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P34902 (IL2RG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 139. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytokine receptor common subunit gamma
Alternative name(s):
Interleukin-2 receptor subunit gamma
Short name=IL-2 receptor subunit gamma
Short name=IL-2R subunit gamma
Short name=IL-2RG
gammaC
p64
CD_antigen=CD132
Gene names
Name:Il2rg
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Common subunit for the receptors for a variety of interleukins.

Subunit structure

The gamma subunit is common to the IL2, IL4, IL7, IL15, IL21 and probably also the IL13 receptors. Interacts with SHB upon interleukin stimulation By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Domain

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

The box 1 motif is required for JAK interaction and/or activation.

Sequence similarities

Belongs to the type I cytokine receptor family. Type 5 subfamily.

Contains 1 fibronectin type-III domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 By similarity
Chain23 – 369347Cytokine receptor common subunit gamma
PRO_0000010867

Regions

Topological domain23 – 263241Extracellular Potential
Transmembrane264 – 28421Helical; Potential
Topological domain285 – 36985Cytoplasmic Potential
Domain156 – 25499Fibronectin type-III
Motif238 – 2425WSXWS motif
Motif286 – 2949Box 1 motif

Amino acid modifications

Glycosylation711N-linked (GlcNAc...) Potential
Glycosylation751N-linked (GlcNAc...) Potential
Glycosylation841N-linked (GlcNAc...) Potential
Glycosylation961N-linked (GlcNAc...) Potential
Glycosylation1591N-linked (GlcNAc...) Potential
Glycosylation1641N-linked (GlcNAc...) Potential
Disulfide bond62 ↔ 72 Potential
Disulfide bond102 ↔ 115 Potential

Sequences

Sequence LengthMass (Da)Tools
P34902 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: CB2D5AB459077AC7

FASTA36942,241
        10         20         30         40         50         60 
MLKLLLSPRS FLVLQLLLLR AGWSSKVLMS SANEDIKADL ILTSTAPEHL SAPTLPLPEV 

        70         80         90        100        110        120 
QCFVFNIEYM NCTWNSSSEP QATNLTLHYR YKVSDNNTFQ ECSHYLFSKE ITSGCQIQKE 

       130        140        150        160        170        180 
DIQLYQTFVV QLQDPQKPQR RAVQKLNLQN LVIPRAPENL TLSNLSESQL ELRWKSRHIK 

       190        200        210        220        230        240 
ERCLQYLVQY RSNRDRSWTE LIVNHEPRFS LPSVDELKRY TFRVRSRYNP ICGSSQQWSK 

       250        260        270        280        290        300 
WSQPVHWGSH TVEENPSLFA LEAVLIPVGT MGLIITLIFV YCWLERMPPI PPIKNLEDLV 

       310        320        330        340        350        360 
TEYQGNFSAW SGVSKGLTES LQPDYSERFC HVSEIPPKGG ALGEGPGGSP CSLHSPYWPP 


PCYSLKPEA 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of the mouse interleukin 2 receptor gamma chain: demonstration of functional differences between the mouse and human receptors."
Kumaki S., Kondo M., Takeshita T., Asao H., Nakamura M., Sugamura K.
Biochem. Biophys. Res. Commun. 193:356-363(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression."
Cao X., Kozak C.A., Liu Y.J., Noguchi M., O'Connell E., Leonard W.J.
Proc. Natl. Acad. Sci. U.S.A. 90:8464-8468(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CBA/Ca.
[3]"Cloning and sequencing of the cDNA encoding a mouse IL-2 receptor gamma."
Kobayashi N., Nakagawa S., Minami Y., Taniguchi T., Kono T.
Gene 130:303-304(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The murine interleukin-2 receptor gamma chain gene: organization, chromosomal localization and expression in the adult thymus."
Disanto J.P., Certain S., Wilson A., Macdonald H.R., Avner P., Fischer A., de Saint Basile G.
Eur. J. Immunol. 24:3014-3018(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Molecular mechanisms regulating the hyaluronan binding activity of the adhesion protein CD44."
Chiu R.K., Droll A., Cooper D.L., Dougherty S.T., Dirks J.F., Dougherty G.J.
J. Neurooncol. 26:231-239(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: B6.S.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D13821 mRNA. Translation: BAA02974.1.
U21795 Genomic DNA. Translation: AAA64279.1.
D13565 mRNA. Translation: BAA02760.1.
L20048 mRNA. Translation: AAA39286.1.
S75852 expand/collapse EMBL AC list , S75844, S75845, S75847, S75848, S75849, S75850, S75851 Genomic DNA. Translation: AAB32904.1.
X75337 mRNA. Translation: CAA53085.1.
BC014720 mRNA. Translation: AAH14720.1.
CCDSCCDS30312.1.
PIRI49280.
RefSeqNP_038591.1. NM_013563.3.
UniGeneMm.2923.

3D structure databases

ProteinModelPortalP34902.
SMRP34902. Positions 54-249.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP34902. 3 interactions.
MINTMINT-1734370.

PTM databases

PhosphoSiteP34902.

Proteomic databases

PRIDEP34902.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033664; ENSMUSP00000033664; ENSMUSG00000031304.
GeneID16186.
KEGGmmu:16186.
UCSCuc009txc.1. mouse.

Organism-specific databases

CTD3561.
MGIMGI:96551. Il2rg.

Phylogenomic databases

HOGENOMHOG000276891.
HOVERGENHBG052111.
KOK05070.
OMADHSWTEQ.
OrthoDBEOG7H4DV0.
PhylomeDBP34902.
TreeFamTF333657.

Gene expression databases

ArrayExpressP34902.
BgeeP34902.
CleanExMM_IL2RG.
GenevestigatorP34902.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR003961. Fibronectin_type3.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
IPR015321. IL-6_rcpt_alpha-bd.
[Graphical view]
PfamPF00041. fn3. 1 hit.
PF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 2 hits.
PROSITEPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio289081.
PROP34902.
SOURCESearch...

Entry information

Entry nameIL2RG_MOUSE
AccessionPrimary (citable) accession number: P34902
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 9, 2014
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot