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P34882

- MTAA_SYNP2

UniProt

P34882 - MTAA_SYNP2

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Protein

Modification methylase AquI subunit alpha

Gene

aquIMA

Organism
Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence CYCGRG, causes specific methylation on C-1 on both strands, and protects the DNA from cleavage by the AquI endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei82 – 821PROSITE-ProRule annotation

GO - Molecular functioni

  1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
  2. DNA binding Source: InterPro

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciSSP32049:GKF7-1188-MONOMER.

Protein family/group databases

REBASEi3283. M.AquI.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase AquI subunit alpha (EC:2.1.1.37)
Short name:
M.AquI subunit alpha
Short name:
M.AquiA
Alternative name(s):
Cytosine-specific methyltransferase AquI subunit alpha
Gene namesi
Name:aquIMA
Synonyms:dcm
Ordered Locus Names:SYNPCC7002_A1188
OrganismiSynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Taxonomic identifieri32049 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001688: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Modification methylase AquI subunit alphaPRO_0000087854Add
BLAST

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.

Protein-protein interaction databases

STRINGi32049.SYNPCC7002_A1188.

Structurei

3D structure databases

ProteinModelPortaliP34882.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 248246SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
BLAST

Domaini

Corresponds to the N-terminal half of the enzymatic domain.

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0270.
KOiK00558.
OMAiEWNCISA.
OrthoDBiEOG6M3PC7.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10629. PTHR10629. 1 hit.
PfamiPF00145. DNA_methylase. 1 hit.
[Graphical view]
PRINTSiPR00105. C5METTRFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00675. dcm. 1 hit.
PROSITEiPS00094. C5_MTASE_1. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34882-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKKLISLFS GAGGMDIGFH AAGFSTAVAV EQDPSCCNTL RLNMPDTPVI
60 70 80 90 100
EGDITSITTQ VILEAAKVNP LEIDLVIGGP PCQSFSLAGK RMGMDDPRGM
110 120 130 140 150
LVLEFLRVVR EALPKCFVME NVKGMINWSK GKALEAIMTE ASQPIKYAGK
160 170 180 190 200
EYKYAVSYHV LNAADFGVPQ FRERVFIVGN RLGKTFQFPE PTHGPSNQAR
210 220 230 240
QIDLFGKQLK PYKTVQDAIS TLPPATPPSA MALRVSQTIK DRIKNHGY
Length:248
Mass (Da):27,161
Last modified:February 1, 1994 - v1
Checksum:iFFF6B42B0997D82F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28051 Genomic DNA. Translation: AAA22067.1.
CP000951 Genomic DNA. Translation: ACA99187.1.
RefSeqiWP_012306810.1. NC_010475.1.
YP_001734443.1. NC_010475.1.

Genome annotation databases

EnsemblBacteriaiACA99187; ACA99187; SYNPCC7002_A1188.
GeneIDi6056178.
KEGGisyp:SYNPCC7002_A1188.
PATRICi23816916. VBISynSp37135_1410.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28051 Genomic DNA. Translation: AAA22067.1 .
CP000951 Genomic DNA. Translation: ACA99187.1 .
RefSeqi WP_012306810.1. NC_010475.1.
YP_001734443.1. NC_010475.1.

3D structure databases

ProteinModelPortali P34882.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 32049.SYNPCC7002_A1188.

Protein family/group databases

REBASEi 3283. M.AquI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA99187 ; ACA99187 ; SYNPCC7002_A1188 .
GeneIDi 6056178.
KEGGi syp:SYNPCC7002_A1188.
PATRICi 23816916. VBISynSp37135_1410.

Phylogenomic databases

eggNOGi COG0270.
KOi K00558.
OMAi EWNCISA.
OrthoDBi EOG6M3PC7.

Enzyme and pathway databases

BioCyci SSP32049:GKF7-1188-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10629. PTHR10629. 1 hit.
Pfami PF00145. DNA_methylase. 1 hit.
[Graphical view ]
PRINTSi PR00105. C5METTRFRASE.
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00675. dcm. 1 hit.
PROSITEi PS00094. C5_MTASE_1. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Agmenellum quadruplicatum M.AquI, a novel modification methylase."
    Karreman C., de Waard A.
    J. Bacteriol. 172:266-272(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequence of Synechococcus sp. PCC 7002."
    Li T., Zhao J., Zhao C., Liu Z., Zhao F., Marquardt J., Nomura C.T., Persson S., Detter J.C., Richardson P.M., Lanz C., Schuster S.C., Wang J., Li S., Huang X., Cai T., Yu Z., Luo J., Zhao J., Bryant D.A.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27264 / PCC 7002 / PR-6.

Entry informationi

Entry nameiMTAA_SYNP2
AccessioniPrimary (citable) accession number: P34882
Secondary accession number(s): B1XKE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 1, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3