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Protein

Gamma-aminobutyric acid receptor subunit alpha-3

Gene

GABRA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

GO - Biological processi

  • chemical synaptic transmission, postsynaptic Source: GOC
  • gamma-aminobutyric acid signaling pathway Source: ProtInc
  • ion transmembrane transport Source: Reactome
  • synaptic transmission Source: Reactome
  • transmembrane transport Source: Reactome
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiR-HSA-975298. Ligand-gated ion channel transport.
R-HSA-977441. GABA A receptor activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit alpha-3
Alternative name(s):
GABA(A) receptor subunit alpha-3
Gene namesi
Name:GABRA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:4077. GABRA3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 276248ExtracellularCuratedAdd
BLAST
Transmembranei277 – 29822HelicalCuratedAdd
BLAST
Transmembranei304 – 32522HelicalCuratedAdd
BLAST
Transmembranei338 – 35922HelicalCuratedAdd
BLAST
Topological domaini360 – 45798CytoplasmicCuratedAdd
BLAST
Transmembranei458 – 47922HelicalCuratedAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

MalaCardsiGABRA3.
Orphaneti79102. Thyrotoxic periodic paralysis.
PharmGKBiPA28491.

Chemistry

ChEMBLiCHEMBL2109243.
DrugBankiDB00659. Acamprosate.
DB00546. Adinazolam.
DB00404. Alprazolam.
DB01351. Amobarbital.
DB00543. Amoxapine.
DB01352. Aprobarbital.
DB01558. Bromazepam.
DB00237. Butabarbital.
DB00241. Butalbital.
DB01353. Butethal.
DB00475. Chlordiazepoxide.
DB01594. Cinolazepam.
DB00349. Clobazam.
DB01068. Clonazepam.
DB00628. Clorazepate.
DB01559. Clotiazepam.
DB01189. Desflurane.
DB00829. Diazepam.
DB00228. Enflurane.
DB01049. Ergoloid mesylate.
DB01215. Estazolam.
DB00402. Eszopiclone.
DB00898. Ethanol.
DB00189. Ethchlorvynol.
DB00292. Etomidate.
DB01567. Fludiazepam.
DB01205. Flumazenil.
DB01544. Flunitrazepam.
DB00690. Flurazepam.
DB01437. Glutethimide.
DB00801. Halazepam.
DB01159. Halothane.
DB01354. Heptabarbital.
DB01355. Hexobarbital.
DB00753. Isoflurane.
DB00186. Lorazepam.
DB00371. Meprobamate.
DB01028. Methoxyflurane.
DB00849. Methylphenobarbital.
DB01107. Methyprylon.
DB00683. Midazolam.
DB01595. Nitrazepam.
DB00334. Olanzapine.
DB00842. Oxazepam.
DB00312. Pentobarbital.
DB01588. Prazepam.
DB00794. Primidone.
DB00818. Propofol.
DB01589. Quazepam.
DB00418. Secobarbital.
DB01236. Sevoflurane.
DB00306. Talbutal.
DB00231. Temazepam.
DB00599. Thiopental.
DB00273. Topiramate.
DB00897. Triazolam.
DB00425. Zolpidem.
DB01198. Zopiclone.
GuidetoPHARMACOLOGYi406.

Polymorphism and mutation databases

BioMutaiGABRA3.
DMDMi462149.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 492464Gamma-aminobutyric acid receptor subunit alpha-3PRO_0000000437Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence analysis
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence analysis
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence analysis
Disulfide bondi191 ↔ 205By similarity
Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence analysis
Modified residuei426 – 4261PhosphoserineBy similarity
Modified residuei427 – 4271PhosphothreonineBy similarity
Modified residuei433 – 4331PhosphoserineBy similarity
Modified residuei442 – 4421PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP34903.
PRIDEiP34903.

PTM databases

PhosphoSiteiP34903.

Expressioni

Gene expression databases

BgeeiP34903.
CleanExiHS_GABRA3.
GenevisibleiP34903. HS.

Organism-specific databases

HPAiHPA000839.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1 (By similarity). Interacts with GPHN (PubMed:26613940).By similarity1 Publication

Protein-protein interaction databases

BioGridi108830. 20 interactions.
IntActiP34903. 3 interactions.
MINTiMINT-7242442.
STRINGi9606.ENSP00000359334.

Chemistry

BindingDBiP34903.

Structurei

3D structure databases

ProteinModelPortaliP34903.
SMRiP34903. Positions 68-479.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3642. Eukaryota.
ENOG410XNQG. LUCA.
GeneTreeiENSGT00760000119010.
HOGENOMiHOG000231337.
HOVERGENiHBG051707.
InParanoidiP34903.
KOiK05175.
OMAiYNIVGTT.
OrthoDBiEOG7JX342.
PhylomeDBiP34903.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR001390. GABAAa_rcpt.
IPR005433. GABBAa3_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01079. GABAARALPHA.
PR01616. GABAARALPHA3.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34903-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIITQTSHCY MTSLGILFLI NILPGTTGQG ESRRQEPGDF VKQDIGGLSP
60 70 80 90 100
KHAPDIPDDS TDNITIFTRI LDRLLDGYDN RLRPGLGDAV TEVKTDIYVT
110 120 130 140 150
SFGPVSDTDM EYTIDVFFRQ TWHDERLKFD GPMKILPLNN LLASKIWTPD
160 170 180 190 200
TFFHNGKKSV AHNMTTPNKL LRLVDNGTLL YTMRLTIHAE CPMHLEDFPM
210 220 230 240 250
DVHACPLKFG SYAYTTAEVV YSWTLGKNKS VEVAQDGSRL NQYDLLGHVV
260 270 280 290 300
GTEIIRSSTG EYVVMTTHFH LKRKIGYFVI QTYLPCIMTV ILSQVSFWLN
310 320 330 340 350
RESVPARTVF GVTTVLTMTT LSISARNSLP KVAYATAMDW FIAVCYAFVF
360 370 380 390 400
SALIEFATVN YFTKRSWAWE GKKVPEALEM KKKTPAAPAK KTSTTFNIVG
410 420 430 440 450
TTYPINLAKD TEFSTISKGA APSASSTPTI IASPKATYVQ DSPTETKTYN
460 470 480 490
SVSKVDKISR IIFPVLFAIF NLVYWATYVN RESAIKGMIR KQ
Length:492
Mass (Da):55,165
Last modified:February 1, 1994 - v1
Checksum:i23A7390C9822691F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti180 – 1801L → P in AAH28629 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S62908 mRNA. Translation: AAB27279.1.
AF166361
, AF165901, AF165902, AF165903, AF165904, AF165905, AF165906, AF166359, AF166360 Genomic DNA. Translation: AAG12455.1.
BC028629 mRNA. Translation: AAH28629.1.
CCDSiCCDS14706.1.
PIRiI77911.
RefSeqiNP_000799.1. NM_000808.3.
UniGeneiHs.123024.

Genome annotation databases

EnsembliENST00000370314; ENSP00000359337; ENSG00000011677.
ENST00000535043; ENSP00000443527; ENSG00000011677.
GeneIDi2556.
KEGGihsa:2556.
UCSCiuc010ntk.2. human.

Cross-referencesi

Web resourcesi

Protein Spotlight

Forbidden fruit - Issue 56 of March 2005

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S62908 mRNA. Translation: AAB27279.1.
AF166361
, AF165901, AF165902, AF165903, AF165904, AF165905, AF165906, AF166359, AF166360 Genomic DNA. Translation: AAG12455.1.
BC028629 mRNA. Translation: AAH28629.1.
CCDSiCCDS14706.1.
PIRiI77911.
RefSeqiNP_000799.1. NM_000808.3.
UniGeneiHs.123024.

3D structure databases

ProteinModelPortaliP34903.
SMRiP34903. Positions 68-479.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108830. 20 interactions.
IntActiP34903. 3 interactions.
MINTiMINT-7242442.
STRINGi9606.ENSP00000359334.

Chemistry

BindingDBiP34903.
ChEMBLiCHEMBL2109243.
DrugBankiDB00659. Acamprosate.
DB00546. Adinazolam.
DB00404. Alprazolam.
DB01351. Amobarbital.
DB00543. Amoxapine.
DB01352. Aprobarbital.
DB01558. Bromazepam.
DB00237. Butabarbital.
DB00241. Butalbital.
DB01353. Butethal.
DB00475. Chlordiazepoxide.
DB01594. Cinolazepam.
DB00349. Clobazam.
DB01068. Clonazepam.
DB00628. Clorazepate.
DB01559. Clotiazepam.
DB01189. Desflurane.
DB00829. Diazepam.
DB00228. Enflurane.
DB01049. Ergoloid mesylate.
DB01215. Estazolam.
DB00402. Eszopiclone.
DB00898. Ethanol.
DB00189. Ethchlorvynol.
DB00292. Etomidate.
DB01567. Fludiazepam.
DB01205. Flumazenil.
DB01544. Flunitrazepam.
DB00690. Flurazepam.
DB01437. Glutethimide.
DB00801. Halazepam.
DB01159. Halothane.
DB01354. Heptabarbital.
DB01355. Hexobarbital.
DB00753. Isoflurane.
DB00186. Lorazepam.
DB00371. Meprobamate.
DB01028. Methoxyflurane.
DB00849. Methylphenobarbital.
DB01107. Methyprylon.
DB00683. Midazolam.
DB01595. Nitrazepam.
DB00334. Olanzapine.
DB00842. Oxazepam.
DB00312. Pentobarbital.
DB01588. Prazepam.
DB00794. Primidone.
DB00818. Propofol.
DB01589. Quazepam.
DB00418. Secobarbital.
DB01236. Sevoflurane.
DB00306. Talbutal.
DB00231. Temazepam.
DB00599. Thiopental.
DB00273. Topiramate.
DB00897. Triazolam.
DB00425. Zolpidem.
DB01198. Zopiclone.
GuidetoPHARMACOLOGYi406.

PTM databases

PhosphoSiteiP34903.

Polymorphism and mutation databases

BioMutaiGABRA3.
DMDMi462149.

Proteomic databases

PaxDbiP34903.
PRIDEiP34903.

Protocols and materials databases

DNASUi2556.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370314; ENSP00000359337; ENSG00000011677.
ENST00000535043; ENSP00000443527; ENSG00000011677.
GeneIDi2556.
KEGGihsa:2556.
UCSCiuc010ntk.2. human.

Organism-specific databases

CTDi2556.
GeneCardsiGABRA3.
HGNCiHGNC:4077. GABRA3.
HPAiHPA000839.
MalaCardsiGABRA3.
MIMi305660. gene.
neXtProtiNX_P34903.
Orphaneti79102. Thyrotoxic periodic paralysis.
PharmGKBiPA28491.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3642. Eukaryota.
ENOG410XNQG. LUCA.
GeneTreeiENSGT00760000119010.
HOGENOMiHOG000231337.
HOVERGENiHBG051707.
InParanoidiP34903.
KOiK05175.
OMAiYNIVGTT.
OrthoDBiEOG7JX342.
PhylomeDBiP34903.
TreeFamiTF315453.

Enzyme and pathway databases

ReactomeiR-HSA-975298. Ligand-gated ion channel transport.
R-HSA-977441. GABA A receptor activation.

Miscellaneous databases

ChiTaRSiGABRA3. human.
GeneWikiiGABRA3.
GenomeRNAii2556.
NextBioi10095.
PROiP34903.
SOURCEiSearch...

Gene expression databases

BgeeiP34903.
CleanExiHS_GABRA3.
GenevisibleiP34903. HS.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR001390. GABAAa_rcpt.
IPR005433. GABBAa3_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01079. GABAARALPHA.
PR01616. GABAARALPHA3.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors."
    Hadingham K.L., Wingrove P., le Bourdelles B., Palmer K.J., Ragan C.I., Whiting P.J.
    Mol. Pharmacol. 43:970-975(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq."
    Amir R., Dahle E.J., Toriolo D., Zoghbi H.Y.
    Am. J. Med. Genet. 90:69-71(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: INTERACTION WITH GPHN.

Entry informationi

Entry nameiGBRA3_HUMAN
AccessioniPrimary (citable) accession number: P34903
Secondary accession number(s): Q8TAF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 11, 2016
This is version 160 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.