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Protein

Heat shock 70 kDa protein 1-like

Gene

HSPA1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity). Positive regulator of PARK2 translocation to damaged mitochondria.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei73ATP1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 17ATP4
Nucleotide bindingi204 – 206ATP3
Nucleotide bindingi270 – 277ATP8
Nucleotide bindingi341 – 344ATP4

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • heat shock protein binding Source: UniProtKB
  • ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
  • unfolded protein binding Source: UniProtKB

GO - Biological processi

  • binding of sperm to zona pellucida Source: Ensembl
  • positive regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
  • protein refolding Source: UniProtKB
  • regulation of cellular response to heat Source: Reactome
  • response to unfolded protein Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:G66-33454-MONOMER.
ReactomeiR-HSA-3371453. Regulation of HSF1-mediated heat shock response.
R-HSA-3371568. Attenuation phase.
R-HSA-3371571. HSF1-dependent transactivation.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 1-like
Short name:
Heat shock 70 kDa protein 1L
Alternative name(s):
Heat shock 70 kDa protein 1-Hom
Short name:
HSP70-Hom
Gene namesi
Name:HSPA1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:5234. HSPA1L.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • cell body Source: Ensembl
  • cytosol Source: UniProtKB
  • mitochondrial matrix Source: Ensembl
  • nucleoplasm Source: Reactome
  • zona pellucida receptor complex Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi73K → E: No rescue of PARK2 translocation deficit in knockout cells. 1 Publication1
Mutagenesisi396L → D: No rescue of PARK2 translocation deficit in knockout cells. 1 Publication1
Mutagenesisi638 – 641Missing : No rescue of PARK2 translocation deficit in knockout cells. 1 Publication4

Organism-specific databases

DisGeNETi3305.
OpenTargetsiENSG00000204390.
ENSG00000234258.
PharmGKBiPA29500.

Polymorphism and mutation databases

BioMutaiHSPA1L.
DMDMi23831140.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000782551 – 641Heat shock 70 kDa protein 1-likeAdd BLAST641

Proteomic databases

EPDiP34931.
MaxQBiP34931.
PaxDbiP34931.
PeptideAtlasiP34931.
PRIDEiP34931.
TopDownProteomicsiP34931.

2D gel databases

UCD-2DPAGEP34931.

PTM databases

iPTMnetiP34931.
PhosphoSitePlusiP34931.
SwissPalmiP34931.

Expressioni

Tissue specificityi

Expressed in spermatids.1 Publication

Inductioni

Not induced by heat shock.1 Publication

Gene expression databases

BgeeiENSG00000204390.
CleanExiHS_HSPA1L.
GenevisibleiP34931. HS.

Organism-specific databases

HPAiHPA043285.
HPA052504.

Interactioni

Subunit structurei

Interacts with PARK2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NFKB1P198383EBI-354912,EBI-300010
TP53P046372EBI-354912,EBI-366083

GO - Molecular functioni

  • heat shock protein binding Source: UniProtKB
  • ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
  • unfolded protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109537. 135 interactors.
IntActiP34931. 54 interactors.
MINTiMINT-1136903.
STRINGi9606.ENSP00000364805.

Structurei

Secondary structure

1641
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 12Combined sources4
Beta strandi15 – 24Combined sources10
Beta strandi27 – 30Combined sources4
Beta strandi38 – 41Combined sources4
Beta strandi44 – 46Combined sources3
Beta strandi51 – 53Combined sources3
Helixi55 – 59Combined sources5
Helixi60 – 63Combined sources4
Helixi65 – 67Combined sources3
Helixi72 – 75Combined sources4
Helixi83 – 89Combined sources7
Beta strandi93 – 99Combined sources7
Beta strandi102 – 109Combined sources8
Beta strandi112 – 116Combined sources5
Helixi118 – 137Combined sources20
Beta strandi143 – 148Combined sources6
Helixi154 – 166Combined sources13
Beta strandi170 – 176Combined sources7
Helixi177 – 184Combined sources8
Turni185 – 188Combined sources4
Beta strandi195 – 202Combined sources8
Beta strandi207 – 215Combined sources9
Beta strandi218 – 227Combined sources10
Helixi232 – 251Combined sources20
Helixi255 – 257Combined sources3
Helixi259 – 275Combined sources17
Turni276 – 278Combined sources3
Beta strandi279 – 290Combined sources12
Beta strandi293 – 300Combined sources8
Helixi301 – 307Combined sources7
Helixi309 – 314Combined sources6
Helixi316 – 325Combined sources10
Helixi330 – 332Combined sources3
Beta strandi335 – 340Combined sources6
Helixi341 – 344Combined sources4
Helixi346 – 355Combined sources10
Turni356 – 358Combined sources3
Turni367 – 369Combined sources3
Helixi370 – 383Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GDQX-ray1.80A1-386[»]
ProteinModelPortaliP34931.
SMRiP34931.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP34931.

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00860000133911.
HOVERGENiHBG051845.
InParanoidiP34931.
KOiK03283.
OMAiQADKPMI.
OrthoDBiEOG091G03SF.
PhylomeDBiP34931.
TreeFamiTF105042.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34931-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAKGIAIG IDLGTTYSCV GVFQHGKVEI IANDQGNRTT PSYVAFTDTE
60 70 80 90 100
RLIGDAAKNQ VAMNPQNTVF DAKRLIGRKF NDPVVQADMK LWPFQVINEG
110 120 130 140 150
GKPKVLVSYK GENKAFYPEE ISSMVLTKLK ETAEAFLGHP VTNAVITVPA
160 170 180 190 200
YFNDSQRQAT KDAGVIAGLN VLRIINEPTA AAIAYGLDKG GQGERHVLIF
210 220 230 240 250
DLGGGTFDVS ILTIDDGIFE VKATAGDTHL GGEDFDNRLV SHFVEEFKRK
260 270 280 290 300
HKKDISQNKR AVRRLRTACE RAKRTLSSST QANLEIDSLY EGIDFYTSIT
310 320 330 340 350
RARFEELCAD LFRGTLEPVE KALRDAKMDK AKIHDIVLVG GSTRIPKVQR
360 370 380 390 400
LLQDYFNGRD LNKSINPDEA VAYGAAVQAA ILMGDKSEKV QDLLLLDVAP
410 420 430 440 450
LSLGLETAGG VMTALIKRNS TIPTKQTQIF TTYSDNQPGV LIQVYEGERA
460 470 480 490 500
MTKDNNLLGR FDLTGIPPAP RGVPQIEVTF DIDANGILNV TATDKSTGKV
510 520 530 540 550
NKITITNDKG RLSKEEIERM VLDAEKYKAE DEVQREKIAA KNALESYAFN
560 570 580 590 600
MKSVVSDEGL KGKISESDKN KILDKCNELL SWLEVNQLAE KDEFDHKRKE
610 620 630 640
LEQMCNPIIT KLYQGGCTGP ACGTGYVPGR PATGPTIEEV D
Length:641
Mass (Da):70,375
Last modified:October 10, 2002 - v2
Checksum:iA9339D7657166FF7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti408A → V in AAA63228 (PubMed:1700760).Curated1
Sequence conflicti416I → M in AAH34483 (PubMed:15489334).Curated1
Sequence conflicti424T → P in AAA63228 (PubMed:1700760).Curated1
Sequence conflicti506T → A in AAH34483 (PubMed:15489334).Curated1
Sequence conflicti627V → M in BAA32521 (PubMed:9685725).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0258418A → P.1 PublicationCorresponds to variant rs9469057dbSNPEnsembl.1
Natural variantiVAR_025842268A → T.1 PublicationCorresponds to variant rs34620296dbSNPEnsembl.1
Natural variantiVAR_025843294D → G.1 PublicationCorresponds to variant rs34360259dbSNPEnsembl.1
Natural variantiVAR_025844479T → M.1 PublicationCorresponds to variant rs482145dbSNPEnsembl.1
Natural variantiVAR_003820493T → M.4 PublicationsCorresponds to variant rs2227956dbSNPEnsembl.1
Natural variantiVAR_025845558E → A.1 PublicationCorresponds to variant rs2227955dbSNPEnsembl.1
Natural variantiVAR_025846602E → K.1 PublicationCorresponds to variant rs2075800dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59829 Genomic DNA. Translation: AAA63228.1.
D85730 mRNA. Translation: BAA32521.1.
AF134726 Genomic DNA. Translation: AAD21817.1.
BA000025 Genomic DNA. Translation: BAB63301.1.
DQ383515 Genomic DNA. Translation: ABC88476.1.
AL662834 Genomic DNA. Translation: CAI17736.1.
AL671762 Genomic DNA. Translation: CAI18215.1.
AL929592 Genomic DNA. Translation: CAI18463.1.
CR388202 Genomic DNA. Translation: CAQ09503.1.
BC034483 mRNA. Translation: AAH34483.1.
CCDSiCCDS34413.1.
PIRiB45871.
RefSeqiNP_005518.3. NM_005527.3.
UniGeneiHs.690634.

Genome annotation databases

EnsembliENST00000375654; ENSP00000364805; ENSG00000204390.
ENST00000383390; ENSP00000372881; ENSG00000206383.
ENST00000417601; ENSP00000396486; ENSG00000234258.
ENST00000456772; ENSP00000408347; ENSG00000236251.
GeneIDi3305.
KEGGihsa:3305.
UCSCiuc003nxh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59829 Genomic DNA. Translation: AAA63228.1.
D85730 mRNA. Translation: BAA32521.1.
AF134726 Genomic DNA. Translation: AAD21817.1.
BA000025 Genomic DNA. Translation: BAB63301.1.
DQ383515 Genomic DNA. Translation: ABC88476.1.
AL662834 Genomic DNA. Translation: CAI17736.1.
AL671762 Genomic DNA. Translation: CAI18215.1.
AL929592 Genomic DNA. Translation: CAI18463.1.
CR388202 Genomic DNA. Translation: CAQ09503.1.
BC034483 mRNA. Translation: AAH34483.1.
CCDSiCCDS34413.1.
PIRiB45871.
RefSeqiNP_005518.3. NM_005527.3.
UniGeneiHs.690634.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GDQX-ray1.80A1-386[»]
ProteinModelPortaliP34931.
SMRiP34931.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109537. 135 interactors.
IntActiP34931. 54 interactors.
MINTiMINT-1136903.
STRINGi9606.ENSP00000364805.

PTM databases

iPTMnetiP34931.
PhosphoSitePlusiP34931.
SwissPalmiP34931.

Polymorphism and mutation databases

BioMutaiHSPA1L.
DMDMi23831140.

2D gel databases

UCD-2DPAGEP34931.

Proteomic databases

EPDiP34931.
MaxQBiP34931.
PaxDbiP34931.
PeptideAtlasiP34931.
PRIDEiP34931.
TopDownProteomicsiP34931.

Protocols and materials databases

DNASUi3305.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375654; ENSP00000364805; ENSG00000204390.
ENST00000383390; ENSP00000372881; ENSG00000206383.
ENST00000417601; ENSP00000396486; ENSG00000234258.
ENST00000456772; ENSP00000408347; ENSG00000236251.
GeneIDi3305.
KEGGihsa:3305.
UCSCiuc003nxh.4. human.

Organism-specific databases

CTDi3305.
DisGeNETi3305.
GeneCardsiHSPA1L.
H-InvDBHIX0165969.
HIX0166127.
HIX0166446.
HIX0167182.
HIX0184230.
HGNCiHGNC:5234. HSPA1L.
HPAiHPA043285.
HPA052504.
MIMi140559. gene.
neXtProtiNX_P34931.
OpenTargetsiENSG00000204390.
ENSG00000234258.
PharmGKBiPA29500.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00860000133911.
HOVERGENiHBG051845.
InParanoidiP34931.
KOiK03283.
OMAiQADKPMI.
OrthoDBiEOG091G03SF.
PhylomeDBiP34931.
TreeFamiTF105042.

Enzyme and pathway databases

BioCyciZFISH:G66-33454-MONOMER.
ReactomeiR-HSA-3371453. Regulation of HSF1-mediated heat shock response.
R-HSA-3371568. Attenuation phase.
R-HSA-3371571. HSF1-dependent transactivation.

Miscellaneous databases

EvolutionaryTraceiP34931.
GeneWikiiHSPA1L.
GenomeRNAii3305.
PROiP34931.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204390.
CleanExiHS_HSPA1L.
GenevisibleiP34931. HS.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHS71L_HUMAN
AccessioniPrimary (citable) accession number: P34931
Secondary accession number(s): A6NNB0
, B0UXW8, O75634, Q2HXR3, Q8NE72, Q96QC9, Q9UQM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 10, 2002
Last modified: November 30, 2016
This is version 160 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.