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P34903

- GBRA3_HUMAN

UniProt

P34903 - GBRA3_HUMAN

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Protein
Gamma-aminobutyric acid receptor subunit alpha-3
Gene
GABRA3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

  1. GABA-A receptor activity Source: InterPro
  2. benzodiazepine receptor activity Source: ProtInc
  3. chloride channel activity Source: UniProtKB-KW
  4. extracellular ligand-gated ion channel activity Source: InterPro

GO - Biological processi

  1. gamma-aminobutyric acid signaling pathway Source: ProtInc
  2. ion transmembrane transport Source: Reactome
  3. synaptic transmission Source: Reactome
  4. transmembrane transport Source: Reactome
  5. transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiREACT_24987. GABA A receptor activation.
REACT_25387. Ligand-gated ion channel transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit alpha-3
Alternative name(s):
GABA(A) receptor subunit alpha-3
Gene namesi
Name:GABRA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:4077. GABRA3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 276248Extracellular Inferred
Add
BLAST
Transmembranei277 – 29822Helical; Inferred
Add
BLAST
Transmembranei304 – 32522Helical; Inferred
Add
BLAST
Transmembranei338 – 35922Helical; Inferred
Add
BLAST
Topological domaini360 – 45798Cytoplasmic Inferred
Add
BLAST
Transmembranei458 – 47922Helical; Inferred
Add
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. chloride channel complex Source: UniProtKB-KW
  3. integral component of plasma membrane Source: ProtInc
  4. plasma membrane Source: Reactome
  5. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

Orphaneti79102. Thyrotoxic periodic paralysis.
PharmGKBiPA28491.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed prediction
Add
BLAST
Chaini29 – 492464Gamma-aminobutyric acid receptor subunit alpha-3
PRO_0000000437Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi63 – 631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi163 – 1631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi176 – 1761N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi191 ↔ 205 By similarity
Glycosylationi228 – 2281N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP34903.
PRIDEiP34903.

PTM databases

PhosphoSiteiP34903.

Expressioni

Gene expression databases

ArrayExpressiP34903.
BgeeiP34903.
CleanExiHS_GABRA3.
GenevestigatoriP34903.

Organism-specific databases

HPAiHPA000839.

Interactioni

Subunit structurei

Binds UBQLN1 By similarity. Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.

Protein-protein interaction databases

BioGridi108830. 3 interactions.
IntActiP34903. 3 interactions.
MINTiMINT-7242442.
STRINGi9606.ENSP00000359334.

Structurei

3D structure databases

ProteinModelPortaliP34903.
SMRiP34903. Positions 68-365.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG238757.
HOGENOMiHOG000231337.
HOVERGENiHBG051707.
InParanoidiP34903.
KOiK05175.
OMAiASPKTTY.
OrthoDBiEOG7JX342.
PhylomeDBiP34903.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR001390. GABAAa_rcpt.
IPR005433. GABBAa3_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 2 hits.
[Graphical view]
PRINTSiPR01079. GABAARALPHA.
PR01616. GABAARALPHA3.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34903-1 [UniParc]FASTAAdd to Basket

« Hide

MIITQTSHCY MTSLGILFLI NILPGTTGQG ESRRQEPGDF VKQDIGGLSP    50
KHAPDIPDDS TDNITIFTRI LDRLLDGYDN RLRPGLGDAV TEVKTDIYVT 100
SFGPVSDTDM EYTIDVFFRQ TWHDERLKFD GPMKILPLNN LLASKIWTPD 150
TFFHNGKKSV AHNMTTPNKL LRLVDNGTLL YTMRLTIHAE CPMHLEDFPM 200
DVHACPLKFG SYAYTTAEVV YSWTLGKNKS VEVAQDGSRL NQYDLLGHVV 250
GTEIIRSSTG EYVVMTTHFH LKRKIGYFVI QTYLPCIMTV ILSQVSFWLN 300
RESVPARTVF GVTTVLTMTT LSISARNSLP KVAYATAMDW FIAVCYAFVF 350
SALIEFATVN YFTKRSWAWE GKKVPEALEM KKKTPAAPAK KTSTTFNIVG 400
TTYPINLAKD TEFSTISKGA APSASSTPTI IASPKATYVQ DSPTETKTYN 450
SVSKVDKISR IIFPVLFAIF NLVYWATYVN RESAIKGMIR KQ 492
Length:492
Mass (Da):55,165
Last modified:February 1, 1994 - v1
Checksum:i23A7390C9822691F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti180 – 1801L → P in AAH28629. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S62908 mRNA. Translation: AAB27279.1.
AF166361
, AF165901, AF165902, AF165903, AF165904, AF165905, AF165906, AF166359, AF166360 Genomic DNA. Translation: AAG12455.1.
BC028629 mRNA. Translation: AAH28629.1.
CCDSiCCDS14706.1.
PIRiI77911.
RefSeqiNP_000799.1. NM_000808.3.
UniGeneiHs.123024.

Genome annotation databases

EnsembliENST00000370314; ENSP00000359337; ENSG00000011677.
ENST00000535043; ENSP00000443527; ENSG00000011677.
GeneIDi2556.
KEGGihsa:2556.
UCSCiuc010ntk.1. human.

Polymorphism databases

DMDMi462149.

Cross-referencesi

Web resourcesi

Protein Spotlight

Forbidden fruit - Issue 56 of March 2005

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S62908 mRNA. Translation: AAB27279.1 .
AF166361
, AF165901 , AF165902 , AF165903 , AF165904 , AF165905 , AF165906 , AF166359 , AF166360 Genomic DNA. Translation: AAG12455.1 .
BC028629 mRNA. Translation: AAH28629.1 .
CCDSi CCDS14706.1.
PIRi I77911.
RefSeqi NP_000799.1. NM_000808.3.
UniGenei Hs.123024.

3D structure databases

ProteinModelPortali P34903.
SMRi P34903. Positions 68-365.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108830. 3 interactions.
IntActi P34903. 3 interactions.
MINTi MINT-7242442.
STRINGi 9606.ENSP00000359334.

Chemistry

BindingDBi P34903.
ChEMBLi CHEMBL2109244.
DrugBanki DB00404. Alprazolam.
DB00829. Diazepam.
DB00189. Ethchlorvynol.
DB01544. Flunitrazepam.
DB00690. Flurazepam.
DB00186. Lorazepam.
DB00371. Meprobamate.
DB00683. Midazolam.
GuidetoPHARMACOLOGYi 406.

PTM databases

PhosphoSitei P34903.

Polymorphism databases

DMDMi 462149.

Proteomic databases

PaxDbi P34903.
PRIDEi P34903.

Protocols and materials databases

DNASUi 2556.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370314 ; ENSP00000359337 ; ENSG00000011677 .
ENST00000535043 ; ENSP00000443527 ; ENSG00000011677 .
GeneIDi 2556.
KEGGi hsa:2556.
UCSCi uc010ntk.1. human.

Organism-specific databases

CTDi 2556.
GeneCardsi GC0XM151334.
HGNCi HGNC:4077. GABRA3.
HPAi HPA000839.
MIMi 305660. gene.
neXtProti NX_P34903.
Orphaneti 79102. Thyrotoxic periodic paralysis.
PharmGKBi PA28491.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG238757.
HOGENOMi HOG000231337.
HOVERGENi HBG051707.
InParanoidi P34903.
KOi K05175.
OMAi ASPKTTY.
OrthoDBi EOG7JX342.
PhylomeDBi P34903.
TreeFami TF315453.

Enzyme and pathway databases

Reactomei REACT_24987. GABA A receptor activation.
REACT_25387. Ligand-gated ion channel transport.

Miscellaneous databases

GeneWikii GABRA3.
GenomeRNAii 2556.
NextBioi 10095.
PROi P34903.
SOURCEi Search...

Gene expression databases

ArrayExpressi P34903.
Bgeei P34903.
CleanExi HS_GABRA3.
Genevestigatori P34903.

Family and domain databases

Gene3Di 2.70.170.10. 1 hit.
InterProi IPR006028. GABAA/Glycine_rcpt.
IPR001390. GABAAa_rcpt.
IPR005433. GABBAa3_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 2 hits.
[Graphical view ]
PRINTSi PR01079. GABAARALPHA.
PR01616. GABAARALPHA3.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsi TIGR00860. LIC. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors."
    Hadingham K.L., Wingrove P., le Bourdelles B., Palmer K.J., Ragan C.I., Whiting P.J.
    Mol. Pharmacol. 43:970-975(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq."
    Amir R., Dahle E.J., Toriolo D., Zoghbi H.Y.
    Am. J. Med. Genet. 90:69-71(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiGBRA3_HUMAN
AccessioniPrimary (citable) accession number: P34903
Secondary accession number(s): Q8TAF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 3, 2014
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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