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Protein

Protein EVI2B

Gene

EVI2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-33877-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein EVI2B
Alternative name(s):
Ecotropic viral integration site 2B protein homolog
Short name:
EVI-2B
CD_antigen: CD361
Gene namesi
Name:EVI2B
Synonyms:EVDB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:3500. EVI2B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 202ExtracellularSequence analysisAdd BLAST181
Transmembranei203 – 226HelicalSequence analysisAdd BLAST24
Topological domaini227 – 448CytoplasmicSequence analysisAdd BLAST222

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi2124.
OpenTargetsiENSG00000185862.
PharmGKBiPA27914.

Polymorphism and mutation databases

BioMutaiEVI2B.
DMDMi281185464.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002121322 – 448Protein EVI2BAdd BLAST427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi16N-linked (GlcNAc...)Sequence analysis1
Glycosylationi50N-linked (GlcNAc...)Sequence analysis1
Glycosylationi114N-linked (GlcNAc...)Sequence analysis1
Modified residuei249PhosphothreonineBy similarity1
Modified residuei268PhosphoserineCombined sources1
Modified residuei271PhosphoserineCombined sources1
Modified residuei278PhosphoserineBy similarity1
Modified residuei294PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP34910.
MaxQBiP34910.
PaxDbiP34910.
PeptideAtlasiP34910.
PRIDEiP34910.

PTM databases

iPTMnetiP34910.
PhosphoSitePlusiP34910.
SwissPalmiP34910.

Expressioni

Tissue specificityi

Bone marrow, peripheral blood mononuclear cells, fibroblasts and Epstein-Barr virus-transformed lymphoblastoid cell lines.

Gene expression databases

BgeeiENSG00000185862.
CleanExiHS_EVI2B.
GenevisibleiP34910. HS.

Organism-specific databases

HPAiHPA007436.
HPA053383.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333779.

Structurei

3D structure databases

ProteinModelPortaliP34910.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVU1. Eukaryota.
ENOG41118NF. LUCA.
GeneTreeiENSGT00390000009142.
HOGENOMiHOG000285986.
HOVERGENiHBG051514.
InParanoidiP34910.
KOiK16854.
OMAiHTSAGQP.
OrthoDBiEOG091G0GGD.
PhylomeDBiP34910.
TreeFamiTF336167.

Family and domain databases

InterProiIPR033239. EVI2B.
[Graphical view]
PANTHERiPTHR15384. PTHR15384. 1 hit.
ProDomiPD140898. PD140898. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P34910-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPKYFILIL FCGHLNNTFF SKTETITTEK QSQPTLFTSS MSQVLANSQN
60 70 80 90 100
TTGNPLGQPT QFSDTFSGQS ISPAKVTAGQ PTPAVYTSSE KPEAHTSAGQ
110 120 130 140 150
PLAYNTKQPT PIANTSSQQA VFTSARQLPS ARTSTTQPPK SFVYTFTQQS
160 170 180 190 200
SSVQIPSRKQ ITVHNPSTQP TSTVKNSPRS TPGFILDTTS NKQTPQKNNY
210 220 230 240 250
NSIAAILIGV LLTSMLVAII IIVLWKCLRK PVLNDQNWAG RSPFADGETP
260 270 280 290 300
DICMDNIREN EISTKRTSII SLTPWKPSKS TLLADDLEIK LFESSENIED
310 320 330 340 350
SNNPKTEKIK DQVNGTSEDS ADGSTVGTAV SSSDDADLPP PPPLLDLEGQ
360 370 380 390 400
ESNQSDKPTM TIVSPLPNDS TSLPPSLDCL NQDCGDHKSE IIQSFPPLDS
410 420 430 440
LNLPLPPVDF MKNQEDSNLE IQCQEFSIPP NSDQDLNESL PPPPAELL
Length:448
Mass (Da):48,666
Last modified:December 15, 2009 - v2
Checksum:i5BF2DC46798577E3
GO
Isoform 2 (identifier: P34910-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLFRYAEKITRKYSEM

Note: No experimental confirmation available.
Show »
Length:463
Mass (Da):50,584
Checksum:i0BAC6993B9427827
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37F → Y in AAA35816 (PubMed:1903357).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05687153G → R.Corresponds to variant rs9903564dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0564611M → MLFRYAEKITRKYSEM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60830 Genomic DNA. Translation: AAA35816.1.
AK297087 mRNA. Translation: BAH12493.1.
AC134669 Genomic DNA. No translation available.
CCDSiCCDS11266.1. [P34910-1]
PIRiA38445.
RefSeqiNP_006486.3. NM_006495.3. [P34910-1]
XP_005258003.1. XM_005257946.3. [P34910-2]
UniGeneiHs.5509.

Genome annotation databases

EnsembliENST00000330927; ENSP00000333779; ENSG00000185862. [P34910-1]
ENST00000577894; ENSP00000462682; ENSG00000185862. [P34910-1]
GeneIDi2124.
KEGGihsa:2124.
UCSCiuc002hgk.3. human. [P34910-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60830 Genomic DNA. Translation: AAA35816.1.
AK297087 mRNA. Translation: BAH12493.1.
AC134669 Genomic DNA. No translation available.
CCDSiCCDS11266.1. [P34910-1]
PIRiA38445.
RefSeqiNP_006486.3. NM_006495.3. [P34910-1]
XP_005258003.1. XM_005257946.3. [P34910-2]
UniGeneiHs.5509.

3D structure databases

ProteinModelPortaliP34910.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000333779.

PTM databases

iPTMnetiP34910.
PhosphoSitePlusiP34910.
SwissPalmiP34910.

Polymorphism and mutation databases

BioMutaiEVI2B.
DMDMi281185464.

Proteomic databases

EPDiP34910.
MaxQBiP34910.
PaxDbiP34910.
PeptideAtlasiP34910.
PRIDEiP34910.

Protocols and materials databases

DNASUi2124.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330927; ENSP00000333779; ENSG00000185862. [P34910-1]
ENST00000577894; ENSP00000462682; ENSG00000185862. [P34910-1]
GeneIDi2124.
KEGGihsa:2124.
UCSCiuc002hgk.3. human. [P34910-1]

Organism-specific databases

CTDi2124.
DisGeNETi2124.
GeneCardsiEVI2B.
H-InvDBHIX0013696.
HGNCiHGNC:3500. EVI2B.
HPAiHPA007436.
HPA053383.
MIMi158381. gene.
neXtProtiNX_P34910.
OpenTargetsiENSG00000185862.
PharmGKBiPA27914.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVU1. Eukaryota.
ENOG41118NF. LUCA.
GeneTreeiENSGT00390000009142.
HOGENOMiHOG000285986.
HOVERGENiHBG051514.
InParanoidiP34910.
KOiK16854.
OMAiHTSAGQP.
OrthoDBiEOG091G0GGD.
PhylomeDBiP34910.
TreeFamiTF336167.

Enzyme and pathway databases

BioCyciZFISH:G66-33877-MONOMER.

Miscellaneous databases

GeneWikiiEVI2B.
GenomeRNAii2124.
PROiP34910.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185862.
CleanExiHS_EVI2B.
GenevisibleiP34910. HS.

Family and domain databases

InterProiIPR033239. EVI2B.
[Graphical view]
PANTHERiPTHR15384. PTHR15384. 1 hit.
ProDomiPD140898. PD140898. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiEVI2B_HUMAN
AccessioniPrimary (citable) accession number: P34910
Secondary accession number(s): B7Z4A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: December 15, 2009
Last modified: November 2, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.