P34931 (HS71L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Heat shock 70 kDa protein 1-like
Short name=Heat shock 70 kDa protein 1L

Alternative name(s):
Heat shock 70 kDa protein 1-Hom
Short name=HSP70-Hom

Gene names

Name:

HSPA1L

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	641 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage By similarity.
Tissue specificity	Expressed in spermatids. Ref.2
Induction	Not induced by heat shock. Ref.1
Sequence similarities	Belongs to the heat shock protein 70 family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	ATP-binding Nucleotide-binding
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	response to unfolded protein Traceable author statement. Source: ProtInc
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 641

641

Heat shock 70 kDa protein 1-like

PRO_0000078255

Natural variations

Natural variant

8

1

A → P. Ref.5
Corresponds to variant rs9469057 [ dbSNP | Ensembl ].

VAR_025841

Natural variant

268

1

A → T. Ref.5

VAR_025842

Natural variant

294

1

D → G. Ref.5

VAR_025843

Natural variant

479

1

T → M. Ref.5
Corresponds to variant rs482145 [ dbSNP | Ensembl ].

VAR_025844

Natural variant

493

1

T → M. Ref.5 Ref.6 Ref.7 Ref.9
Corresponds to variant rs2227956 [ dbSNP | Ensembl ].

VAR_003820

Natural variant

558

1

E → A. Ref.5
Corresponds to variant rs2227955 [ dbSNP | Ensembl ].

VAR_025845

Natural variant

602

1

E → K. Ref.5
Corresponds to variant rs2075800 [ dbSNP | Ensembl ].

VAR_025846

Experimental info

Sequence conflict

408

1

A → V in AAA63228. Ref.1

Sequence conflict

416

1

I → M in AAH34483. Ref.7

Sequence conflict

424

1

T → P in AAA63228. Ref.1

Sequence conflict

506

1

T → A in AAH34483. Ref.7

Sequence conflict

627

1

V → M in BAA32521. Ref.2

Secondary structure

1

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641

Helix Strand Turn

Details...

Beta strand

17 – 19

3

Beta strand

39 – 41

3

Beta strand

44 – 46

3

Helix

56 – 59

4

Helix

60 – 63

4

Helix

65 – 67

3

Helix

72 – 75

4

Helix

83 – 89

7

Beta strand

93 – 98

6

Beta strand

103 – 108

6

Beta strand

113 – 116

4

Helix

118 – 136

19

Beta strand

143 – 148

6

Helix

154 – 162

9

Beta strand

170 – 176

7

Helix

177 – 184

8

Beta strand

195 – 202

8

Beta strand

208 – 214

7

Beta strand

219 – 225

7

Helix

234 – 251

18

Helix

255 – 258

4

Helix

259 – 275

17

Turn

276 – 278

3

Beta strand

279 – 286

8

Beta strand

295 – 300

6

Helix

301 – 307

7

Helix

309 – 312

4

Helix

316 – 325

10

Helix

330 – 332

3

Beta strand

335 – 339

5

Helix

346 – 355

10

Turn

367 – 372

6

Helix

376 – 382

7

Sequences

	Sequence		Length	Mass (Da)
	P34931 [UniParc]. Last modified October 10, 2002. Version 2. Checksum: A9339D7657166FF7	FASTA	641	70,375
	10 20 30 40 50 60 MATAKGIAIG IDLGTTYSCV GVFQHGKVEI IANDQGNRTT PSYVAFTDTE RLIGDAAKNQ 70 80 90 100 110 120 VAMNPQNTVF DAKRLIGRKF NDPVVQADMK LWPFQVINEG GKPKVLVSYK GENKAFYPEE 130 140 150 160 170 180 ISSMVLTKLK ETAEAFLGHP VTNAVITVPA YFNDSQRQAT KDAGVIAGLN VLRIINEPTA 190 200 210 220 230 240 AAIAYGLDKG GQGERHVLIF DLGGGTFDVS ILTIDDGIFE VKATAGDTHL GGEDFDNRLV 250 260 270 280 290 300 SHFVEEFKRK HKKDISQNKR AVRRLRTACE RAKRTLSSST QANLEIDSLY EGIDFYTSIT 310 320 330 340 350 360 RARFEELCAD LFRGTLEPVE KALRDAKMDK AKIHDIVLVG GSTRIPKVQR LLQDYFNGRD 370 380 390 400 410 420 LNKSINPDEA VAYGAAVQAA ILMGDKSEKV QDLLLLDVAP LSLGLETAGG VMTALIKRNS 430 440 450 460 470 480 TIPTKQTQIF TTYSDNQPGV LIQVYEGERA MTKDNNLLGR FDLTGIPPAP RGVPQIEVTF 490 500 510 520 530 540 DIDANGILNV TATDKSTGKV NKITITNDKG RLSKEEIERM VLDAEKYKAE DEVQREKIAA 550 560 570 580 590 600 KNALESYAFN MKSVVSDEGL KGKISESDKN KILDKCNELL SWLEVNQLAE KDEFDHKRKE 610 620 630 640 LEQMCNPIIT KLYQGGCTGP ACGTGYVPGR PATGPTIEEV D

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and expression of the three MHC-linked HSP70 genes." Milner C.M., Campbell R.D. Immunogenetics 32:242-251(1990) [PubMed: 1700760] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
[2]	"Genomic structure of the spermatid-specific HSP70 homolog gene located in the class III region of the major histocompatibility complex of mouse and man." Ito Y., Ando A., Ando H., Ando J., Saijoh Y., Inoko H., Fujimoto H. J. Biochem. 124:347-353(1998) [PubMed: 9685725] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY. Tissue: Testis.
[3]	"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse." Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L. Genome Res. 13:2621-2636(2003) [PubMed: 14656967] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region." Shiina S., Tamiya G., Oka A., Inoko H. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	NIEHS SNPs program Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS PRO-8; THR-268; GLY-294; MET-479; MET-493; ALA-558 AND LYS-602.
[6]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-493.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-493. Tissue: Testis.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]	"Polymorphic analysis of the three MHC-linked HSP70 genes." Milner C.M., Campbell R.D. Immunogenetics 36:357-362(1992) [PubMed: 1356099] [Abstract] Cited for: VARIANT MET-493.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M59829 Genomic DNA. Translation: AAA63228.1.
D85730 mRNA. Translation: BAA32521.1.
AF134726 Genomic DNA. Translation: AAD21817.1.
BA000025 Genomic DNA. Translation: BAB63301.1.
DQ383515 Genomic DNA. Translation: ABC88476.1.
AL662834 Genomic DNA. Translation: CAI17736.1.
AL671762 Genomic DNA. Translation: CAI18215.1.
AL929592 Genomic DNA. Translation: CAI18463.1.
CR388202 Genomic DNA. Translation: CAQ09503.1.
BC034483 mRNA. Translation: AAH34483.1.

IPI

IPI00939442.

PIR

B45871.

RefSeq

NP_005518.3. NM_005527.3.

UniGene

Hs.690634.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3GDQ	X-ray	1.80	A	1-386	[»]

ProteinModelPortal

P34931.

SMR

P34931. Positions 4-615.

ModBase

Search...

Protein-protein interaction databases

IntAct

P34931. 21 interactions.

MINT

MINT-1136903.

STRING

P34931.

PTM databases

PhosphoSite

P34931.

Polymorphism databases

DMDM

23831140.

2D gel databases

UCD-2DPAGE

P34931.

Proteomic databases

PRIDE

P34931.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000375654; ENSP00000364805; ENSG00000204390.
ENST00000417601; ENSP00000396486; ENSG00000234258.

GeneID

3305.

KEGG

hsa:3305.

UCSC

uc003nxh.1. human.

Organism-specific databases

CTD

3305.

GeneCards

GC06M031777.

HGNC

HGNC:5234. HSPA1L.

HPA

HPA043285.

MIM

140559. gene.

neXtProt

NX_P34931.

PharmGKB

PA29500.

GenAtlas

Search...

Phylogenomic databases

GeneTree

ENSGT00550000074467.

HOVERGEN

HBG051845.

InParanoid

P34931.

OMA

MVSYKGE.

OrthoDB

EOG4W6NVK.

PhylomeDB

P34931.

Gene expression databases

CleanEx

HS_HSPA1L.

Genevestigator

P34931.

GermOnline

ENSG00000204390. Homo sapiens.

Family and domain databases

InterPro

IPR018181. Heat_shock_70_CS.
IPR001023. Hsp70.
IPR013126. Hsp_70.
[Graphical view]

KO

K03283.

PANTHER

PTHR19375. Hsp70. 1 hit.

Pfam

PF00012. HSP70. 1 hit.
[Graphical view]

PRINTS

PR00301. HEATSHOCK70.

PROSITE

PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

13111.

SOURCE

Search...

Entry information

Entry name

HS71L_HUMAN

Accession

Primary (citable) accession number: P34931
Secondary accession number(s): A6NNB0 , B0UXW8, O75634, Q2HXR3, Q8NE72, Q96QC9, Q9UQM1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	October 10, 2002
Last modified:	January 25, 2012
This is version 109 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.