P34821 (BMP8A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bone morphogenetic protein 8A
Short name=BMP-8A

Alternative name(s):
Osteogenic protein 2
Short name=OP-2

Gene names

Name:	Bmp8a
Synonyms:	Bmp-8, Bmp8

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	399 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis By similarity.
Subunit structure	Homodimer; disulfide-linked.
Subcellular location	Secreted By similarity.
Developmental stage	Extensive expression found in 8-day embryos, fell drastically in 10-day embryos and virtually absent in 17-day embryos.
Sequence similarities	Belongs to the TGF-beta family.

Ontologies

Keywords
Biological process	Chondrogenesis Differentiation Osteogenesis
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine Developmental protein Growth factor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cartilage development Inferred from electronic annotation. Source: UniProtKB-KW germ cell development Inferred from mutant phenotype PubMed 10894154. Source: MGI growth Inferred from electronic annotation. Source: InterPro ossification Inferred from electronic annotation. Source: UniProtKB-KW spermatogenesis Inferred from mutant phenotype PubMed 9463357. Source: MGI transforming growth factor beta receptor signaling pathway Traceable author statement PubMed 9463357. Source: MGI
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cytokine activity Traceable author statement PubMed 9463357. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Propeptide	20 – 260	241	Potential		PRO_0000033884
	Chain	261 – 399	139	Bone morphogenetic protein 8A		PRO_0000033885
Amino acid modifications
	Glycosylation	155	1	N-linked (GlcNAc...) Potential
	Glycosylation	340	1	N-linked (GlcNAc...) Potential
	Disulfide bond	298 ↔ 364		By similarity
	Disulfide bond	327 ↔ 396		By similarity
	Disulfide bond	331 ↔ 398		By similarity
	Disulfide bond	363		Interchain By similarity

Sequences

	Sequence		Length	Mass (Da)
	P34821 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: B75FE32D6125E40C	FASTA	399	44,764
	10 20 30 40 50 60 MAMRPGPLWL LGLALCALGG GHGPRPPHTC PQRRLGARER RDMQREILAV LGLPGRPRPR 70 80 90 100 110 120 AQPAAARQPA SAPLFMLDLY HAMTDDDDGG PPQAHLGRAD LVMSFVNMVE RDRTLGYQEP 130 140 150 160 170 180 HWKEFHFDLT QIPAGEAVTA AEFRIYKEPS THPLNTTLHI SMFEVVQEHS NRESDLFFLD 190 200 210 220 230 240 LQTLRSGDEG WLVLDITAAS DRWLLNHHKD LGLRLYVETA DGHSMDPGLA GLLGRQAPRS 250 260 270 280 290 300 RQPFMVTFFR ASQSPVRAPR AARPLKRRQP KKTNELPHPN KLPGIFDDGH GSRGREVCRR 310 320 330 340 350 360 HELYVSFRDL GWLDWVIAPQ GYSAYYCEGE CAFPLDSCMN ATNHAILQSL VHLMKPDVVP 370 380 390 KACCAPTKLS ATSVLYYDSS NNVILRKHRN MVVKACGCH

References

[1]	"Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis." Oezkaynak E., Schnegelsberg P.N.J., Jin D.F., Clifford G.M., Warren F.D., Drier E.A., Oppermann H. J. Biol. Chem. 267:25220-25227(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M97017 mRNA. Translation: AAB01365.1.
IPI	IPI00118572.
RefSeq	NP_031584.1. NM_007558.3.
UniGene	Mm.439749.
3D structure databases
ProteinModelPortal	P34821.
SMR	P34821. Positions 23-399.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000037779.
PTM databases
PhosphoSite	P34821.
Proteomic databases
PRIDE	P34821.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000102641; ENSMUSP00000099701; ENSMUSG00000032726.
GeneID	12163.
KEGG	mmu:12163.
Organism-specific databases
CTD	353500.
MGI	MGI:104515. Bmp8a.
Phylogenomic databases
eggNOG	NOG323541.
GeneTree	ENSGT00620000087601.
HOGENOM	HOG000249476.
HOVERGEN	HBG004860.
KO	K16622.
Gene expression databases
ArrayExpress	P34821.
Bgee	P34821.
CleanEx	MM_BMP8A.
Genevestigator	P34821.
GermOnline	ENSMUSG00000032726. Mus musculus.
Family and domain databases
InterPro	IPR001839. TGF-b_C. IPR001111. TGF-b_N. IPR015615. TGF-beta-rel. IPR017948. TGFb_CS. [Graphical view]
PANTHER	PTHR11848. PTHR11848. 1 hit.
Pfam	PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit. [Graphical view]
SMART	SM00204. TGFB. 1 hit. [Graphical view]
PROSITE	PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	280519.
SOURCE	Search...

Entry information

Entry name

BMP8A_MOUSE

Accession

Primary (citable) accession number: P34821

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	May 1, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program