HSPA5

Functionⁱ

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	8 – 11	ATPBy similarity		4

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW

Complete GO annotation...

GO - Biological processⁱ

maintenance of protein localization in endoplasmic reticulum Source: UniProtKB
positive regulation of cell migration Source: UniProtKB

Complete GO annotation...

Keywordsⁱ

Ligand	ATP-binding, Nucleotide-binding

Ligand

ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 78 kDa glucose-regulated protein Short name: GRP-78 Alternative name(s): Heat shock 70 kDa protein 5 Immunoglobulin heavy chain-binding protein Short name: BiP
Gene namesⁱ	Name:HSPA5 Synonyms:GRP78
Organismⁱ	Sus scrofa (Pig)
Taxonomic identifierⁱ	9823 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus
Proteomesⁱ	UP000008227 Componentⁱ: Unplaced

Subcellular locationⁱ

Endoplasmic reticulum lumen By similarity
Melanosome By similarity
Cytoplasm By similarity

GO - Cellular componentⁱ

endoplasmic reticulum lumen Source: UniProtKB-SubCell
melanosome Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm, Endoplasmic reticulum

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000078663	‹1 – ›262	78 kDa glucose-regulated proteinAdd BLAST		›262

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	91	N6-succinyllysineBy similarity	1
Modified residueⁱ	136	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	162	PhosphothreonineBy similarity	1
Modified residueⁱ	229	N6,N6,N6-trimethyllysine; by METTL21A; in vitroBy similarity	1
Modified residueⁱ	229	N6,N6-dimethyllysine; alternateBy similarity	1
Modified residueⁱ	229	N6-methyllysine; alternateBy similarity	1
Modified residueⁱ	235	N6-methyllysineBy similarity	1

Keywords - PTMⁱ

Methylation, Phosphoprotein

Proteomic databases

PaxDbⁱ	P34935.
PeptideAtlas More...PeptideAtlasⁱ	P34935.
PRIDEⁱ	P34935.

Interactionⁱ

Subunit structureⁱ

Interacts with DNAJC1 (via J domain). Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with TMEM132A and TRIM21. May form a complex with ERLEC1, OS9, SEL1L and SYVN1. Interacts with DNAJC10. Interacts with MX1. Interacts with METTL23. Interacts with CEMIP; the interaction induces calcium leakage from the endoplasmic reticulum and cell migration. Interacts with PCSK4 form; the interaction takes place in the endoplasmic reticulum. Interacts with CIPC. Interacts with CCDC88B (via C-terminus); the interaction opposes ERN1-mediated JNK activation, protecting against apoptosis.By similarity

Protein-protein interaction databases

STRINGⁱ	9823.ENSSSCP00000006000.

STRINGⁱ

9823.ENSSSCP00000006000.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P34935.
SMRⁱ	P34935.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0101. Eukaryota. COG0443. LUCA.
HOGENOMⁱ	HOG000228135.
HOVERGENⁱ	HBG051845.
InParanoidⁱ	P34935.

Family and domain databases

Gene3Dⁱ	1.20.1270.10. 1 hit. 2.60.34.10. 1 hit.
InterProⁱ	View protein in InterPro IPR018181. Heat_shock_70_CS. IPR029048. HSP70_C. IPR029047. HSP70_peptide-bd. IPR013126. Hsp_70_fam.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00012. HSP70. 1 hit.
PRINTSⁱ	PR00301. HEATSHOCK70.
SUPFAMⁱ	SSF100920. SSF100920. 1 hit. SSF100934. SSF100934. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01036. HSP70_3. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

P34935-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
DEIVLVGGST RIPKIQQLVK EFFNGKEPSR GINPDEAVAY GAAVQAGVLS 
        60         70         80         90        100
GDQDTGDLVL LDVCPLTLGI ETVGGVMTKL IPRNTVVPTK KSQIFSTASD 
       110        120        130        140        150
NQPTVTIKVY EGERPLTKDN HLLGTFDLTG IPPAPRGVPQ IEVTFEIDVN 
       160        170        180        190        200
GILRVTAEDK GTGNKNKITI TNDQNRLTPE EIERMVNDAE KFAEEDKKLK 
       210        220        230        240        250
ERIDTRNELE SYAYCLKNQI GDKEKLGGKL SSEDKETMEK AVEEKIEWLE 
       260 
SHQDADIEDF KA

Length:262

Mass (Da):28,912

Last modified:July 11, 2001 - v2

Checksum:ⁱAA6CE50EC083977B

GO

Sequence cautionⁱ

The sequence AAA31006 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	1			1
Non-terminal residueⁱ	262			1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03214 mRNA. Translation: AAA31006.2. Frameshift.
UniGeneⁱ	Ssc.1717.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03214 mRNA. Translation: AAA31006.2. Frameshift.
UniGeneⁱ	Ssc.1717.

3D structure databases

ProteinModelPortalⁱ	P34935.
SMRⁱ	P34935.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9823.ENSSSCP00000006000.

STRINGⁱ

9823.ENSSSCP00000006000.

Proteomic databases

PaxDbⁱ	P34935.
PeptideAtlas More...PeptideAtlasⁱ	P34935.
PRIDEⁱ	P34935.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Phylogenomic databases

eggNOGⁱ	KOG0101. Eukaryota. COG0443. LUCA.
HOGENOMⁱ	HOG000228135.
HOVERGENⁱ	HBG051845.
InParanoidⁱ	P34935.

Family and domain databases

Gene3Dⁱ	1.20.1270.10. 1 hit. 2.60.34.10. 1 hit.
InterProⁱ	View protein in InterPro IPR018181. Heat_shock_70_CS. IPR029048. HSP70_C. IPR029047. HSP70_peptide-bd. IPR013126. Hsp_70_fam.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00012. HSP70. 1 hit.
PRINTSⁱ	PR00301. HEATSHOCK70.
SUPFAMⁱ	SSF100920. SSF100920. 1 hit. SSF100934. SSF100934. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01036. HSP70_3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GRP78_PIG
Accessionⁱ	P34935Primary (citable) accession number: P34935
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
	Last sequence update:	July 11, 2001
	Last modified:	February 15, 2017
	This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P34935 (GRP78_PIG)

Your basket is currently empty.

78 kDa glucose-regulated protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ