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P34882

- MTAA_SYNP2

UniProt

P34882 - MTAA_SYNP2

Protein

Modification methylase AquI subunit alpha

Gene

aquIMA

Organism
Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    This methylase recognizes the double-stranded sequence CYCGRG, causes specific methylation on C-1 on both strands, and protects the DNA from cleavage by the AquI endonuclease.

    Catalytic activityi

    S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei82 – 821PROSITE-ProRule annotation

    GO - Molecular functioni

    1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
    2. DNA binding Source: InterPro

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Restriction system

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciSSP32049:GKF7-1188-MONOMER.

    Protein family/group databases

    REBASEi3283. M.AquI.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Modification methylase AquI subunit alpha (EC:2.1.1.37)
    Short name:
    M.AquI subunit alpha
    Short name:
    M.AquiA
    Alternative name(s):
    Cytosine-specific methyltransferase AquI subunit alpha
    Gene namesi
    Name:aquIMA
    Synonyms:dcm
    Ordered Locus Names:SYNPCC7002_A1188
    OrganismiSynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
    Taxonomic identifieri32049 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001688: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 248248Modification methylase AquI subunit alphaPRO_0000087854Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit.

    Protein-protein interaction databases

    STRINGi32049.SYNPCC7002_A1188.

    Structurei

    3D structure databases

    ProteinModelPortaliP34882.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 248246SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Corresponds to the N-terminal half of the enzymatic domain.

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
    Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0270.
    KOiK00558.
    OMAiEWNCISA.
    OrthoDBiEOG6M3PC7.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR10629. PTHR10629. 1 hit.
    PfamiPF00145. DNA_methylase. 1 hit.
    [Graphical view]
    PRINTSiPR00105. C5METTRFRASE.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00675. dcm. 1 hit.
    PROSITEiPS00094. C5_MTASE_1. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P34882-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKKLISLFS GAGGMDIGFH AAGFSTAVAV EQDPSCCNTL RLNMPDTPVI    50
    EGDITSITTQ VILEAAKVNP LEIDLVIGGP PCQSFSLAGK RMGMDDPRGM 100
    LVLEFLRVVR EALPKCFVME NVKGMINWSK GKALEAIMTE ASQPIKYAGK 150
    EYKYAVSYHV LNAADFGVPQ FRERVFIVGN RLGKTFQFPE PTHGPSNQAR 200
    QIDLFGKQLK PYKTVQDAIS TLPPATPPSA MALRVSQTIK DRIKNHGY 248
    Length:248
    Mass (Da):27,161
    Last modified:February 1, 1994 - v1
    Checksum:iFFF6B42B0997D82F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M28051 Genomic DNA. Translation: AAA22067.1.
    CP000951 Genomic DNA. Translation: ACA99187.1.
    RefSeqiWP_012306810.1. NC_010475.1.
    YP_001734443.1. NC_010475.1.

    Genome annotation databases

    EnsemblBacteriaiACA99187; ACA99187; SYNPCC7002_A1188.
    GeneIDi6056178.
    KEGGisyp:SYNPCC7002_A1188.
    PATRICi23816916. VBISynSp37135_1410.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M28051 Genomic DNA. Translation: AAA22067.1 .
    CP000951 Genomic DNA. Translation: ACA99187.1 .
    RefSeqi WP_012306810.1. NC_010475.1.
    YP_001734443.1. NC_010475.1.

    3D structure databases

    ProteinModelPortali P34882.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 32049.SYNPCC7002_A1188.

    Protein family/group databases

    REBASEi 3283. M.AquI.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA99187 ; ACA99187 ; SYNPCC7002_A1188 .
    GeneIDi 6056178.
    KEGGi syp:SYNPCC7002_A1188.
    PATRICi 23816916. VBISynSp37135_1410.

    Phylogenomic databases

    eggNOGi COG0270.
    KOi K00558.
    OMAi EWNCISA.
    OrthoDBi EOG6M3PC7.

    Enzyme and pathway databases

    BioCyci SSP32049:GKF7-1188-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR10629. PTHR10629. 1 hit.
    Pfami PF00145. DNA_methylase. 1 hit.
    [Graphical view ]
    PRINTSi PR00105. C5METTRFRASE.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00675. dcm. 1 hit.
    PROSITEi PS00094. C5_MTASE_1. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Agmenellum quadruplicatum M.AquI, a novel modification methylase."
      Karreman C., de Waard A.
      J. Bacteriol. 172:266-272(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete sequence of Synechococcus sp. PCC 7002."
      Li T., Zhao J., Zhao C., Liu Z., Zhao F., Marquardt J., Nomura C.T., Persson S., Detter J.C., Richardson P.M., Lanz C., Schuster S.C., Wang J., Li S., Huang X., Cai T., Yu Z., Luo J., Zhao J., Bryant D.A.
      Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27264 / PCC 7002 / PR-6.

    Entry informationi

    Entry nameiMTAA_SYNP2
    AccessioniPrimary (citable) accession number: P34882
    Secondary accession number(s): B1XKE1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3