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P34906

- MTF1_FUSNU

UniProt

P34906 - MTF1_FUSNU

Protein

Modification methylase FnuDI

Gene

fnuDIM

Organism
Fusobacterium nucleatum
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    • Comment

    Functioni

    This methylase recognizes the double-stranded sequence GGCC, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the FnuDI endonuclease.

    Catalytic activityi

    S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei71 – 711PROSITE-ProRule annotation

    GO - Molecular functioni

    1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
    2. DNA binding Source: InterPro

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Restriction system

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Protein family/group databases

    REBASEi3402. M.FnuDI.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Modification methylase FnuDI (EC:2.1.1.37)
    Short name:
    M.FnuDI
    Alternative name(s):
    Cytosine-specific methyltransferase FnuDI
    Gene namesi
    Name:fnuDIM
    OrganismiFusobacterium nucleatum
    Taxonomic identifieri851 [NCBI]
    Taxonomic lineageiBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 344344Modification methylase FnuDIPRO_0000087876Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP34906.
    SMRiP34906. Positions 1-327.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 330330SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
    Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR10629. PTHR10629. 1 hit.
    PfamiPF00145. DNA_methylase. 1 hit.
    [Graphical view]
    PRINTSiPR00105. C5METTRFRASE.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00675. dcm. 1 hit.
    PROSITEiPS00094. C5_MTASE_1. 1 hit.
    PS00095. C5_MTASE_2. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P34906-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLLSLFSGA GGLDLGFERA GFEIIVANEY DKTIWETYEK NHKAKLIKKD    50
    IREILSEELP KSDGIIGGPP CQSWSEAGSL RGINDPRGKL FYEYIRILKD 100
    IQPKFFLAEN VKGMLSKRNT EAVKDIIKEF EEAGYNVFIK LLNAFDYGVA 150
    QDRERVFYVG FRKDLNISNF EFPYPISEKE RKYLKDSIWD LKDNALPGKD 200
    KNKTNADDCI VENHEYLTGS YSTIFMSRNR VRQWEQPAFT VQASGRQCQL 250
    HPQAPTMIKI DKNMYKFVAG KENLYRRLSI RECARIQGFP DTFKFYYTSL 300
    EDGYKMVGNA VPVDLAYIIA KRIKETLTDK EKIKKEIRQK TLFD 344
    Length:344
    Mass (Da):39,913
    Last modified:February 1, 1994 - v1
    Checksum:i7B0CB6C9721FE91C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF051374 Genomic DNA. Translation: AAC05695.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF051374 Genomic DNA. Translation: AAC05695.1 .

    3D structure databases

    ProteinModelPortali P34906.
    SMRi P34906. Positions 1-327.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    REBASEi 3402. M.FnuDI.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR10629. PTHR10629. 1 hit.
    Pfami PF00145. DNA_methylase. 1 hit.
    [Graphical view ]
    PRINTSi PR00105. C5METTRFRASE.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00675. dcm. 1 hit.
    PROSITEi PS00094. C5_MTASE_1. 1 hit.
    PS00095. C5_MTASE_2. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Method for producing the FnuDI restriction endonuclease and methylase."
      Zhang B.-H., Wilson G.G.
      Patent number US4988620, 29-JAN-1991
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: D.

    Entry informationi

    Entry nameiMTF1_FUSNU
    AccessioniPrimary (citable) accession number: P34906
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3