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P34821 (BMP8A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bone morphogenetic protein 8A

Short name=BMP-8A
Alternative name(s):
Osteogenic protein 2
Short name=OP-2
Gene names
Name:Bmp8a
Synonyms:Bmp-8, Bmp8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length399 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis By similarity. Has only marginal osteoinductive activity in mesenchymal progenitor and osteoprogenior cells but shows activity in committed osteoblastic cells. Ref.6

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Secreted Probable.

Tissue specificity

Expressed in testis. expressed in trophoblast cells of the labyrinthine region of the placenta and in the inner root sheath of hair follicles of early postnatal skin. Ref.5

Developmental stage

Extensive expression found in 8-day embryos, fell drastically in 10-day embryos and virtually absent in 17-day embryos. Expressed during specific stages of spermatogenesis, with the highest levels in stage 6-8 round spermatids after 3 weeks of age. Ref.5

Induction

By dexamethasone in calvarial osteoblasts. Ref.7

Sequence similarities

Belongs to the TGF-beta family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P34821-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P34821-2)

The sequence of this isoform differs from the canonical sequence as follows:
     351-351: V → VSTTVACCDRWSGV

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 260241 Potential
PRO_0000033884
Chain261 – 399139Bone morphogenetic protein 8A
PRO_0000033885

Amino acid modifications

Glycosylation1551N-linked (GlcNAc...) Potential
Glycosylation3401N-linked (GlcNAc...) Potential
Disulfide bond298 ↔ 364 By similarity
Disulfide bond327 ↔ 396 By similarity
Disulfide bond331 ↔ 398 By similarity
Disulfide bond363Interchain By similarity

Natural variations

Alternative sequence3511V → VSTTVACCDRWSGV in isoform 2.
VSP_046527

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: B75FE32D6125E40C

FASTA39944,764
        10         20         30         40         50         60 
MAMRPGPLWL LGLALCALGG GHGPRPPHTC PQRRLGARER RDMQREILAV LGLPGRPRPR 

        70         80         90        100        110        120 
AQPAAARQPA SAPLFMLDLY HAMTDDDDGG PPQAHLGRAD LVMSFVNMVE RDRTLGYQEP 

       130        140        150        160        170        180 
HWKEFHFDLT QIPAGEAVTA AEFRIYKEPS THPLNTTLHI SMFEVVQEHS NRESDLFFLD 

       190        200        210        220        230        240 
LQTLRSGDEG WLVLDITAAS DRWLLNHHKD LGLRLYVETA DGHSMDPGLA GLLGRQAPRS 

       250        260        270        280        290        300 
RQPFMVTFFR ASQSPVRAPR AARPLKRRQP KKTNELPHPN KLPGIFDDGH GSRGREVCRR 

       310        320        330        340        350        360 
HELYVSFRDL GWLDWVIAPQ GYSAYYCEGE CAFPLDSCMN ATNHAILQSL VHLMKPDVVP 

       370        380        390 
KACCAPTKLS ATSVLYYDSS NNVILRKHRN MVVKACGCH 

« Hide

Isoform 2 [UniParc].

Checksum: F7EAEF654225E56C
Show »

FASTA41246,131

References

« Hide 'large scale' references
[1]"Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis."
Oezkaynak E., Schnegelsberg P.N.J., Jin D.F., Clifford G.M., Warren F.D., Drier E.A., Oppermann H.
J. Biol. Chem. 267:25220-25227(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Embryo.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6.
Tissue: Embryo.
[5]"Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development."
Zhao G.Q., Hogan B.L.
Mech. Dev. 57:159-168(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[6]"Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs)."
Cheng H., Jiang W., Phillips F.M., Haydon R.C., Peng Y., Zhou L., Luu H.H., An N., Breyer B., Vanichakarn P., Szatkowski J.P., Park J.Y., He T.C.
J. Bone and Join Surg. 85:1544-1552(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"The protective role of bone morphogenetic protein-8 in the glucocorticoid-induced apoptosis on bone cells."
Kosa J.P., Kis A., Bacsi K., Balla B., Nagy Z., Takacs I., Speer G., Lakatos P.
Bone 48:1052-1057(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M97017 mRNA. Translation: AAB01365.1.
RefSeqNP_031584.1. NM_007558.3.
UniGeneMm.439749.

3D structure databases

ProteinModelPortalP34821.
SMRP34821. Positions 23-399.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000037779.

PTM databases

PhosphoSiteP34821.

Proteomic databases

PRIDEP34821.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000040496; ENSMUSP00000037779; ENSMUSG00000032726. [P34821-2]
ENSMUST00000102641; ENSMUSP00000099701; ENSMUSG00000032726. [P34821-1]
GeneID12163.
KEGGmmu:12163.
UCSCuc008upg.2. mouse. [P34821-1]

Organism-specific databases

CTD353500.
MGIMGI:104515. Bmp8a.

Phylogenomic databases

eggNOGNOG323541.
GeneTreeENSGT00730000110505.
HOGENOMHOG000249476.
HOVERGENHBG004860.
KOK16622.
OMAGREKKEM.
PhylomeDBP34821.

Gene expression databases

BgeeP34821.
CleanExMM_BMP8A.
GenevestigatorP34821.

Family and domain databases

InterProIPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio280519.
PROP34821.
SOURCESearch...

Entry information

Entry nameBMP8A_MOUSE
AccessionPrimary (citable) accession number: P34821
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot