##gff-version 3 P34897 UniProtKB Transit peptide 1 29 . . . Note=Mitochondrion;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14519 P34897 UniProtKB Chain 30 504 . . . ID=PRO_0000032562;Note=Serine hydroxymethyltransferase%2C mitochondrial P34897 UniProtKB Region 30 51 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P34897 UniProtKB Modified residue 103 103 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P34897 UniProtKB Modified residue 181 181 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P34897 UniProtKB Modified residue 196 196 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P34897 UniProtKB Modified residue 280 280 . . . Note=N6-(pyridoxal phosphate)lysine%3B alternate;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:29364879;Dbxref=PMID:29364879 P34897 UniProtKB Modified residue 280 280 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29180469;Dbxref=PMID:29180469 P34897 UniProtKB Modified residue 297 297 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P34897 UniProtKB Modified residue 356 356 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P34897 UniProtKB Modified residue 464 464 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P34897 UniProtKB Modified residue 469 469 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P34897 UniProtKB Modified residue 470 470 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P34897 UniProtKB Modified residue 474 474 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P34897 UniProtKB Alternative sequence 1 21 . . . ID=VSP_043844;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 P34897 UniProtKB Alternative sequence 199 208 . . . ID=VSP_043088;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 P34897 UniProtKB Natural variant 157 157 . . . ID=VAR_085466;Note=In NEDCASB%3B uncertain significance. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33015733;Dbxref=dbSNP:rs1426413125,PMID:33015733 P34897 UniProtKB Natural variant 186 186 . . . ID=VAR_085467;Note=In NEDCASB%3B uncertain significance. T->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33015733;Dbxref=PMID:33015733 P34897 UniProtKB Natural variant 379 379 . . . ID=VAR_085468;Note=In NEDCASB%3B uncertain significance. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33015733;Dbxref=dbSNP:rs2037432429,PMID:33015733 P34897 UniProtKB Natural variant 423 423 . . . ID=VAR_085469;Note=In NEDCASB%3B uncertain significance. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33015733;Dbxref=dbSNP:rs751223752,PMID:33015733 P34897 UniProtKB Natural variant 435 435 . . . ID=VAR_085470;Note=In NEDCASB%3B uncertain significance. Q->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33015733;Dbxref=dbSNP:rs2037448764,PMID:33015733 P34897 UniProtKB Natural variant 499 499 . . . ID=VAR_085471;Note=In NEDCASB%3B no effect on protein abundance%3B decreased glycine hydroxymethyltransferase activity%3B associated with altered mitochondrial redox metabolism. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33015733;Dbxref=dbSNP:rs2037465152,PMID:33015733 P34897 UniProtKB Mutagenesis 98 98 . . . Note=Abolishes serine hydroxymethyltransferase activity%2C leading to oxidative phosphorylation deficiency%3B when associated with F-106. E->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29364879;Dbxref=PMID:29364879 P34897 UniProtKB Mutagenesis 103 103 . . . Note=Does not affect succinylation level or hydroxymethyltransferase activity. K->R%2CE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29180469;Dbxref=PMID:29180469 P34897 UniProtKB Mutagenesis 106 106 . . . Note=Abolishes serine hydroxymethyltransferase activity%2C leading to oxidative phosphorylation deficiency%3B when associated with L-98. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29364879;Dbxref=PMID:29364879 P34897 UniProtKB Mutagenesis 280 280 . . . Note=Abolishes pyridoxal phosphate-binding%2C leading to oxidative phosphorylation deficiency. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29364879;Dbxref=PMID:29364879 P34897 UniProtKB Mutagenesis 280 280 . . . Note=Decreased succinylation level and hydroxymethyltransferase activity. K->R%2CE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29180469;Dbxref=PMID:29180469 P34897 UniProtKB Mutagenesis 302 302 . . . Note=Does not affect succinylation level or hydroxymethyltransferase activity. K->R%2CE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29180469;Dbxref=PMID:29180469 P34897 UniProtKB Mutagenesis 356 356 . . . Note=Does not affect succinylation level or hydroxymethyltransferase activity. K->R%2CE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29180469;Dbxref=PMID:29180469 P34897 UniProtKB Mutagenesis 464 464 . . . Note=Does not affect succinylation level or hydroxymethyltransferase activity. K->R%2CE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29180469;Dbxref=PMID:29180469 P34897 UniProtKB Mutagenesis 469 469 . . . Note=Does not affect succinylation level or hydroxymethyltransferase activity. K->R%2CE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29180469;Dbxref=PMID:29180469 P34897 UniProtKB Mutagenesis 474 474 . . . Note=Does not affect succinylation level or hydroxymethyltransferase activity. K->R%2CE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29180469;Dbxref=PMID:29180469 P34897 UniProtKB Sequence conflict 308 308 . . . Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 P34897 UniProtKB Helix 49 52 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Helix 54 69 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Beta strand 70 72 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Helix 82 88 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Helix 91 94 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Beta strand 103 107 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QVL P34897 UniProtKB Helix 111 126 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Turn 131 133 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Beta strand 134 137 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Helix 143 154 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Beta strand 160 164 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QVL P34897 UniProtKB Helix 166 168 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QVL P34897 UniProtKB Helix 172 174 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QVL P34897 UniProtKB Helix 186 189 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QVL P34897 UniProtKB Beta strand 190 195 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QVL P34897 UniProtKB Turn 199 201 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Beta strand 202 204 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6QVL P34897 UniProtKB Helix 206 216 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Beta strand 219 223 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Helix 234 244 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Beta strand 247 251 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Helix 253 255 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Helix 256 260 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Helix 267 269 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Beta strand 272 280 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Beta strand 288 293 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Beta strand 295 299 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Beta strand 301 303 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6M5O P34897 UniProtKB Beta strand 306 308 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Helix 312 319 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Turn 320 323 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Helix 329 342 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Helix 345 367 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Helix 373 375 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Beta strand 378 385 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Helix 387 389 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Helix 393 402 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Beta strand 408 410 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Beta strand 418 420 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Beta strand 422 428 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Helix 429 433 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Helix 438 460 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Helix 465 474 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3 P34897 UniProtKB Helix 476 493 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6DK3