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P34821

- BMP8A_MOUSE

UniProt

P34821 - BMP8A_MOUSE

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Protein

Bone morphogenetic protein 8A

Gene

Bmp8a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Has only marginal osteoinductive activity in mesenchymal progenitor and osteoprogenior cells but shows activity in committed osteoblastic cells.By similarity1 Publication

GO - Molecular functioni

  1. cytokine activity Source: MGI

GO - Biological processi

  1. cartilage development Source: UniProtKB-KW
  2. germ cell development Source: MGI
  3. growth Source: InterPro
  4. osteoblast differentiation Source: UniProtKB
  5. spermatogenesis Source: MGI
  6. transforming growth factor beta receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 8A
Short name:
BMP-8A
Alternative name(s):
Osteogenic protein 2
Short name:
OP-2
Gene namesi
Name:Bmp8a
Synonyms:Bmp-8, Bmp8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:104515. Bmp8a.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 260241Sequence AnalysisPRO_0000033884Add
BLAST
Chaini261 – 399139Bone morphogenetic protein 8APRO_0000033885Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi298 ↔ 364By similarity
Disulfide bondi327 ↔ 396By similarity
Disulfide bondi331 ↔ 398By similarity
Glycosylationi340 – 3401N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi363 – 363InterchainBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP34821.

PTM databases

PhosphoSiteiP34821.

Expressioni

Tissue specificityi

Expressed in testis. expressed in trophoblast cells of the labyrinthine region of the placenta and in the inner root sheath of hair follicles of early postnatal skin.1 Publication

Developmental stagei

Extensive expression found in 8-day embryos, fell drastically in 10-day embryos and virtually absent in 17-day embryos. Expressed during specific stages of spermatogenesis, with the highest levels in stage 6-8 round spermatids after 3 weeks of age.1 Publication

Inductioni

By dexamethasone in calvarial osteoblasts.1 Publication

Gene expression databases

BgeeiP34821.
CleanExiMM_BMP8A.
ExpressionAtlasiP34821. baseline and differential.
GenevestigatoriP34821.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037779.

Structurei

3D structure databases

ProteinModelPortaliP34821.
SMRiP34821. Positions 23-399.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG323541.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP34821.
KOiK16622.
OMAiGREKKEM.
PhylomeDBiP34821.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P34821) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMRPGPLWL LGLALCALGG GHGPRPPHTC PQRRLGARER RDMQREILAV
60 70 80 90 100
LGLPGRPRPR AQPAAARQPA SAPLFMLDLY HAMTDDDDGG PPQAHLGRAD
110 120 130 140 150
LVMSFVNMVE RDRTLGYQEP HWKEFHFDLT QIPAGEAVTA AEFRIYKEPS
160 170 180 190 200
THPLNTTLHI SMFEVVQEHS NRESDLFFLD LQTLRSGDEG WLVLDITAAS
210 220 230 240 250
DRWLLNHHKD LGLRLYVETA DGHSMDPGLA GLLGRQAPRS RQPFMVTFFR
260 270 280 290 300
ASQSPVRAPR AARPLKRRQP KKTNELPHPN KLPGIFDDGH GSRGREVCRR
310 320 330 340 350
HELYVSFRDL GWLDWVIAPQ GYSAYYCEGE CAFPLDSCMN ATNHAILQSL
360 370 380 390
VHLMKPDVVP KACCAPTKLS ATSVLYYDSS NNVILRKHRN MVVKACGCH
Length:399
Mass (Da):44,764
Last modified:February 1, 1994 - v1
Checksum:iB75FE32D6125E40C
GO
Isoform 2 (identifier: P34821-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-351: V → VSTTVACCDRWSGV

Show »
Length:412
Mass (Da):46,131
Checksum:iF7EAEF654225E56C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei351 – 3511V → VSTTVACCDRWSGV in isoform 2. 1 PublicationVSP_046527

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M97017 mRNA. Translation: AAB01365.1.
CCDSiCCDS18616.1. [P34821-1]
CCDS57293.1. [P34821-2]
RefSeqiNP_031584.1. NM_007558.3. [P34821-1]
UniGeneiMm.439749.

Genome annotation databases

EnsembliENSMUST00000040496; ENSMUSP00000037779; ENSMUSG00000032726. [P34821-2]
ENSMUST00000102641; ENSMUSP00000099701; ENSMUSG00000032726. [P34821-1]
GeneIDi12163.
KEGGimmu:12163.
UCSCiuc008upg.2. mouse. [P34821-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M97017 mRNA. Translation: AAB01365.1 .
CCDSi CCDS18616.1. [P34821-1 ]
CCDS57293.1. [P34821-2 ]
RefSeqi NP_031584.1. NM_007558.3. [P34821-1 ]
UniGenei Mm.439749.

3D structure databases

ProteinModelPortali P34821.
SMRi P34821. Positions 23-399.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000037779.

PTM databases

PhosphoSitei P34821.

Proteomic databases

PRIDEi P34821.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040496 ; ENSMUSP00000037779 ; ENSMUSG00000032726 . [P34821-2 ]
ENSMUST00000102641 ; ENSMUSP00000099701 ; ENSMUSG00000032726 . [P34821-1 ]
GeneIDi 12163.
KEGGi mmu:12163.
UCSCi uc008upg.2. mouse. [P34821-1 ]

Organism-specific databases

CTDi 353500.
MGIi MGI:104515. Bmp8a.

Phylogenomic databases

eggNOGi NOG323541.
GeneTreei ENSGT00760000118883.
HOGENOMi HOG000249476.
HOVERGENi HBG004860.
InParanoidi P34821.
KOi K16622.
OMAi GREKKEM.
PhylomeDBi P34821.

Miscellaneous databases

NextBioi 280519.
PROi P34821.
SOURCEi Search...

Gene expression databases

Bgeei P34821.
CleanExi MM_BMP8A.
ExpressionAtlasi P34821. baseline and differential.
Genevestigatori P34821.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis."
    Oezkaynak E., Schnegelsberg P.N.J., Jin D.F., Clifford G.M., Warren F.D., Drier E.A., Oppermann H.
    J. Biol. Chem. 267:25220-25227(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Embryo.
  5. "Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development."
    Zhao G.Q., Hogan B.L.
    Mech. Dev. 57:159-168(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  6. "Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs)."
    Cheng H., Jiang W., Phillips F.M., Haydon R.C., Peng Y., Zhou L., Luu H.H., An N., Breyer B., Vanichakarn P., Szatkowski J.P., Park J.Y., He T.C.
    J. Bone and Join Surg. 85:1544-1552(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "The protective role of bone morphogenetic protein-8 in the glucocorticoid-induced apoptosis on bone cells."
    Kosa J.P., Kis A., Bacsi K., Balla B., Nagy Z., Takacs I., Speer G., Lakatos P.
    Bone 48:1052-1057(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiBMP8A_MOUSE
AccessioniPrimary (citable) accession number: P34821
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3