Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P34906

- MTF1_FUSNU

UniProt

P34906 - MTF1_FUSNU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Modification methylase FnuDI

Gene

fnuDIM

Organism
Fusobacterium nucleatum
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GGCC, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the FnuDI endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei71 – 711PROSITE-ProRule annotation

GO - Molecular functioni

  1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
  2. DNA binding Source: InterPro

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi3402. M.FnuDI.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase FnuDI (EC:2.1.1.37)
Short name:
M.FnuDI
Alternative name(s):
Cytosine-specific methyltransferase FnuDI
Gene namesi
Name:fnuDIM
OrganismiFusobacterium nucleatum
Taxonomic identifieri851 [NCBI]
Taxonomic lineageiBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Modification methylase FnuDIPRO_0000087876Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP34906.
SMRiP34906. Positions 1-327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 330330SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10629. PTHR10629. 1 hit.
PfamiPF00145. DNA_methylase. 1 hit.
[Graphical view]
PRINTSiPR00105. C5METTRFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00675. dcm. 1 hit.
PROSITEiPS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34906-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLLSLFSGA GGLDLGFERA GFEIIVANEY DKTIWETYEK NHKAKLIKKD
60 70 80 90 100
IREILSEELP KSDGIIGGPP CQSWSEAGSL RGINDPRGKL FYEYIRILKD
110 120 130 140 150
IQPKFFLAEN VKGMLSKRNT EAVKDIIKEF EEAGYNVFIK LLNAFDYGVA
160 170 180 190 200
QDRERVFYVG FRKDLNISNF EFPYPISEKE RKYLKDSIWD LKDNALPGKD
210 220 230 240 250
KNKTNADDCI VENHEYLTGS YSTIFMSRNR VRQWEQPAFT VQASGRQCQL
260 270 280 290 300
HPQAPTMIKI DKNMYKFVAG KENLYRRLSI RECARIQGFP DTFKFYYTSL
310 320 330 340
EDGYKMVGNA VPVDLAYIIA KRIKETLTDK EKIKKEIRQK TLFD
Length:344
Mass (Da):39,913
Last modified:February 1, 1994 - v1
Checksum:i7B0CB6C9721FE91C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF051374 Genomic DNA. Translation: AAC05695.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF051374 Genomic DNA. Translation: AAC05695.1 .

3D structure databases

ProteinModelPortali P34906.
SMRi P34906. Positions 1-327.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 3402. M.FnuDI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10629. PTHR10629. 1 hit.
Pfami PF00145. DNA_methylase. 1 hit.
[Graphical view ]
PRINTSi PR00105. C5METTRFRASE.
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00675. dcm. 1 hit.
PROSITEi PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Method for producing the FnuDI restriction endonuclease and methylase."
    Zhang B.-H., Wilson G.G.
    Patent number US4988620, 29-JAN-1991
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: D.

Entry informationi

Entry nameiMTF1_FUSNU
AccessioniPrimary (citable) accession number: P34906
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 1, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3