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P34957 (QOX2_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Quinol oxidase subunit 2

EC=1.10.3.-
Alternative name(s):
Oxidase aa(3)-600 subunit 2
Quinol oxidase aa3-600, subunit QoxA
Quinol oxidase polypeptide II
Gene names
Name:qoxA
Ordered Locus Names:BSU38170
ORF Names:ipa-37d
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Major component for energy conversion during vegetative growth. Subunit II transfers the electrons from a quinol to the binuclear center of the catalytic subunit I By similarity.

Catalytic activity

Ubiquinol-8 + O2 = Ubiquinone-8 + H2O.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence caution

The sequence AAA22686.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 By similarity
Chain26 – 321296Quinol oxidase subunit 2
PRO_0000006069

Regions

Transmembrane49 – 6921Helical; Potential
Transmembrane90 – 11021Helical; Potential

Amino acid modifications

Lipidation261N-palmitoyl cysteine Potential
Lipidation261S-diacylglycerol cysteine Potential

Experimental info

Sequence conflict381V → VD in AAA22686. Ref.1
Sequence conflict381V → VD in CAA51593. Ref.2
Sequence conflict1671F → C in AAA22686. Ref.1
Sequence conflict1671F → C in CAA51593. Ref.2
Sequence conflict3001S → C in AAA22686. Ref.1
Sequence conflict3001S → C in CAA51593. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P34957 [UniParc].

Last modified June 16, 2009. Version 4.
Checksum: 6E4573332345DE7D

FASTA32136,282
        10         20         30         40         50         60 
MIFLFRALKP LLVLALLTVV FVLGGCSNAS VLDPKGPVAE QQSDLILLSI GFMLFIVGVV 

        70         80         90        100        110        120 
FVLFTIILVK YRDRKGKDNG SYNPEIHGNT FLEVVWTVIP ILIVIALSVP TVQTIYSLEK 

       130        140        150        160        170        180 
APEATKDKEP LVVYATSVDW KWVFSYPEQD IETVNYLNIP VDRPILFKIS SADSMASLWI 

       190        200        210        220        230        240 
PQLGGQKYAM AGMLMDQYLQ ADKVGTYEGR NANFTGEHFA DQEFDVNAVT EKDFNSWVKK 

       250        260        270        280        290        300 
TQNEAPKLTK EKYDELMLPE NVDELTFSST HLKYVDHGQD AEYAMEARKR LGYQAVSPHS 

       310        320 
KTDPFENVKK NEFKKSDDTE E 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning, sequencing, and physiological characterization of the qox operon from Bacillus subtilis encoding the aa3-600 quinol oxidase."
Santana M., Kunst F., Hullo M.-F., Rapoport G., Danchin A., Glaser P.
J. Biol. Chem. 267:10225-10231(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[2]"Bacillus subtilis genome project: cloning and sequencing of the 97 kb region from 325 degrees to 333 degrees."
Glaser P., Kunst F., Arnaud M., Coudart M.P., Gonzales W., Hullo M.-F., Ionescu M., Lubochinsky B., Marcelino L., Moszer I., Presecan E., Santana M., Schneider E., Schweizer J., Vertes A., Rapoport G., Danchin A.
Mol. Microbiol. 10:371-384(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[3]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[4]"From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION TO 38; 167 AND 300.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M86548 Genomic DNA. Translation: AAA22686.1. Different initiation.
X73124 Genomic DNA. Translation: CAA51593.1.
AL009126 Genomic DNA. Translation: CAB15843.2.
PIRE69687.
RefSeqNP_391696.2. NC_000964.3.

3D structure databases

ProteinModelPortalP34957.
SMRP34957. Positions 30-271.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224308.BSU38170.

Proteomic databases

PaxDbP34957.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB15843; CAB15843; BSU38170.
GeneID937295.
KEGGbsu:BSU38170.
PATRIC18979678. VBIBacSub10457_4001.

Organism-specific databases

GenoListBSU38170. [Micado]

Phylogenomic databases

eggNOGCOG1622.
HOGENOMHOG000084157.
KOK02826.
OrthoDBEOG6PS5TJ.
PhylomeDBP34957.

Enzyme and pathway databases

BioCycBSUB:BSU38170-MONOMER.
MetaCyc:BSU38170-MONOMER.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR012141. Bo-type_Ubol_Oxase_su_II.
IPR010514. COX_ARM.
IPR008972. Cupredoxin.
IPR006332. Cyt_aa3_quinol_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF02790. COX2_TM. 1 hit.
PF06481. COX_ARM. 1 hit.
[Graphical view]
PIRSFPIRSF000292. Ubi_od_II. 1 hit.
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR01432. QOXA. 1 hit.
PROSITEPS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQOX2_BACSU
AccessionPrimary (citable) accession number: P34957
Secondary accession number(s): O32281
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 16, 2009
Last modified: July 9, 2014
This is version 122 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList