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P34968 (5HT2C_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5-hydroxytryptamine receptor 2C
Short name=5-HT-2C
Short name=5-HT2C
Short name=5-HTR2C
Alternative name(s):
5-hydroxytryptamine receptor 1C
Short name=5-HT-1C
Short name=5-HT1C
Serotonin receptor 2C
Gene names
Name:Htr2c
Synonyms:5ht1c, Htr1c
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subunit structure

Interacts with MPDZ. Interacts with ARRB2 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Domain

The PDZ domain-binding motif is involved in the interaction with MPDZ By similarity.

Post-translational modification

N-glycosylated By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4594595-hydroxytryptamine receptor 2C
PRO_0000068959

Regions

Topological domain1 – 5353Extracellular By similarity
Transmembrane54 – 7926Helical; Name=1; By similarity
Topological domain80 – 9011Cytoplasmic By similarity
Transmembrane91 – 11121Helical; Name=2; By similarity
Topological domain112 – 12817Extracellular By similarity
Transmembrane129 – 15123Helical; Name=3; By similarity
Topological domain152 – 17120Cytoplasmic By similarity
Transmembrane172 – 19423Helical; Name=4; By similarity
Topological domain195 – 21420Extracellular By similarity
Transmembrane215 – 23622Helical; Name=5; By similarity
Topological domain237 – 31276Cytoplasmic By similarity
Transmembrane313 – 33422Helical; Name=6; By similarity
Topological domain335 – 34915Extracellular By similarity
Transmembrane350 – 37223Helical; Name=7; By similarity
Topological domain373 – 45987Cytoplasmic By similarity
Motif457 – 4593PDZ-binding

Amino acid modifications

Glycosylation391N-linked (GlcNAc...) By similarity
Glycosylation2041N-linked (GlcNAc...) Potential
Glycosylation2051N-linked (GlcNAc...) Potential
Disulfide bond128 ↔ 208 By similarity

Experimental info

Sequence conflict157 – 1615IRNPI → VRSPV in CAA51031. Ref.1
Sequence conflict157 – 1615IRNPI → VRSPV in AAA10521. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P34968 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: AA3C537B2ADCB0C9

FASTA45951,929
        10         20         30         40         50         60 
MVNLGTAVRS LLVHLIGLLV WQFDISISPV AAIVTDTFNS SDGGRLFQFP DGVQNWPALS 

        70         80         90        100        110        120 
IVVIIIMTIG GNILVIMAVS MEKKLHNATN YFLMSLAIAD MLVGLLVMPL SLLAILYDYV 

       130        140        150        160        170        180 
WPLPRYLCPV WISLDVLFST ASIMHLCAIS LDRYVAIRNP IEHSRFNSRT KAIMKIAIVW 

       190        200        210        220        230        240 
AISIGVSVPI PVIGLRDESK VFVNNTTCVL NDPNFVLIGS FVAFFIPLTI MVITYFLTIY 

       250        260        270        280        290        300 
VLRRQTLMLL RGHTEEELRN ISLNFLKCCC KKGDEEENAP NPNPDQKPRR KKKEKRPRGT 

       310        320        330        340        350        360 
MQAINNEKKA SKVLGIVFFV FLIMWCPFFI TNILSVLCGK ACNQKLMEKL LNVFVWIGYV 

       370        380        390        400        410        420 
CSGINPLVYT LFNKIYRRAF SKYLRCDYKP DKKPPVRQIP RVAATALSGR ELNVNIYRHT 

       430        440        450 
NERVVRKAND TEPGIEMQVE NLELPVNPSN VVSERISSV

« Hide

References

« Hide 'large scale' references
[1]"The mouse 5-HT1C receptor contains eight hydrophobic domains and is X-linked."
Yu L., Nguyen H., Le H., Bloem L.J., Kozak C.A., Hoffman B.J., Snutch T.P., Lester H.A., Davidson N., Luebbert H.
Brain Res. Mol. Brain Res. 11:143-149(1991) [PubMed: 1661811] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structure of the mouse 5-HT1C, 5-HT2 and stomach fundus serotonin receptor genes."
Foguet M., Nguyen H., Le H., Luebbert H.
NeuroReport 3:345-348(1992) [PubMed: 1381232] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X72230 mRNA. Translation: CAA51031.1.
S44559 expand/collapse EMBL AC list , S44556, S44557, S44558 Genomic DNA. Translation: AAA10521.1.
AL808014, AL662932 Genomic DNA. Translation: CAM15060.1.
AL662932, AL808014 Genomic DNA. Translation: CAM15766.1.
IPIIPI00314137.
PIRA43951.
RefSeqNP_032338.3. NM_008312.4.
UniGeneMm.439670.

3D structure databases

ProteinModelPortalP34968.
SMRP34968. Positions 56-385.
ModBaseSearch...

Protein-protein interaction databases

STRINGP34968.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP34968.

Proteomic databases

PRIDEP34968.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000036303; ENSMUSP00000043936; ENSMUSG00000041380.
ENSMUST00000096299; ENSMUSP00000094021; ENSMUSG00000041380.
GeneID15560.
KEGGmmu:15560.

Organism-specific databases

CTD3358.
MGIMGI:96281. Htr2c.

Phylogenomic databases

eggNOGroNOG05307.
HOGENOMHBG445348.
HOVERGENHBG107487.
InParanoidP34968.
OrthoDBEOG4M0F2D.

Gene expression databases

ArrayExpressP34968.
BgeeP34968.
CleanExMM_HTR2C.
GenevestigatorP34968.
GermOnlineENSMUSG00000041380. Mus musculus.

Family and domain databases

InterProIPR000377. 5HT2C_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. 7TM_GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
KOK04157.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00517. 5HT2CRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry name5HT2C_MOUSE
AccessionPrimary (citable) accession number: P34968
Secondary accession number(s): B1ATN5, Q5WRU6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: July 27, 2011
Last modified: December 14, 2011
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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