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P34947

- GRK5_HUMAN

UniProt

P34947 - GRK5_HUMAN

Protein

G protein-coupled receptor kinase 5

Gene

GRK5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro).5 Publications

    Catalytic activityi

    ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.

    Enzyme regulationi

    Inhibited by calmodulin with an IC50 of 50 nM. Calmodulin inhibits GRK5 association with receptor and phospholipid.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei215 – 2151ATPPROSITE-ProRule annotation
    Active sitei311 – 3111Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi192 – 2009ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. G-protein coupled receptor kinase activity Source: UniProtKB-EC
    3. phospholipid binding Source: ProtInc
    4. protein binding Source: UniProtKB
    5. protein kinase C binding Source: ProtInc
    6. protein serine/threonine kinase activity Source: UniProtKB

    GO - Biological processi

    1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: ProtInc
    2. apoptotic process Source: UniProtKB-KW
    3. negative regulation of apoptotic process Source: UniProtKB
    4. protein autophosphorylation Source: UniProtKB
    5. regulation of G-protein coupled receptor protein signaling pathway Source: ProtInc
    6. tachykinin receptor signaling pathway Source: BHF-UCL
    7. termination of G-protein coupled receptor signaling pathway Source: InterPro
    8. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Apoptosis, Wnt signaling pathway

    Keywords - Ligandi

    ATP-binding, Lipid-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.16. 2681.
    ReactomeiREACT_18283. G alpha (q) signalling events.
    SignaLinkiP34947.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G protein-coupled receptor kinase 5 (EC:2.7.11.16)
    Alternative name(s):
    G protein-coupled receptor kinase GRK5
    Gene namesi
    Name:GRK5
    Synonyms:GPRK5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:4544. GRK5.

    Subcellular locationi

    Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein
    Note: Predominantly localized at the plasma membrane; targeted to the cell surface through the interaction with phospholipids. Nucleus localization is regulated in a GPCR and Ca2+/calmodulin-dependent fashion.

    GO - Cellular componenti

    1. cytoplasm Source: ProtInc
    2. nucleus Source: UniProtKB-SubCell
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi215 – 2151K → R: Failed to phosphorylate p53/TP53. 1 Publication
    Mutagenesisi388 – 3881R → A: Nuclear exclusion; when associated with A-389; A-391; A-393 and A-394. 1 Publication
    Mutagenesisi389 – 3891K → A: Nuclear exclusion; when associated with A-388; A-391; A-393 and A-394. 1 Publication
    Mutagenesisi391 – 3911K → A: Nuclear exclusion; when associated with A-388; A-389; A-393 and A-394. 1 Publication
    Mutagenesisi393 – 3931K → A: Nuclear exclusion; when associated with A-388; A-389; A-391 and A-394. 1 Publication
    Mutagenesisi394 – 3941R → A: Nuclear exclusion; when associated with A-388; A-389; A-391 and A-393. 1 Publication
    Mutagenesisi484 – 4841S → A: 15-20 fold defects in kinase activity; when associated with A-485. 1 Publication
    Mutagenesisi485 – 4851T → A: 15-20 fold defects in kinase activity; when associated with A-484. 1 Publication
    Mutagenesisi550 – 5501L → A: No detectable plasma membrane localization; when associated with A-551; A-554; and A-555. 1 Publication
    Mutagenesisi551 – 5511L → A: No detectable plasma membrane localization; when associated with A-550; A-554; and A-555. 1 Publication
    Mutagenesisi554 – 5541L → A: No detectable plasma membrane localization; when associated with A-550; A-551; and A-555. 1 Publication
    Mutagenesisi555 – 5551F → A: No detectable plasma membrane localization; when associated with A-550; A-551; and A-554. 1 Publication

    Organism-specific databases

    PharmGKBiPA180.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 590590G protein-coupled receptor kinase 5PRO_0000085971Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei484 – 4841Phosphoserine; by autocatalysis1 Publication
    Modified residuei485 – 4851Phosphothreonine; by autocatalysis1 Publication

    Post-translational modificationi

    Autophosphorylated. Autophosphorylation may play a critical role in the regulation of GRK5 kinase activity.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP34947.
    PRIDEiP34947.

    PTM databases

    PhosphoSiteiP34947.

    Expressioni

    Tissue specificityi

    Highest levels in heart, placenta, lung > skeletal muscle > brain, liver, pancreas > kidney.1 Publication

    Inductioni

    Overexpressed during heart failure.1 Publication

    Gene expression databases

    ArrayExpressiP34947.
    BgeeiP34947.
    CleanExiHS_GRK5.
    GenevestigatoriP34947.

    Organism-specific databases

    HPAiCAB025579.

    Interactioni

    Subunit structurei

    Interacts with ST13 (via the C-terminus 303-319 AA). Interacts with TP53/p53. Interacts with HTR4 (via C-terminus 330-346 AA); this interaction is promoted by 5-HT (serotonin). Interacts with HDAC5 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Htr4P972888EBI-7149314,EBI-7149283From a different organism.

    Protein-protein interaction databases

    BioGridi109127. 171 interactions.
    DIPiDIP-57457N.
    IntActiP34947. 2 interactions.
    MINTiMINT-3013589.
    STRINGi9606.ENSP00000376609.

    Structurei

    3D structure databases

    ProteinModelPortaliP34947.
    SMRiP34947. Positions 2-555.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini53 – 171119RGSPROSITE-ProRule annotationAdd
    BLAST
    Domaini186 – 448263Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini449 – 51466AGC-kinase C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 185185N-terminalAdd
    BLAST
    Regioni20 – 3920Interaction with calmodulinAdd
    BLAST
    Regioni546 – 56520Sufficient for membrane localizationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi388 – 3958Nuclear localization signal1 Publication

    Sequence similaritiesi

    Contains 1 AGC-kinase C-terminal domain.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000006742.
    HOVERGENiHBG004532.
    InParanoidiP34947.
    KOiK08291.
    OMAiEMMETEC.
    OrthoDBiEOG7V1FQK.
    PhylomeDBiP34947.
    TreeFamiTF313940.

    Family and domain databases

    InterProiIPR000961. AGC-kinase_C.
    IPR000239. GPCR_kinase.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR00717. GPCRKINASE.
    SMARTiSM00315. RGS. 1 hit.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P34947-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELENIVANT VLLKAREGGG GKRKGKSKKW KEILKFPHIS QCEDLRRTID    50
    RDYCSLCDKQ PIGRLLFRQF CETRPGLECY IQFLDSVAEY EVTPDEKLGE 100
    KGKEIMTKYL TPKSPVFIAQ VGQDLVSQTE EKLLQKPCKE LFSACAQSVH 150
    EYLRGEPFHE YLDSMFFDRF LQWKWLERQP VTKNTFRQYR VLGKGGFGEV 200
    CACQVRATGK MYACKRLEKK RIKKRKGESM ALNEKQILEK VNSQFVVNLA 250
    YAYETKDALC LVLTIMNGGD LKFHIYNMGN PGFEEERALF YAAEILCGLE 300
    DLHRENTVYR DLKPENILLD DYGHIRISDL GLAVKIPEGD LIRGRVGTVG 350
    YMAPEVLNNQ RYGLSPDYWG LGCLIYEMIE GQSPFRGRKE KVKREEVDRR 400
    VLETEEVYSH KFSEEAKSIC KMLLTKDAKQ RLGCQEEGAA EVKRHPFFRN 450
    MNFKRLEAGM LDPPFVPDPR AVYCKDVLDI EQFSTVKGVN LDHTDDDFYS 500
    KFSTGSVSIP WQNEMIETEC FKELNVFGPN GTLPPDLNRN HPPEPPKKGL 550
    LQRLFKRQHQ NNSKSSPSSK TSFNHHINSN HVSSNSTGSS 590
    Length:590
    Mass (Da):67,787
    Last modified:February 1, 1994 - v1
    Checksum:iD363567ECFF5CF21
    GO

    Polymorphismi

    Variant Leu-41 variant is rare in European-Americans individuals but common in African-Americans individuals (40% of the African-American individuals studied carry at least one allele). Variant leu-41 is associated with decreased mortality in African-Americans with heart failure or cardiac ischemia.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti41 – 411Q → L Exerts a protective effect in heart failure and ischemia. 2 Publications
    Corresponds to variant rs17098707 [ dbSNP | Ensembl ].
    VAR_040517
    Natural varianti119 – 1191A → V.1 Publication
    Corresponds to variant rs55980792 [ dbSNP | Ensembl ].
    VAR_040518
    Natural varianti122 – 1221G → S.1 Publication
    Corresponds to variant rs55902633 [ dbSNP | Ensembl ].
    VAR_040519
    Natural varianti129 – 1291T → M.1 Publication
    Corresponds to variant rs34679178 [ dbSNP | Ensembl ].
    VAR_040520
    Natural varianti141 – 1411L → I.1 Publication
    Corresponds to variant rs56254855 [ dbSNP | Ensembl ].
    VAR_040521
    Natural varianti163 – 1631D → E in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication
    VAR_040522
    Natural varianti172 – 1721Q → H.
    Corresponds to variant rs45630572 [ dbSNP | Ensembl ].
    VAR_059766
    Natural varianti304 – 3041R → H.1 Publication
    Corresponds to variant rs2230349 [ dbSNP | Ensembl ].
    VAR_040523

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L15388 mRNA. Translation: AAA58620.1.
    AL355273, AL355861, AL583824 Genomic DNA. Translation: CAI16487.1.
    AL355861, AL355273, AL583824 Genomic DNA. Translation: CAI15804.1.
    AL583824, AL355273, AL355861 Genomic DNA. Translation: CAI16759.1.
    CH471066 Genomic DNA. Translation: EAW49394.1.
    CH471066 Genomic DNA. Translation: EAW49395.1.
    BC064506 mRNA. Translation: AAH64506.1.
    CCDSiCCDS7612.1.
    PIRiA48277.
    B48682.
    RefSeqiNP_005299.1. NM_005308.2.
    UniGeneiHs.524625.
    Hs.736460.

    Genome annotation databases

    EnsembliENST00000392870; ENSP00000376609; ENSG00000198873.
    GeneIDi2869.
    KEGGihsa:2869.
    UCSCiuc001led.3. human.

    Polymorphism databases

    DMDMi462203.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L15388 mRNA. Translation: AAA58620.1 .
    AL355273 , AL355861 , AL583824 Genomic DNA. Translation: CAI16487.1 .
    AL355861 , AL355273 , AL583824 Genomic DNA. Translation: CAI15804.1 .
    AL583824 , AL355273 , AL355861 Genomic DNA. Translation: CAI16759.1 .
    CH471066 Genomic DNA. Translation: EAW49394.1 .
    CH471066 Genomic DNA. Translation: EAW49395.1 .
    BC064506 mRNA. Translation: AAH64506.1 .
    CCDSi CCDS7612.1.
    PIRi A48277.
    B48682.
    RefSeqi NP_005299.1. NM_005308.2.
    UniGenei Hs.524625.
    Hs.736460.

    3D structure databases

    ProteinModelPortali P34947.
    SMRi P34947. Positions 2-555.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109127. 171 interactions.
    DIPi DIP-57457N.
    IntActi P34947. 2 interactions.
    MINTi MINT-3013589.
    STRINGi 9606.ENSP00000376609.

    Chemistry

    BindingDBi P34947.
    ChEMBLi CHEMBL5678.
    GuidetoPHARMACOLOGYi 1469.

    PTM databases

    PhosphoSitei P34947.

    Polymorphism databases

    DMDMi 462203.

    Proteomic databases

    PaxDbi P34947.
    PRIDEi P34947.

    Protocols and materials databases

    DNASUi 2869.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000392870 ; ENSP00000376609 ; ENSG00000198873 .
    GeneIDi 2869.
    KEGGi hsa:2869.
    UCSCi uc001led.3. human.

    Organism-specific databases

    CTDi 2869.
    GeneCardsi GC10P120957.
    HGNCi HGNC:4544. GRK5.
    HPAi CAB025579.
    MIMi 600870. gene.
    neXtProti NX_P34947.
    PharmGKBi PA180.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000006742.
    HOVERGENi HBG004532.
    InParanoidi P34947.
    KOi K08291.
    OMAi EMMETEC.
    OrthoDBi EOG7V1FQK.
    PhylomeDBi P34947.
    TreeFami TF313940.

    Enzyme and pathway databases

    BRENDAi 2.7.11.16. 2681.
    Reactomei REACT_18283. G alpha (q) signalling events.
    SignaLinki P34947.

    Miscellaneous databases

    ChiTaRSi GRK5. human.
    GeneWikii GRK5.
    GenomeRNAii 2869.
    NextBioi 11319.
    PROi P34947.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P34947.
    Bgeei P34947.
    CleanExi HS_GRK5.
    Genevestigatori P34947.

    Family and domain databases

    InterProi IPR000961. AGC-kinase_C.
    IPR000239. GPCR_kinase.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR00717. GPCRKINASE.
    SMARTi SM00315. RGS. 1 hit.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family."
      Kunapuli P., Benovic J.L.
      Proc. Natl. Acad. Sci. U.S.A. 90:5588-5592(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    5. "Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart."
      Ungerer M., Bohm M., Elce J.S., Erdmann E., Lohse M.J.
      Circulation 87:454-463(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    6. "Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5."
      Kunapuli P., Gurevich V.V., Benovic J.L.
      J. Biol. Chem. 269:10209-10212(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: AUTOPHOSPHORYLATION, MUTAGENESIS OF SER-484 AND THR-485.
    7. "Regulation of G protein-coupled receptor kinases by calmodulin and localization of the calmodulin binding domain."
      Pronin A.N., Satpaev D.K., Slepak V.Z., Benovic J.L.
      J. Biol. Chem. 272:18273-18280(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION.
    8. Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF LEU-550; LEU-551; LEU-554 AND PHE-555.
    9. "G protein-coupled receptor kinase 5 contains a DNA-binding nuclear localization sequence."
      Johnson L.R., Scott M.G., Pitcher J.A.
      Mol. Cell. Biol. 24:10169-10179(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNAL, MUTAGENESIS OF ARG-388; LYS-389; LYS-391; LYS-393 AND ARG-394.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-484 AND THR-485, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: FUNCTION IN PHOSPHORYLATION OF ARRB1, INTERACTION WITH HTR4.
    12. "G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway."
      Chen M., Philipp M., Wang J., Premont R.T., Garrison T.R., Caron M.G., Lefkowitz R.J., Chen W.
      J. Biol. Chem. 284:35040-35048(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PHOSPHORYLATION OF LRP6.
    13. "G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis."
      Chen X., Zhu H., Yuan M., Fu J., Zhou Y., Ma L.
      J. Biol. Chem. 285:12823-12830(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PHOSPHORYLATION OF TP53, INTERACTION WITH TP53, MUTAGENESIS OF LYS-215.
    14. "Role for the regulator of G-protein signaling homology domain of G protein-coupled receptor kinases 5 and 6 in beta 2-adrenergic receptor and rhodopsin phosphorylation."
      Baameur F., Morgan D.H., Yao H., Tran T.M., Hammitt R.A., Sabui S., McMurray J.S., Lichtarge O., Clark R.B.
      Mol. Pharmacol. 77:405-415(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PHOSPHORYLATION OF ADRB2, AUTOPHOSPHORYLATION.
    15. "G protein-coupled receptor kinase 5 phosphorylation of Hip regulates internalization of the chemokine receptor CXCR4."
      Barker B.L., Benovic J.L.
      Biochemistry 50:6933-6941(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PHOSPHORYLATION OF ST13, INTERACTION WITH ST13.
    16. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-41; VAL-119; SER-122; MET-129; ILE-141; GLU-163 AND HIS-304.
    17. "A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure."
      Liggett S.B., Cresci S., Kelly R.J., Syed F.M., Matkovich S.J., Hahn H.S., Diwan A., Martini J.S., Sparks L., Parekh R.R., Spertus J.A., Koch W.J., Kardia S.L., Dorn G.W. II
      Nat. Med. 14:510-517(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT LEU-41, CHARACTERIZATION OF VARIANT LEU-41, POLYMORPHISM, POSSIBLE PROTECTIVE ROLE IN THE PROGRESSION OF HEART FAILURE.

    Entry informationi

    Entry nameiGRK5_HUMAN
    AccessioniPrimary (citable) accession number: P34947
    Secondary accession number(s): D3DRD0, Q5T059
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 145 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3