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P34883

- MTAB_SYNP2

UniProt

P34883 - MTAB_SYNP2

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Protein
Modification methylase AquI subunit beta
Gene
aquIMB, SYNPCC7002_A1188.1
Organism
Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence CYCGRG, causes specific methylation on C-1 on both strands, and protects the DNA from cleavage by the AquI endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.

GO - Molecular functioni

  1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
  2. DNA binding Source: InterPro

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciSSP32049:GKF7-1189-MONOMER.

Protein family/group databases

REBASEi3283. M.AquI.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase AquI subunit beta (EC:2.1.1.37)
Short name:
M.AquI subunit beta
Short name:
M.AquIB
Alternative name(s):
Cytosine-specific methyltransferase AquI subunit beta
Gene namesi
Name:aquIMB
Ordered Locus Names:SYNPCC7002_A1188.1
OrganismiSynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Taxonomic identifieri32049 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001688: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 139139Modification methylase AquI subunit beta
PRO_0000087855Add
BLAST

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.

Structurei

3D structure databases

ProteinModelPortaliP34883.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 135135SAM-dependent MTase C5-type
Add
BLAST

Domaini

Corresponds to the C-terminal half of the enzymatic domain.

Sequence similaritiesi

Family and domain databases

InterProiIPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10629. PTHR10629. 1 hit.
PfamiPF00145. DNA_methylase. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34883-1 [UniParc]FASTAAdd to Basket

« Hide

MDIKNVHIKN HEQTAHAPST LEKIRKVKQG GKLSEQTKTF GSTYRRLDPN    50
QPSPTVTRSG YRDFIHPFED RMLTVRELAC LQTFPLDWEF TGTRLDSYSS 100
KRKVTMTQFG QVGNAVPPLL AEAVAKAVSE QLLDVIDEK 139
Length:139
Mass (Da):15,760
Last modified:February 1, 1994 - v1
Checksum:i8550B7E0194CE006
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28051 Genomic DNA. Translation: AAA22068.1.
CP000951 Genomic DNA. No translation available.
RefSeqiWP_012308460.1. NC_010475.1.
YP_003828901.1. NC_010475.1.

Genome annotation databases

GeneIDi9488071.
KEGGisyp:SYNPCC7002_A2880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28051 Genomic DNA. Translation: AAA22068.1 .
CP000951 Genomic DNA. No translation available.
RefSeqi WP_012308460.1. NC_010475.1.
YP_003828901.1. NC_010475.1.

3D structure databases

ProteinModelPortali P34883.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 3283. M.AquI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9488071.
KEGGi syp:SYNPCC7002_A2880.

Enzyme and pathway databases

BioCyci SSP32049:GKF7-1189-MONOMER.

Family and domain databases

InterProi IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10629. PTHR10629. 1 hit.
Pfami PF00145. DNA_methylase. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Agmenellum quadruplicatum M.AquI, a novel modification methylase."
    Karreman C., de Waard A.
    J. Bacteriol. 172:266-272(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequence of Synechococcus sp. PCC 7002."
    Li T., Zhao J., Zhao C., Liu Z., Zhao F., Marquardt J., Nomura C.T., Persson S., Detter J.C., Richardson P.M., Lanz C., Schuster S.C., Wang J., Li S., Huang X., Cai T., Yu Z., Luo J., Zhao J., Bryant D.A.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27264 / PCC 7002 / PR-6.

Entry informationi

Entry nameiMTAB_SYNP2
AccessioniPrimary (citable) accession number: P34883
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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