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Protein

Alpha-1-antiproteinase

Gene

SERPINA1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Inhibits trypsin, chymotrypsin and plasminogen activator (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei380 – 381Reactive bond2

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiR-BTA-114608. Platelet degranulation.
R-BTA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-BTA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-BTA-5694530. Cargo concentration in the ER.
R-BTA-6798695. Neutrophil degranulation.
R-BTA-8957275. Post-translational protein phosphorylation.

Protein family/group databases

MEROPSiI04.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1-antiproteinase
Alternative name(s):
Alpha-1-antitrypsin
Alpha-1-proteinase inhibitor
Serpin A1
Gene namesi
Name:SERPINA1
Synonyms:PI
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000003238025 – 416Alpha-1-antiproteinaseAdd BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi269N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei381PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP34955.
PeptideAtlasiP34955.
PRIDEiP34955.

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

BgeeiENSBTAG00000018843.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004927.

Structurei

3D structure databases

ProteinModelPortaliP34955.
SMRiP34955.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni371 – 390RCLAdd BLAST20

Domaini

The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable (By similarity).By similarity

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238521.
HOVERGENiHBG005957.
InParanoidiP34955.
KOiK03984.
OMAiFFLPDEG.
OrthoDBiEOG091G0ION.
TreeFamiTF343201.

Family and domain databases

InterProiView protein in InterPro
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiView protein in Pfam
PF00079. Serpin. 1 hit.
SMARTiView protein in SMART
SM00093. SERPIN. 1 hit.
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiView protein in PROSITE
PS00284. SERPIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34955-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSITRGLL LLAALCCLAP ISLAGVLQGH AVQETDDTSH QEAACHKIAP
60 70 80 90 100
NLANFAFSIY HHLAHQSNTS NIFFSPVSIA SAFAMLSLGA KGNTHTEILK
110 120 130 140 150
GLGFNLTELA EAEIHKGFQH LLHTLNQPNH QLQLTTGNGL FINESAKLVD
160 170 180 190 200
TFLEDVKNLY HSEAFSINFR DAEEAKKKIN DYVEKGSHGK IVELVKVLDP
210 220 230 240 250
NTVFALVNYI SFKGKWEKPF EMKHTTERDF HVDEQTTVKV PMMNRLGMFD
260 270 280 290 300
LHYCDKLASW VLLLDYVGNV TACFILPDLG KLQQLEDKLN NELLAKFLEK
310 320 330 340 350
KYASSANLHL PKLSISETYD LKSVLGDVGI TEVFSDRADL SGITKEQPLK
360 370 380 390 400
VSKALHKAAL TIDEKGTEAV GSTFLEAIPM SLPPDVEFNR PFLCILYDRN
410
TKSPLFVGKV VNPTQA
Length:416
Mass (Da):46,104
Last modified:February 1, 1994 - v1
Checksum:i3280CDAF42DA35E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63129 mRNA. Translation: CAA44840.1.
BT025459 mRNA. Translation: ABF57415.1.
BC102730 mRNA. Translation: AAI02731.1.
PIRiS21097.
RefSeqiNP_776307.1. NM_173882.2.
XP_005222164.1. XM_005222107.2.
UniGeneiBt.982.

Genome annotation databases

EnsembliENSBTAT00000004927; ENSBTAP00000004927; ENSBTAG00000018843.
GeneIDi280699.
KEGGibta:280699.

Similar proteinsi

Entry informationi

Entry nameiA1AT_BOVIN
AccessioniPrimary (citable) accession number: P34955
Secondary accession number(s): Q3SZS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 27, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families