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P34842 (COX3_ANOGA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:COIII
Encoded onMitochondrion
OrganismAnopheles gambiae (African malaria mosquito) [Reference proteome]
Taxonomic identifier7165 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 262262Cytochrome c oxidase subunit 3
PRO_0000183732

Regions

Transmembrane39 – 5921Helical; Potential
Transmembrane83 – 10321Helical; Potential
Transmembrane120 – 14021Helical; Potential
Transmembrane163 – 18321Helical; Potential
Transmembrane201 – 22121Helical; Potential
Transmembrane240 – 26021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P34842 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 5906C09CF7A5C739

FASTA26230,132
        10         20         30         40         50         60 
MSTHANHPFH LVDYSPWPLT GAIGAMTTVS GLVQWFHQYT MTLFILGNVI TILTMYQWWR 

        70         80         90        100        110        120 
DISREGTFQG LHTFPVTIGL RWGMILFIVS EVFFFISFFW AFFHSSLSPT IELGMTWPPV 

       130        140        150        160        170        180 
GIAAFNPFQI PLLNTAILLA SGVTVTWAHH ALMEGNHSQA TQGLFFTIVL GVYFTILQAY 

       190        200        210        220        230        240 
EYIEAPFTIA DAVYGSTFYM ATGFHGLHVL IGTTFLLICF LRHINYHFSK NHHFGFEAAA 

       250        260 
WYWHFVDVVW LFLYITIYWW GS 

« Hide

References

[1]"The mitochondrial genome of the mosquito Anopheles gambiae: DNA sequence, genome organization, and comparisons with mitochondrial sequences of other insects."
Beard C.B., Hamm D.M., Collins F.H.
Insect Mol. Biol. 2:103-124(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: G3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L20934 Genomic DNA. Translation: AAD12195.1.
PIRT09805.
RefSeqNP_008074.1. NC_002084.1.

3D structure databases

ProteinModelPortalP34842.
SMRP34842. Positions 3-262.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1267418.
KEGGaga:COX3.

Organism-specific databases

CTD4514.

Phylogenomic databases

KOK02262.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. SSF81452. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX3_ANOGA
AccessionPrimary (citable) accession number: P34842
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families