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Protein

Asialoglycoprotein receptor 1

Gene

Asgr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi190 – 1901Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi196 – 1961Calcium 1By similarity
Metal bindingi215 – 2151Calcium 2By similarity
Metal bindingi239 – 2391Calcium 3By similarity
Binding sitei239 – 2391CarbohydrateBy similarity
Metal bindingi241 – 2411Calcium 3By similarity
Binding sitei243 – 2431CarbohydrateBy similarity
Metal bindingi252 – 2521Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi252 – 2521Calcium 3By similarity
Binding sitei252 – 2521CarbohydrateBy similarity
Metal bindingi253 – 2531Calcium 2By similarity
Metal bindingi264 – 2641Calcium 3By similarity
Metal bindingi265 – 2651Calcium 3By similarity
Metal bindingi277 – 2771Calcium 1By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to extracellular stimulus Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Calcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Asialoglycoprotein receptor 1
Short name:
ASGP-R 1
Short name:
ASGPR 1
Alternative name(s):
Hepatic lectin 1
Short name:
HL-1
Short name:
mHL-1
Gene namesi
Name:Asgr1
Synonyms:Asgr-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:88081. Asgr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939CytoplasmicSequence analysisAdd
BLAST
Transmembranei40 – 6021Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini61 – 284224ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL5066.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Asialoglycoprotein receptor 1PRO_0000046651Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi35 – 351S-palmitoyl cysteineBy similarity
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence analysis
Glycosylationi78 – 781N-linked (GlcNAc...)Sequence analysis
Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence analysis
Disulfide bondi153 ↔ 164PROSITE-ProRule annotation
Disulfide bondi181 ↔ 276PROSITE-ProRule annotation
Disulfide bondi254 ↔ 268PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated on a cytoplasmic Ser residue.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiP34927.
PaxDbiP34927.
PeptideAtlasiP34927.
PRIDEiP34927.

PTM databases

iPTMnetiP34927.
PhosphoSiteiP34927.
SwissPalmiP34927.

Expressioni

Tissue specificityi

Expressed exclusively in hepatic parenchymal cells.

Gene expression databases

CleanExiMM_ASGR1.
ExpressionAtlasiP34927. baseline and differential.
GenevisibleiP34927. MM.

Interactioni

Subunit structurei

Interacts with LASS2.By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

IntActiP34927. 3 interactions.
MINTiMINT-4121801.
STRINGi10090.ENSMUSP00000018699.

Chemistry

BindingDBiP34927.

Structurei

3D structure databases

ProteinModelPortaliP34927.
SMRiP34927. Positions 153-280.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini160 – 277118C-type lectinPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili59 – 11759Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi5 – 84Endocytosis signalSequence analysis

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000034093.
HOVERGENiHBG000270.
InParanoidiP34927.
KOiK10063.
OMAiQHHMGPV.
OrthoDBiEOG7XDBGR.
TreeFamiTF352155.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR005640. Lectin_N.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF03954. Lectin_N. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34927-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKDYQDFQH LDNDNDHHQL RRGPPPTPRL LQRLCSGSRL LLLSSSLSIL
60 70 80 90 100
LLVVVCVITS QNSQLREDLL ALRQNFSNLT VSTEDQVKAL STQGSSVGRK
110 120 130 140 150
MKLVESKLEK QQKDLTEDHS SLLLHVKQLV SDVRSLSCQM AAFRGNGSER
160 170 180 190 200
TCCPINWVEY EGSCYWFSSS VRPWTEADKY CQLENAHLVV VTSRDEQNFL
210 220 230 240 250
QRHMGPLNTW IGLTDQNGPW KWVDGTDYET GFQNWRPEQP DNWYGHGLGG
260 270 280
GEDCAHFTTD GRWNDDVCRR PYRWVCETKL DKAN
Length:284
Mass (Da):32,591
Last modified:October 3, 2012 - v4
Checksum:i671F043968047DB7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti151 – 1511T → I in AAB60440 (PubMed:7958950).Curated
Sequence conflicti151 – 1511T → I in AAB60441 (PubMed:7958950).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13517 mRNA. Translation: BAA02734.1.
U09362 mRNA. Translation: AAB60441.1.
U08372 mRNA. Translation: AAB60440.1.
AF182811 Genomic DNA. Translation: AAF29495.1.
AK132959 mRNA. Translation: BAE21442.1.
AL596185 Genomic DNA. Translation: CAI35175.1.
CH466596 Genomic DNA. Translation: EDL12529.1.
BC022106 mRNA. Translation: AAH22106.1.
CCDSiCCDS24933.1.
PIRiS29855.
RefSeqiNP_001278060.1. NM_001291131.1.
NP_001278061.1. NM_001291132.1.
NP_033844.1. NM_009714.3.
UniGeneiMm.6559.

Genome annotation databases

EnsembliENSMUST00000018699; ENSMUSP00000018699; ENSMUSG00000020884.
ENSMUST00000092959; ENSMUSP00000090637; ENSMUSG00000020884.
ENSMUST00000146411; ENSMUSP00000121842; ENSMUSG00000020884.
GeneIDi11889.
KEGGimmu:11889.
UCSCiuc007jtr.2. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Hepatic asialoglycoprotein receptor subunit 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13517 mRNA. Translation: BAA02734.1.
U09362 mRNA. Translation: AAB60441.1.
U08372 mRNA. Translation: AAB60440.1.
AF182811 Genomic DNA. Translation: AAF29495.1.
AK132959 mRNA. Translation: BAE21442.1.
AL596185 Genomic DNA. Translation: CAI35175.1.
CH466596 Genomic DNA. Translation: EDL12529.1.
BC022106 mRNA. Translation: AAH22106.1.
CCDSiCCDS24933.1.
PIRiS29855.
RefSeqiNP_001278060.1. NM_001291131.1.
NP_001278061.1. NM_001291132.1.
NP_033844.1. NM_009714.3.
UniGeneiMm.6559.

3D structure databases

ProteinModelPortaliP34927.
SMRiP34927. Positions 153-280.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP34927. 3 interactions.
MINTiMINT-4121801.
STRINGi10090.ENSMUSP00000018699.

Chemistry

BindingDBiP34927.
ChEMBLiCHEMBL5066.

PTM databases

iPTMnetiP34927.
PhosphoSiteiP34927.
SwissPalmiP34927.

Proteomic databases

EPDiP34927.
PaxDbiP34927.
PeptideAtlasiP34927.
PRIDEiP34927.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018699; ENSMUSP00000018699; ENSMUSG00000020884.
ENSMUST00000092959; ENSMUSP00000090637; ENSMUSG00000020884.
ENSMUST00000146411; ENSMUSP00000121842; ENSMUSG00000020884.
GeneIDi11889.
KEGGimmu:11889.
UCSCiuc007jtr.2. mouse.

Organism-specific databases

CTDi432.
MGIiMGI:88081. Asgr1.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000034093.
HOVERGENiHBG000270.
InParanoidiP34927.
KOiK10063.
OMAiQHHMGPV.
OrthoDBiEOG7XDBGR.
TreeFamiTF352155.

Miscellaneous databases

PROiP34927.
SOURCEiSearch...

Gene expression databases

CleanExiMM_ASGR1.
ExpressionAtlasiP34927. baseline and differential.
GenevisibleiP34927. MM.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR005640. Lectin_N.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF03954. Lectin_N. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Determination of mouse major asialoglycoprotein receptor cDNA sequence."
    Takezawa R., Shinzawa K., Watanabe Y., Akaike T.
    Biochim. Biophys. Acta 1172:220-222(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The major form of the murine asialoglycoprotein receptor: cDNA sequence and expression in liver, testis and epididymis."
    Monroe R.S., Huber B.E.
    Gene 148:237-244(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Liver.
  3. "Organization of the mouse ASGR1 gene encoding the major subunit of the hepatic asialoglycoprotein receptor."
    Soukharev S., Berlin W., Hanover J.A., Bethke B., Sauer B.
    Gene 241:233-240(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
    Tissue: Liver.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  6. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiASGR1_MOUSE
AccessioniPrimary (citable) accession number: P34927
Secondary accession number(s): Q64363, Q91Y84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 3, 2012
Last modified: July 6, 2016
This is version 135 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Calcium is required for ligand binding.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.