Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Modification methylase SsoII

Gene

ssoIIM

Organism
Shigella sonnei
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence CCNGG, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the SsoII endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei142PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Methyltransferase, Transferase
Biological processRestriction system, Transcription, Transcription regulation
LigandS-adenosyl-L-methionine

Protein family/group databases

REBASEi3509 M.SsoII

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase SsoII (EC:2.1.1.37)
Short name:
M.SsoII
Alternative name(s):
Cytosine-specific methyltransferase SsoII
Gene namesi
Name:ssoIIM
Encoded oniPlasmid P40 Publication
OrganismiShigella sonnei
Taxonomic identifieri624 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000879061 – 379Modification methylase SsoIIAdd BLAST379

Proteomic databases

PRIDEiP34879

Structurei

3D structure databases

ProteinModelPortaliP34879
SMRiP34879
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 66HTH cro/C1-typePROSITE-ProRule annotationAdd BLAST58
Domaini72 – 379SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST308

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Family and domain databases

CDDicd00093 HTH_XRE, 1 hit
InterProiView protein in InterPro
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR031303 C5_meth_CS
IPR001387 Cro/C1-type_HTH
IPR010982 Lambda_DNA-bd_dom_sf
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF00145 DNA_methylase, 1 hit
PF01381 HTH_3, 1 hit
PRINTSiPR00105 C5METTRFRASE
SMARTiView protein in SMART
SM00530 HTH_XRE, 1 hit
SUPFAMiSSF47413 SSF47413, 1 hit
SSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00675 dcm, 1 hit
PROSITEiView protein in PROSITE
PS00094 C5_MTASE_1, 1 hit
PS00095 C5_MTASE_2, 1 hit
PS50943 HTH_CROC1, 1 hit
PS51679 SAM_MT_C5, 1 hit

Sequencei

Sequence statusi: Complete.

P34879-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDNIAATIK EKRERLHMTQ KEFADALGLS KYGDRTIRRW ERGETKPTGA
60 70 80 90 100
ELKAVIDFPD TPPYPNNENG RYRMIDLFAG IGGTRLGFHQ TNAVNVVFSS
110 120 130 140 150
EWDKFAQKTY HANYGDFPDG DITKIDEKDI PDHEILVGGF PCVAFSQAGL
160 170 180 190 200
KKGFNDTRGT LFFDIARIIK EKKPHAFLLE NVKNLLGHDK GRTFSIIKNT
210 220 230 240 250
LEELNYTVYY NIFAAKDFGV PQNRERIYIV GFNKEKVRNH EHFTFPTPLK
260 270 280 290 300
TKTRVGDILE KSVDNKYTLS DALWNGHQRR KLVNAAAGKG FGYGLFNENS
310 320 330 340 350
PYTNTISARY YKDGSEILIE QKGSNPRKIT PREASRLQGF PSDFIIPVSD
360 370
TQAYKQFGNS VAVPVINAIA EKIISTLDS
Length:379
Mass (Da):42,890
Last modified:February 1, 1994 - v1
Checksum:i97440A79FC6AB275
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86545 Genomic DNA Translation: AAA98279.1
PIRiJT0744
RefSeqiWP_000131511.1, NZ_FUCL01000223.1

Similar proteinsi

Entry informationi

Entry nameiMTS2_SHISO
AccessioniPrimary (citable) accession number: P34879
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health