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Protein

Syndecan-2

Gene

Sdc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity).By similarity

GO - Biological processi

  • cell migration Source: GO_Central
  • dendrite morphogenesis Source: RGD
  • regulation of dendrite morphogenesis Source: UniProtKB
  • response to caffeine Source: RGD
  • response to hypoxia Source: RGD
  • wound healing Source: RGD
Complete GO annotation...

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-RNO-3000170. Syndecan interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Syndecan-2
Short name:
SYND2
Alternative name(s):
Fibroglycan
Heparan sulfate proteoglycan core protein
Short name:
HSPG
CD_antigen: CD362
Gene namesi
Name:Sdc2
Synonyms:Hspg1, Synd2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3649. Sdc2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 144126ExtracellularSequence analysisAdd
BLAST
Transmembranei145 – 16925HelicalSequence analysisAdd
BLAST
Topological domaini170 – 20132CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: GO_Central
  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body Source: RGD
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 201183Syndecan-2PRO_0000033505Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411O-linked (Xyl...) (heparan sulfate)Sequence analysis
Glycosylationi55 – 551O-linked (Xyl...) (heparan sulfate)Sequence analysis
Glycosylationi57 – 571O-linked (Xyl...) (heparan sulfate)Sequence analysis
Modified residuei115 – 1151PhosphoserineBy similarity
Modified residuei187 – 1871PhosphoserineBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei142 – 1432Cleavage of ectodomainSequence analysis

Keywords - PTMi

Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbiP34900.
PRIDEiP34900.

PTM databases

iPTMnetiP34900.
PhosphoSiteiP34900.

Interactioni

Subunit structurei

Interacts (via cytoplasmic domain) with SARM1. Forms a complex with SDCBP and PDCD6IP.By similarity

Protein-protein interaction databases

BioGridi247644. 3 interactions.
IntActiP34900. 3 interactions.
MINTiMINT-198515.
STRINGi10116.ENSRNOP00000007255.

Structurei

3D structure databases

ProteinModelPortaliP34900.
SMRiP34900. Positions 170-201.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the syndecan proteoglycan family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW5I. Eukaryota.
ENOG4111QSA. LUCA.
HOVERGENiHBG004501.
InParanoidiP34900.
KOiK16336.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR031201. Syndecan-2.
IPR027789. Syndecan/Neurexin_dom.
IPR030479. Syndecan_CS.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 1 hit.
PTHR10915:SF6. PTHR10915:SF6. 1 hit.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34900-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRAWILLTL GLMACVSAET RAELTSDKDM YLDSSSIEEA SGLYPIDDDD
60 70 80 90 100
YSSASGSGAY EDKGSPDLTT SQLIPRISLT SAAPEVETMT LKTQSITPTQ
110 120 130 140 150
TESPEETDKK EFEISEAEEK QDPAVKSTDV YTEKHSDNLF KRTEVLAAVI
160 170 180 190 200
AGGVIGFLFA IFLILLLVYR MRKKDEGSYD LGERKPSSAA YQKAPTKEFY

A
Length:201
Mass (Da):22,149
Last modified:November 1, 1995 - v2
Checksum:i02E08455754C5E5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81687 mRNA. Translation: AAA41355.1.
PIRiA42261.
RefSeqiNP_037214.1. NM_013082.3.
UniGeneiRn.11127.

Genome annotation databases

GeneIDi25615.
KEGGirno:25615.
UCSCiRGD:3649. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81687 mRNA. Translation: AAA41355.1.
PIRiA42261.
RefSeqiNP_037214.1. NM_013082.3.
UniGeneiRn.11127.

3D structure databases

ProteinModelPortaliP34900.
SMRiP34900. Positions 170-201.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247644. 3 interactions.
IntActiP34900. 3 interactions.
MINTiMINT-198515.
STRINGi10116.ENSRNOP00000007255.

PTM databases

iPTMnetiP34900.
PhosphoSiteiP34900.

Proteomic databases

PaxDbiP34900.
PRIDEiP34900.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25615.
KEGGirno:25615.
UCSCiRGD:3649. rat.

Organism-specific databases

CTDi6383.
RGDi3649. Sdc2.

Phylogenomic databases

eggNOGiENOG410IW5I. Eukaryota.
ENOG4111QSA. LUCA.
HOVERGENiHBG004501.
InParanoidiP34900.
KOiK16336.

Enzyme and pathway databases

ReactomeiR-RNO-3000170. Syndecan interactions.

Miscellaneous databases

PROiP34900.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR031201. Syndecan-2.
IPR027789. Syndecan/Neurexin_dom.
IPR030479. Syndecan_CS.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 1 hit.
PTHR10915:SF6. PTHR10915:SF6. 1 hit.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of the major cell surface heparan sulfate proteoglycan from rat liver."
    Pierce A., Lyon M., Hampson I., Cowling G.J., Gallagher J.
    J. Biol. Chem. 267:3894-3900(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiSDC2_RAT
AccessioniPrimary (citable) accession number: P34900
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 1, 1995
Last modified: July 6, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.