Gamma-aminobutyric acid receptor subunit alpha-3 precursor

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Reviewed, UniProtKB/Swiss-Prot P34903 (GBRA3_HUMAN)

Last modified November 3, 2009. Version 99. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Gamma-aminobutyric acid receptor subunit alpha-3
Alternative name(s):
GABA(A) receptor subunit alpha-3

Gene names

Name:

GABRA3

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	492 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Subunit structure	Binds UBQLN1 By similarity. Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
Subcellular location	Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the ligand-gated ionic channel (TC 1.A.9) family. [View classification]

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Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Domain	Signal Transmembrane
Ligand	Chloride
Molecular function	Chloride channel Ionic channel
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chloride transport Inferred from electronic annotation. Source: InterPro gamma-aminobutyric acid signaling pathway Ref.1 Traceable author statement. Source: ProtInc
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW chloride channel complex Inferred from electronic annotation. Source: UniProtKB-KW integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	GABA-A receptor activity Inferred from electronic annotation. Source: InterPro benzodiazepine receptor activity Ref.1 Traceable author statement. Source: ProtInc chloride channel activity Inferred from electronic annotation. Source: UniProtKB-KW chloride ion binding Inferred from electronic annotation. Source: UniProtKB-KW extracellular ligand-gated ion channel activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct	Notes
PIK3R1	P27986	1	EBI-1763805,EBI-79464

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 28

Potential

Chain

29 – 492

464

Gamma-aminobutyric acid receptor subunit alpha-3

PRO_0000000437

Regions

Topological domain

29 – 276

248

Extracellular Probable

Transmembrane

277 – 298

Probable

Transmembrane

304 – 325

Probable

Transmembrane

338 – 359

Probable

Topological domain

360 – 457

Cytoplasmic Probable

Transmembrane

458 – 479

Probable

Amino acid modifications

Modified residue

433

Phosphoserine By similarity

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

163

N-linked (GlcNAc...) Potential

Glycosylation

176

N-linked (GlcNAc...) Potential

Glycosylation

228

N-linked (GlcNAc...) Potential

Disulfide bond

191 ↔ 205

By similarity

Experimental info

Sequence conflict

180

L → P in AAH28629. Ref.3

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Sequences

Sequence

Length

Mass (Da)

Tools

P34903-1 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 23A7390C9822691F
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FASTA

492

55,165

        10         20         30         40         50         60 
MIITQTSHCY MTSLGILFLI NILPGTTGQG ESRRQEPGDF VKQDIGGLSP KHAPDIPDDS 

        70         80         90        100        110        120 
TDNITIFTRI LDRLLDGYDN RLRPGLGDAV TEVKTDIYVT SFGPVSDTDM EYTIDVFFRQ 

       130        140        150        160        170        180 
TWHDERLKFD GPMKILPLNN LLASKIWTPD TFFHNGKKSV AHNMTTPNKL LRLVDNGTLL 

       190        200        210        220        230        240 
YTMRLTIHAE CPMHLEDFPM DVHACPLKFG SYAYTTAEVV YSWTLGKNKS VEVAQDGSRL 

       250        260        270        280        290        300 
NQYDLLGHVV GTEIIRSSTG EYVVMTTHFH LKRKIGYFVI QTYLPCIMTV ILSQVSFWLN 

       310        320        330        340        350        360 
RESVPARTVF GVTTVLTMTT LSISARNSLP KVAYATAMDW FIAVCYAFVF SALIEFATVN 

       370        380        390        400        410        420 
YFTKRSWAWE GKKVPEALEM KKKTPAAPAK KTSTTFNIVG TTYPINLAKD TEFSTISKGA 

       430        440        450        460        470        480 
APSASSTPTI IASPKATYVQ DSPTETKTYN SVSKVDKISR IIFPVLFAIF NLVYWATYVN 

       490 
RESAIKGMIR KQ

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors." Hadingham K.L., Wingrove P., le Bourdelles B., Palmer K.J., Ragan C.I., Whiting P.J. Mol. Pharmacol. 43:970-975(1993) [PubMed: 8391122] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq." Amir R., Dahle E.J., Toriolo D., Zoghbi H.Y. Am. J. Med. Genet. 90:69-71(2000) [PubMed: 10602120] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

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Web resources

Protein Spotlight

Forbidden fruit - Issue 56 of March 2005

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Cross-references

Sequence databases
	S62908 mRNA. Translation: AAB27279.1. AF166361 AF166360 Genomic DNA. Translation: AAG12455.1. BC028629 mRNA. Translation: AAH28629.1.
IPI	IPI00002897.
PIR	I77911.
RefSeq	NP_000799.1.
UniGene	Hs.123024
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P34903. 1 interaction.
STRING	P34903.
PTM databases
PhosphoSite	P34903.
Proteomic databases
PRIDE	P34903.
Genome annotation databases
Ensembl	ENST00000370311; ENSP00000359334; ENSG00000011677; Homo sapiens. [Genome view] ENST00000370314; ENSP00000359337; ENSG00000011677; Homo sapiens. [Genome view] ENST00000417858; ENSP00000413772; ENSG00000011677; Homo sapiens. [Genome view]
GeneID	2556.
KEGG	hsa:2556.
UCSC	uc010ntk.1. human.
Organism-specific databases
CTD	2556.
GeneCards	GC0XM151085.
H-InvDB	HIX0017117.
HGNC	HGNC:4077. GABRA3.
HPA	HPA000839.
MIM	305660. gene.
PharmGKB	PA28491.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P34903.
HOVERGEN	P34903.
OMA	ASPKTTY.
Gene expression databases
ArrayExpress	P34903.
Bgee	P34903.
CleanEx	HS_GABRA3.
Genevestigator	P34903.
GermOnline	ENSG00000011677. Homo sapiens.
Family and domain databases
InterPro	IPR006028. GABAA_rcpt. IPR001390. GABAAa_rcpt. IPR005433. GABBAa3_rcpt. IPR006029. Neu_channel_TM. IPR006202. Neur_chan_lig_bd. IPR006201. Neur_channel. IPR018000. Neurotransmitter_ion_chnl_CS. [Graphical view]
Gene3D	G3DSA:2.70.170.10. Neur_chan_lig_bd. 1 hit.
PANTHER	PTHR18945. Neur_channel. 1 hit.
Pfam	PF02931. Neur_chan_LBD. 1 hit. PF02932. Neur_chan_memb. 1 hit. [Graphical view]
PRINTS	PR01079. GABAARALPHA. PR01616. GABAARALPHA3. PR00253. GABAARECEPTR. PR00252. NRIONCHANNEL.
TIGRFAMs	TIGR00860. LIC. 1 hit.
PROSITE	PS00236. NEUROTR_ION_CHANNEL. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB00404. Alprazolam. DB00829. Diazepam. DB00189. Ethchlorvynol. DB01544. Flunitrazepam. DB00690. Flurazepam. DB00186. Lorazepam. DB00371. Meprobamate. DB00683. Midazolam.
NextBio	10095.
SOURCE	Search...

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Entry information

Entry name

GBRA3_HUMAN

Accession

Primary (citable) accession number: P34903
Secondary accession number(s): Q8TAF9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	November 3, 2009
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents