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Protein

Adenosine receptor A1

Gene

ADORA1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A1
Gene namesi
Name:ADORA1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10ExtracellularSequence analysis10
Transmembranei11 – 33Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini34 – 46CytoplasmicSequence analysisAdd BLAST13
Transmembranei47 – 69Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini70 – 80ExtracellularSequence analysisAdd BLAST11
Transmembranei81 – 102Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini103 – 123CytoplasmicSequence analysisAdd BLAST21
Transmembranei124 – 146Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini147 – 176ExtracellularSequence analysisAdd BLAST30
Transmembranei177 – 201Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini202 – 235CytoplasmicSequence analysisAdd BLAST34
Transmembranei236 – 259Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini260 – 267ExtracellularSequence analysis8
Transmembranei268 – 292Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini293 – 328CytoplasmicSequence analysisAdd BLAST36

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3947.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689931 – 328Adenosine receptor A1Add BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi80 ↔ 169PROSITE-ProRule annotation
Glycosylationi159N-linked (GlcNAc...)Sequence analysis1
Lipidationi309S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000009475.

Chemistry databases

BindingDBiP34970.

Structurei

3D structure databases

ProteinModelPortaliP34970.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiP34970.
KOiK04265.

Family and domain databases

InterProiIPR001068. Adeno_A1_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00552. ADENOSINEA1R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34970-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS
60 70 80 90 100
LAVADVAVGA LVIPLAILIN IGPETYFHTC LMVACPVLIL TQSSILALLA
110 120 130 140 150
IAVDRYLRVK IPLRYKAVVT PRRAAVAIAG CWILSLVVGL TPMFGWNNLR
160 170 180 190 200
EVQRAWAANG SVGEPVIKCE FEKVISMEYM VYFNFFVWVL PPLLLMVLIY
210 220 230 240 250
LEVFYLIRRQ LSKKASASSG DPHKYYGKEL KIAKSLALIL FLFALSWLPL
260 270 280 290 300
HILNCVTLFC PSCQKPSILV YTAIFLTHGN SAMNPIVYAF RIHKFRVTFL
310 320
KIWNDHFRCR PAPAGDGDED LPEEKPND
Length:328
Mass (Da):36,556
Last modified:February 1, 1994 - v1
Checksum:i0F9B53E6AEC25968
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01700 mRNA. Translation: AAA31148.1.
PIRiJN0675.
RefSeqiNP_001164544.1. NM_001171073.1.
UniGeneiOcu.7475.

Genome annotation databases

GeneIDi100328615.
KEGGiocu:100328615.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01700 mRNA. Translation: AAA31148.1.
PIRiJN0675.
RefSeqiNP_001164544.1. NM_001171073.1.
UniGeneiOcu.7475.

3D structure databases

ProteinModelPortaliP34970.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000009475.

Chemistry databases

BindingDBiP34970.
ChEMBLiCHEMBL3947.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100328615.
KEGGiocu:100328615.

Organism-specific databases

CTDi134.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiP34970.
KOiK04265.

Family and domain databases

InterProiIPR001068. Adeno_A1_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00552. ADENOSINEA1R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAA1R_RABIT
AccessioniPrimary (citable) accession number: P34970
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 30, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.