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P34896

- GLYC_HUMAN

UniProt

P34896 - GLYC_HUMAN

Protein

Serine hydroxymethyltransferase, cytosolic

Gene

SHMT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 153 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Interconversion of serine and glycine.

    Catalytic activityi

    5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.

    Cofactori

    Pyridoxal phosphate.

    Pathwayi

    GO - Molecular functioni

    1. amino acid binding Source: Ensembl
    2. glycine hydroxymethyltransferase activity Source: UniProtKB
    3. L-allo-threonine aldolase activity Source: Ensembl
    4. protein homodimerization activity Source: UniProtKB
    5. pyridoxal phosphate binding Source: UniProtKB

    GO - Biological processi

    1. carnitine biosynthetic process Source: Reactome
    2. cellular nitrogen compound metabolic process Source: Reactome
    3. folic acid metabolic process Source: UniProtKB
    4. glycine biosynthetic process from serine Source: Ensembl
    5. L-serine catabolic process Source: UniProtKB
    6. protein homotetramerization Source: Ensembl
    7. protein tetramerization Source: UniProtKB
    8. purine nucleobase biosynthetic process Source: UniProtKB
    9. small molecule metabolic process Source: Reactome
    10. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
    11. vitamin metabolic process Source: Reactome
    12. water-soluble vitamin metabolic process Source: Reactome

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciMetaCyc:HS11114-MONOMER.
    ReactomeiREACT_11167. Metabolism of folate and pterines.
    REACT_2125. Carnitine synthesis.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine hydroxymethyltransferase, cytosolic (EC:2.1.2.1)
    Short name:
    SHMT
    Alternative name(s):
    Glycine hydroxymethyltransferase
    Serine methylase
    Gene namesi
    Name:SHMT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:10850. SHMT1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: UniProtKB
    3. extracellular vesicular exosome Source: UniProt
    4. mitochondrion Source: Ensembl
    5. nucleus Source: HPA

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35753.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 483482Serine hydroxymethyltransferase, cytosolicPRO_0000113504Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei257 – 2571N6-(pyridoxal phosphate)lysine

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP34896.
    PaxDbiP34896.
    PRIDEiP34896.

    PTM databases

    PhosphoSiteiP34896.

    Expressioni

    Gene expression databases

    ArrayExpressiP34896.
    BgeeiP34896.
    CleanExiHS_SHMT1.
    GenevestigatoriP34896.

    Organism-specific databases

    HPAiHPA023314.

    Interactioni

    Subunit structurei

    Homotetramer.

    Protein-protein interaction databases

    BioGridi112366. 34 interactions.
    IntActiP34896. 5 interactions.
    STRINGi9606.ENSP00000318868.

    Structurei

    Secondary structure

    1
    483
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi13 – 219
    Helixi26 – 294
    Helixi31 – 4616
    Beta strandi47 – 493
    Helixi59 – 657
    Helixi68 – 703
    Beta strandi80 – 845
    Helixi87 – 10317
    Turni108 – 1103
    Beta strandi111 – 1144
    Helixi120 – 13112
    Beta strandi137 – 1415
    Helixi143 – 1453
    Helixi149 – 1513
    Helixi162 – 1665
    Beta strandi167 – 1726
    Turni176 – 1783
    Helixi183 – 19311
    Beta strandi196 – 2005
    Helixi211 – 22010
    Beta strandi224 – 2285
    Helixi230 – 2323
    Helixi233 – 2375
    Helixi244 – 2463
    Beta strandi249 – 2568
    Helixi257 – 2593
    Beta strandi265 – 2706
    Beta strandi272 – 2765
    Turni278 – 2803
    Beta strandi283 – 2853
    Helixi288 – 2969
    Turni297 – 3004
    Helixi306 – 31813
    Helixi322 – 34423
    Beta strandi355 – 3628
    Helixi363 – 3664
    Helixi370 – 37910
    Beta strandi385 – 3873
    Beta strandi400 – 4045
    Helixi406 – 4105
    Helixi415 – 43824
    Helixi445 – 4528
    Beta strandi453 – 4553
    Helixi458 – 47215

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BJ4X-ray2.65A11-480[»]
    ProteinModelPortaliP34896.
    SMRiP34896. Positions 11-480.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP34896.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SHMT family.Curated

    Phylogenomic databases

    eggNOGiCOG0112.
    HOGENOMiHOG000239405.
    HOVERGENiHBG002807.
    InParanoidiP34896.
    KOiK00600.
    OMAiQAMTLEF.
    OrthoDBiEOG7327NN.
    PhylomeDBiP34896.
    TreeFamiTF314667.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_00051. SHMT.
    InterProiIPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    IPR001085. Ser_HO-MeTrfase.
    IPR019798. Ser_HO-MeTrfase_PLP_BS.
    [Graphical view]
    PANTHERiPTHR11680. PTHR11680. 1 hit.
    PfamiPF00464. SHMT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000412. SHMT. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00096. SHMT. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P34896-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTMPVNGAHK DADLWSSHDK MLAQPLKDSD VEVYNIIKKE SNRQRVGLEL    50
    IASENFASRA VLEALGSCLN NKYSEGYPGQ RYYGGTEFID ELETLCQKRA 100
    LQAYKLDPQC WGVNVQPYSG SPANFAVYTA LVEPHGRIMG LDLPDGGHLT 150
    HGFMTDKKKI SATSIFFESM PYKVNPDTGY INYDQLEENA RLFHPKLIIA 200
    GTSCYSRNLE YARLRKIADE NGAYLMADMA HISGLVAAGV VPSPFEHCHV 250
    VTTTTHKTLR GCRAGMIFYR KGVKSVDPKT GKEILYNLES LINSAVFPGL 300
    QGGPHNHAIA GVAVALKQAM TLEFKVYQHQ VVANCRALSE ALTELGYKIV 350
    TGGSDNHLIL VDLRSKGTDG GRAEKVLEAC SIACNKNTCP GDRSALRPSG 400
    LRLGTPALTS RGLLEKDFQK VAHFIHRGIE LTLQIQSDTG VRATLKEFKE 450
    RLAGDKYQAA VQALREEVES FASLFPLPGL PDF 483
    Length:483
    Mass (Da):53,083
    Last modified:February 1, 1994 - v1
    Checksum:i6CDD6CA06D017C19
    GO
    Isoform 2 (identifier: P34896-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         274-312: Missing.

    Note: Contains a N6-acetyllysine at position 271.

    Show »
    Length:444
    Mass (Da):49,028
    Checksum:i92091DCEB64B65D1
    GO
    Isoform 3 (identifier: P34896-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         273-352: Missing.

    Show »
    Length:403
    Mass (Da):44,552
    Checksum:i9CE930DFA6FC1FF7
    GO
    Isoform 4 (identifier: P34896-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-138: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:345
    Mass (Da):37,672
    Checksum:iDD683D88B3A1D1FA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti340 – 3401E → Q.
    Corresponds to variant rs7215148 [ dbSNP | Ensembl ].
    VAR_059795
    Natural varianti474 – 4741L → F.2 Publications
    Corresponds to variant rs1979277 [ dbSNP | Ensembl ].
    VAR_022010

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 138138Missing in isoform 4. 1 PublicationVSP_054610Add
    BLAST
    Alternative sequencei273 – 35280Missing in isoform 3. CuratedVSP_006096Add
    BLAST
    Alternative sequencei274 – 31239Missing in isoform 2. 1 PublicationVSP_006095Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L11931 mRNA. Translation: AAA63257.1.
    L23928 mRNA. Translation: AAA36020.1.
    L23928 mRNA. Translation: AAA36019.1.
    L23928 mRNA. Translation: AAA36018.1.
    Y14485 mRNA. Translation: CAB54838.1.
    Y14486 mRNA. Translation: CAB54839.1.
    Y14487 mRNA. Translation: CAB54840.1.
    AK298415 mRNA. Translation: BAG60641.1.
    AC127537 Genomic DNA. No translation available.
    AL353997 Genomic DNA. No translation available.
    CH471196 Genomic DNA. Translation: EAW55637.1.
    CH471196 Genomic DNA. Translation: EAW55640.1.
    CH471196 Genomic DNA. Translation: EAW55641.1.
    BC007979 mRNA. Translation: AAH07979.1.
    BC022874 mRNA. Translation: AAH22874.1.
    BC038598 mRNA. Translation: AAH38598.1.
    CCDSiCCDS11196.1. [P34896-1]
    CCDS11197.1. [P34896-2]
    CCDS62112.1. [P34896-4]
    PIRiA46746.
    RefSeqiNP_001268715.1. NM_001281786.1. [P34896-4]
    NP_004160.3. NM_004169.4. [P34896-1]
    NP_683718.1. NM_148918.2. [P34896-2]
    XP_005256824.1. XM_005256767.1. [P34896-1]
    UniGeneiHs.513987.
    Hs.592944.
    Hs.636044.

    Genome annotation databases

    EnsembliENST00000316694; ENSP00000318868; ENSG00000176974. [P34896-1]
    ENST00000352886; ENSP00000345881; ENSG00000176974. [P34896-3]
    ENST00000354098; ENSP00000318805; ENSG00000176974. [P34896-2]
    GeneIDi6470.
    KEGGihsa:6470.
    UCSCiuc002gsz.3. human. [P34896-1]
    uc002gtb.3. human. [P34896-2]

    Polymorphism databases

    DMDMi462184.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L11931 mRNA. Translation: AAA63257.1 .
    L23928 mRNA. Translation: AAA36020.1 .
    L23928 mRNA. Translation: AAA36019.1 .
    L23928 mRNA. Translation: AAA36018.1 .
    Y14485 mRNA. Translation: CAB54838.1 .
    Y14486 mRNA. Translation: CAB54839.1 .
    Y14487 mRNA. Translation: CAB54840.1 .
    AK298415 mRNA. Translation: BAG60641.1 .
    AC127537 Genomic DNA. No translation available.
    AL353997 Genomic DNA. No translation available.
    CH471196 Genomic DNA. Translation: EAW55637.1 .
    CH471196 Genomic DNA. Translation: EAW55640.1 .
    CH471196 Genomic DNA. Translation: EAW55641.1 .
    BC007979 mRNA. Translation: AAH07979.1 .
    BC022874 mRNA. Translation: AAH22874.1 .
    BC038598 mRNA. Translation: AAH38598.1 .
    CCDSi CCDS11196.1. [P34896-1 ]
    CCDS11197.1. [P34896-2 ]
    CCDS62112.1. [P34896-4 ]
    PIRi A46746.
    RefSeqi NP_001268715.1. NM_001281786.1. [P34896-4 ]
    NP_004160.3. NM_004169.4. [P34896-1 ]
    NP_683718.1. NM_148918.2. [P34896-2 ]
    XP_005256824.1. XM_005256767.1. [P34896-1 ]
    UniGenei Hs.513987.
    Hs.592944.
    Hs.636044.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BJ4 X-ray 2.65 A 11-480 [» ]
    ProteinModelPortali P34896.
    SMRi P34896. Positions 11-480.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112366. 34 interactions.
    IntActi P34896. 5 interactions.
    STRINGi 9606.ENSP00000318868.

    Chemistry

    BindingDBi P34896.
    ChEMBLi CHEMBL1772927.
    DrugBanki DB00145. Glycine.
    DB01055. Mimosine.
    DB00114. Pyridoxal Phosphate.
    DB00116. Tetrahydrofolic acid.

    PTM databases

    PhosphoSitei P34896.

    Polymorphism databases

    DMDMi 462184.

    Proteomic databases

    MaxQBi P34896.
    PaxDbi P34896.
    PRIDEi P34896.

    Protocols and materials databases

    DNASUi 6470.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000316694 ; ENSP00000318868 ; ENSG00000176974 . [P34896-1 ]
    ENST00000352886 ; ENSP00000345881 ; ENSG00000176974 . [P34896-3 ]
    ENST00000354098 ; ENSP00000318805 ; ENSG00000176974 . [P34896-2 ]
    GeneIDi 6470.
    KEGGi hsa:6470.
    UCSCi uc002gsz.3. human. [P34896-1 ]
    uc002gtb.3. human. [P34896-2 ]

    Organism-specific databases

    CTDi 6470.
    GeneCardsi GC17M018231.
    HGNCi HGNC:10850. SHMT1.
    HPAi HPA023314.
    MIMi 182144. gene.
    neXtProti NX_P34896.
    PharmGKBi PA35753.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0112.
    HOGENOMi HOG000239405.
    HOVERGENi HBG002807.
    InParanoidi P34896.
    KOi K00600.
    OMAi QAMTLEF.
    OrthoDBi EOG7327NN.
    PhylomeDBi P34896.
    TreeFami TF314667.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci MetaCyc:HS11114-MONOMER.
    Reactomei REACT_11167. Metabolism of folate and pterines.
    REACT_2125. Carnitine synthesis.

    Miscellaneous databases

    ChiTaRSi SHMT1. human.
    EvolutionaryTracei P34896.
    GenomeRNAii 6470.
    NextBioi 25133.
    PROi P34896.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P34896.
    Bgeei P34896.
    CleanExi HS_SHMT1.
    Genevestigatori P34896.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_00051. SHMT.
    InterProi IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    IPR001085. Ser_HO-MeTrfase.
    IPR019798. Ser_HO-MeTrfase_PLP_BS.
    [Graphical view ]
    PANTHERi PTHR11680. PTHR11680. 1 hit.
    Pfami PF00464. SHMT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000412. SHMT. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00096. SHMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of human cDNAs encoding mitochondrial and cytosolic serine hydroxymethyltransferases and chromosomal localization."
      Garrow T.A., Brenner A.A., Whitehead M.V., Chen X.-N., Duncan R.G., Korenberg J.R., Shane B.
      J. Biol. Chem. 268:11910-11916(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Xu L., Mangum J.H., Robertson D.L.
      Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    3. "Isolation and characterisation of human genomic sequences encoding cytosolic serine hydroxymethyltransferase."
      Chave K.J., Snell K., Sanders P.G.
      Biochem. Soc. Trans. 25:53-53(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Mammary gland.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Liver.
    5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-474.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT PHE-474.
      Tissue: Bone marrow, Lymph and Testis.
    8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-271 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "The crystal structure of human cytosolic serine hydroxymethyltransferase: a target for cancer chemotherapy."
      Renwick S.B., Snell K., Baumann U.
      Structure 6:1105-1116(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 11-480.

    Entry informationi

    Entry nameiGLYC_HUMAN
    AccessioniPrimary (citable) accession number: P34896
    Secondary accession number(s): B4DPM9
    , D3DXD0, Q96HY0, Q9UMD1, Q9UMD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 153 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    In eukaryotes there are two forms of the enzymes: a cytosolic one and a mitochondrial one.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3