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P34928

- APOC1_MOUSE

UniProt

P34928 - APOC1_MOUSE

Protein

Apolipoprotein C-I

Gene

Apoc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Appears to modulate the interaction of APOE with beta-migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification.1 Publication

    GO - Molecular functioni

    1. fatty acid binding Source: Ensembl
    2. phospholipase inhibitor activity Source: Ensembl

    GO - Biological processi

    1. cholesterol efflux Source: Ensembl
    2. cholesterol metabolic process Source: MGI
    3. chylomicron remnant clearance Source: Ensembl
    4. lipoprotein metabolic process Source: InterPro
    5. negative regulation of cholesterol transport Source: Ensembl
    6. negative regulation of fatty acid biosynthetic process Source: Ensembl
    7. negative regulation of lipoprotein lipase activity Source: Ensembl
    8. negative regulation of phosphatidylcholine catabolic process Source: Ensembl
    9. negative regulation of receptor-mediated endocytosis Source: Ensembl
    10. negative regulation of very-low-density lipoprotein particle clearance Source: Ensembl
    11. phospholipid efflux Source: Ensembl
    12. plasma lipoprotein particle remodeling Source: Ensembl
    13. triglyceride metabolic process Source: MGI
    14. very-low-density lipoprotein particle clearance Source: Ensembl

    Keywords - Biological processi

    Lipid transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apolipoprotein C-I
    Short name:
    Apo-CIB
    Short name:
    ApoC-IB
    Alternative name(s):
    Apolipoprotein C1
    Cleaved into the following chain:
    Truncated apolipoprotein C-I
    Short name:
    Apo-CIB'
    Short name:
    ApoC-IB'
    Gene namesi
    Name:Apoc1
    Synonyms:Apoc1b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:88053. Apoc1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. high-density lipoprotein particle Source: Ensembl
    3. very-low-density lipoprotein particle Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted, VLDL

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626By similarityAdd
    BLAST
    Chaini27 – 8862Apolipoprotein C-IPRO_0000002015Add
    BLAST
    Chaini29 – 8860Truncated apolipoprotein C-IPRO_0000391844Add
    BLAST

    Proteomic databases

    MaxQBiP34928.
    PaxDbiP34928.
    PRIDEiP34928.

    PTM databases

    PhosphoSiteiP34928.

    Expressioni

    Tissue specificityi

    Secreted in plasma.

    Gene expression databases

    BgeeiP34928.
    CleanExiMM_APOC1.
    GenevestigatoriP34928.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000104091.

    Structurei

    3D structure databases

    ProteinModelPortaliP34928.
    SMRiP34928. Positions 28-84.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the apolipoprotein C1 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47204.
    GeneTreeiENSGT00390000011584.
    HOGENOMiHOG000034001.
    HOVERGENiHBG050547.
    InParanoidiP34928.
    OMAiQSDIPAK.
    OrthoDBiEOG7PK92M.
    PhylomeDBiP34928.
    TreeFamiTF330940.

    Family and domain databases

    Gene3Di4.10.260.30. 1 hit.
    InterProiIPR006781. ApoC-I.
    [Graphical view]
    PANTHERiPTHR16565. PTHR16565. 1 hit.
    PfamiPF04691. ApoC-I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P34928-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLFIALPVL IVVVAMTLEG PAPAQAAPDL SGTLESIPDK LKEFGNTLED   50
    KARAAIEHIK QKEILTKTRA WFSEAFGKVK EKLKTTFS 88
    Length:88
    Mass (Da):9,696
    Last modified:February 1, 1994 - v1
    Checksum:iCF35C2144BBDCC43
    GO

    Mass spectrometryi

    Molecular mass is 6993±0.707 Da from positions 27 - 88. Determined by ESI. Strain C57BL/6. Without methionine sulfoxide.1 Publication
    Molecular mass is 6825.6±0.495 Da from positions 29 - 88. Determined by ESI. Strain C57BL/6. Without methionine sulfoxide.1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22661, Z22660 Genomic DNA. Translation: CAA80375.1.
    AK011358 mRNA. Translation: BAB27566.1.
    BC019398 mRNA. Translation: AAH19398.1.
    BC094638 mRNA. Translation: AAH94638.1.
    CCDSiCCDS39802.1.
    PIRiI48251.
    RefSeqiNP_001103479.1. NM_001110009.2.
    NP_031495.1. NM_007469.5.
    UniGeneiMm.182440.

    Genome annotation databases

    EnsembliENSMUST00000045035; ENSMUSP00000045571; ENSMUSG00000040564.
    ENSMUST00000108451; ENSMUSP00000104091; ENSMUSG00000040564.
    GeneIDi11812.
    KEGGimmu:11812.
    UCSCiuc009fmv.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22661 , Z22660 Genomic DNA. Translation: CAA80375.1 .
    AK011358 mRNA. Translation: BAB27566.1 .
    BC019398 mRNA. Translation: AAH19398.1 .
    BC094638 mRNA. Translation: AAH94638.1 .
    CCDSi CCDS39802.1.
    PIRi I48251.
    RefSeqi NP_001103479.1. NM_001110009.2.
    NP_031495.1. NM_007469.5.
    UniGenei Mm.182440.

    3D structure databases

    ProteinModelPortali P34928.
    SMRi P34928. Positions 28-84.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000104091.

    PTM databases

    PhosphoSitei P34928.

    Proteomic databases

    MaxQBi P34928.
    PaxDbi P34928.
    PRIDEi P34928.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000045035 ; ENSMUSP00000045571 ; ENSMUSG00000040564 .
    ENSMUST00000108451 ; ENSMUSP00000104091 ; ENSMUSG00000040564 .
    GeneIDi 11812.
    KEGGi mmu:11812.
    UCSCi uc009fmv.2. mouse.

    Organism-specific databases

    CTDi 341.
    MGIi MGI:88053. Apoc1.

    Phylogenomic databases

    eggNOGi NOG47204.
    GeneTreei ENSGT00390000011584.
    HOGENOMi HOG000034001.
    HOVERGENi HBG050547.
    InParanoidi P34928.
    OMAi QSDIPAK.
    OrthoDBi EOG7PK92M.
    PhylomeDBi P34928.
    TreeFami TF330940.

    Miscellaneous databases

    ChiTaRSi APOC1. mouse.
    NextBioi 279687.
    PROi P34928.
    SOURCEi Search...

    Gene expression databases

    Bgeei P34928.
    CleanExi MM_APOC1.
    Genevestigatori P34928.

    Family and domain databases

    Gene3Di 4.10.260.30. 1 hit.
    InterProi IPR006781. ApoC-I.
    [Graphical view ]
    PANTHERi PTHR16565. PTHR16565. 1 hit.
    Pfami PF04691. ApoC-I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mouse apolipoprotein C1 gene: structure and expression."
      Hoffer M.J.V., van Eck M.M., Havekes L.M., Hofker M.H., Frants R.R.
      Genomics 18:37-42(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and FVB/N.
      Tissue: Liver and Mammary gland.
    4. "Mass spectral analysis of the apolipoproteins on mouse high density lipoproteins. Detection of post-translational modifications."
      Puppione D.L., Yam L.M., Bassilian S., Souda P., Castellani L.W., Schumaker V.N., Whitelegge J.P.
      Biochim. Biophys. Acta 1764:1363-1371(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 43-51, MASS SPECTROMETRY.
    5. "Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification."
      Westerterp M., Berbee J.F., Delsing D.J., Jong M.C., Gijbels M.J., Dahlmans V.E., Offerman E.H., Romijn J.A., Havekes L.M., Rensen P.C.
      J. Lipid Res. 48:1353-1361(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiAPOC1_MOUSE
    AccessioniPrimary (citable) accession number: P34928
    Secondary accession number(s): Q505B2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3