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P34821

- BMP8A_MOUSE

UniProt

P34821 - BMP8A_MOUSE

Protein

Bone morphogenetic protein 8A

Gene

Bmp8a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis By similarity. Has only marginal osteoinductive activity in mesenchymal progenitor and osteoprogenior cells but shows activity in committed osteoblastic cells.By similarity1 Publication

    GO - Molecular functioni

    1. cytokine activity Source: MGI

    GO - Biological processi

    1. cartilage development Source: UniProtKB-KW
    2. germ cell development Source: MGI
    3. growth Source: InterPro
    4. osteoblast differentiation Source: UniProtKB
    5. spermatogenesis Source: MGI
    6. transforming growth factor beta receptor signaling pathway Source: MGI

    Keywords - Molecular functioni

    Cytokine, Developmental protein, Growth factor

    Keywords - Biological processi

    Chondrogenesis, Differentiation, Osteogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bone morphogenetic protein 8A
    Short name:
    BMP-8A
    Alternative name(s):
    Osteogenic protein 2
    Short name:
    OP-2
    Gene namesi
    Name:Bmp8a
    Synonyms:Bmp-8, Bmp8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:104515. Bmp8a.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 260241Sequence AnalysisPRO_0000033884Add
    BLAST
    Chaini261 – 399139Bone morphogenetic protein 8APRO_0000033885Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi298 ↔ 364By similarity
    Disulfide bondi327 ↔ 396By similarity
    Disulfide bondi331 ↔ 398By similarity
    Glycosylationi340 – 3401N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi363 – 363InterchainBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP34821.

    PTM databases

    PhosphoSiteiP34821.

    Expressioni

    Tissue specificityi

    Expressed in testis. expressed in trophoblast cells of the labyrinthine region of the placenta and in the inner root sheath of hair follicles of early postnatal skin.1 Publication

    Developmental stagei

    Extensive expression found in 8-day embryos, fell drastically in 10-day embryos and virtually absent in 17-day embryos. Expressed during specific stages of spermatogenesis, with the highest levels in stage 6-8 round spermatids after 3 weeks of age.1 Publication

    Inductioni

    By dexamethasone in calvarial osteoblasts.1 Publication

    Gene expression databases

    BgeeiP34821.
    CleanExiMM_BMP8A.
    GenevestigatoriP34821.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000037779.

    Structurei

    3D structure databases

    ProteinModelPortaliP34821.
    SMRiP34821. Positions 23-399.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG323541.
    GeneTreeiENSGT00730000110505.
    HOGENOMiHOG000249476.
    HOVERGENiHBG004860.
    KOiK16622.
    OMAiGREKKEM.
    PhylomeDBiP34821.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P34821-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAMRPGPLWL LGLALCALGG GHGPRPPHTC PQRRLGARER RDMQREILAV    50
    LGLPGRPRPR AQPAAARQPA SAPLFMLDLY HAMTDDDDGG PPQAHLGRAD 100
    LVMSFVNMVE RDRTLGYQEP HWKEFHFDLT QIPAGEAVTA AEFRIYKEPS 150
    THPLNTTLHI SMFEVVQEHS NRESDLFFLD LQTLRSGDEG WLVLDITAAS 200
    DRWLLNHHKD LGLRLYVETA DGHSMDPGLA GLLGRQAPRS RQPFMVTFFR 250
    ASQSPVRAPR AARPLKRRQP KKTNELPHPN KLPGIFDDGH GSRGREVCRR 300
    HELYVSFRDL GWLDWVIAPQ GYSAYYCEGE CAFPLDSCMN ATNHAILQSL 350
    VHLMKPDVVP KACCAPTKLS ATSVLYYDSS NNVILRKHRN MVVKACGCH 399
    Length:399
    Mass (Da):44,764
    Last modified:February 1, 1994 - v1
    Checksum:iB75FE32D6125E40C
    GO
    Isoform 2 (identifier: P34821-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         351-351: V → VSTTVACCDRWSGV

    Show »
    Length:412
    Mass (Da):46,131
    Checksum:iF7EAEF654225E56C
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei351 – 3511V → VSTTVACCDRWSGV in isoform 2. 1 PublicationVSP_046527

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M97017 mRNA. Translation: AAB01365.1.
    CCDSiCCDS18616.1. [P34821-1]
    CCDS57293.1. [P34821-2]
    RefSeqiNP_031584.1. NM_007558.3. [P34821-1]
    UniGeneiMm.439749.

    Genome annotation databases

    EnsembliENSMUST00000040496; ENSMUSP00000037779; ENSMUSG00000032726. [P34821-2]
    ENSMUST00000102641; ENSMUSP00000099701; ENSMUSG00000032726. [P34821-1]
    GeneIDi12163.
    KEGGimmu:12163.
    UCSCiuc008upg.2. mouse. [P34821-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M97017 mRNA. Translation: AAB01365.1 .
    CCDSi CCDS18616.1. [P34821-1 ]
    CCDS57293.1. [P34821-2 ]
    RefSeqi NP_031584.1. NM_007558.3. [P34821-1 ]
    UniGenei Mm.439749.

    3D structure databases

    ProteinModelPortali P34821.
    SMRi P34821. Positions 23-399.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000037779.

    PTM databases

    PhosphoSitei P34821.

    Proteomic databases

    PRIDEi P34821.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000040496 ; ENSMUSP00000037779 ; ENSMUSG00000032726 . [P34821-2 ]
    ENSMUST00000102641 ; ENSMUSP00000099701 ; ENSMUSG00000032726 . [P34821-1 ]
    GeneIDi 12163.
    KEGGi mmu:12163.
    UCSCi uc008upg.2. mouse. [P34821-1 ]

    Organism-specific databases

    CTDi 353500.
    MGIi MGI:104515. Bmp8a.

    Phylogenomic databases

    eggNOGi NOG323541.
    GeneTreei ENSGT00730000110505.
    HOGENOMi HOG000249476.
    HOVERGENi HBG004860.
    KOi K16622.
    OMAi GREKKEM.
    PhylomeDBi P34821.

    Miscellaneous databases

    NextBioi 280519.
    PROi P34821.
    SOURCEi Search...

    Gene expression databases

    Bgeei P34821.
    CleanExi MM_BMP8A.
    Genevestigatori P34821.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis."
      Oezkaynak E., Schnegelsberg P.N.J., Jin D.F., Clifford G.M., Warren F.D., Drier E.A., Oppermann H.
      J. Biol. Chem. 267:25220-25227(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Embryo.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6.
      Tissue: Embryo.
    5. "Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development."
      Zhao G.Q., Hogan B.L.
      Mech. Dev. 57:159-168(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    6. "Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs)."
      Cheng H., Jiang W., Phillips F.M., Haydon R.C., Peng Y., Zhou L., Luu H.H., An N., Breyer B., Vanichakarn P., Szatkowski J.P., Park J.Y., He T.C.
      J. Bone and Join Surg. 85:1544-1552(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "The protective role of bone morphogenetic protein-8 in the glucocorticoid-induced apoptosis on bone cells."
      Kosa J.P., Kis A., Bacsi K., Balla B., Nagy Z., Takacs I., Speer G., Lakatos P.
      Bone 48:1052-1057(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiBMP8A_MOUSE
    AccessioniPrimary (citable) accession number: P34821
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3