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P34947

- GRK5_HUMAN

UniProt

P34947 - GRK5_HUMAN

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Protein

G protein-coupled receptor kinase 5

Gene

GRK5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro).5 Publications

Catalytic activityi

ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.

Enzyme regulationi

Inhibited by calmodulin with an IC50 of 50 nM. Calmodulin inhibits GRK5 association with receptor and phospholipid.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei215 – 2151ATPPROSITE-ProRule annotation
Active sitei311 – 3111Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi192 – 2009ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. G-protein coupled receptor kinase activity Source: UniProtKB-EC
  3. phospholipid binding Source: ProtInc
  4. protein kinase C binding Source: ProtInc
  5. protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: ProtInc
  2. apoptotic process Source: UniProtKB-KW
  3. negative regulation of apoptotic process Source: UniProtKB
  4. protein autophosphorylation Source: UniProtKB
  5. regulation of G-protein coupled receptor protein signaling pathway Source: ProtInc
  6. tachykinin receptor signaling pathway Source: BHF-UCL
  7. termination of G-protein coupled receptor signaling pathway Source: InterPro
  8. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Apoptosis, Wnt signaling pathway

Keywords - Ligandi

ATP-binding, Lipid-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.16. 2681.
ReactomeiREACT_18283. G alpha (q) signalling events.
SignaLinkiP34947.

Names & Taxonomyi

Protein namesi
Recommended name:
G protein-coupled receptor kinase 5 (EC:2.7.11.16)
Alternative name(s):
G protein-coupled receptor kinase GRK5
Gene namesi
Name:GRK5
Synonyms:GPRK5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:4544. GRK5.

Subcellular locationi

Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein
Note: Predominantly localized at the plasma membrane; targeted to the cell surface through the interaction with phospholipids. Nucleus localization is regulated in a GPCR and Ca2+/calmodulin-dependent fashion.

GO - Cellular componenti

  1. cytoplasm Source: ProtInc
  2. nucleus Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi215 – 2151K → R: Failed to phosphorylate p53/TP53. 1 Publication
Mutagenesisi388 – 3881R → A: Nuclear exclusion; when associated with A-389; A-391; A-393 and A-394. 1 Publication
Mutagenesisi389 – 3891K → A: Nuclear exclusion; when associated with A-388; A-391; A-393 and A-394. 1 Publication
Mutagenesisi391 – 3911K → A: Nuclear exclusion; when associated with A-388; A-389; A-393 and A-394. 1 Publication
Mutagenesisi393 – 3931K → A: Nuclear exclusion; when associated with A-388; A-389; A-391 and A-394. 1 Publication
Mutagenesisi394 – 3941R → A: Nuclear exclusion; when associated with A-388; A-389; A-391 and A-393. 1 Publication
Mutagenesisi484 – 4841S → A: 15-20 fold defects in kinase activity; when associated with A-485. 1 Publication
Mutagenesisi485 – 4851T → A: 15-20 fold defects in kinase activity; when associated with A-484. 1 Publication
Mutagenesisi550 – 5501L → A: No detectable plasma membrane localization; when associated with A-551; A-554; and A-555. 1 Publication
Mutagenesisi551 – 5511L → A: No detectable plasma membrane localization; when associated with A-550; A-554; and A-555. 1 Publication
Mutagenesisi554 – 5541L → A: No detectable plasma membrane localization; when associated with A-550; A-551; and A-555. 1 Publication
Mutagenesisi555 – 5551F → A: No detectable plasma membrane localization; when associated with A-550; A-551; and A-554. 1 Publication

Organism-specific databases

PharmGKBiPA180.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 590590G protein-coupled receptor kinase 5PRO_0000085971Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei484 – 4841Phosphoserine; by autocatalysis1 Publication
Modified residuei485 – 4851Phosphothreonine; by autocatalysis1 Publication

Post-translational modificationi

Autophosphorylated. Autophosphorylation may play a critical role in the regulation of GRK5 kinase activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP34947.
PaxDbiP34947.
PRIDEiP34947.

PTM databases

PhosphoSiteiP34947.

Expressioni

Tissue specificityi

Highest levels in heart, placenta, lung > skeletal muscle > brain, liver, pancreas > kidney.1 Publication

Inductioni

Overexpressed during heart failure.1 Publication

Gene expression databases

BgeeiP34947.
CleanExiHS_GRK5.
ExpressionAtlasiP34947. baseline and differential.
GenevestigatoriP34947.

Organism-specific databases

HPAiCAB025579.

Interactioni

Subunit structurei

Interacts with ST13 (via the C-terminus 303-319 AA). Interacts with TP53/p53. Interacts with HTR4 (via C-terminus 330-346 AA); this interaction is promoted by 5-HT (serotonin). Interacts with HDAC5 By similarity.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Htr4P972888EBI-7149314,EBI-7149283From a different organism.

Protein-protein interaction databases

BioGridi109127. 171 interactions.
DIPiDIP-57457N.
IntActiP34947. 2 interactions.
MINTiMINT-3013589.
STRINGi9606.ENSP00000376609.

Structurei

3D structure databases

ProteinModelPortaliP34947.
SMRiP34947. Positions 2-555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 171119RGSPROSITE-ProRule annotationAdd
BLAST
Domaini186 – 448263Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini449 – 51466AGC-kinase C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 185185N-terminalAdd
BLAST
Regioni20 – 3920Interaction with calmodulinAdd
BLAST
Regioni546 – 56520Sufficient for membrane localizationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi388 – 3958Nuclear localization signal1 Publication

Sequence similaritiesi

Contains 1 AGC-kinase C-terminal domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118793.
HOGENOMiHOG000006742.
HOVERGENiHBG004532.
InParanoidiP34947.
KOiK08291.
OMAiEMMETEC.
OrthoDBiEOG7V1FQK.
PhylomeDBiP34947.
TreeFamiTF313940.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR00717. GPCRKINASE.
SMARTiSM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34947-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELENIVANT VLLKAREGGG GKRKGKSKKW KEILKFPHIS QCEDLRRTID
60 70 80 90 100
RDYCSLCDKQ PIGRLLFRQF CETRPGLECY IQFLDSVAEY EVTPDEKLGE
110 120 130 140 150
KGKEIMTKYL TPKSPVFIAQ VGQDLVSQTE EKLLQKPCKE LFSACAQSVH
160 170 180 190 200
EYLRGEPFHE YLDSMFFDRF LQWKWLERQP VTKNTFRQYR VLGKGGFGEV
210 220 230 240 250
CACQVRATGK MYACKRLEKK RIKKRKGESM ALNEKQILEK VNSQFVVNLA
260 270 280 290 300
YAYETKDALC LVLTIMNGGD LKFHIYNMGN PGFEEERALF YAAEILCGLE
310 320 330 340 350
DLHRENTVYR DLKPENILLD DYGHIRISDL GLAVKIPEGD LIRGRVGTVG
360 370 380 390 400
YMAPEVLNNQ RYGLSPDYWG LGCLIYEMIE GQSPFRGRKE KVKREEVDRR
410 420 430 440 450
VLETEEVYSH KFSEEAKSIC KMLLTKDAKQ RLGCQEEGAA EVKRHPFFRN
460 470 480 490 500
MNFKRLEAGM LDPPFVPDPR AVYCKDVLDI EQFSTVKGVN LDHTDDDFYS
510 520 530 540 550
KFSTGSVSIP WQNEMIETEC FKELNVFGPN GTLPPDLNRN HPPEPPKKGL
560 570 580 590
LQRLFKRQHQ NNSKSSPSSK TSFNHHINSN HVSSNSTGSS
Length:590
Mass (Da):67,787
Last modified:February 1, 1994 - v1
Checksum:iD363567ECFF5CF21
GO

Polymorphismi

Variant Leu-41 variant is rare in European-Americans individuals but common in African-Americans individuals (40% of the African-American individuals studied carry at least one allele). Variant leu-41 is associated with decreased mortality in African-Americans with heart failure or cardiac ischemia.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti41 – 411Q → L Exerts a protective effect in heart failure and ischemia. 2 Publications
Corresponds to variant rs17098707 [ dbSNP | Ensembl ].
VAR_040517
Natural varianti119 – 1191A → V.1 Publication
Corresponds to variant rs55980792 [ dbSNP | Ensembl ].
VAR_040518
Natural varianti122 – 1221G → S.1 Publication
Corresponds to variant rs55902633 [ dbSNP | Ensembl ].
VAR_040519
Natural varianti129 – 1291T → M.1 Publication
Corresponds to variant rs34679178 [ dbSNP | Ensembl ].
VAR_040520
Natural varianti141 – 1411L → I.1 Publication
Corresponds to variant rs56254855 [ dbSNP | Ensembl ].
VAR_040521
Natural varianti163 – 1631D → E in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication
VAR_040522
Natural varianti172 – 1721Q → H.
Corresponds to variant rs45630572 [ dbSNP | Ensembl ].
VAR_059766
Natural varianti304 – 3041R → H.1 Publication
Corresponds to variant rs2230349 [ dbSNP | Ensembl ].
VAR_040523

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L15388 mRNA. Translation: AAA58620.1.
AL355273, AL355861, AL583824 Genomic DNA. Translation: CAI16487.1.
AL355861, AL355273, AL583824 Genomic DNA. Translation: CAI15804.1.
AL583824, AL355273, AL355861 Genomic DNA. Translation: CAI16759.1.
CH471066 Genomic DNA. Translation: EAW49394.1.
CH471066 Genomic DNA. Translation: EAW49395.1.
BC064506 mRNA. Translation: AAH64506.1.
CCDSiCCDS7612.1.
PIRiA48277.
B48682.
RefSeqiNP_005299.1. NM_005308.2.
UniGeneiHs.524625.
Hs.736460.

Genome annotation databases

EnsembliENST00000392870; ENSP00000376609; ENSG00000198873.
GeneIDi2869.
KEGGihsa:2869.
UCSCiuc001led.3. human.

Polymorphism databases

DMDMi462203.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L15388 mRNA. Translation: AAA58620.1 .
AL355273 , AL355861 , AL583824 Genomic DNA. Translation: CAI16487.1 .
AL355861 , AL355273 , AL583824 Genomic DNA. Translation: CAI15804.1 .
AL583824 , AL355273 , AL355861 Genomic DNA. Translation: CAI16759.1 .
CH471066 Genomic DNA. Translation: EAW49394.1 .
CH471066 Genomic DNA. Translation: EAW49395.1 .
BC064506 mRNA. Translation: AAH64506.1 .
CCDSi CCDS7612.1.
PIRi A48277.
B48682.
RefSeqi NP_005299.1. NM_005308.2.
UniGenei Hs.524625.
Hs.736460.

3D structure databases

ProteinModelPortali P34947.
SMRi P34947. Positions 2-555.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109127. 171 interactions.
DIPi DIP-57457N.
IntActi P34947. 2 interactions.
MINTi MINT-3013589.
STRINGi 9606.ENSP00000376609.

Chemistry

BindingDBi P34947.
ChEMBLi CHEMBL5678.
GuidetoPHARMACOLOGYi 1469.

PTM databases

PhosphoSitei P34947.

Polymorphism databases

DMDMi 462203.

Proteomic databases

MaxQBi P34947.
PaxDbi P34947.
PRIDEi P34947.

Protocols and materials databases

DNASUi 2869.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000392870 ; ENSP00000376609 ; ENSG00000198873 .
GeneIDi 2869.
KEGGi hsa:2869.
UCSCi uc001led.3. human.

Organism-specific databases

CTDi 2869.
GeneCardsi GC10P120957.
HGNCi HGNC:4544. GRK5.
HPAi CAB025579.
MIMi 600870. gene.
neXtProti NX_P34947.
PharmGKBi PA180.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118793.
HOGENOMi HOG000006742.
HOVERGENi HBG004532.
InParanoidi P34947.
KOi K08291.
OMAi EMMETEC.
OrthoDBi EOG7V1FQK.
PhylomeDBi P34947.
TreeFami TF313940.

Enzyme and pathway databases

BRENDAi 2.7.11.16. 2681.
Reactomei REACT_18283. G alpha (q) signalling events.
SignaLinki P34947.

Miscellaneous databases

ChiTaRSi GRK5. human.
GeneWikii GRK5.
GenomeRNAii 2869.
NextBioi 11319.
PROi P34947.
SOURCEi Search...

Gene expression databases

Bgeei P34947.
CleanExi HS_GRK5.
ExpressionAtlasi P34947. baseline and differential.
Genevestigatori P34947.

Family and domain databases

InterProi IPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR00717. GPCRKINASE.
SMARTi SM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family."
    Kunapuli P., Benovic J.L.
    Proc. Natl. Acad. Sci. U.S.A. 90:5588-5592(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  5. "Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart."
    Ungerer M., Bohm M., Elce J.S., Erdmann E., Lohse M.J.
    Circulation 87:454-463(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  6. "Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5."
    Kunapuli P., Gurevich V.V., Benovic J.L.
    J. Biol. Chem. 269:10209-10212(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: AUTOPHOSPHORYLATION, MUTAGENESIS OF SER-484 AND THR-485.
  7. "Regulation of G protein-coupled receptor kinases by calmodulin and localization of the calmodulin binding domain."
    Pronin A.N., Satpaev D.K., Slepak V.Z., Benovic J.L.
    J. Biol. Chem. 272:18273-18280(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME REGULATION.
  8. Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF LEU-550; LEU-551; LEU-554 AND PHE-555.
  9. "G protein-coupled receptor kinase 5 contains a DNA-binding nuclear localization sequence."
    Johnson L.R., Scott M.G., Pitcher J.A.
    Mol. Cell. Biol. 24:10169-10179(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNAL, MUTAGENESIS OF ARG-388; LYS-389; LYS-391; LYS-393 AND ARG-394.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-484 AND THR-485, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: FUNCTION IN PHOSPHORYLATION OF ARRB1, INTERACTION WITH HTR4.
  12. "G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway."
    Chen M., Philipp M., Wang J., Premont R.T., Garrison T.R., Caron M.G., Lefkowitz R.J., Chen W.
    J. Biol. Chem. 284:35040-35048(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOSPHORYLATION OF LRP6.
  13. "G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis."
    Chen X., Zhu H., Yuan M., Fu J., Zhou Y., Ma L.
    J. Biol. Chem. 285:12823-12830(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOSPHORYLATION OF TP53, INTERACTION WITH TP53, MUTAGENESIS OF LYS-215.
  14. "Role for the regulator of G-protein signaling homology domain of G protein-coupled receptor kinases 5 and 6 in beta 2-adrenergic receptor and rhodopsin phosphorylation."
    Baameur F., Morgan D.H., Yao H., Tran T.M., Hammitt R.A., Sabui S., McMurray J.S., Lichtarge O., Clark R.B.
    Mol. Pharmacol. 77:405-415(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOSPHORYLATION OF ADRB2, AUTOPHOSPHORYLATION.
  15. "G protein-coupled receptor kinase 5 phosphorylation of Hip regulates internalization of the chemokine receptor CXCR4."
    Barker B.L., Benovic J.L.
    Biochemistry 50:6933-6941(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOSPHORYLATION OF ST13, INTERACTION WITH ST13.
  16. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-41; VAL-119; SER-122; MET-129; ILE-141; GLU-163 AND HIS-304.
  17. "A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure."
    Liggett S.B., Cresci S., Kelly R.J., Syed F.M., Matkovich S.J., Hahn H.S., Diwan A., Martini J.S., Sparks L., Parekh R.R., Spertus J.A., Koch W.J., Kardia S.L., Dorn G.W. II
    Nat. Med. 14:510-517(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT LEU-41, CHARACTERIZATION OF VARIANT LEU-41, POLYMORPHISM, POSSIBLE PROTECTIVE ROLE IN THE PROGRESSION OF HEART FAILURE.

Entry informationi

Entry nameiGRK5_HUMAN
AccessioniPrimary (citable) accession number: P34947
Secondary accession number(s): D3DRD0, Q5T059
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3