Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Syndecan-2

Gene

Sdc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity).By similarity

GO - Molecular functioni

  • identical protein binding Source: RGD
  • PDZ domain binding Source: RGD

GO - Biological processi

  • cell migration Source: GO_Central
  • dendrite morphogenesis Source: RGD
  • regulation of dendrite morphogenesis Source: UniProtKB
  • response to caffeine Source: RGD
  • response to hypoxia Source: RGD
  • wound healing Source: RGD

Keywordsi

Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Syndecan-2
Short name:
SYND2
Alternative name(s):
Fibroglycan
Heparan sulfate proteoglycan core protein
Short name:
HSPG
CD_antigen: CD362
Gene namesi
Name:Sdc2
Synonyms:Hspg1, Synd2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3649 Sdc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 144ExtracellularSequence analysisAdd BLAST126
Transmembranei145 – 169HelicalSequence analysisAdd BLAST25
Topological domaini170 – 201CytoplasmicSequence analysisAdd BLAST32

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000003350519 – 201Syndecan-2Add BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi55O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi57O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Modified residuei115PhosphoserineBy similarity1
Modified residuei187PhosphoserineBy similarity1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei142 – 143Cleavage of ectodomainSequence analysis2

Keywords - PTMi

Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbiP34900
PRIDEiP34900

PTM databases

iPTMnetiP34900
PhosphoSitePlusiP34900

Interactioni

Subunit structurei

Interacts (via cytoplasmic domain) with SARM1. Forms a complex with SDCBP and PDCD6IP.By similarity

GO - Molecular functioni

  • identical protein binding Source: RGD
  • PDZ domain binding Source: RGD

Protein-protein interaction databases

BioGridi2476445 interactors.
CORUMiP34900
IntActiP34900 3 interactors.
STRINGi10116.ENSRNOP00000007255

Structurei

3D structure databases

ProteinModelPortaliP34900
SMRiP34900
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the syndecan proteoglycan family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW5I Eukaryota
ENOG4111QSA LUCA
HOVERGENiHBG004501
InParanoidiP34900
KOiK16336

Family and domain databases

InterProiView protein in InterPro
IPR003585 Neurexin-like
IPR001050 Syndecan
IPR031201 Syndecan-2
IPR027789 Syndecan/Neurexin_dom
IPR030479 Syndecan_CS
PANTHERiPTHR10915 PTHR10915, 1 hit
PTHR10915:SF6 PTHR10915:SF6, 1 hit
PfamiView protein in Pfam
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
PROSITEiView protein in PROSITE
PS00964 SYNDECAN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34900-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRAWILLTL GLMACVSAET RAELTSDKDM YLDSSSIEEA SGLYPIDDDD
60 70 80 90 100
YSSASGSGAY EDKGSPDLTT SQLIPRISLT SAAPEVETMT LKTQSITPTQ
110 120 130 140 150
TESPEETDKK EFEISEAEEK QDPAVKSTDV YTEKHSDNLF KRTEVLAAVI
160 170 180 190 200
AGGVIGFLFA IFLILLLVYR MRKKDEGSYD LGERKPSSAA YQKAPTKEFY

A
Length:201
Mass (Da):22,149
Last modified:November 1, 1995 - v2
Checksum:i02E08455754C5E5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81687 mRNA Translation: AAA41355.1
PIRiA42261
RefSeqiNP_037214.1, NM_013082.3
UniGeneiRn.11127

Genome annotation databases

GeneIDi25615
KEGGirno:25615
UCSCiRGD:3649 rat

Similar proteinsi

Entry informationi

Entry nameiSDC2_RAT
AccessioniPrimary (citable) accession number: P34900
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 1, 1995
Last modified: February 28, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome