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P34820

- BMP8B_HUMAN

UniProt

P34820 - BMP8B_HUMAN

Protein

Bone morphogenetic protein 8B

Gene

BMP8B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 2 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis By similarity.By similarity

    GO - Biological processi

    1. cartilage development Source: UniProtKB-KW
    2. cell differentiation Source: UniProtKB-KW
    3. growth Source: InterPro
    4. ossification Source: UniProtKB-KW
    5. skeletal system development Source: ProtInc

    Keywords - Molecular functioni

    Cytokine, Developmental protein, Growth factor

    Keywords - Biological processi

    Chondrogenesis, Differentiation, Osteogenesis

    Enzyme and pathway databases

    SignaLinkiP34820.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bone morphogenetic protein 8B
    Short name:
    BMP-8
    Short name:
    BMP-8B
    Alternative name(s):
    Osteogenic protein 2
    Short name:
    OP-2
    Gene namesi
    Name:BMP8B
    Synonyms:BMP8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:1075. BMP8B.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25385.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 263244Sequence AnalysisPRO_0000033882Add
    BLAST
    Chaini264 – 402139Bone morphogenetic protein 8BPRO_0000033883Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi301 ↔ 367By similarity
    Disulfide bondi330 ↔ 399By similarity
    Disulfide bondi334 ↔ 401By similarity
    Glycosylationi343 – 3431N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi366 – 366InterchainBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP34820.
    PRIDEiP34820.

    PTM databases

    PhosphoSiteiP34820.

    Expressioni

    Gene expression databases

    ArrayExpressiP34820.
    BgeeiP34820.
    CleanExiHS_BMP8B.
    GenevestigatoriP34820.

    Organism-specific databases

    HPAiHPA044883.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Protein-protein interaction databases

    BioGridi107124. 1 interaction.
    IntActiP34820. 4 interactions.
    MINTiMINT-7241133.
    STRINGi9606.ENSP00000361915.

    Structurei

    3D structure databases

    ProteinModelPortaliP34820.
    SMRiP34820. Positions 162-402.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG323541.
    HOGENOMiHOG000249476.
    HOVERGENiHBG004860.
    InParanoidiP34820.
    KOiK16622.
    OMAiGREKKEM.
    OrthoDBiEOG7J9VPQ.
    PhylomeDBiP34820.
    TreeFamiTF316134.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR002405. Inhibin_asu.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    PRINTSiPR00669. INHIBINA.
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P34820-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTALPGPLWL LGLALCALGG GGPGLRPPPG CPQRRLGARE RRDVQREILA    50
    VLGLPGRPRP RAPPAASRLP ASAPLFMLDL YHAMAGDDDE DGAPAERRLG 100
    RADLVMSFVN MVERDRALGH QEPHWKEFRF DLTQIPAGEA VTAAEFRIYK 150
    VPSIHLLNRT LHVSMFQVVQ EQSNRESDLF FLDLQTLRAG DEGWLVLDVT 200
    AASDCWLLKR HKDLGLRLYV ETEDGHSVDP GLAGLLGQRA PRSQQPFVVT 250
    FFRASPSPIR TPRAVRPLRR RQPKKSNELP QANRLPGIFD DVHGSHGRQV 300
    CRRHELYVSF QDLGWLDWVI APQGYSAYYC EGECSFPLDS CMNATNHAIL 350
    QSLVHLMMPD AVPKACCAPT KLSATSVLYY DSSNNVILRK HRNMVVKACG 400
    CH 402
    Length:402
    Mass (Da):44,768
    Last modified:March 21, 2006 - v2
    Checksum:iAE2330F1547E83A7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti358 – 3603MPD → KPN in AAB01360. (PubMed:1460021)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti293 – 2931H → R.
    Corresponds to variant rs6525 [ dbSNP | Ensembl ].
    VAR_014474

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M97016 mRNA. Translation: AAB01360.1.
    AY303955 mRNA. Translation: AAP74560.1.
    AL033527 Genomic DNA. Translation: CAB75681.1.
    CCDSiCCDS444.1.
    PIRiA45056.
    RefSeqiNP_001711.2. NM_001720.3.
    UniGeneiHs.734367.

    Genome annotation databases

    EnsembliENST00000372827; ENSP00000361915; ENSG00000116985.
    GeneIDi656.
    KEGGihsa:656.
    UCSCiuc001cdz.1. human.

    Polymorphism databases

    DMDMi90110010.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Bone morphogenetic protein 8b entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M97016 mRNA. Translation: AAB01360.1 .
    AY303955 mRNA. Translation: AAP74560.1 .
    AL033527 Genomic DNA. Translation: CAB75681.1 .
    CCDSi CCDS444.1.
    PIRi A45056.
    RefSeqi NP_001711.2. NM_001720.3.
    UniGenei Hs.734367.

    3D structure databases

    ProteinModelPortali P34820.
    SMRi P34820. Positions 162-402.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107124. 1 interaction.
    IntActi P34820. 4 interactions.
    MINTi MINT-7241133.
    STRINGi 9606.ENSP00000361915.

    PTM databases

    PhosphoSitei P34820.

    Polymorphism databases

    DMDMi 90110010.

    Proteomic databases

    PaxDbi P34820.
    PRIDEi P34820.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372827 ; ENSP00000361915 ; ENSG00000116985 .
    GeneIDi 656.
    KEGGi hsa:656.
    UCSCi uc001cdz.1. human.

    Organism-specific databases

    CTDi 656.
    GeneCardsi GC01M040222.
    HGNCi HGNC:1075. BMP8B.
    HPAi HPA044883.
    MIMi 602284. gene.
    neXtProti NX_P34820.
    PharmGKBi PA25385.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG323541.
    HOGENOMi HOG000249476.
    HOVERGENi HBG004860.
    InParanoidi P34820.
    KOi K16622.
    OMAi GREKKEM.
    OrthoDBi EOG7J9VPQ.
    PhylomeDBi P34820.
    TreeFami TF316134.

    Enzyme and pathway databases

    SignaLinki P34820.

    Miscellaneous databases

    GeneWikii Bone_morphogenetic_protein_8b.
    GenomeRNAii 656.
    NextBioi 2668.
    PROi P34820.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P34820.
    Bgeei P34820.
    CleanExi HS_BMP8B.
    Genevestigatori P34820.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR002405. Inhibin_asu.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    PRINTSi PR00669. INHIBINA.
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis."
      Oezkaynak E., Schnegelsberg P.N.J., Jin D.F., Clifford G.M., Warren F.D., Drier E.A., Oppermann H.
      J. Biol. Chem. 267:25220-25227(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Hippocampus.
    2. "Evolution of testis specific Scot-t genes encoding succinyl-CoA:3-oxoacid CoA-transferase, functional retroposons generated from somatic tissue-type paralog."
      Onishi M., Yasunaga T., Tanaka H., Nishimune Y., Nozaki M.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiBMP8B_HUMAN
    AccessioniPrimary (citable) accession number: P34820
    Secondary accession number(s): Q53ZM7, Q9NUF0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3