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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

Gene

NDUFA10

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Cofactori

FADNote: Binds 1 FAD per subunit.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

FAD, Flavoprotein

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
Alternative name(s):
Complex I-42kD
Short name:
CI-42kD
NADH-ubiquinone oxidoreductase 42 kDa subunit
Gene namesi
Name:NDUFA10
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrial respiratory chain complex I Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2323MitochondrionAdd
BLAST
Chaini24 – 343320NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialPRO_0000019987Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei110 – 1101N6-acetyllysine; alternateBy similarity
Modified residuei110 – 1101N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP34942.
PeptideAtlasiP34942.
PRIDEiP34942.

PTM databases

iPTMnetiP34942.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.2 Publications

Protein-protein interaction databases

IntActiP34942. 1 interaction.
STRINGi9913.ENSBTAP00000004245.

Structurei

3D structure databases

ProteinModelPortaliP34942.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi191 – 20212Val-richAdd
BLAST

Sequence similaritiesi

Belongs to the complex I NDUFA10 subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3877. Eukaryota.
ENOG41101CN. LUCA.
HOGENOMiHOG000267026.
HOVERGENiHBG002308.
InParanoidiP34942.
KOiK03954.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR031314. DNK_dom.
IPR015828. NDUFA10.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01712. dNK. 1 hit.
[Graphical view]
PIRSFiPIRSF000543. NADH_UQ_42KD. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34942-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRLLRLVP PRVGGIHTSV QFKLQYGPLA YILGEKATKK MTEKSKLITV
60 70 80 90 100
DGNICSGKSK LAKEIAEKLG LKHFPEAGIH YVDSTTGDGK PLPVQFSGNC
110 120 130 140 150
SLEKFYDDPK SNDGNSYRLQ AWLYASRLLQ YADALEHLLS TGQGVVLERS
160 170 180 190 200
IYSDFVFLEA MYRQGFIRKQ CVDHYNQVKK VTICEYLPPH VVVYVDVPVP
210 220 230 240 250
EVQSRIQKKG NPHEMKITSA YLQDIENAYK GTFLPEMSEK CEVLQYSAWE
260 270 280 290 300
AQDAEKVVED IEYLKYDKGP WLDQNDRNLH KLRMLVQDKL EVLNYTSIPV
310 320 330 340
FLPEVTVGAH QSDQVFQEFT ELPGRKYRAG YNEDVGDKWI WLK
Length:343
Mass (Da):39,264
Last modified:February 1, 1994 - v1
Checksum:iF1AA5A93B438BA42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59419 mRNA. Translation: CAA42054.1.
PIRiS17677.
RefSeqiNP_788828.1. NM_176655.2.
UniGeneiBt.4473.

Genome annotation databases

GeneIDi338060.
KEGGibta:338060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59419 mRNA. Translation: CAA42054.1.
PIRiS17677.
RefSeqiNP_788828.1. NM_176655.2.
UniGeneiBt.4473.

3D structure databases

ProteinModelPortaliP34942.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP34942. 1 interaction.
STRINGi9913.ENSBTAP00000004245.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

PTM databases

iPTMnetiP34942.

Proteomic databases

PaxDbiP34942.
PeptideAtlasiP34942.
PRIDEiP34942.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi338060.
KEGGibta:338060.

Organism-specific databases

CTDi4705.

Phylogenomic databases

eggNOGiKOG3877. Eukaryota.
ENOG41101CN. LUCA.
HOGENOMiHOG000267026.
HOVERGENiHBG002308.
InParanoidiP34942.
KOiK03954.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR031314. DNK_dom.
IPR015828. NDUFA10.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01712. dNK. 1 hit.
[Graphical view]
PIRSFiPIRSF000543. NADH_UQ_42KD. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "NADH:ubiquinone oxidoreductase from bovine heart mitochondria. cDNA sequences of the import precursors of the nuclear-encoded 39 kDa and 42 kDa subunits."
    Fearnley I.M., Finel M., Skehel J.M., Walker J.E.
    Biochem. J. 278:821-829(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Heart.
  2. "Resolution of the membrane domain of bovine complex I into subcomplexes: implications for the structural organization of the enzyme."
    Sazanov L.A., Peak-Chew S.Y., Fearnley I.M., Walker J.E.
    Biochemistry 39:7229-7235(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, SUBUNIT, IDENTIFICATION IN COMPLEX I.
  3. "Subunit analysis of bovine heart complex I by reversed-phase high-performance liquid chromatography, electrospray ionization-tandem mass spectrometry, and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry."
    Lemma-Gray P., Valusova E., Carroll C.A., Weintraub S.T., Musatov A., Robinson N.C.
    Anal. Biochem. 382:116-121(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, IDENTIFICATION IN COMPLEX I.

Entry informationi

Entry nameiNDUAA_BOVIN
AccessioniPrimary (citable) accession number: P34942
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 6, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.