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P34902

- IL2RG_MOUSE

UniProt

P34902 - IL2RG_MOUSE

Protein

Cytokine receptor common subunit gamma

Gene

Il2rg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Common subunit for the receptors for a variety of interleukins.

    GO - Molecular functioni

    1. cytokine receptor activity Source: InterPro
    2. interleukin-2 binding Source: MGI

    GO - Biological processi

    1. positive regulation of B cell differentiation Source: MGI
    2. positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation Source: MGI
    3. positive regulation of gene expression Source: MGI
    4. positive regulation of lymphocyte differentiation Source: MGI
    5. positive regulation of T cell differentiation in thymus Source: MGI
    6. regulation of gene expression Source: MGI

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_198701. Interleukin-7 signaling.
    REACT_210793. Interleukin receptor SHC signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytokine receptor common subunit gamma
    Alternative name(s):
    Interleukin-2 receptor subunit gamma
    Short name:
    IL-2 receptor subunit gamma
    Short name:
    IL-2R subunit gamma
    Short name:
    IL-2RG
    gammaC
    p64
    CD_antigen: CD132
    Gene namesi
    Name:Il2rg
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:96551. Il2rg.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222By similarityAdd
    BLAST
    Chaini23 – 369347Cytokine receptor common subunit gammaPRO_0000010867Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi62 ↔ 72Sequence Analysis
    Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi102 ↔ 115Sequence Analysis
    Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP34902.

    PTM databases

    PhosphoSiteiP34902.

    Expressioni

    Gene expression databases

    ArrayExpressiP34902.
    BgeeiP34902.
    CleanExiMM_IL2RG.
    GenevestigatoriP34902.

    Interactioni

    Subunit structurei

    The gamma subunit is common to the IL2, IL4, IL7, IL15, IL21 and probably also the IL13 receptors. Interacts with SHB upon interleukin stimulation By similarity.By similarity

    Protein-protein interaction databases

    IntActiP34902. 3 interactions.
    MINTiMINT-1734370.

    Structurei

    3D structure databases

    ProteinModelPortaliP34902.
    SMRiP34902. Positions 54-249.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 263241ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini285 – 36985CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei264 – 28421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini156 – 25499Fibronectin type-IIIPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi238 – 2425WSXWS motif
    Motifi286 – 2949Box 1 motif

    Domaini

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.

    Sequence similaritiesi

    Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000276891.
    HOVERGENiHBG052111.
    KOiK05070.
    OMAiDHSWTEQ.
    OrthoDBiEOG7H4DV0.
    PhylomeDBiP34902.
    TreeFamiTF333657.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR003531. Hempt_rcpt_S_F1_CS.
    IPR013783. Ig-like_fold.
    IPR015321. IL-6_rcpt_alpha-bd.
    [Graphical view]
    PfamiPF00041. fn3. 1 hit.
    PF09240. IL6Ra-bind. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS50853. FN3. 1 hit.
    PS01355. HEMATOPO_REC_S_F1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P34902-1 [UniParc]FASTAAdd to Basket

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    MLKLLLSPRS FLVLQLLLLR AGWSSKVLMS SANEDIKADL ILTSTAPEHL    50
    SAPTLPLPEV QCFVFNIEYM NCTWNSSSEP QATNLTLHYR YKVSDNNTFQ 100
    ECSHYLFSKE ITSGCQIQKE DIQLYQTFVV QLQDPQKPQR RAVQKLNLQN 150
    LVIPRAPENL TLSNLSESQL ELRWKSRHIK ERCLQYLVQY RSNRDRSWTE 200
    LIVNHEPRFS LPSVDELKRY TFRVRSRYNP ICGSSQQWSK WSQPVHWGSH 250
    TVEENPSLFA LEAVLIPVGT MGLIITLIFV YCWLERMPPI PPIKNLEDLV 300
    TEYQGNFSAW SGVSKGLTES LQPDYSERFC HVSEIPPKGG ALGEGPGGSP 350
    CSLHSPYWPP PCYSLKPEA 369
    Length:369
    Mass (Da):42,241
    Last modified:February 1, 1994 - v1
    Checksum:iCB2D5AB459077AC7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13821 mRNA. Translation: BAA02974.1.
    U21795 Genomic DNA. Translation: AAA64279.1.
    D13565 mRNA. Translation: BAA02760.1.
    L20048 mRNA. Translation: AAA39286.1.
    S75852
    , S75844, S75845, S75847, S75848, S75849, S75850, S75851 Genomic DNA. Translation: AAB32904.1.
    X75337 mRNA. Translation: CAA53085.1.
    BC014720 mRNA. Translation: AAH14720.1.
    CCDSiCCDS30312.1.
    PIRiI49280.
    RefSeqiNP_038591.1. NM_013563.3.
    UniGeneiMm.2923.

    Genome annotation databases

    EnsembliENSMUST00000033664; ENSMUSP00000033664; ENSMUSG00000031304.
    GeneIDi16186.
    KEGGimmu:16186.
    UCSCiuc009txc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13821 mRNA. Translation: BAA02974.1 .
    U21795 Genomic DNA. Translation: AAA64279.1 .
    D13565 mRNA. Translation: BAA02760.1 .
    L20048 mRNA. Translation: AAA39286.1 .
    S75852
    , S75844 , S75845 , S75847 , S75848 , S75849 , S75850 , S75851 Genomic DNA. Translation: AAB32904.1 .
    X75337 mRNA. Translation: CAA53085.1 .
    BC014720 mRNA. Translation: AAH14720.1 .
    CCDSi CCDS30312.1.
    PIRi I49280.
    RefSeqi NP_038591.1. NM_013563.3.
    UniGenei Mm.2923.

    3D structure databases

    ProteinModelPortali P34902.
    SMRi P34902. Positions 54-249.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P34902. 3 interactions.
    MINTi MINT-1734370.

    PTM databases

    PhosphoSitei P34902.

    Proteomic databases

    PRIDEi P34902.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033664 ; ENSMUSP00000033664 ; ENSMUSG00000031304 .
    GeneIDi 16186.
    KEGGi mmu:16186.
    UCSCi uc009txc.1. mouse.

    Organism-specific databases

    CTDi 3561.
    MGIi MGI:96551. Il2rg.

    Phylogenomic databases

    HOGENOMi HOG000276891.
    HOVERGENi HBG052111.
    KOi K05070.
    OMAi DHSWTEQ.
    OrthoDBi EOG7H4DV0.
    PhylomeDBi P34902.
    TreeFami TF333657.

    Enzyme and pathway databases

    Reactomei REACT_198701. Interleukin-7 signaling.
    REACT_210793. Interleukin receptor SHC signaling.

    Miscellaneous databases

    NextBioi 289081.
    PROi P34902.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P34902.
    Bgeei P34902.
    CleanExi MM_IL2RG.
    Genevestigatori P34902.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR003531. Hempt_rcpt_S_F1_CS.
    IPR013783. Ig-like_fold.
    IPR015321. IL-6_rcpt_alpha-bd.
    [Graphical view ]
    Pfami PF00041. fn3. 1 hit.
    PF09240. IL6Ra-bind. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS50853. FN3. 1 hit.
    PS01355. HEMATOPO_REC_S_F1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the mouse interleukin 2 receptor gamma chain: demonstration of functional differences between the mouse and human receptors."
      Kumaki S., Kondo M., Takeshita T., Asao H., Nakamura M., Sugamura K.
      Biochem. Biophys. Res. Commun. 193:356-363(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression."
      Cao X., Kozak C.A., Liu Y.J., Noguchi M., O'Connell E., Leonard W.J.
      Proc. Natl. Acad. Sci. U.S.A. 90:8464-8468(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CBA/Ca.
    3. "Cloning and sequencing of the cDNA encoding a mouse IL-2 receptor gamma."
      Kobayashi N., Nakagawa S., Minami Y., Taniguchi T., Kono T.
      Gene 130:303-304(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The murine interleukin-2 receptor gamma chain gene: organization, chromosomal localization and expression in the adult thymus."
      Disanto J.P., Certain S., Wilson A., Macdonald H.R., Avner P., Fischer A., de Saint Basile G.
      Eur. J. Immunol. 24:3014-3018(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Molecular mechanisms regulating the hyaluronan binding activity of the adhesion protein CD44."
      Chiu R.K., Droll A., Cooper D.L., Dougherty S.T., Dirks J.F., Dougherty G.J.
      J. Neurooncol. 26:231-239(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: B6.S.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiIL2RG_MOUSE
    AccessioniPrimary (citable) accession number: P34902
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 141 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3