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Protein

Bone morphogenetic protein 8A

Gene

Bmp8a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Has only marginal osteoinductive activity in mesenchymal progenitor and osteoprogenior cells but shows activity in committed osteoblastic cells.By similarity1 Publication

GO - Molecular functioni

  • BMP receptor binding Source: GO_Central
  • cytokine activity Source: MGI
  • transforming growth factor beta receptor binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 8A
Short name:
BMP-8A
Alternative name(s):
Osteogenic protein 2
Short name:
OP-2
Gene namesi
Name:Bmp8a
Synonyms:Bmp-8, Bmp8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:104515. Bmp8a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000003388420 – 260Sequence analysisAdd BLAST241
ChainiPRO_0000033885261 – 399Bone morphogenetic protein 8AAdd BLAST139

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi155N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi298 ↔ 364By similarity
Disulfide bondi327 ↔ 396By similarity
Disulfide bondi331 ↔ 398By similarity
Glycosylationi340N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi363InterchainBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP34821.
PRIDEiP34821.

PTM databases

PhosphoSitePlusiP34821.

Expressioni

Tissue specificityi

Expressed in testis. expressed in trophoblast cells of the labyrinthine region of the placenta and in the inner root sheath of hair follicles of early postnatal skin.1 Publication

Developmental stagei

Extensive expression found in 8-day embryos, fell drastically in 10-day embryos and virtually absent in 17-day embryos. Expressed during specific stages of spermatogenesis, with the highest levels in stage 6-8 round spermatids after 3 weeks of age.1 Publication

Inductioni

By dexamethasone in calvarial osteoblasts.1 Publication

Gene expression databases

BgeeiENSMUSG00000032726.
CleanExiMM_BMP8A.
ExpressionAtlasiP34821. baseline and differential.
GenevisibleiP34821. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

  • BMP receptor binding Source: GO_Central
  • cytokine activity Source: MGI
  • transforming growth factor beta receptor binding Source: GO_Central

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037779.

Structurei

3D structure databases

ProteinModelPortaliP34821.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP34821.
KOiK16622.
OMAiGREKKEM.
PhylomeDBiP34821.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P34821-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMRPGPLWL LGLALCALGG GHGPRPPHTC PQRRLGARER RDMQREILAV
60 70 80 90 100
LGLPGRPRPR AQPAAARQPA SAPLFMLDLY HAMTDDDDGG PPQAHLGRAD
110 120 130 140 150
LVMSFVNMVE RDRTLGYQEP HWKEFHFDLT QIPAGEAVTA AEFRIYKEPS
160 170 180 190 200
THPLNTTLHI SMFEVVQEHS NRESDLFFLD LQTLRSGDEG WLVLDITAAS
210 220 230 240 250
DRWLLNHHKD LGLRLYVETA DGHSMDPGLA GLLGRQAPRS RQPFMVTFFR
260 270 280 290 300
ASQSPVRAPR AARPLKRRQP KKTNELPHPN KLPGIFDDGH GSRGREVCRR
310 320 330 340 350
HELYVSFRDL GWLDWVIAPQ GYSAYYCEGE CAFPLDSCMN ATNHAILQSL
360 370 380 390
VHLMKPDVVP KACCAPTKLS ATSVLYYDSS NNVILRKHRN MVVKACGCH
Length:399
Mass (Da):44,764
Last modified:February 1, 1994 - v1
Checksum:iB75FE32D6125E40C
GO
Isoform 2 (identifier: P34821-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-351: V → VSTTVACCDRWSGV

Show »
Length:412
Mass (Da):46,131
Checksum:iF7EAEF654225E56C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_046527351V → VSTTVACCDRWSGV in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97017 mRNA. Translation: AAB01365.1.
CCDSiCCDS18616.1. [P34821-1]
CCDS57293.1. [P34821-2]
RefSeqiNP_031584.1. NM_007558.3. [P34821-1]
UniGeneiMm.439749.

Genome annotation databases

EnsembliENSMUST00000040496; ENSMUSP00000037779; ENSMUSG00000032726. [P34821-2]
ENSMUST00000102641; ENSMUSP00000099701; ENSMUSG00000032726. [P34821-1]
GeneIDi12163.
KEGGimmu:12163.
UCSCiuc008upg.2. mouse. [P34821-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97017 mRNA. Translation: AAB01365.1.
CCDSiCCDS18616.1. [P34821-1]
CCDS57293.1. [P34821-2]
RefSeqiNP_031584.1. NM_007558.3. [P34821-1]
UniGeneiMm.439749.

3D structure databases

ProteinModelPortaliP34821.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037779.

PTM databases

PhosphoSitePlusiP34821.

Proteomic databases

PaxDbiP34821.
PRIDEiP34821.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040496; ENSMUSP00000037779; ENSMUSG00000032726. [P34821-2]
ENSMUST00000102641; ENSMUSP00000099701; ENSMUSG00000032726. [P34821-1]
GeneIDi12163.
KEGGimmu:12163.
UCSCiuc008upg.2. mouse. [P34821-1]

Organism-specific databases

CTDi353500.
MGIiMGI:104515. Bmp8a.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP34821.
KOiK16622.
OMAiGREKKEM.
PhylomeDBiP34821.

Miscellaneous databases

PROiP34821.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032726.
CleanExiMM_BMP8A.
ExpressionAtlasiP34821. baseline and differential.
GenevisibleiP34821. MM.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBMP8A_MOUSE
AccessioniPrimary (citable) accession number: P34821
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.