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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

Gene

NDUFA10

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Cofactori

FADNote: Binds 1 FAD per subunit.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

FAD, Flavoprotein

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
Alternative name(s):
Complex I-42kD
Short name:
CI-42kD
NADH-ubiquinone oxidoreductase 42 kDa subunit
Gene namesi
Name:NDUFA10
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrial respiratory chain complex I Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 23MitochondrionAdd BLAST23
ChainiPRO_000001998724 – 343NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialAdd BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei110N6-acetyllysine; alternateBy similarity1
Modified residuei110N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP34942.
PeptideAtlasiP34942.
PRIDEiP34942.

PTM databases

iPTMnetiP34942.

Expressioni

Gene expression databases

BgeeiENSBTAG00000003279.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.2 Publications

Protein-protein interaction databases

IntActiP34942. 1 interactor.
STRINGi9913.ENSBTAP00000004245.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35O114-341[»]
5LDWelectron microscopy4.27O114-343[»]
5LDXelectron microscopy5.60O114-341[»]
ProteinModelPortaliP34942.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi191 – 202Val-richAdd BLAST12

Sequence similaritiesi

Belongs to the complex I NDUFA10 subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3877. Eukaryota.
ENOG41101CN. LUCA.
HOGENOMiHOG000267026.
HOVERGENiHBG002308.
InParanoidiP34942.
KOiK03954.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR031314. DNK_dom.
IPR015828. NDUFA10.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01712. dNK. 1 hit.
[Graphical view]
PIRSFiPIRSF000543. NADH_UQ_42KD. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34942-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRLLRLVP PRVGGIHTSV QFKLQYGPLA YILGEKATKK MTEKSKLITV
60 70 80 90 100
DGNICSGKSK LAKEIAEKLG LKHFPEAGIH YVDSTTGDGK PLPVQFSGNC
110 120 130 140 150
SLEKFYDDPK SNDGNSYRLQ AWLYASRLLQ YADALEHLLS TGQGVVLERS
160 170 180 190 200
IYSDFVFLEA MYRQGFIRKQ CVDHYNQVKK VTICEYLPPH VVVYVDVPVP
210 220 230 240 250
EVQSRIQKKG NPHEMKITSA YLQDIENAYK GTFLPEMSEK CEVLQYSAWE
260 270 280 290 300
AQDAEKVVED IEYLKYDKGP WLDQNDRNLH KLRMLVQDKL EVLNYTSIPV
310 320 330 340
FLPEVTVGAH QSDQVFQEFT ELPGRKYRAG YNEDVGDKWI WLK
Length:343
Mass (Da):39,264
Last modified:February 1, 1994 - v1
Checksum:iF1AA5A93B438BA42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59419 mRNA. Translation: CAA42054.1.
PIRiS17677.
RefSeqiNP_788828.1. NM_176655.2.
UniGeneiBt.4473.

Genome annotation databases

GeneIDi338060.
KEGGibta:338060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59419 mRNA. Translation: CAA42054.1.
PIRiS17677.
RefSeqiNP_788828.1. NM_176655.2.
UniGeneiBt.4473.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35O114-341[»]
5LDWelectron microscopy4.27O114-343[»]
5LDXelectron microscopy5.60O114-341[»]
ProteinModelPortaliP34942.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP34942. 1 interactor.
STRINGi9913.ENSBTAP00000004245.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

PTM databases

iPTMnetiP34942.

Proteomic databases

PaxDbiP34942.
PeptideAtlasiP34942.
PRIDEiP34942.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi338060.
KEGGibta:338060.

Organism-specific databases

CTDi4705.

Phylogenomic databases

eggNOGiKOG3877. Eukaryota.
ENOG41101CN. LUCA.
HOGENOMiHOG000267026.
HOVERGENiHBG002308.
InParanoidiP34942.
KOiK03954.

Gene expression databases

BgeeiENSBTAG00000003279.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR031314. DNK_dom.
IPR015828. NDUFA10.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01712. dNK. 1 hit.
[Graphical view]
PIRSFiPIRSF000543. NADH_UQ_42KD. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNDUAA_BOVIN
AccessioniPrimary (citable) accession number: P34942
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.