Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P34903

- GBRA3_HUMAN

UniProt

P34903 - GBRA3_HUMAN

Protein

Gamma-aminobutyric acid receptor subunit alpha-3

Gene

GABRA3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

    GO - Molecular functioni

    1. benzodiazepine receptor activity Source: ProtInc
    2. chloride channel activity Source: UniProtKB-KW
    3. extracellular ligand-gated ion channel activity Source: InterPro
    4. GABA-A receptor activity Source: InterPro

    GO - Biological processi

    1. gamma-aminobutyric acid signaling pathway Source: ProtInc
    2. ion transmembrane transport Source: Reactome
    3. synaptic transmission Source: Reactome
    4. transmembrane transport Source: Reactome
    5. transport Source: ProtInc

    Keywords - Molecular functioni

    Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Chloride

    Enzyme and pathway databases

    ReactomeiREACT_24987. GABA A receptor activation.
    REACT_25387. Ligand-gated ion channel transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-aminobutyric acid receptor subunit alpha-3
    Alternative name(s):
    GABA(A) receptor subunit alpha-3
    Gene namesi
    Name:GABRA3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:4077. GABRA3.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. chloride channel complex Source: UniProtKB-KW
    3. integral component of plasma membrane Source: ProtInc
    4. plasma membrane Source: Reactome
    5. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti79102. Thyrotoxic periodic paralysis.
    PharmGKBiPA28491.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 492464Gamma-aminobutyric acid receptor subunit alpha-3PRO_0000000437Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi191 ↔ 205By similarity
    Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP34903.
    PRIDEiP34903.

    PTM databases

    PhosphoSiteiP34903.

    Expressioni

    Gene expression databases

    ArrayExpressiP34903.
    BgeeiP34903.
    CleanExiHS_GABRA3.
    GenevestigatoriP34903.

    Organism-specific databases

    HPAiHPA000839.

    Interactioni

    Subunit structurei

    Binds UBQLN1 By similarity. Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.By similarity

    Protein-protein interaction databases

    BioGridi108830. 3 interactions.
    IntActiP34903. 3 interactions.
    MINTiMINT-7242442.
    STRINGi9606.ENSP00000359334.

    Structurei

    3D structure databases

    ProteinModelPortaliP34903.
    SMRiP34903. Positions 68-365.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini29 – 276248ExtracellularCuratedAdd
    BLAST
    Topological domaini360 – 45798CytoplasmicCuratedAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei277 – 29822HelicalCuratedAdd
    BLAST
    Transmembranei304 – 32522HelicalCuratedAdd
    BLAST
    Transmembranei338 – 35922HelicalCuratedAdd
    BLAST
    Transmembranei458 – 47922HelicalCuratedAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG238757.
    HOGENOMiHOG000231337.
    HOVERGENiHBG051707.
    InParanoidiP34903.
    KOiK05175.
    OMAiASPKTTY.
    OrthoDBiEOG7JX342.
    PhylomeDBiP34903.
    TreeFamiTF315453.

    Family and domain databases

    Gene3Di2.70.170.10. 1 hit.
    InterProiIPR006028. GABAA/Glycine_rcpt.
    IPR001390. GABAAa_rcpt.
    IPR005433. GABBAa3_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 2 hits.
    [Graphical view]
    PRINTSiPR01079. GABAARALPHA.
    PR01616. GABAARALPHA3.
    PR00253. GABAARECEPTR.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P34903-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIITQTSHCY MTSLGILFLI NILPGTTGQG ESRRQEPGDF VKQDIGGLSP    50
    KHAPDIPDDS TDNITIFTRI LDRLLDGYDN RLRPGLGDAV TEVKTDIYVT 100
    SFGPVSDTDM EYTIDVFFRQ TWHDERLKFD GPMKILPLNN LLASKIWTPD 150
    TFFHNGKKSV AHNMTTPNKL LRLVDNGTLL YTMRLTIHAE CPMHLEDFPM 200
    DVHACPLKFG SYAYTTAEVV YSWTLGKNKS VEVAQDGSRL NQYDLLGHVV 250
    GTEIIRSSTG EYVVMTTHFH LKRKIGYFVI QTYLPCIMTV ILSQVSFWLN 300
    RESVPARTVF GVTTVLTMTT LSISARNSLP KVAYATAMDW FIAVCYAFVF 350
    SALIEFATVN YFTKRSWAWE GKKVPEALEM KKKTPAAPAK KTSTTFNIVG 400
    TTYPINLAKD TEFSTISKGA APSASSTPTI IASPKATYVQ DSPTETKTYN 450
    SVSKVDKISR IIFPVLFAIF NLVYWATYVN RESAIKGMIR KQ 492
    Length:492
    Mass (Da):55,165
    Last modified:February 1, 1994 - v1
    Checksum:i23A7390C9822691F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti180 – 1801L → P in AAH28629. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S62908 mRNA. Translation: AAB27279.1.
    AF166361
    , AF165901, AF165902, AF165903, AF165904, AF165905, AF165906, AF166359, AF166360 Genomic DNA. Translation: AAG12455.1.
    BC028629 mRNA. Translation: AAH28629.1.
    CCDSiCCDS14706.1.
    PIRiI77911.
    RefSeqiNP_000799.1. NM_000808.3.
    UniGeneiHs.123024.

    Genome annotation databases

    EnsembliENST00000370314; ENSP00000359337; ENSG00000011677.
    ENST00000535043; ENSP00000443527; ENSG00000011677.
    GeneIDi2556.
    KEGGihsa:2556.
    UCSCiuc010ntk.1. human.

    Polymorphism databases

    DMDMi462149.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Forbidden fruit - Issue 56 of March 2005

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S62908 mRNA. Translation: AAB27279.1 .
    AF166361
    , AF165901 , AF165902 , AF165903 , AF165904 , AF165905 , AF165906 , AF166359 , AF166360 Genomic DNA. Translation: AAG12455.1 .
    BC028629 mRNA. Translation: AAH28629.1 .
    CCDSi CCDS14706.1.
    PIRi I77911.
    RefSeqi NP_000799.1. NM_000808.3.
    UniGenei Hs.123024.

    3D structure databases

    ProteinModelPortali P34903.
    SMRi P34903. Positions 68-365.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108830. 3 interactions.
    IntActi P34903. 3 interactions.
    MINTi MINT-7242442.
    STRINGi 9606.ENSP00000359334.

    Chemistry

    BindingDBi P34903.
    ChEMBLi CHEMBL2109244.
    DrugBanki DB00659. Acamprosate.
    DB00546. Adinazolam.
    DB00404. Alprazolam.
    DB01351. Amobarbital.
    DB00543. Amoxapine.
    DB01352. Aprobarbital.
    DB01558. Bromazepam.
    DB00237. Butabarbital.
    DB00241. Butalbital.
    DB01353. Butethal.
    DB00475. Chlordiazepoxide.
    DB01594. Cinolazepam.
    DB00349. Clobazam.
    DB01068. Clonazepam.
    DB00628. Clorazepate.
    DB01559. Clotiazepam.
    DB01189. Desflurane.
    DB00829. Diazepam.
    DB00228. Enflurane.
    DB01049. Ergoloid mesylate.
    DB01215. Estazolam.
    DB00402. Eszopiclone.
    DB00189. Ethchlorvynol.
    DB00292. Etomidate.
    DB01567. Fludiazepam.
    DB01205. Flumazenil.
    DB01544. Flunitrazepam.
    DB00690. Flurazepam.
    DB01437. Glutethimide.
    DB00801. Halazepam.
    DB01159. Halothane.
    DB01354. Heptabarbital.
    DB01355. Hexobarbital.
    DB00753. Isoflurane.
    DB00186. Lorazepam.
    DB00371. Meprobamate.
    DB01028. Methoxyflurane.
    DB00849. Methylphenobarbital.
    DB01107. Methyprylon.
    DB00683. Midazolam.
    DB01595. Nitrazepam.
    DB00334. Olanzapine.
    DB00842. Oxazepam.
    DB00312. Pentobarbital.
    DB01588. Prazepam.
    DB00794. Primidone.
    DB00818. Propofol.
    DB01589. Quazepam.
    DB00418. Secobarbital.
    DB01236. Sevoflurane.
    DB00306. Talbutal.
    DB00231. Temazepam.
    DB00599. Thiopental.
    DB00273. Topiramate.
    DB00897. Triazolam.
    DB00425. Zolpidem.
    DB01198. Zopiclone.
    GuidetoPHARMACOLOGYi 406.

    PTM databases

    PhosphoSitei P34903.

    Polymorphism databases

    DMDMi 462149.

    Proteomic databases

    PaxDbi P34903.
    PRIDEi P34903.

    Protocols and materials databases

    DNASUi 2556.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370314 ; ENSP00000359337 ; ENSG00000011677 .
    ENST00000535043 ; ENSP00000443527 ; ENSG00000011677 .
    GeneIDi 2556.
    KEGGi hsa:2556.
    UCSCi uc010ntk.1. human.

    Organism-specific databases

    CTDi 2556.
    GeneCardsi GC0XM151334.
    HGNCi HGNC:4077. GABRA3.
    HPAi HPA000839.
    MIMi 305660. gene.
    neXtProti NX_P34903.
    Orphaneti 79102. Thyrotoxic periodic paralysis.
    PharmGKBi PA28491.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG238757.
    HOGENOMi HOG000231337.
    HOVERGENi HBG051707.
    InParanoidi P34903.
    KOi K05175.
    OMAi ASPKTTY.
    OrthoDBi EOG7JX342.
    PhylomeDBi P34903.
    TreeFami TF315453.

    Enzyme and pathway databases

    Reactomei REACT_24987. GABA A receptor activation.
    REACT_25387. Ligand-gated ion channel transport.

    Miscellaneous databases

    GeneWikii GABRA3.
    GenomeRNAii 2556.
    NextBioi 10095.
    PROi P34903.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P34903.
    Bgeei P34903.
    CleanExi HS_GABRA3.
    Genevestigatori P34903.

    Family and domain databases

    Gene3Di 2.70.170.10. 1 hit.
    InterProi IPR006028. GABAA/Glycine_rcpt.
    IPR001390. GABAAa_rcpt.
    IPR005433. GABBAa3_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 2 hits.
    [Graphical view ]
    PRINTSi PR01079. GABAARALPHA.
    PR01616. GABAARALPHA3.
    PR00253. GABAARECEPTR.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors."
      Hadingham K.L., Wingrove P., le Bourdelles B., Palmer K.J., Ragan C.I., Whiting P.J.
      Mol. Pharmacol. 43:970-975(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq."
      Amir R., Dahle E.J., Toriolo D., Zoghbi H.Y.
      Am. J. Med. Genet. 90:69-71(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiGBRA3_HUMAN
    AccessioniPrimary (citable) accession number: P34903
    Secondary accession number(s): Q8TAF9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 145 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3