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P34928 (APOC1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Apolipoprotein C-I

Short name=Apo-CIB
Short name=ApoC-IB
Alternative name(s):
Apolipoprotein C1

Cleaved into the following chain:

  1. Truncated apolipoprotein C-I
    Short name=Apo-CIB'
    Short name=ApoC-IB'
Gene names
Name:Apoc1
Synonyms:Apoc1b
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length88 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Appears to modulate the interaction of APOE with beta-migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification. Ref.5

Subcellular location

Secreted.

Tissue specificity

Secreted in plasma.

Sequence similarities

Belongs to the apolipoprotein C1 family.

Mass spectrometry

Molecular mass is 6993±0.707 Da from positions 27 - 88. Determined by ESI. Strain C57BL/6. Without methionine sulfoxide. Ref.4

Molecular mass is 6825.6±0.495 Da from positions 29 - 88. Determined by ESI. Strain C57BL/6. Without methionine sulfoxide. Ref.4

Ontologies

Keywords
   Biological processLipid transport
Transport
   Cellular componentSecreted
VLDL
   DomainSignal
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcholesterol efflux

Inferred from electronic annotation. Source: Ensembl

cholesterol metabolic process

Inferred from mutant phenotype PubMed 7848292. Source: MGI

chylomicron remnant clearance

Inferred from electronic annotation. Source: Ensembl

lipoprotein metabolic process

Inferred from electronic annotation. Source: InterPro

negative regulation of cholesterol transport

Inferred from electronic annotation. Source: Ensembl

negative regulation of fatty acid biosynthetic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of lipoprotein lipase activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of phosphatidylcholine catabolic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of receptor-mediated endocytosis

Inferred from electronic annotation. Source: Ensembl

negative regulation of very-low-density lipoprotein particle clearance

Inferred from electronic annotation. Source: Ensembl

phospholipid efflux

Inferred from electronic annotation. Source: Ensembl

plasma lipoprotein particle remodeling

Inferred from electronic annotation. Source: Ensembl

triglyceride metabolic process

Inferred from mutant phenotype PubMed 7848292. Source: MGI

very-low-density lipoprotein particle clearance

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentendoplasmic reticulum

Inferred from electronic annotation. Source: Ensembl

high-density lipoprotein particle

Inferred from electronic annotation. Source: Ensembl

very-low-density lipoprotein particle

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionfatty acid binding

Inferred from electronic annotation. Source: Ensembl

phospholipase inhibitor activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 By similarity
Chain27 – 8862Apolipoprotein C-I
PRO_0000002015
Chain29 – 8860Truncated apolipoprotein C-I
PRO_0000391844

Sequences

Sequence LengthMass (Da)Tools
P34928 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: CF35C2144BBDCC43

FASTA889,696
        10         20         30         40         50         60 
MRLFIALPVL IVVVAMTLEG PAPAQAAPDL SGTLESIPDK LKEFGNTLED KARAAIEHIK 

        70         80 
QKEILTKTRA WFSEAFGKVK EKLKTTFS 

« Hide

References

« Hide 'large scale' references
[1]"The mouse apolipoprotein C1 gene: structure and expression."
Hoffer M.J.V., van Eck M.M., Havekes L.M., Hofker M.H., Frants R.R.
Genomics 18:37-42(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and FVB/N.
Tissue: Liver and Mammary gland.
[4]"Mass spectral analysis of the apolipoproteins on mouse high density lipoproteins. Detection of post-translational modifications."
Puppione D.L., Yam L.M., Bassilian S., Souda P., Castellani L.W., Schumaker V.N., Whitelegge J.P.
Biochim. Biophys. Acta 1764:1363-1371(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 43-51, MASS SPECTROMETRY.
[5]"Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification."
Westerterp M., Berbee J.F., Delsing D.J., Jong M.C., Gijbels M.J., Dahlmans V.E., Offerman E.H., Romijn J.A., Havekes L.M., Rensen P.C.
J. Lipid Res. 48:1353-1361(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z22661, Z22660 Genomic DNA. Translation: CAA80375.1.
AK011358 mRNA. Translation: BAB27566.1.
BC019398 mRNA. Translation: AAH19398.1.
BC094638 mRNA. Translation: AAH94638.1.
CCDSCCDS39802.1.
PIRI48251.
RefSeqNP_001103479.1. NM_001110009.2.
NP_031495.1. NM_007469.5.
UniGeneMm.182440.

3D structure databases

ProteinModelPortalP34928.
SMRP34928. Positions 28-84.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000104091.

PTM databases

PhosphoSiteP34928.

Proteomic databases

MaxQBP34928.
PaxDbP34928.
PRIDEP34928.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000045035; ENSMUSP00000045571; ENSMUSG00000040564.
ENSMUST00000108451; ENSMUSP00000104091; ENSMUSG00000040564.
GeneID11812.
KEGGmmu:11812.
UCSCuc009fmv.2. mouse.

Organism-specific databases

CTD341.
MGIMGI:88053. Apoc1.

Phylogenomic databases

eggNOGNOG47204.
GeneTreeENSGT00390000011584.
HOGENOMHOG000034001.
HOVERGENHBG050547.
InParanoidP34928.
OMAQSDIPAK.
OrthoDBEOG7PK92M.
PhylomeDBP34928.
TreeFamTF330940.

Gene expression databases

BgeeP34928.
CleanExMM_APOC1.
GenevestigatorP34928.

Family and domain databases

Gene3D4.10.260.30. 1 hit.
InterProIPR006781. ApoC-I.
[Graphical view]
PANTHERPTHR16565. PTHR16565. 1 hit.
PfamPF04691. ApoC-I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAPOC1. mouse.
NextBio279687.
PROP34928.
SOURCESearch...

Entry information

Entry nameAPOC1_MOUSE
AccessionPrimary (citable) accession number: P34928
Secondary accession number(s): Q505B2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot