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Protein

Heat shock 70 kDa protein 4

Gene

HSPA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ATP binding Source: UniProtKB

GO - Biological processi

  • chaperone-mediated protein complex assembly Source: BHF-UCL
  • protein import into mitochondrial outer membrane Source: BHF-UCL
  • response to unfolded protein Source: UniProtKB

Keywordsi

Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 4
Alternative name(s):
HSP70RY
Heat shock 70-related protein APG-2
Gene namesi
Name:HSPA4
Synonyms:APG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000170606.13
HGNCiHGNC:5237 HSPA4
MIMi601113 gene
neXtProtiNX_P34932

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi3308
OpenTargetsiENSG00000170606
PharmGKBiPA29503

Polymorphism and mutation databases

BioMutaiHSPA4
DMDMi206729934

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000782621 – 840Heat shock 70 kDa protein 4Add BLAST840

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53N6-acetyllysineBy similarity1
Modified residuei76PhosphoserineCombined sources1
Modified residuei89PhosphotyrosineCombined sources1
Modified residuei336PhosphotyrosineCombined sources1
Modified residuei393PhosphoserineCombined sources1
Modified residuei415PhosphoserineBy similarity1
Modified residuei430N6-acetyllysineCombined sources1
Modified residuei538PhosphothreonineCombined sources1
Modified residuei546PhosphoserineCombined sources1
Modified residuei647PhosphoserineCombined sources1
Modified residuei660PhosphotyrosineBy similarity1
Modified residuei679N6-acetyllysineCombined sources1
Modified residuei756PhosphoserineCombined sources1
Modified residuei773N6-methyllysineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP34932
MaxQBiP34932
PaxDbiP34932
PeptideAtlasiP34932
PRIDEiP34932

2D gel databases

DOSAC-COBS-2DPAGEiP34932
REPRODUCTION-2DPAGEiIPI00002966
P34932

PTM databases

iPTMnetiP34932
PhosphoSitePlusiP34932
SwissPalmiP34932

Expressioni

Gene expression databases

BgeeiENSG00000170606
CleanExiHS_HSPA4
ExpressionAtlasiP34932 baseline and differential
GenevisibleiP34932 HS

Organism-specific databases

HPAiCAB025529
HPA010023

Interactioni

Subunit structurei

Interacts with TJP1/ZO-1.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi109540, 355 interactors
CORUMiP34932
DIPiDIP-460N
IntActiP34932, 48 interactors
MINTiP34932
STRINGi9606.ENSP00000302961

Structurei

3D structure databases

ProteinModelPortaliP34932
SMRiP34932
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0103 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00390000016919
HOGENOMiHOG000228138
HOVERGENiHBG047955
InParanoidiP34932
KOiK09489
OMAiKMDQPPQ
OrthoDBiEOG091G04Y6
PhylomeDBiP34932
TreeFamiTF105043

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 2 hits
SSF100934 SSF100934, 2 hits
PROSITEiView protein in PROSITE
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P34932-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVVGIDLGF QSCYVAVARA GGIETIANEY SDRCTPACIS FGPKNRSIGA
60 70 80 90 100
AAKSQVISNA KNTVQGFKRF HGRAFSDPFV EAEKSNLAYD IVQLPTGLTG
110 120 130 140 150
IKVTYMEEER NFTTEQVTAM LLSKLKETAE SVLKKPVVDC VVSVPCFYTD
160 170 180 190 200
AERRSVMDAT QIAGLNCLRL MNETTAVALA YGIYKQDLPA LEEKPRNVVF
210 220 230 240 250
VDMGHSAYQV SVCAFNRGKL KVLATAFDTT LGGRKFDEVL VNHFCEEFGK
260 270 280 290 300
KYKLDIKSKI RALLRLSQEC EKLKKLMSAN ASDLPLSIEC FMNDVDVSGT
310 320 330 340 350
MNRGKFLEMC NDLLARVEPP LRSVLEQTKL KKEDIYAVEI VGGATRIPAV
360 370 380 390 400
KEKISKFFGK ELSTTLNADE AVTRGCALQC AILSPAFKVR EFSITDVVPY
410 420 430 440 450
PISLRWNSPA EEGSSDCEVF SKNHAAPFSK VLTFYRKEPF TLEAYYSSPQ
460 470 480 490 500
DLPYPDPAIA QFSVQKVTPQ SDGSSSKVKV KVRVNVHGIF SVSSASLVEV
510 520 530 540 550
HKSEENEEPM ETDQNAKEEE KMQVDQEEPH VEEQQQQTPA ENKAESEEME
560 570 580 590 600
TSQAGSKDKK MDQPPQAKKA KVKTSTVDLP IENQLLWQID REMLNLYIEN
610 620 630 640 650
EGKMIMQDKL EKERNDAKNA VEEYVYEMRD KLSGEYEKFV SEDDRNSFTL
660 670 680 690 700
KLEDTENWLY EDGEDQPKQV YVDKLAELKN LGQPIKIRFQ ESEERPKLFE
710 720 730 740 750
ELGKQIQQYM KIISSFKNKE DQYDHLDAAD MTKVEKSTNE AMEWMNNKLN
760 770 780 790 800
LQNKQSLTMD PVVKSKEIEA KIKELTSTCS PIISKPKPKV EPPKEEQKNA
810 820 830 840
EQNGPVDGQG DNPGPQAAEQ GTDTAVPSDS DKKLPEMDID
Length:840
Mass (Da):94,331
Last modified:September 23, 2008 - v4
Checksum:i8B690A52A0729C2A
GO
Isoform 2 (identifier: P34932-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-800: Missing.

Show »
Length:148
Mass (Da):15,689
Checksum:iC269BCA9925F562F
GO

Sequence cautioni

The sequence AAA02807 differs from that shown. Reason: Frameshift at positions 567, 586, 697, 715 and 722.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94L → W in AAA02807 (PubMed:8335910).Curated1
Sequence conflicti190A → R in AAA02807 (PubMed:8335910).Curated1
Sequence conflicti583 – 586NQLL → ESAI in AAA02807 (PubMed:8335910).Curated4
Sequence conflicti622E → R in BAA75062 (Ref. 1) Curated1
Sequence conflicti644D → G in BAA75062 (Ref. 1) Curated1
Sequence conflicti746 – 749NNKL → EVTP in AAA02807 (PubMed:8335910).Curated4

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056885109 – 800Missing in isoform 2. 2 PublicationsAdd BLAST692

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023420 mRNA Translation: BAA75062.1
BT007375 mRNA Translation: AAP36039.1
AC113410 Genomic DNA No translation available.
BC002526 mRNA Translation: AAH02526.1
BC110861 mRNA Translation: AAI10862.1
BC126122 mRNA Translation: AAI26123.1
BC126124 mRNA Translation: AAI26125.1
L12723 mRNA Translation: AAA02807.1 Frameshift.
CCDSiCCDS4166.1 [P34932-1]
PIRiI56208
RefSeqiNP_002145.3, NM_002154.3 [P34932-1]
UniGeneiHs.90093

Genome annotation databases

EnsembliENST00000304858; ENSP00000302961; ENSG00000170606 [P34932-1]
GeneIDi3308
KEGGihsa:3308
UCSCiuc003kyj.4 human [P34932-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHSP74_HUMAN
AccessioniPrimary (citable) accession number: P34932
Secondary accession number(s): O95756, Q2TAL4, Q9BUK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: September 23, 2008
Last modified: April 25, 2018
This is version 182 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health