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P34928

- APOC1_MOUSE

UniProt

P34928 - APOC1_MOUSE

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Protein

Apolipoprotein C-I

Gene
Apoc1, Apoc1b
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Appears to modulate the interaction of APOE with beta-migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification.1 Publication

GO - Molecular functioni

  1. fatty acid binding Source: Ensembl
  2. phospholipase inhibitor activity Source: Ensembl

GO - Biological processi

  1. cholesterol efflux Source: Ensembl
  2. cholesterol metabolic process Source: MGI
  3. chylomicron remnant clearance Source: Ensembl
  4. lipoprotein metabolic process Source: InterPro
  5. negative regulation of cholesterol transport Source: Ensembl
  6. negative regulation of fatty acid biosynthetic process Source: Ensembl
  7. negative regulation of lipoprotein lipase activity Source: Ensembl
  8. negative regulation of phosphatidylcholine catabolic process Source: Ensembl
  9. negative regulation of receptor-mediated endocytosis Source: Ensembl
  10. negative regulation of very-low-density lipoprotein particle clearance Source: Ensembl
  11. phospholipid efflux Source: Ensembl
  12. plasma lipoprotein particle remodeling Source: Ensembl
  13. triglyceride metabolic process Source: MGI
  14. very-low-density lipoprotein particle clearance Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein C-I
Short name:
Apo-CIB
Short name:
ApoC-IB
Alternative name(s):
Apolipoprotein C1
Cleaved into the following chain:
Truncated apolipoprotein C-I
Short name:
Apo-CIB'
Short name:
ApoC-IB'
Gene namesi
Name:Apoc1
Synonyms:Apoc1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:88053. Apoc1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. high-density lipoprotein particle Source: Ensembl
  3. very-low-density lipoprotein particle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 By similarityAdd
BLAST
Chaini27 – 8862Apolipoprotein C-IPRO_0000002015Add
BLAST
Chaini29 – 8860Truncated apolipoprotein C-IPRO_0000391844Add
BLAST

Proteomic databases

MaxQBiP34928.
PaxDbiP34928.
PRIDEiP34928.

PTM databases

PhosphoSiteiP34928.

Expressioni

Tissue specificityi

Secreted in plasma.

Gene expression databases

BgeeiP34928.
CleanExiMM_APOC1.
GenevestigatoriP34928.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104091.

Structurei

3D structure databases

ProteinModelPortaliP34928.
SMRiP34928. Positions 28-84.

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein C1 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47204.
GeneTreeiENSGT00390000011584.
HOGENOMiHOG000034001.
HOVERGENiHBG050547.
InParanoidiP34928.
OMAiQSDIPAK.
OrthoDBiEOG7PK92M.
PhylomeDBiP34928.
TreeFamiTF330940.

Family and domain databases

Gene3Di4.10.260.30. 1 hit.
InterProiIPR006781. ApoC-I.
[Graphical view]
PANTHERiPTHR16565. PTHR16565. 1 hit.
PfamiPF04691. ApoC-I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34928-1 [UniParc]FASTAAdd to Basket

« Hide

MRLFIALPVL IVVVAMTLEG PAPAQAAPDL SGTLESIPDK LKEFGNTLED   50
KARAAIEHIK QKEILTKTRA WFSEAFGKVK EKLKTTFS 88
Length:88
Mass (Da):9,696
Last modified:February 1, 1994 - v1
Checksum:iCF35C2144BBDCC43
GO

Mass spectrometryi

Molecular mass is 6993±0.707 Da from positions 27 - 88. Determined by ESI. Strain C57BL/6. Without methionine sulfoxide.1 Publication
Molecular mass is 6825.6±0.495 Da from positions 29 - 88. Determined by ESI. Strain C57BL/6. Without methionine sulfoxide.1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z22661, Z22660 Genomic DNA. Translation: CAA80375.1.
AK011358 mRNA. Translation: BAB27566.1.
BC019398 mRNA. Translation: AAH19398.1.
BC094638 mRNA. Translation: AAH94638.1.
CCDSiCCDS39802.1.
PIRiI48251.
RefSeqiNP_001103479.1. NM_001110009.2.
NP_031495.1. NM_007469.5.
UniGeneiMm.182440.

Genome annotation databases

EnsembliENSMUST00000045035; ENSMUSP00000045571; ENSMUSG00000040564.
ENSMUST00000108451; ENSMUSP00000104091; ENSMUSG00000040564.
GeneIDi11812.
KEGGimmu:11812.
UCSCiuc009fmv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z22661 , Z22660 Genomic DNA. Translation: CAA80375.1 .
AK011358 mRNA. Translation: BAB27566.1 .
BC019398 mRNA. Translation: AAH19398.1 .
BC094638 mRNA. Translation: AAH94638.1 .
CCDSi CCDS39802.1.
PIRi I48251.
RefSeqi NP_001103479.1. NM_001110009.2.
NP_031495.1. NM_007469.5.
UniGenei Mm.182440.

3D structure databases

ProteinModelPortali P34928.
SMRi P34928. Positions 28-84.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000104091.

PTM databases

PhosphoSitei P34928.

Proteomic databases

MaxQBi P34928.
PaxDbi P34928.
PRIDEi P34928.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000045035 ; ENSMUSP00000045571 ; ENSMUSG00000040564 .
ENSMUST00000108451 ; ENSMUSP00000104091 ; ENSMUSG00000040564 .
GeneIDi 11812.
KEGGi mmu:11812.
UCSCi uc009fmv.2. mouse.

Organism-specific databases

CTDi 341.
MGIi MGI:88053. Apoc1.

Phylogenomic databases

eggNOGi NOG47204.
GeneTreei ENSGT00390000011584.
HOGENOMi HOG000034001.
HOVERGENi HBG050547.
InParanoidi P34928.
OMAi QSDIPAK.
OrthoDBi EOG7PK92M.
PhylomeDBi P34928.
TreeFami TF330940.

Miscellaneous databases

ChiTaRSi APOC1. mouse.
NextBioi 279687.
PROi P34928.
SOURCEi Search...

Gene expression databases

Bgeei P34928.
CleanExi MM_APOC1.
Genevestigatori P34928.

Family and domain databases

Gene3Di 4.10.260.30. 1 hit.
InterProi IPR006781. ApoC-I.
[Graphical view ]
PANTHERi PTHR16565. PTHR16565. 1 hit.
Pfami PF04691. ApoC-I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse apolipoprotein C1 gene: structure and expression."
    Hoffer M.J.V., van Eck M.M., Havekes L.M., Hofker M.H., Frants R.R.
    Genomics 18:37-42(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Liver and Mammary gland.
  4. "Mass spectral analysis of the apolipoproteins on mouse high density lipoproteins. Detection of post-translational modifications."
    Puppione D.L., Yam L.M., Bassilian S., Souda P., Castellani L.W., Schumaker V.N., Whitelegge J.P.
    Biochim. Biophys. Acta 1764:1363-1371(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 43-51, MASS SPECTROMETRY.
  5. "Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification."
    Westerterp M., Berbee J.F., Delsing D.J., Jong M.C., Gijbels M.J., Dahlmans V.E., Offerman E.H., Romijn J.A., Havekes L.M., Rensen P.C.
    J. Lipid Res. 48:1353-1361(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiAPOC1_MOUSE
AccessioniPrimary (citable) accession number: P34928
Secondary accession number(s): Q505B2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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