ID   IL2RG_MOUSE             Reviewed;         369 AA.
AC   P34902;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   27-MAR-2024, entry version 198.
DE   RecName: Full=Cytokine receptor common subunit gamma;
DE   AltName: Full=Interleukin-2 receptor subunit gamma;
DE            Short=IL-2 receptor subunit gamma;
DE            Short=IL-2R subunit gamma;
DE            Short=IL-2RG;
DE   AltName: Full=gammaC;
DE   AltName: Full=p64;
DE   AltName: CD_antigen=CD132;
DE   Flags: Precursor;
GN   Name=Il2rg;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8503926; DOI=10.1006/bbrc.1993.1631;
RA   Kumaki S., Kondo M., Takeshita T., Asao H., Nakamura M., Sugamura K.;
RT   "Cloning of the mouse interleukin 2 receptor gamma chain: demonstration of
RT   functional differences between the mouse and human receptors.";
RL   Biochem. Biophys. Res. Commun. 193:356-363(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=CBA/CaJ;
RX   PubMed=8378320; DOI=10.1073/pnas.90.18.8464;
RA   Cao X., Kozak C.A., Liu Y.J., Noguchi M., O'Connell E., Leonard W.J.;
RT   "Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-
RT   2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma
RT   chain expression.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:8464-8468(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8359699; DOI=10.1016/0378-1119(93)90436-7;
RA   Kobayashi N., Nakagawa S., Minami Y., Taniguchi T., Kono T.;
RT   "Cloning and sequencing of the cDNA encoding a mouse IL-2 receptor gamma.";
RL   Gene 130:303-304(1993).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7805729; DOI=10.1002/eji.1830241214;
RA   Disanto J.P., Certain S., Wilson A., Macdonald H.R., Avner P., Fischer A.,
RA   de Saint Basile G.;
RT   "The murine interleukin-2 receptor gamma chain gene: organization,
RT   chromosomal localization and expression in the adult thymus.";
RL   Eur. J. Immunol. 24:3014-3018(1994).
RN   [5]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=B6.S;
RX   PubMed=8750189; DOI=10.1007/bf01052626;
RA   Chiu R.K., Droll A., Cooper D.L., Dougherty S.T., Dirks J.F.,
RA   Dougherty G.J.;
RT   "Molecular mechanisms regulating the hyaluronan binding activity of the
RT   adhesion protein CD44.";
RL   J. Neurooncol. 26:231-239(1995).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Salivary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   FUNCTION, AND INTERACTION WITH IL9.
RX   PubMed=7718508; DOI=10.1093/intimm/7.1.115;
RA   Kimura Y., Takeshita T., Kondo M., Ishii N., Nakamura M., Van Snick J.,
RA   Sugamura K.;
RT   "Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor
RT   complex.";
RL   Int. Immunol. 7:115-120(1995).
CC   -!- FUNCTION: Common subunit for the receptors for a variety of
CC       interleukins (PubMed:7718508). Probably in association with IL15RA,
CC       involved in the stimulation of neutrophil phagocytosis by IL15 (By
CC       similarity). {ECO:0000250|UniProtKB:P31785,
CC       ECO:0000269|PubMed:7718508}.
CC   -!- SUBUNIT: The gamma subunit is common to the IL2, IL4, IL7, IL15, IL21
CC       and probably also the IL13 receptors. Interacts with SHB upon
CC       interleukin stimulation (By similarity). Interacts with IL9
CC       (PubMed:7718508). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P31785};
CC       Single-pass type I membrane protein {ECO:0000255}. Cell surface
CC       {ECO:0000250|UniProtKB:P31785}.
CC   -!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
CC       folding and thereby efficient intracellular transport and cell-surface
CC       receptor binding.
CC   -!- DOMAIN: The box 1 motif is required for JAK interaction and/or
CC       activation.
CC   -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 5
CC       subfamily. {ECO:0000305}.
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DR   EMBL; D13821; BAA02974.1; -; mRNA.
DR   EMBL; U21795; AAA64279.1; -; Genomic_DNA.
DR   EMBL; D13565; BAA02760.1; -; mRNA.
DR   EMBL; L20048; AAA39286.1; -; mRNA.
DR   EMBL; S75852; AAB32904.1; -; Genomic_DNA.
DR   EMBL; S75844; AAB32904.1; JOINED; Genomic_DNA.
DR   EMBL; S75845; AAB32904.1; JOINED; Genomic_DNA.
DR   EMBL; S75847; AAB32904.1; JOINED; Genomic_DNA.
DR   EMBL; S75848; AAB32904.1; JOINED; Genomic_DNA.
DR   EMBL; S75849; AAB32904.1; JOINED; Genomic_DNA.
DR   EMBL; S75850; AAB32904.1; JOINED; Genomic_DNA.
DR   EMBL; S75851; AAB32904.1; JOINED; Genomic_DNA.
DR   EMBL; X75337; CAA53085.1; -; mRNA.
DR   EMBL; BC014720; AAH14720.1; -; mRNA.
DR   CCDS; CCDS30312.1; -.
DR   PIR; I49280; I49280.
DR   RefSeq; NP_038591.1; NM_013563.4.
DR   PDB; 6DG5; X-ray; 2.52 A; C=56-254.
DR   PDB; 8DDC; NMR; -; A=253-286.
DR   PDB; 8DDD; NMR; -; A=253-286.
DR   PDBsum; 6DG5; -.
DR   PDBsum; 8DDC; -.
DR   PDBsum; 8DDD; -.
DR   AlphaFoldDB; P34902; -.
DR   SMR; P34902; -.
DR   IntAct; P34902; 3.
DR   STRING; 10090.ENSMUSP00000033664; -.
DR   GlyCosmos; P34902; 6 sites, No reported glycans.
DR   GlyGen; P34902; 6 sites.
DR   iPTMnet; P34902; -.
DR   PhosphoSitePlus; P34902; -.
DR   SwissPalm; P34902; -.
DR   EPD; P34902; -.
DR   PaxDb; 10090-ENSMUSP00000033664; -.
DR   ProteomicsDB; 267323; -.
DR   DNASU; 16186; -.
DR   Ensembl; ENSMUST00000033664.14; ENSMUSP00000033664.8; ENSMUSG00000031304.19.
DR   GeneID; 16186; -.
DR   KEGG; mmu:16186; -.
DR   UCSC; uc009txc.1; mouse.
DR   AGR; MGI:96551; -.
DR   CTD; 3561; -.
DR   MGI; MGI:96551; Il2rg.
DR   VEuPathDB; HostDB:ENSMUSG00000031304; -.
DR   eggNOG; ENOG502S289; Eukaryota.
DR   GeneTree; ENSGT00510000048979; -.
DR   HOGENOM; CLU_060544_1_0_1; -.
DR   InParanoid; P34902; -.
DR   OMA; TAGCWLQ; -.
DR   OrthoDB; 5174285at2759; -.
DR   PhylomeDB; P34902; -.
DR   TreeFam; TF333657; -.
DR   Reactome; R-MMU-1266695; Interleukin-7 signaling.
DR   Reactome; R-MMU-5673001; RAF/MAP kinase cascade.
DR   Reactome; R-MMU-6785807; Interleukin-4 and Interleukin-13 signaling.
DR   Reactome; R-MMU-8983432; Interleukin-15 signaling.
DR   Reactome; R-MMU-8985947; Interleukin-9 signaling.
DR   Reactome; R-MMU-9020558; Interleukin-2 signaling.
DR   Reactome; R-MMU-9020958; Interleukin-21 signaling.
DR   Reactome; R-MMU-912526; Interleukin receptor SHC signaling.
DR   BioGRID-ORCS; 16186; 4 hits in 78 CRISPR screens.
DR   ChiTaRS; Il2rg; mouse.
DR   PRO; PR:P34902; -.
DR   Proteomes; UP000000589; Chromosome X.
DR   RNAct; P34902; Protein.
DR   Bgee; ENSMUSG00000031304; Expressed in mesenteric lymph node and 117 other cell types or tissues.
DR   ExpressionAtlas; P34902; baseline and differential.
DR   GO; GO:0009986; C:cell surface; ISS:UniProtKB.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR   GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR   GO; GO:0015026; F:coreceptor activity; ISO:MGI.
DR   GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
DR   GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
DR   GO; GO:0042010; F:interleukin-15 receptor activity; ISS:UniProtKB.
DR   GO; GO:0019976; F:interleukin-2 binding; IPI:MGI.
DR   GO; GO:0030183; P:B cell differentiation; IMP:MGI.
DR   GO; GO:0002361; P:CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; IMP:MGI.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0010467; P:gene expression; IMP:MGI.
DR   GO; GO:0035723; P:interleukin-15-mediated signaling pathway; ISS:UniProtKB.
DR   GO; GO:0038110; P:interleukin-2-mediated signaling pathway; ISO:MGI.
DR   GO; GO:0038113; P:interleukin-9-mediated signaling pathway; ISO:MGI.
DR   GO; GO:0030098; P:lymphocyte differentiation; IMP:MGI.
DR   GO; GO:0002335; P:mature B cell differentiation; IMP:MGI.
DR   GO; GO:0045579; P:positive regulation of B cell differentiation; IMP:MGI.
DR   GO; GO:0032831; P:positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; IMP:MGI.
DR   GO; GO:0010628; P:positive regulation of gene expression; IMP:MGI.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; ISS:UniProtKB.
DR   GO; GO:0033089; P:positive regulation of T cell differentiation in thymus; IMP:MGI.
DR   GO; GO:0010468; P:regulation of gene expression; IMP:MGI.
DR   GO; GO:0033077; P:T cell differentiation in thymus; IMP:MGI.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR048648; CRLF2-like_D2.
DR   InterPro; IPR048651; CRLF2_D1.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR003531; Hempt_rcpt_S_F1_CS.
DR   InterPro; IPR013783; Ig-like_fold.
DR   PANTHER; PTHR23037; CYTOKINE RECEPTOR; 1.
DR   PANTHER; PTHR23037:SF41; CYTOKINE RECEPTOR-LIKE FACTOR 2-RELATED; 1.
DR   Pfam; PF21605; CRLF2-like_D2; 1.
DR   Pfam; PF21604; CRLF2_D1; 1.
DR   SMART; SM00060; FN3; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 2.
DR   PROSITE; PS50853; FN3; 1.
DR   PROSITE; PS01355; HEMATOPO_REC_S_F1; 1.
DR   Genevisible; P34902; MM.
PE   1: Evidence at protein level;
KW   3D-structure; Cell membrane; Disulfide bond; Glycoprotein; Membrane;
KW   Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   CHAIN           23..369
FT                   /note="Cytokine receptor common subunit gamma"
FT                   /id="PRO_0000010867"
FT   TOPO_DOM        23..263
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        285..369
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          156..254
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   MOTIF           238..242
FT                   /note="WSXWS motif"
FT   MOTIF           286..294
FT                   /note="Box 1 motif"
FT   CARBOHYD        71
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        75
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        84
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        96
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        159
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        164
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        62..72
FT                   /evidence="ECO:0000255"
FT   DISULFID        102..115
FT                   /evidence="ECO:0000255"
FT   STRAND          61..65
FT                   /evidence="ECO:0007829|PDB:6DG5"
FT   TURN            66..68
FT                   /evidence="ECO:0007829|PDB:6DG5"
FT   STRAND          69..73
FT                   /evidence="ECO:0007829|PDB:6DG5"
FT   HELIX           76..78
FT                   /evidence="ECO:0007829|PDB:6DG5"
FT   STRAND          79..81
FT                   /evidence="ECO:0007829|PDB:6DG5"
FT   STRAND          86..92
FT                   /evidence="ECO:0007829|PDB:6DG5"
FT   STRAND          103..108
FT                   /evidence="ECO:0007829|PDB:6DG5"
FT   STRAND          111..118
FT                   /evidence="ECO:0007829|PDB:6DG5"
FT   HELIX           119..121
FT                   /evidence="ECO:0007829|PDB:6DG5"
FT   STRAND          128..133
FT                   /evidence="ECO:0007829|PDB:6DG5"
FT   STRAND          141..146
FT                   /evidence="ECO:0007829|PDB:6DG5"
FT   HELIX           148..150
FT                   /evidence="ECO:0007829|PDB:6DG5"
FT   STRAND          151..153
FT                   /evidence="ECO:0007829|PDB:6DG5"
FT   STRAND          158..163
FT                   /evidence="ECO:0007829|PDB:6DG5"
FT   STRAND          165..168
FT                   /evidence="ECO:0007829|PDB:6DG5"
FT   STRAND          170..175
FT                   /evidence="ECO:0007829|PDB:6DG5"
FT   STRAND          177..179
FT                   /evidence="ECO:0007829|PDB:6DG5"
FT   TURN            181..183
FT                   /evidence="ECO:0007829|PDB:6DG5"
FT   STRAND          185..191
FT                   /evidence="ECO:0007829|PDB:6DG5"
FT   STRAND          199..206
FT                   /evidence="ECO:0007829|PDB:6DG5"
FT   STRAND          208..211
FT                   /evidence="ECO:0007829|PDB:6DG5"
FT   STRAND          216..218
FT                   /evidence="ECO:0007829|PDB:6DG5"
FT   STRAND          220..227
FT                   /evidence="ECO:0007829|PDB:6DG5"
FT   STRAND          230..232
FT                   /evidence="ECO:0007829|PDB:6DG5"
FT   STRAND          245..247
FT                   /evidence="ECO:0007829|PDB:6DG5"
FT   TURN            257..260
FT                   /evidence="ECO:0007829|PDB:8DDC"
FT   HELIX           262..265
FT                   /evidence="ECO:0007829|PDB:8DDC"
FT   HELIX           267..284
FT                   /evidence="ECO:0007829|PDB:8DDC"
SQ   SEQUENCE   369 AA;  42241 MW;  CB2D5AB459077AC7 CRC64;
     MLKLLLSPRS FLVLQLLLLR AGWSSKVLMS SANEDIKADL ILTSTAPEHL SAPTLPLPEV
     QCFVFNIEYM NCTWNSSSEP QATNLTLHYR YKVSDNNTFQ ECSHYLFSKE ITSGCQIQKE
     DIQLYQTFVV QLQDPQKPQR RAVQKLNLQN LVIPRAPENL TLSNLSESQL ELRWKSRHIK
     ERCLQYLVQY RSNRDRSWTE LIVNHEPRFS LPSVDELKRY TFRVRSRYNP ICGSSQQWSK
     WSQPVHWGSH TVEENPSLFA LEAVLIPVGT MGLIITLIFV YCWLERMPPI PPIKNLEDLV
     TEYQGNFSAW SGVSKGLTES LQPDYSERFC HVSEIPPKGG ALGEGPGGSP CSLHSPYWPP
     PCYSLKPEA
//