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Protein

Modification methylase AquI subunit alpha

Gene

aquIMA

Organism
Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence CYCGRG, causes specific methylation on C-1 on both strands, and protects the DNA from cleavage by the AquI endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei82PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRestriction system
LigandS-adenosyl-L-methionine

Protein family/group databases

REBASEi3283 M.AquI

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase AquI subunit alpha (EC:2.1.1.37)
Short name:
M.AquI subunit alpha
Short name:
M.AquiA
Alternative name(s):
Cytosine-specific methyltransferase AquI subunit alpha
Gene namesi
Name:aquIMA
Synonyms:dcm
Ordered Locus Names:SYNPCC7002_A1188
OrganismiSynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Taxonomic identifieri32049 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000001688 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000878541 – 248Modification methylase AquI subunit alphaAdd BLAST248

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.

Protein-protein interaction databases

STRINGi32049.SYNPCC7002_A1188

Structurei

3D structure databases

ProteinModelPortaliP34882
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 248SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST246

Domaini

Corresponds to the N-terminal half of the enzymatic domain.

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105NI8 Bacteria
COG0270 LUCA
KOiK00558
OMAiLWPEMFR
OrthoDBiPOG091H02EL

Family and domain databases

InterProiView protein in InterPro
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF00145 DNA_methylase, 1 hit
PRINTSiPR00105 C5METTRFRASE
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00675 dcm, 1 hit
PROSITEiView protein in PROSITE
PS00094 C5_MTASE_1, 1 hit
PS51679 SAM_MT_C5, 1 hit

Sequencei

Sequence statusi: Complete.

P34882-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKKLISLFS GAGGMDIGFH AAGFSTAVAV EQDPSCCNTL RLNMPDTPVI
60 70 80 90 100
EGDITSITTQ VILEAAKVNP LEIDLVIGGP PCQSFSLAGK RMGMDDPRGM
110 120 130 140 150
LVLEFLRVVR EALPKCFVME NVKGMINWSK GKALEAIMTE ASQPIKYAGK
160 170 180 190 200
EYKYAVSYHV LNAADFGVPQ FRERVFIVGN RLGKTFQFPE PTHGPSNQAR
210 220 230 240
QIDLFGKQLK PYKTVQDAIS TLPPATPPSA MALRVSQTIK DRIKNHGY
Length:248
Mass (Da):27,161
Last modified:February 1, 1994 - v1
Checksum:iFFF6B42B0997D82F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28051 Genomic DNA Translation: AAA22067.1
CP000951 Genomic DNA Translation: ACA99187.1
RefSeqiWP_012306810.1, NC_010475.1

Genome annotation databases

EnsemblBacteriaiACA99187; ACA99187; SYNPCC7002_A1188
KEGGisyp:SYNPCC7002_A1188

Similar proteinsi

Entry informationi

Entry nameiMTAA_SYNP2
AccessioniPrimary (citable) accession number: P34882
Secondary accession number(s): B1XKE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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