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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

Gene

NDUFA9

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

Cofactori

FADNote: Binds 1 FAD per subunit.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
Alternative name(s):
Complex I-39kD
Short name:
CI-39kD
NADH-ubiquinone oxidoreductase 39 kDa subunit
Gene namesi
Name:NDUFA9
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 35MitochondrionAdd BLAST35
ChainiPRO_000001999136 – 380NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrialAdd BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei175N6-succinyllysineBy similarity1
Modified residuei189N6-acetyllysineBy similarity1

Post-translational modificationi

Acetylated on lysine residues. BLOC1S1 is required for acetylation.By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP34943.
PeptideAtlasiP34943.
PRIDEiP34943.

Expressioni

Gene expression databases

BgeeiENSBTAG00000005465.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction (PubMed:10852722, PubMed:18721790). Interacts with BLOC1S1 (By similarity). Interacts with SLC2A4 (By similarity).By similarity2 Publications

Protein-protein interaction databases

CORUMiP34943.
DIPiDIP-38819N.
IntActiP34943. 3 interactors.
STRINGi9913.ENSBTAP00000007189.

Structurei

3D structure databases

ProteinModelPortaliP34943.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA9 subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2865. Eukaryota.
COG0702. LUCA.
GeneTreeiENSGT00390000006865.
HOGENOMiHOG000168008.
HOVERGENiHBG006546.
InParanoidiP34943.
KOiK03953.
OMAiKFIHVSH.
OrthoDBiEOG091G07EJ.
TreeFamiTF105961.

Family and domain databases

InterProiView protein in InterPro
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF13460. NAD_binding_10. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVHPRVV RVLPMSRSSV PALAASVFHS PPQRQLHHAV IPHGKGGRSS
60 70 80 90 100
VSGIVATVFG ATGFLGRYVV NHLGRMGSQV IVPHRCEPYD TMHLRPMGDL
110 120 130 140 150
GQIIFMDWNG RDKDSIRRAV EHSSVVINLV GREWETQNFD FEDVFVKIPQ
160 170 180 190 200
AIAQVSKEAG VEKFIHISHL NADIKSSSKY LRSKAVGEKE VRETFPEATI
210 220 230 240 250
IKPAEIFGRE DRFLNYFANI RWFGGVPLIS LGKKTVKQPV YIVDVTKGII
260 270 280 290 300
NAIKDPDARG KTFAFVGPSR YLLFDLVQYV FAVAHRPFLP YPLPHFAYRW
310 320 330 340 350
IGRLFEISPF EPWTTRDKVE RIHTTDKILP HLPGLEDLGV EATPLELKAI
360 370 380
EVLRRHRTYR WLSSEIEDVQ PAKTIPTSGP
Length:380
Mass (Da):42,849
Last modified:February 1, 1994 - v1
Checksum:iB453FA19D48D03CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59418 mRNA. Translation: CAA42053.1.
BC102359 mRNA. Translation: AAI02360.1.
PIRiS17676.
RefSeqiNP_991386.1. NM_205817.1.
UniGeneiBt.5541.

Genome annotation databases

EnsembliENSBTAT00000007189; ENSBTAP00000007189; ENSBTAG00000005465.
GeneIDi404188.
KEGGibta:404188.

Similar proteinsi

Entry informationi

Entry nameiNDUA9_BOVIN
AccessioniPrimary (citable) accession number: P34943
Secondary accession number(s): Q3T0K3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 27, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families