P34902 (IL2RG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytokine receptor common subunit gamma

Alternative name(s):
Interleukin-2 receptor subunit gamma
Short name=IL-2 receptor subunit gamma
Short name=IL-2R subunit gamma
Short name=IL-2RG
gammaC
p64
CD_antigen=CD132

Gene names

Name:

Il2rg

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	369 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Common subunit for the receptors for a variety of interleukins.
Subunit structure	The gamma subunit is common to the IL2, IL4, IL7, IL15, IL21 and probably also the IL13 receptors. Interacts with SHB upon interleukin stimulation By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Domain	The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation.
Sequence similarities	Belongs to the type I cytokine receptor family. Type 5 subfamily. Contains 1 fibronectin type-III domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cytokine-mediated signaling pathway Inferred from electronic annotation. Source: GOC positive regulation of B cell differentiation Inferred from mutant phenotype PubMed 9252128. Source: MGI positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation Inferred from mutant phenotype PubMed 16227984. Source: MGI positive regulation of T cell differentiation in thymus Inferred from mutant phenotype PubMed 9252128PubMed 9916699. Source: MGI positive regulation of gene expression Inferred from mutant phenotype PubMed 18958875. Source: MGI
Cellular_component	external side of plasma membrane Inferred from direct assay PubMed 8262055. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cytokine receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	By similarity
	Chain	23 – 369	347	Cytokine receptor common subunit gamma		PRO_0000010867
Regions
	Topological domain	23 – 263	241	Extracellular Potential
	Transmembrane	264 – 284	21	Helical; Potential
	Topological domain	285 – 369	85	Cytoplasmic Potential
	Domain	154 – 242	89	Fibronectin type-III
	Motif	238 – 242	5	WSXWS motif
	Motif	286 – 294	9	Box 1 motif
Amino acid modifications
	Modified residue	161	1	Phosphothreonine Ref.8
	Modified residue	325	1	Phosphotyrosine Ref.7
	Glycosylation	71	1	N-linked (GlcNAc...) Potential
	Glycosylation	75	1	N-linked (GlcNAc...) Potential
	Glycosylation	84	1	N-linked (GlcNAc...) Potential
	Glycosylation	96	1	N-linked (GlcNAc...) Potential
	Glycosylation	159	1	N-linked (GlcNAc...) Potential
	Glycosylation	164	1	N-linked (GlcNAc...) Potential
	Disulfide bond	62 ↔ 72		Potential
	Disulfide bond	102 ↔ 115		Potential

Sequences

	Sequence		Length	Mass (Da)
	P34902 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: CB2D5AB459077AC7	FASTA	369	42,241
	10 20 30 40 50 60 MLKLLLSPRS FLVLQLLLLR AGWSSKVLMS SANEDIKADL ILTSTAPEHL SAPTLPLPEV 70 80 90 100 110 120 QCFVFNIEYM NCTWNSSSEP QATNLTLHYR YKVSDNNTFQ ECSHYLFSKE ITSGCQIQKE 130 140 150 160 170 180 DIQLYQTFVV QLQDPQKPQR RAVQKLNLQN LVIPRAPENL TLSNLSESQL ELRWKSRHIK 190 200 210 220 230 240 ERCLQYLVQY RSNRDRSWTE LIVNHEPRFS LPSVDELKRY TFRVRSRYNP ICGSSQQWSK 250 260 270 280 290 300 WSQPVHWGSH TVEENPSLFA LEAVLIPVGT MGLIITLIFV YCWLERMPPI PPIKNLEDLV 310 320 330 340 350 360 TEYQGNFSAW SGVSKGLTES LQPDYSERFC HVSEIPPKGG ALGEGPGGSP CSLHSPYWPP PCYSLKPEA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of the mouse interleukin 2 receptor gamma chain: demonstration of functional differences between the mouse and human receptors." Kumaki S., Kondo M., Takeshita T., Asao H., Nakamura M., Sugamura K. Biochem. Biophys. Res. Commun. 193:356-363(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression." Cao X., Kozak C.A., Liu Y.J., Noguchi M., O'Connell E., Leonard W.J. Proc. Natl. Acad. Sci. U.S.A. 90:8464-8468(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: CBA/Ca.
[3]	"Cloning and sequencing of the cDNA encoding a mouse IL-2 receptor gamma." Kobayashi N., Nakagawa S., Minami Y., Taniguchi T., Kono T. Gene 130:303-304(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The murine interleukin-2 receptor gamma chain gene: organization, chromosomal localization and expression in the adult thymus." Disanto J.P., Certain S., Wilson A., Macdonald H.R., Avner P., Fischer A., de Saint Basile G. Eur. J. Immunol. 24:3014-3018(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"Molecular mechanisms regulating the hyaluronan binding activity of the adhesion protein CD44." Chiu R.K., Droll A., Cooper D.L., Dougherty S.T., Dirks J.F., Dougherty G.J. J. Neurooncol. 26:231-239(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: B6.S.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Salivary gland.
[7]	"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling." Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R. J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-325, MASS SPECTROMETRY. Tissue: Mast cell.
[8]	"Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry." Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R. J. Proteome Res. 6:250-262(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-161, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D13821 mRNA. Translation: BAA02974.1. U21795 Genomic DNA. Translation: AAA64279.1. D13565 mRNA. Translation: BAA02760.1. L20048 mRNA. Translation: AAA39286.1. S75852 , S75844, S75845, S75847, S75848, S75849, S75850, S75851 Genomic DNA. Translation: AAB32904.1. X75337 mRNA. Translation: CAA53085.1. BC014720 mRNA. Translation: AAH14720.1.
IPI	IPI00119612.
PIR	I49280.
RefSeq	NP_038591.1. NM_013563.3.
UniGene	Mm.2923.
3D structure databases
ProteinModelPortal	P34902.
SMR	P34902. Positions 54-249.
ModBase	Search...
Protein-protein interaction databases
IntAct	P34902. 3 interactions.
PTM databases
PhosphoSite	P34902.
Proteomic databases
PRIDE	P34902.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000033664; ENSMUSP00000033664; ENSMUSG00000031304.
GeneID	16186.
KEGG	mmu:16186.
Organism-specific databases
CTD	3561.
MGI	MGI:96551. Il2rg.
Phylogenomic databases
HOGENOM	HOG000276891.
HOVERGEN	HBG052111.
KO	K05070.
Enzyme and pathway databases
Reactome	REACT_107772. Immune System.
Gene expression databases
ArrayExpress	P34902.
Bgee	P34902.
CleanEx	MM_IL2RG.
Genevestigator	P34902.
GermOnline	ENSMUSG00000031304. Mus musculus.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR003961. Fibronectin_type3. IPR003531. Hempt_rcpt_S_F1_CS. IPR013783. Ig-like_fold. IPR015321. IL6_recept-bd. [Graphical view]
Pfam	PF00041. fn3. 1 hit. PF09240. IL6Ra-bind. 1 hit. [Graphical view]
SMART	SM00060. FN3. 1 hit. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 2 hits.
PROSITE	PS50853. FN3. 1 hit. PS01355. HEMATOPO_REC_S_F1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	289081.
SOURCE	Search...

Entry information

Entry name

IL2RG_MOUSE

Accession

Primary (citable) accession number: P34902

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	April 3, 2013
This is version 126 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program