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Protein

Apolipoprotein C-I

Gene

Apoc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein (By similarity). Binds free fatty acids and reduces their intracellular esterification.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein C-I
Short name:
Apo-CI
Short name:
ApoC-I
Alternative name(s):
Apolipoprotein C1
Cleaved into the following chain:
Gene namesi
Name:Apoc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:88053. Apoc1.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626By similarityAdd
BLAST
Chaini27 – 8862Apolipoprotein C-IPRO_0000002015Add
BLAST
Chaini29 – 8860Truncated apolipoprotein C-IBy similarityPRO_0000391844Add
BLAST

Proteomic databases

MaxQBiP34928.
PaxDbiP34928.
PRIDEiP34928.

PTM databases

PhosphoSiteiP34928.

Expressioni

Tissue specificityi

Adult and fetal liver.1 Publication

Gene expression databases

BgeeiP34928.
CleanExiMM_APOC1.
GenevisibleiP34928. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045571.

Structurei

3D structure databases

ProteinModelPortaliP34928.
SMRiP34928. Positions 28-84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein C1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47204.
GeneTreeiENSGT00390000011584.
HOGENOMiHOG000034001.
HOVERGENiHBG050547.
InParanoidiP34928.
OMAiTLEDKAW.
OrthoDBiEOG7PK92M.
PhylomeDBiP34928.
TreeFamiTF330940.

Family and domain databases

InterProiIPR006781. ApoC-I.
[Graphical view]
PANTHERiPTHR16565. PTHR16565. 1 hit.
PfamiPF04691. ApoC-I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34928-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLFIALPVL IVVVAMTLEG PAPAQAAPDL SGTLESIPDK LKEFGNTLED
60 70 80
KARAAIEHIK QKEILTKTRA WFSEAFGKVK EKLKTTFS
Length:88
Mass (Da):9,696
Last modified:February 1, 1994 - v1
Checksum:iCF35C2144BBDCC43
GO

Mass spectrometryi

Molecular mass is 6993±0.707 Da from positions 27 - 88. Determined by ESI. Strain C57BL/6. Without methionine sulfoxide.1 Publication
Molecular mass is 6825.6±0.495 Da from positions 29 - 88. Determined by ESI. Strain C57BL/6. Without methionine sulfoxide.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22661, Z22660 Genomic DNA. Translation: CAA80375.1.
AK011358 mRNA. Translation: BAB27566.1.
BC019398 mRNA. Translation: AAH19398.1.
BC094638 mRNA. Translation: AAH94638.1.
CCDSiCCDS39802.1.
PIRiI48251.
RefSeqiNP_001103479.1. NM_001110009.2.
NP_031495.1. NM_007469.5.
UniGeneiMm.182440.

Genome annotation databases

EnsembliENSMUST00000045035; ENSMUSP00000045571; ENSMUSG00000040564.
ENSMUST00000108451; ENSMUSP00000104091; ENSMUSG00000040564.
GeneIDi11812.
KEGGimmu:11812.
UCSCiuc009fmv.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22661, Z22660 Genomic DNA. Translation: CAA80375.1.
AK011358 mRNA. Translation: BAB27566.1.
BC019398 mRNA. Translation: AAH19398.1.
BC094638 mRNA. Translation: AAH94638.1.
CCDSiCCDS39802.1.
PIRiI48251.
RefSeqiNP_001103479.1. NM_001110009.2.
NP_031495.1. NM_007469.5.
UniGeneiMm.182440.

3D structure databases

ProteinModelPortaliP34928.
SMRiP34928. Positions 28-84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045571.

PTM databases

PhosphoSiteiP34928.

Proteomic databases

MaxQBiP34928.
PaxDbiP34928.
PRIDEiP34928.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045035; ENSMUSP00000045571; ENSMUSG00000040564.
ENSMUST00000108451; ENSMUSP00000104091; ENSMUSG00000040564.
GeneIDi11812.
KEGGimmu:11812.
UCSCiuc009fmv.3. mouse.

Organism-specific databases

CTDi341.
MGIiMGI:88053. Apoc1.

Phylogenomic databases

eggNOGiNOG47204.
GeneTreeiENSGT00390000011584.
HOGENOMiHOG000034001.
HOVERGENiHBG050547.
InParanoidiP34928.
OMAiTLEDKAW.
OrthoDBiEOG7PK92M.
PhylomeDBiP34928.
TreeFamiTF330940.

Miscellaneous databases

ChiTaRSiApoc1. mouse.
NextBioi279687.
PROiP34928.
SOURCEiSearch...

Gene expression databases

BgeeiP34928.
CleanExiMM_APOC1.
GenevisibleiP34928. MM.

Family and domain databases

InterProiIPR006781. ApoC-I.
[Graphical view]
PANTHERiPTHR16565. PTHR16565. 1 hit.
PfamiPF04691. ApoC-I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse apolipoprotein C1 gene: structure and expression."
    Hoffer M.J.V., van Eck M.M., Havekes L.M., Hofker M.H., Frants R.R.
    Genomics 18:37-42(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Liver and Mammary gland.
  4. "Mass spectral analysis of the apolipoproteins on mouse high density lipoproteins. Detection of post-translational modifications."
    Puppione D.L., Yam L.M., Bassilian S., Souda P., Castellani L.W., Schumaker V.N., Whitelegge J.P.
    Biochim. Biophys. Acta 1764:1363-1371(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 43-51, MASS SPECTROMETRY.
  5. "Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification."
    Westerterp M., Berbee J.F., Delsing D.J., Jong M.C., Gijbels M.J., Dahlmans V.E., Offerman E.H., Romijn J.A., Havekes L.M., Rensen P.C.
    J. Lipid Res. 48:1353-1361(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiAPOC1_MOUSE
AccessioniPrimary (citable) accession number: P34928
Secondary accession number(s): Q505B2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 22, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.