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P34926 (MAP1A_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Microtubule-associated protein 1A
Short name=MAP-1A

Cleaved into the following 2 chains:

  1. MAP1A heavy chain
  2. MAP1 light chain LC2
Gene names
Name:Map1a
Synonyms:Mtap1a
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length2774 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.

Subunit structure

Interacts with TIAM2 By similarity. 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. Interacts with guanylate kinase-like domain of DLG1, DLG2 and DLG4. Binds to CSNK1D. Ref.2 Ref.3

Subcellular location

Cytoplasm › cytoskeleton Probable.

Tissue specificity

Brain, heart and muscle.

Developmental stage

Expressed late during neuronal development appearing when axons and dendrites begin to solidify and stabilize their morphology.

Domain

The basic region containing the repeats may be responsible for the binding of MAP1A to microtubules.

Post-translational modification

Phosphorylated by CSNK1D. Ref.3

LC2 is generated from MAP1A by proteolytic processing. It is free to associate with both MAP1A and MAP1B.

Sequence similarities

Belongs to the MAP1 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Dlg1Q626962EBI-631571,EBI-389325
Dlg2Q636224EBI-631571,EBI-396947
Dlg4P3101612EBI-631571,EBI-375655

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 27742774Microtubule-associated protein 1A
PRO_0000018602
Chain1 – 25412541MAP1A heavy chain
PRO_0000418378
Chain2542 – 2774233MAP1 light chain LC2
PRO_0000018603

Regions

Repeat336 – 33831
Repeat415 – 41732
Repeat420 – 42233
Repeat424 – 42634
Repeat427 – 42935
Repeat431 – 43336
Repeat436 – 43837
Repeat440 – 44238
Repeat444 – 44639
Repeat449 – 451310
Repeat539 – 541311
Region336 – 54120611 X 3 AA repeats of K-K-[DE]
Compositional bias309 – 496188Lys-rich (basic)

Amino acid modifications

Modified residue1141Phosphoserine By similarity
Modified residue1771Phosphotyrosine By similarity
Modified residue5261Phosphoserine By similarity
Modified residue5271Phosphoserine By similarity
Modified residue6111Phosphoserine By similarity
Modified residue6431Phosphoserine By similarity
Modified residue6661Phosphoserine By similarity
Modified residue8941Phosphoserine By similarity
Modified residue9901Phosphoserine By similarity
Modified residue10021Phosphothreonine By similarity
Modified residue10071Phosphoserine By similarity
Modified residue10611Phosphoserine By similarity
Modified residue11481Phosphoserine By similarity
Modified residue12061Phosphoserine By similarity
Modified residue13011Phosphoserine By similarity
Modified residue13041Phosphoserine By similarity
Modified residue16221Phosphoserine By similarity
Modified residue16431Phosphoserine By similarity
Modified residue17421Phosphoserine By similarity
Modified residue17571Phosphoserine By similarity
Modified residue17631Phosphoserine By similarity
Modified residue17671Phosphoserine By similarity
Modified residue19881Phosphoserine By similarity
Modified residue20771Phosphoserine By similarity
Modified residue24241Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P34926 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 3DEF74427BA9D7D7

FASTA2,774299,531
        10         20         30         40         50         60 
MDGVAEFSEY VSETVDVPSP FDLLEPPTSG GFLKLSKPCC YIFPGGRGDS ALFAVNGFNI 

        70         80         90        100        110        120 
LVDGGSDRKS CFWKLVRHLD RIDSVLLTHI GADNLPGING LLQRKVAELE EEQSQGSSSY 

       130        140        150        160        170        180 
SDWVKNLISP ELGVVFFNVP DKLRLPDASR KAKRSIEEAC LTLQHLNRLG IQAEPLYRVV 

       190        200        210        220        230        240 
SNTIEPLTLF HKMGVGRLDM YVLNPVKDSK EMQFLMQKWA GNSKAKTGIV LANGKEAEIS 

       250        260        270        280        290        300 
VPYLTSITAL VVWLPANPTE KIVRVLFPGN APQNKILEGL EKLRHLDFLR YPVATQKDLA 

       310        320        330        340        350        360 
AGAVPANLKP SKIKHRADSK ESLKAAPKTA VSKLAKREEV LEEGAKEARS ELAKELAKTE 

       370        380        390        400        410        420 
KKAKEPSEKP PEKPSKSERV RGESSEALKA EKRRLIKDKA GKKHLKEKIS KLEEKKDKEK 

       430        440        450        460        470        480 
KEIKKERKEL KKEEGRKEEK KDAKKDEKRK DTKPEVKKLS KPDLKPFTPE VRKTLYKAKA 

       490        500        510        520        530        540 
PGRVKVDKGR AARGEKELSS EPRTPPAQKG AAPPAAVSGH RELALSSPED LTQDFEELKR 

       550        560        570        580        590        600 
EERGLLAEQR DTGLGEKPLP ADATEQGHPS AAIQVTQPSG PVLEGEHVER EKEVVPDSPG 

       610        620        630        640        650        660 
DKGSTNRGPD SGAEVEKEKE TWEERKQREA ELGPENTAAR EESEAEVKED VIEKAELEEM 

       670        680        690        700        710        720 
EETHPSDEEG EETKAESFYQ KHTQEALKAS PKSREALGGR DLGFQGKAPE KETASFLSSL 

       730        740        750        760        770        780 
ATPAGATEHV SYIQDETIPG YSETEQTISD EEIHDEPDER PAPPRFPTST YDLSGPEGPG 

       790        800        810        820        830        840 
PFEASQAADS AVPASSSKTY GAPETELTYP PNMVAAPLAE EEHVSSATSI TECDKLSSFA 

       850        860        870        880        890        900 
TSVAEDQSVA SLTAPQTEET GKSSLLLDTV TSIPSSRTEA TQGLDYVPSA GTISPTSSLE 

       910        920        930        940        950        960 
EDKGFKSPPC EDFSVTGESE KKGETVGRGL SGEKAVGKEE KYVVTSEKLS GQYAAVFGAP 

       970        980        990       1000       1010       1020 
GHTLPPGEPA LGEVEERCLS PDDSTVKMAS PPPSGPPSAA HTPFHQSPVE DKSEPRDFQE 

      1030       1040       1050       1060       1070       1080 
DSWGETKHSP GVSKEDSEEQ TVKPGPEEGT SEEGKGPPTR SPQAQDMPVS IAGGQTGCTI 

      1090       1100       1110       1120       1130       1140 
QLLPEQDKAI VFETGEAGSN LGAGTLPGEV RTSTEEATEP QKDEVLRFTD QSLSPEDAES 

      1150       1160       1170       1180       1190       1200 
LSVLSVVSPD TTKQEATPRS PCSLKEQQPH KDLWPMVSPE DTQSLSFSEE SPSKETSLDI 

      1210       1220       1230       1240       1250       1260 
SSKQLSPESL GTLQFGELNL GKEERGPVMK AEDDSCHLAP VSIPEPHRAT VSPSTDETPA 

      1270       1280       1290       1300       1310       1320 
GTLPGGSFSH SALSVDRKHS PGEITGPGGH FMTSDSSLTK SPESLSSPAM EDLAVEWEGK 

      1330       1340       1350       1360       1370       1380 
APGKEKEPEL KSETRQQKGQ ILPEKVAVVE QDLIIHQKDG ALDEENKPGR QQDKTPEQKG 

      1390       1400       1410       1420       1430       1440 
RDLDEKDTAA ELDKGPEPKE KDLDREDQGQ RAGPPAEKDK ASEQRDTDLQ QTQATEPRDR 

      1450       1460       1470       1480       1490       1500 
AQERRDSEEK DKSLELRDRT PEEKDRILVQ EDRAPEHSIP EPTQTDRAPD RKGTDDKEQK 

      1510       1520       1530       1540       1550       1560 
EEASEEKEQV LEQKDWALGK EGETLDQEAR TAEQKDETLK EDKTQGQKSS FVEDKTTTSK 

      1570       1580       1590       1600       1610       1620 
ETVLDQKSAE KADSVEQQDG AALEKTRALG LEESPAEGSK AREQEKKYWK EQDVVQGWRE 

      1630       1640       1650       1660       1670       1680 
TSPTRGEPVG GQKEPVPAWE GKSPEQEVRY WRDRDITLQQ DAYWRELSCD RKVWFPHELD 

      1690       1700       1710       1720       1730       1740 
GQGARPRYCE ERESTFLDEG PDEQEITPLQ HTPRSPWTSD FKDFQEPLPQ KGLEVERWLA 

      1750       1760       1770       1780       1790       1800 
ESPVGLPPEE EDKLTRSPFE IISPPASPPE MTGQRVPSAP GQESPVPDTE STAPMRNEPT 

      1810       1820       1830       1840       1850       1860 
TPSWLAEIPP WVPKDRPLPP APLSPAPAPP TPAPEPHTPV PFSWGLAEYD SVVAAVQEGA 

      1870       1880       1890       1900       1910       1920 
AELEGGPYSP LGKDYRKAEG EREGEGGAGA PDSSSFSPKV PEAGESLATR DTEQTEPEQR 

      1930       1940       1950       1960       1970       1980 
EPTPYPDERS FQYADIYEQM MLTGLGPACP TREPPLGASG DWPPHLSTKE EAAGCNTSAE 

      1990       2000       2010       2020       2030       2040 
KETSSPASPQ NLQSDTPAFS YASLAGPAVP PRQEPDPGPN VEPSITPPAV PPRAPISLSK 

      2050       2060       2070       2080       2090       2100 
DLSPPLNGST VSCSPDRRTP SPKETGRGHW DDGTNDSDLE KGAREQPEKE TRSPSPHHPM 

      2110       2120       2130       2140       2150       2160 
PMGHSSLWPE TEAYSSLSSD SHLGSVRPSL DFPASAFGFS SLQPAPPQLP SPAEPRSAPC 

      2170       2180       2190       2200       2210       2220 
GSLAFSGDRA LALVPGTPTR TRHDEYLEVT KAPSLDSSLP QLPSPSSPGG PLLSNLPRPA 

      2230       2240       2250       2260       2270       2280 
SPALSEGSSS EATTPVISSV AERFPPGLEA AEQSAEGLGS GKESAAHSLW DLTPLSPAPS 

      2290       2300       2310       2320       2330       2340 
ASLDLAPAPA PAPAPAPGLP GDLGDGTLPC RPECTGELTK KPSPFLSPSG DHEANGPGET 

      2350       2360       2370       2380       2390       2400 
SLNPPGFVTA TAEKEEAEAP HAWERGSWPE GAERSSRPDT LLSSEQPLRP GKSSGGPPCS 

      2410       2420       2430       2440       2450       2460 
LSSEVEAGPQ GCATDPRPHC GELSPSFLNP PLPPSTDDSD LSTEEARLAG KGGRRRVGRP 

      2470       2480       2490       2500       2510       2520 
GATGGPCPMA DETPPTSASD SGSSQSDSDV PPETEECPSI TAEAALDSDE DGDFLPVDKA 

      2530       2540       2550       2560       2570       2580 
GGVSGTHHPR PGHDPPPTPL PDPRPSPPRP DVCMADPEGL SSESGRVERL REKGRPGRRA 

      2590       2600       2610       2620       2630       2640 
PGRAKPASPA RRLDIRGKRS PTPGKGPVDR TSRTVPRPRS TPSQVTSAEE KDGHSPMSKG 

      2650       2660       2670       2680       2690       2700 
LVNGLKAGST ALGSKGGSGP PVYVDLAYIP NHCSGKTADQ DFFRRVRASY YVVSGNDPAN 

      2710       2720       2730       2740       2750       2760 
GEPSRAVLDA LLEGKAQWGE NLQVTLIPTH DTEVTREWYQ QTHEQQQQLN VLVLASSSTV 

      2770 
VMQDESFPAC KIEF

« Hide

References

[1]"Microtubule-associated proteins 1A and LC2. Two proteins encoded in one messenger RNA."
Langkopf A., Hammarback J.A., Mueller R., Vallee R.B., Garner C.C.
J. Biol. Chem. 267:16561-16566(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A."
Brenman J.E., Topinka J.R., Cooper E.C., McGee A.W., Rosen J., Milroy T., Ralston H.J., Bredt D.S.
J. Neurosci. 18:8805-8813(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH DLG1; DLG2 AND DLG4.
[3]"Interaction of casein kinase 1 delta (CK1 delta) with the light chain LC2 of microtubule associated protein 1A (MAP1A)."
Wolff S., Xiao Z., Wittau M., Suessner N., Stoeter M., Knippschild U.
Biochim. Biophys. Acta 1745:196-206(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CSNK1D, PHOSPHORYLATION BY CSNK1D.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M83196 mRNA. Translation: AAB48069.1.
IPIIPI00199693.
PIRA43359.
RefSeqNP_112257.1. NM_030995.1.
UniGeneRn.11402.

3D structure databases

ProteinModelPortalP34926.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-29265N.
IntActP34926. 4 interactions.
MINTMINT-199032.
STRING10116.ENSRNOP00000019215.

PTM databases

PhosphoSiteP34926.

Proteomic databases

PaxDbP34926.
PRIDEP34926.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID25152.
KEGGrno:25152.
UCSCRGD:3042. rat.

Organism-specific databases

CTD4130.
RGD3042. Map1a.

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000231839.
HOVERGENHBG052408.
InParanoidP34926.
KOK10429.

Gene expression databases

ArrayExpressP34926.
GenevestigatorP34926.
GermOnlineENSRNOG00000014230. Rattus norvegicus.

Family and domain databases

InterProIPR026074. MAP1.
IPR015656. MAP1A.
[Graphical view]
PANTHERPTHR13843. PTHR13843. 1 hit.
PTHR13843:SF6. PTHR13843:SF6. 1 hit.
ProtoNetSearch...

Other

NextBio605599.

Entry information

Entry nameMAP1A_RAT
AccessionPrimary (citable) accession number: P34926
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents