inflammatory response Source: Ensembl
  6. negative regulation of mast cell activation Source: Ensembl
  7. negative regulation of nitric-oxide synthase activity Source: Ensembl
  8. negative regulation of synaptic transmission, GABAergic Source: Ensembl
  9. response to amphetamine Source: Ensembl
  10. response to lipopolysaccharide Source: Ensembl
  11. sensory perception of pain Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_14828. Class A/1 (Rhodopsin-like receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Cannabinoid receptor 2
Short name:
CB-2
Short name:
CB2
Short name:
hCB2
Alternative name(s):
CX5
Gene namesi
Name:CNR2
Synonyms:CB2A, CB2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:2160. CNR2.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Cell projectiondendrite By similarity. Perikaryon By similarity
Note: Localizes to apical dendrite of pyramidal neurons By similarity.2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333Extracellular Reviewed prediction
Add
BLAST
Transmembranei34 – 5926Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini60 – 7112Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei72 – 9221Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini93 – 10412Extracellular Reviewed prediction
Add
BLAST
Transmembranei105 – 12925Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini130 – 14920Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei150 – 17223Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini173 – 18816Extracellular Reviewed prediction
Add
BLAST
Transmembranei189 – 21426Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini215 – 24632Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei247 – 26721Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini268 – 27912Extracellular Reviewed prediction
Add
BLAST
Transmembranei280 – 30122Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini302 – 36059Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. dendrite Source: UniProtKB-SubCell
  2. extrinsic component of cytoplasmic side of plasma membrane Source: Ensembl
  3. integral component of plasma membrane Source: ProtInc
  4. perikaryon Source: UniProtKB-SubCell
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi109 – 1091K → A: No effect on agonist binding. Affects cannabinoid agonist binding; when associated with G-112. 1 Publication
Mutagenesisi109 – 1091K → R: No effect on agonist binding. 1 Publication
Mutagenesisi112 – 1121S → G: Affects cannabinoid agonist binding; when associated with A-109. 1 Publication
Mutagenesisi130 – 1301D → A: Loss of ligand binding. Alters agonist-induced inhibitory effect on adenylate cyclase. 1 Publication
Mutagenesisi131 – 1311R → A: No effect on ligand binding. Alters agonist-induced inhibitory effect on adenylate cyclase. 1 Publication
Mutagenesisi201 – 2011L → P: Abolishes ligand binding and agonist-induced inhibitory effect on adenylate cyclase. 1 Publication
Mutagenesisi207 – 2071Y → A: Abolishes agonist-induced inhibitory effect on adenylate cyclase. No effect on ligand binding. 1 Publication
Mutagenesisi244 – 2441A → E: Loss of ligand binding. Alters agonist-induced inhibitory effect on adenylate cyclase. 1 Publication

Organism-specific databases

PharmGKBiPA26682.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360Cannabinoid receptor 2
PRO_0000069323Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi11 – 111N-linked (GlcNAc...) Reviewed prediction
Modified residuei335 – 3351Phosphoserine By similarity
Modified residuei336 – 3361Phosphoserine By similarity
Modified residuei338 – 3381Phosphothreonine By similarity
Modified residuei352 – 3521Phosphoserine1 Publication

Post-translational modificationi

Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP34972.
PaxDbiP34972.
PRIDEiP34972.

PTM databases

PhosphoSiteiP34972.

Expressioni

Tissue specificityi

Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. 1 Publication could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes.7 Publications

Gene expression databases

ArrayExpressiP34972.
BgeeiP34972.
CleanExiHS_CNR2.
GenevestigatoriP34972.

Organism-specific databases

HPAiCAB009719.
HPA028718.

Interactioni

Protein-protein interaction databases

IntActiP34972. 2 interactions.
STRINGi9606.ENSP00000363596.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi242 – 2454
Helixi246 – 2549
Turni255 – 2573
Beta strandi258 – 2603
Helixi261 – 2655
Turni266 – 2694

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KI9NMR-A240-272[»]
ProteinModelPortaliP34972.
SMRiP34972. Positions 28-317.

Miscellaneous databases

EvolutionaryTraceiP34972.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG276403.
HOGENOMiHOG000049272.
HOVERGENiHBG051045.
InParanoidiP34972.
KOiK04278.
OMAiVNFHVFH.
OrthoDBiEOG7CK36K.
PhylomeDBiP34972.
TreeFamiTF330052.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001551. Canbinoid_rcpt_2.
IPR002230. Cnbnoid_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR22750:SF11. PTHR22750:SF11. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00523. CANABINOID2R.
PR00362. CANNABINOIDR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34972-1 [UniParc]FASTAAdd to Basket

« Hide

MEECWVTEIA NGSKDGLDSN PMKDYMILSG PQKTAVAVLC TLLGLLSALE    50
NVAVLYLILS SHQLRRKPSY LFIGSLAGAD FLASVVFACS FVNFHVFHGV 100
DSKAVFLLKI GSVTMTFTAS VGSLLLTAID RYLCLRYPPS YKALLTRGRA 150
LVTLGIMWVL SALVSYLPLM GWTCCPRPCS ELFPLIPNDY LLSWLLFIAF 200
LFSGIIYTYG HVLWKAHQHV ASLSGHQDRQ VPGMARMRLD VRLAKTLGLV 250
LAVLLICWFP VLALMAHSLA TTLSDQVKKA FAFCSMLCLI NSMVNPVIYA 300
LRSGEIRSSA HHCLAHWKKC VRGLGSEAKE EAPRSSVTET EADGKITPWP 350
DSRDLDLSDC 360
Length:360
Mass (Da):39,681
Last modified:February 1, 1994 - v1
Checksum:iA7ECF68C16E7514B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631Q → R High incidence in Japanese depressed subjects. 2 Publications
Corresponds to variant rs2501432 [ dbSNP | Ensembl ].
VAR_054310
Natural varianti316 – 3161H → Y.3 Publications
Corresponds to variant rs2229579 [ dbSNP | Ensembl ].
VAR_029209

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1731T → A in AAH95545. 1 Publication
Sequence conflicti307 – 3071R → H in AAH69722. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74328 mRNA. Translation: CAA52376.1.
EU517121 mRNA. Translation: ACD31539.1.
AJ430063 mRNA. Translation: CAD22548.1.
AJ430064 Genomic DNA. Translation: CAD22549.1.
AY242132 Genomic DNA. Translation: AAO92299.1.
AM156854 mRNA. Translation: CAJ42137.1.
AM156855 mRNA. Translation: CAJ42138.1.
AM156856 mRNA. Translation: CAJ42139.1.
AL590609 Genomic DNA. Translation: CAI14799.1.
CH471134 Genomic DNA. Translation: EAW95099.1.
BC069722 mRNA. Translation: AAH69722.1.
BC074767 mRNA. Translation: AAH74767.1.
BC095545 mRNA. Translation: AAH95545.1.
CCDSiCCDS245.1.
PIRiS36750.
RefSeqiNP_001832.1. NM_001841.2.
XP_005245793.1. XM_005245736.2.
XP_005245794.1. XM_005245737.2.
XP_005245795.1. XM_005245738.2.
UniGeneiHs.73037.

Genome annotation databases

EnsembliENST00000374472; ENSP00000363596; ENSG00000188822.
ENST00000536471; ENSP00000442830; ENSG00000188822.
GeneIDi1269.
KEGGihsa:1269.
UCSCiuc001bif.3. human.

Polymorphism databases

DMDMi461697.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74328 mRNA. Translation: CAA52376.1 .
EU517121 mRNA. Translation: ACD31539.1 .
AJ430063 mRNA. Translation: CAD22548.1 .
AJ430064 Genomic DNA. Translation: CAD22549.1 .
AY242132 Genomic DNA. Translation: AAO92299.1 .
AM156854 mRNA. Translation: CAJ42137.1 .
AM156855 mRNA. Translation: CAJ42138.1 .
AM156856 mRNA. Translation: CAJ42139.1 .
AL590609 Genomic DNA. Translation: CAI14799.1 .
CH471134 Genomic DNA. Translation: EAW95099.1 .
BC069722 mRNA. Translation: AAH69722.1 .
BC074767 mRNA. Translation: AAH74767.1 .
BC095545 mRNA. Translation: AAH95545.1 .
CCDSi CCDS245.1.
PIRi S36750.
RefSeqi NP_001832.1. NM_001841.2.
XP_005245793.1. XM_005245736.2.
XP_005245794.1. XM_005245737.2.
XP_005245795.1. XM_005245738.2.
UniGenei Hs.73037.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2KI9 NMR - A 240-272 [» ]
ProteinModelPortali P34972.
SMRi P34972. Positions 28-317.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P34972. 2 interactions.
STRINGi 9606.ENSP00000363596.

Chemistry

BindingDBi P34972.
ChEMBLi CHEMBL253.
DrugBanki DB00486. Nabilone.
GuidetoPHARMACOLOGYi 57.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P34972.

Polymorphism databases

DMDMi 461697.

Proteomic databases

MaxQBi P34972.
PaxDbi P34972.
PRIDEi P34972.

Protocols and materials databases

DNASUi 1269.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374472 ; ENSP00000363596 ; ENSG00000188822 .
ENST00000536471 ; ENSP00000442830 ; ENSG00000188822 .
GeneIDi 1269.
KEGGi hsa:1269.
UCSCi uc001bif.3. human.

Organism-specific databases

CTDi 1269.
GeneCardsi GC01M024197.
H-InvDB HIX0160038.
HGNCi HGNC:2160. CNR2.
HPAi CAB009719.
HPA028718.
MIMi 605051. gene.
neXtProti NX_P34972.
PharmGKBi PA26682.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG276403.
HOGENOMi HOG000049272.
HOVERGENi HBG051045.
InParanoidi P34972.
KOi K04278.
OMAi VNFHVFH.
OrthoDBi EOG7CK36K.
PhylomeDBi P34972.
TreeFami TF330052.

Enzyme and pathway databases

Reactomei REACT_14828. Class A/1 (Rhodopsin-like receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

EvolutionaryTracei P34972.
GeneWikii Cannabinoid_receptor_type_2.
GenomeRNAii 1269.
NextBioi 5139.
PROi P34972.
SOURCEi Search...

Gene expression databases

ArrayExpressi P34972.
Bgeei P34972.
CleanExi HS_CNR2.
Genevestigatori P34972.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001551. Canbinoid_rcpt_2.
IPR002230. Cnbnoid_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR22750:SF11. PTHR22750:SF11. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00523. CANABINOID2R.
PR00362. CANNABINOIDR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of a peripheral receptor for cannabinoids."
    Munro S., Thomas K.L., Abu-Shaar M.
    Nature 365:61-65(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands."
    Liu Q.-R., Pan C.H., Hishimoto A., Li C.Y., Xi Z.X., Llorente-Berzal A., Viveros M.P., Ishiguro H., Arinami T., Onaivi E.S., Uhl G.R.
    Genes Brain Behav. 8:519-530(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Spleen.
  3. "Cannabinoid receptors and their genes."
    Bruess M., Boenisch H.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Blood.
  4. "Isolation of complete coding sequence for cannabinoid receptor 2 (CNR2)."
    Warren C.N., Aronstam R.S., Sharma S.V.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Amplification and cloning of human cannabinoid receptor 2 gene from Asiatic origin."
    Saravanan T., Chugh A., Kant R.
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT TYR-316.
    Tissue: Blood.
  6. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-63 AND TYR-316.
    Tissue: Brain.
  9. "Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations."
    Galiegue S., Mary S., Marchand J., Dussossoy D., Carriere D., Carayon P., Bouaboula M., Shire D., Le Fur G., Casellas P.
    Eur. J. Biochem. 232:54-61(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  10. "Regulation of peripheral cannabinoid receptor CB2 phosphorylation by the inverse agonist SR 144528. Implications for receptor biological responses."
    Bouaboula M., Dussossoy D., Casellas P.
    J. Biol. Chem. 274:20397-20405(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-352, SUBCELLULAR LOCATION.
  11. "Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity."
    Tao Q., McAllister S.D., Andreassi J., Nowell K.W., Cabral G.A., Hurst D.P., Bachtel K., Ekman M.C., Reggio P.H., Abood M.E.
    Mol. Pharmacol. 55:605-613(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF LYS-109 AND SER-112.
  12. "Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells."
    Sugiura T., Kondo S., Kishimoto S., Miyashita T., Nakane S., Kodaka T., Suhara Y., Takayama H., Waku K.
    J. Biol. Chem. 275:605-612(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF 2-ARACHIDONOYLGLYCEROL AS AN ENDOGENOUS LIGAND.
  13. "Presence and regulation of the endocannabinoid system in human dendritic cells."
    Matias I., Pochard P., Orlando P., Salzet M., Pestel J., Di Marzo V.
    Eur. J. Biochem. 269:3771-3778(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  14. "Absence of a conserved proline and presence of a conserved tyrosine in the CB2 cannabinoid receptor are crucial for its function."
    Song Z.H., Feng W.
    FEBS Lett. 531:290-294(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF LEU-201 AND TYR-207.
  15. "Effects of D3.49A, R3.50A, and A6.34E mutations on ligand binding and activation of the cannabinoid-2 (CB2) receptor."
    Feng W., Song Z.H.
    Biochem. Pharmacol. 65:1077-1085(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF ASP-130; ARG-131 AND ALA-244.
  16. "2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism."
    Kishimoto S., Gokoh M., Oka S., Muramatsu M., Kajiwara T., Waku K., Sugiura T.
    J. Biol. Chem. 278:24469-24475(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  17. "Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors."
    Casanova M.L., Blazquez C., Martinez-Palacio J., Villanueva C., Fernandez-Acenero M.J., Huffman J.W., Jorcano J.L., Guzman M.
    J. Clin. Invest. 111:43-50(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  18. "Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains."
    Benito C., Nunez E., Tolon R.M., Carrier E.J., Rabano A., Hillard C.J., Romero J.
    J. Neurosci. 23:11136-11141(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  19. "Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study."
    Nunez E., Benito C., Pazos M.R., Barbachano A., Fajardo O., Gonzalez S., Tolon R.M., Romero J.
    Synapse 53:208-213(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  20. "Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons."
    Anand U., Otto W.R., Sanchez-Herrera D., Facer P., Yiangou Y., Korchev Y., Birch R., Benham C., Bountra C., Chessell I.P., Anand P.
    Pain 138:667-680(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  21. "Structural biology of human cannabinoid receptor-2 helix 6 in membrane-mimetic environments."
    Tiburu E.K., Tyukhtenko S., Deshmukh L., Vinogradova O., Janero D.R., Makriyannis A.
    Biochem. Biophys. Res. Commun. 384:243-248(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 240-272.
  22. Cited for: VARIANTS ARG-63 AND TYR-316.

Entry informationi

Entry nameiCNR2_HUMAN
AccessioniPrimary (citable) accession number: P34972
Secondary accession number(s): C6ES44
, Q4VBK8, Q5JRH7, Q6B0G7, Q6NSY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 3, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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