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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway:ioxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Iron (heme A axial ligand)Curated
Metal bindingi239 – 2391Copper BCurated
Metal bindingi243 – 2431Copper BCurated
Metal bindingi289 – 2891Copper BCurated
Metal bindingi290 – 2901Copper BCurated
Metal bindingi375 – 3751Iron (heme A3 axial ligand)Curated
Metal bindingi377 – 3771Iron (heme A axial ligand)Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiAnopheles gambiae (African malaria mosquito)
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
ProteomesiUP000007062 Componenti: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence AnalysisAdd
BLAST
Transmembranei55 – 7521HelicalSequence AnalysisAdd
BLAST
Transmembranei101 – 12121HelicalSequence AnalysisAdd
BLAST
Transmembranei144 – 16421HelicalSequence AnalysisAdd
BLAST
Transmembranei182 – 20221HelicalSequence AnalysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence AnalysisAdd
BLAST
Transmembranei267 – 28721HelicalSequence AnalysisAdd
BLAST
Transmembranei304 – 32421HelicalSequence AnalysisAdd
BLAST
Transmembranei337 – 35721HelicalSequence AnalysisAdd
BLAST
Transmembranei379 – 39921HelicalSequence AnalysisAdd
BLAST
Transmembranei415 – 43521HelicalSequence AnalysisAdd
BLAST
Transmembranei451 – 47121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Cytochrome c oxidase subunit 1PRO_0000183282Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki239 ↔ 2431'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliP34838.
SMRiP34838. Positions 4-506.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP34838.
KOiK02256.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34838-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQWLFSTN HKDIGTLYFI FGAWAGMVGT SLSILIRAEL GHPGAFIGDD
60 70 80 90 100
QIYNVIVTAH AFIMIFFMVM PIMIGGFGNW LVPLMLGAPD MAFPRMNNMS
110 120 130 140 150
FWMLPPSLTL LISSSMVENG AGTGWTVYPP LSSGIAHAGA SVDLAIFSLH
160 170 180 190 200
LAGISSILGA VNFITTVINM RSPGITLDRM PLFVWSVVIT AVLLLLSLPV
210 220 230 240 250
LAGAITMLLT DRNLNTSFFD PAGGGDPILY QHLFWFFGHP EVYILILPGF
260 270 280 290 300
GMISHIITQE SGKKETFGNL GMIYAMLAIG LLGFIVWAHH MFTVGMDVDT
310 320 330 340 350
RAYFTSATMI IAVPTGIKIF SWLATLHGTQ LTYSPAMLWA FGFVFLFTVG
360 370 380 390 400
GLTGVVLANS SIDIVLHDTY YVVAHFHYVL SMGAVFAIMA GFVHWYPLLT
410 420 430 440 450
GLTMNPTWLK IQFSIMFVGV NLTFFPQHFL GLAGMPRRYS DFPDSYLTWN
460 470 480 490 500
VVSSLGSTIS LFAILYFLFI IWESMITQRT PAFPMQLSSS IEWYHTLPPA
510
EHTYAELPLL TNNF
Length:514
Mass (Da):56,841
Last modified:February 1, 1994 - v1
Checksum:i6459AC46AD258336
GO

Sequence cautioni

The sequence AAD12191.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20934 Genomic DNA. Translation: AAD12191.1. Different initiation.
PIRiT09801.
RefSeqiNP_008070.1. NC_002084.1.

Genome annotation databases

GeneIDi1267414.
KEGGiaga:COX1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20934 Genomic DNA. Translation: AAD12191.1. Different initiation.
PIRiT09801.
RefSeqiNP_008070.1. NC_002084.1.

3D structure databases

ProteinModelPortaliP34838.
SMRiP34838. Positions 4-506.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1267414.
KEGGiaga:COX1.

Organism-specific databases

CTDi4512.

Phylogenomic databases

InParanoidiP34838.
KOiK02256.

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The mitochondrial genome of the mosquito Anopheles gambiae: DNA sequence, genome organization, and comparisons with mitochondrial sequences of other insects."
    Beard C.B., Hamm D.M., Collins F.H.
    Insect Mol. Biol. 2:103-124(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: G3.

Entry informationi

Entry nameiCOX1_ANOGA
AccessioniPrimary (citable) accession number: P34838
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: January 7, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.