P34910 (EVI2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein EVI2B

Alternative name(s):
Ecotropic viral integration site 2B protein homolog
Short name=EVI-2B
CD_antigen=CD361

Gene names

Name:	EVI2B
Synonyms:	EVDB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Bone marrow, peripheral blood mononuclear cells, fibroblasts and Epstein-Barr virus-transformed lymphoblastoid cell lines.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Disease	Proto-oncogene
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 448	427	Protein EVI2B		PRO_0000021213
Regions
	Topological domain	22 – 202	181	Extracellular Potential
	Transmembrane	203 – 226	24	Helical; Potential
	Topological domain	227 – 448	222	Cytoplasmic Potential
Amino acid modifications
	Modified residue	268	1	Phosphoserine By similarity
	Modified residue	271	1	Phosphoserine By similarity
	Modified residue	278	1	Phosphoserine By similarity
	Modified residue	294	1	Phosphoserine By similarity
	Glycosylation	16	1	N-linked (GlcNAc...) Potential
	Glycosylation	50	1	N-linked (GlcNAc...) Potential
	Glycosylation	114	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	53	1	G → R. Corresponds to variant rs9903564 [ dbSNP | Ensembl ].		VAR_056871
Experimental info
	Sequence conflict	37	1	F → Y in AAA35816. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P34910 [UniParc]. Last modified December 15, 2009. Version 2. Checksum: 5BF2DC46798577E3	FASTA	448	48,666
	10 20 30 40 50 60 MDPKYFILIL FCGHLNNTFF SKTETITTEK QSQPTLFTSS MSQVLANSQN TTGNPLGQPT 70 80 90 100 110 120 QFSDTFSGQS ISPAKVTAGQ PTPAVYTSSE KPEAHTSAGQ PLAYNTKQPT PIANTSSQQA 130 140 150 160 170 180 VFTSARQLPS ARTSTTQPPK SFVYTFTQQS SSVQIPSRKQ ITVHNPSTQP TSTVKNSPRS 190 200 210 220 230 240 TPGFILDTTS NKQTPQKNNY NSIAAILIGV LLTSMLVAII IIVLWKCLRK PVLNDQNWAG 250 260 270 280 290 300 RSPFADGETP DICMDNIREN EISTKRTSII SLTPWKPSKS TLLADDLEIK LFESSENIED 310 320 330 340 350 360 SNNPKTEKIK DQVNGTSEDS ADGSTVGTAV SSSDDADLPP PPPLLDLEGQ ESNQSDKPTM 370 380 390 400 410 420 TIVSPLPNDS TSLPPSLDCL NQDCGDHKSE IIQSFPPLDS LNLPLPPVDF MKNQEDSNLE 430 440 IQCQEFSIPP NSDQDLNESL PPPPAELL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA sequence and genomic structure of EVI2B, a gene lying within an intron of the neurofibromatosis type 1 gene." Cawthon R.M., Andersen L.B., Buchberg A.M., Xu G., O'Connell P., Viskochil D., Weiss R.B., Wallace M.R., Marchuk D.A., Culver M., Stevens J., Jenkins N.A., Copeland N.G., Collins F.S., White R. Genomics 9:446-460(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Bone marrow.
[2]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M60830 Genomic DNA. Translation: AAA35816.1. AC134669 Genomic DNA. No translation available.
IPI	IPI01014207.
PIR	A38445.
RefSeq	NP_006486.3. NM_006495.3.
UniGene	Hs.5509.
3D structure databases
ProteinModelPortal	P34910.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000333779.
PTM databases
PhosphoSite	P34910.
Polymorphism databases
DMDM	281185464.
Proteomic databases
PaxDb	P34910.
PRIDE	P34910.
Protocols and materials databases
DNASU	2124.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000330927; ENSP00000333779; ENSG00000185862. ENST00000577894; ENSP00000462682; ENSG00000185862.
GeneID	2124.
KEGG	hsa:2124.
UCSC	uc002hgk.2. human.
Organism-specific databases
CTD	2124.
GeneCards	GC17M029630.
H-InvDB	HIX0013696.
HGNC	HGNC:3500. EVI2B.
HPA	HPA007436.
MIM	158381. gene.
neXtProt	NX_P34910.
PharmGKB	PA27914.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG44114.
HOVERGEN	HBG051514.
InParanoid	P34910.
KO	K16854.
OrthoDB	EOG48PMK6.
PhylomeDB	P34910.
Gene expression databases
ArrayExpress	P34910.
Bgee	P34910.
CleanEx	HS_EVI2B.
Genevestigator	P34910.
GermOnline	ENSG00000185862. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	2124.
NextBio	8593.
SOURCE	Search...

Entry information

Entry name

EVI2B_HUMAN

Accession

Primary (citable) accession number: P34910

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	December 15, 2009
Last modified:	May 1, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.