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Protein

Cytokine receptor common subunit gamma

Gene

Il2rg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Common subunit for the receptors for a variety of interleukins.

GO - Molecular functioni

  1. cytokine receptor activity Source: InterPro
  2. interleukin-2 binding Source: MGI

GO - Biological processi

  1. positive regulation of B cell differentiation Source: MGI
  2. positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation Source: MGI
  3. positive regulation of gene expression Source: MGI
  4. positive regulation of lymphocyte differentiation Source: MGI
  5. positive regulation of T cell differentiation in thymus Source: MGI
  6. regulation of gene expression Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_273845. Interleukin-2 signaling.
REACT_276590. Interleukin-7 signaling.
REACT_291272. G beta:gamma signalling through PI3Kgamma.
REACT_303160. Interleukin receptor SHC signaling.
REACT_337915. GPVI-mediated activation cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytokine receptor common subunit gamma
Alternative name(s):
Interleukin-2 receptor subunit gamma
Short name:
IL-2 receptor subunit gamma
Short name:
IL-2R subunit gamma
Short name:
IL-2RG
gammaC
p64
CD_antigen: CD132
Gene namesi
Name:Il2rg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:96551. Il2rg.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 263241ExtracellularSequence AnalysisAdd
BLAST
Transmembranei264 – 28421HelicalSequence AnalysisAdd
BLAST
Topological domaini285 – 36985CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: MGI
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 369347Cytokine receptor common subunit gammaPRO_0000010867Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi62 ↔ 72Sequence Analysis
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi102 ↔ 115Sequence Analysis
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP34902.
PRIDEiP34902.

PTM databases

PhosphoSiteiP34902.

Expressioni

Gene expression databases

BgeeiP34902.
CleanExiMM_IL2RG.
ExpressionAtlasiP34902. baseline and differential.
GenevestigatoriP34902.

Interactioni

Subunit structurei

The gamma subunit is common to the IL2, IL4, IL7, IL15, IL21 and probably also the IL13 receptors. Interacts with SHB upon interleukin stimulation (By similarity).By similarity

Protein-protein interaction databases

IntActiP34902. 3 interactions.
MINTiMINT-1734370.

Structurei

3D structure databases

ProteinModelPortaliP34902.
SMRiP34902. Positions 54-249.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini156 – 25499Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi238 – 2425WSXWS motif
Motifi286 – 2949Box 1 motif

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000276891.
HOVERGENiHBG052111.
InParanoidiP34902.
KOiK05070.
OMAiDHSWTEQ.
OrthoDBiEOG7H4DV0.
PhylomeDBiP34902.
TreeFamiTF333657.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
IPR015321. IL-6_rcpt_alpha-bd.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKLLLSPRS FLVLQLLLLR AGWSSKVLMS SANEDIKADL ILTSTAPEHL
60 70 80 90 100
SAPTLPLPEV QCFVFNIEYM NCTWNSSSEP QATNLTLHYR YKVSDNNTFQ
110 120 130 140 150
ECSHYLFSKE ITSGCQIQKE DIQLYQTFVV QLQDPQKPQR RAVQKLNLQN
160 170 180 190 200
LVIPRAPENL TLSNLSESQL ELRWKSRHIK ERCLQYLVQY RSNRDRSWTE
210 220 230 240 250
LIVNHEPRFS LPSVDELKRY TFRVRSRYNP ICGSSQQWSK WSQPVHWGSH
260 270 280 290 300
TVEENPSLFA LEAVLIPVGT MGLIITLIFV YCWLERMPPI PPIKNLEDLV
310 320 330 340 350
TEYQGNFSAW SGVSKGLTES LQPDYSERFC HVSEIPPKGG ALGEGPGGSP
360
CSLHSPYWPP PCYSLKPEA
Length:369
Mass (Da):42,241
Last modified:January 31, 1994 - v1
Checksum:iCB2D5AB459077AC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13821 mRNA. Translation: BAA02974.1.
U21795 Genomic DNA. Translation: AAA64279.1.
D13565 mRNA. Translation: BAA02760.1.
L20048 mRNA. Translation: AAA39286.1.
S75852
, S75844, S75845, S75847, S75848, S75849, S75850, S75851 Genomic DNA. Translation: AAB32904.1.
X75337 mRNA. Translation: CAA53085.1.
BC014720 mRNA. Translation: AAH14720.1.
CCDSiCCDS30312.1.
PIRiI49280.
RefSeqiNP_038591.1. NM_013563.3.
UniGeneiMm.2923.

Genome annotation databases

EnsembliENSMUST00000033664; ENSMUSP00000033664; ENSMUSG00000031304.
GeneIDi16186.
KEGGimmu:16186.
UCSCiuc009txc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13821 mRNA. Translation: BAA02974.1.
U21795 Genomic DNA. Translation: AAA64279.1.
D13565 mRNA. Translation: BAA02760.1.
L20048 mRNA. Translation: AAA39286.1.
S75852
, S75844, S75845, S75847, S75848, S75849, S75850, S75851 Genomic DNA. Translation: AAB32904.1.
X75337 mRNA. Translation: CAA53085.1.
BC014720 mRNA. Translation: AAH14720.1.
CCDSiCCDS30312.1.
PIRiI49280.
RefSeqiNP_038591.1. NM_013563.3.
UniGeneiMm.2923.

3D structure databases

ProteinModelPortaliP34902.
SMRiP34902. Positions 54-249.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP34902. 3 interactions.
MINTiMINT-1734370.

PTM databases

PhosphoSiteiP34902.

Proteomic databases

MaxQBiP34902.
PRIDEiP34902.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033664; ENSMUSP00000033664; ENSMUSG00000031304.
GeneIDi16186.
KEGGimmu:16186.
UCSCiuc009txc.1. mouse.

Organism-specific databases

CTDi3561.
MGIiMGI:96551. Il2rg.

Phylogenomic databases

HOGENOMiHOG000276891.
HOVERGENiHBG052111.
InParanoidiP34902.
KOiK05070.
OMAiDHSWTEQ.
OrthoDBiEOG7H4DV0.
PhylomeDBiP34902.
TreeFamiTF333657.

Enzyme and pathway databases

ReactomeiREACT_273845. Interleukin-2 signaling.
REACT_276590. Interleukin-7 signaling.
REACT_291272. G beta:gamma signalling through PI3Kgamma.
REACT_303160. Interleukin receptor SHC signaling.
REACT_337915. GPVI-mediated activation cascade.

Miscellaneous databases

NextBioi289081.
PROiP34902.
SOURCEiSearch...

Gene expression databases

BgeeiP34902.
CleanExiMM_IL2RG.
ExpressionAtlasiP34902. baseline and differential.
GenevestigatoriP34902.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
IPR015321. IL-6_rcpt_alpha-bd.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the mouse interleukin 2 receptor gamma chain: demonstration of functional differences between the mouse and human receptors."
    Kumaki S., Kondo M., Takeshita T., Asao H., Nakamura M., Sugamura K.
    Biochem. Biophys. Res. Commun. 193:356-363(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression."
    Cao X., Kozak C.A., Liu Y.J., Noguchi M., O'Connell E., Leonard W.J.
    Proc. Natl. Acad. Sci. U.S.A. 90:8464-8468(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CBA/Ca.
  3. "Cloning and sequencing of the cDNA encoding a mouse IL-2 receptor gamma."
    Kobayashi N., Nakagawa S., Minami Y., Taniguchi T., Kono T.
    Gene 130:303-304(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The murine interleukin-2 receptor gamma chain gene: organization, chromosomal localization and expression in the adult thymus."
    Disanto J.P., Certain S., Wilson A., Macdonald H.R., Avner P., Fischer A., de Saint Basile G.
    Eur. J. Immunol. 24:3014-3018(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Molecular mechanisms regulating the hyaluronan binding activity of the adhesion protein CD44."
    Chiu R.K., Droll A., Cooper D.L., Dougherty S.T., Dirks J.F., Dougherty G.J.
    J. Neurooncol. 26:231-239(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B6.S.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiIL2RG_MOUSE
AccessioniPrimary (citable) accession number: P34902
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 1994
Last sequence update: January 31, 1994
Last modified: March 31, 2015
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.