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P34820

- BMP8B_HUMAN

UniProt

P34820 - BMP8B_HUMAN

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Protein
Bone morphogenetic protein 8B
Gene
BMP8B, BMP8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis By similarity.

GO - Biological processi

  1. cartilage development Source: UniProtKB-KW
  2. cell differentiation Source: UniProtKB-KW
  3. growth Source: InterPro
  4. ossification Source: UniProtKB-KW
  5. skeletal system development Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Enzyme and pathway databases

SignaLinkiP34820.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 8B
Short name:
BMP-8
Short name:
BMP-8B
Alternative name(s):
Osteogenic protein 2
Short name:
OP-2
Gene namesi
Name:BMP8B
Synonyms:BMP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:1075. BMP8B.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25385.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Propeptidei20 – 263244 Reviewed prediction
PRO_0000033882Add
BLAST
Chaini264 – 402139Bone morphogenetic protein 8B
PRO_0000033883Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi158 – 1581N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi301 ↔ 367 By similarity
Disulfide bondi330 ↔ 399 By similarity
Disulfide bondi334 ↔ 401 By similarity
Glycosylationi343 – 3431N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi366 – 366Interchain By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP34820.
PRIDEiP34820.

PTM databases

PhosphoSiteiP34820.

Expressioni

Gene expression databases

ArrayExpressiP34820.
BgeeiP34820.
CleanExiHS_BMP8B.
GenevestigatoriP34820.

Organism-specific databases

HPAiHPA044883.

Interactioni

Subunit structurei

Homodimer; disulfide-linked By similarity.

Protein-protein interaction databases

BioGridi107124. 1 interaction.
IntActiP34820. 4 interactions.
MINTiMINT-7241133.
STRINGi9606.ENSP00000361915.

Structurei

3D structure databases

ProteinModelPortaliP34820.
SMRiP34820. Positions 162-402.

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG323541.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP34820.
KOiK16622.
OMAiGREKKEM.
OrthoDBiEOG7J9VPQ.
PhylomeDBiP34820.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34820-1 [UniParc]FASTAAdd to Basket

« Hide

MTALPGPLWL LGLALCALGG GGPGLRPPPG CPQRRLGARE RRDVQREILA    50
VLGLPGRPRP RAPPAASRLP ASAPLFMLDL YHAMAGDDDE DGAPAERRLG 100
RADLVMSFVN MVERDRALGH QEPHWKEFRF DLTQIPAGEA VTAAEFRIYK 150
VPSIHLLNRT LHVSMFQVVQ EQSNRESDLF FLDLQTLRAG DEGWLVLDVT 200
AASDCWLLKR HKDLGLRLYV ETEDGHSVDP GLAGLLGQRA PRSQQPFVVT 250
FFRASPSPIR TPRAVRPLRR RQPKKSNELP QANRLPGIFD DVHGSHGRQV 300
CRRHELYVSF QDLGWLDWVI APQGYSAYYC EGECSFPLDS CMNATNHAIL 350
QSLVHLMMPD AVPKACCAPT KLSATSVLYY DSSNNVILRK HRNMVVKACG 400
CH 402
Length:402
Mass (Da):44,768
Last modified:March 21, 2006 - v2
Checksum:iAE2330F1547E83A7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti293 – 2931H → R.
Corresponds to variant rs6525 [ dbSNP | Ensembl ].
VAR_014474

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti358 – 3603MPD → KPN in AAB01360. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M97016 mRNA. Translation: AAB01360.1.
AY303955 mRNA. Translation: AAP74560.1.
AL033527 Genomic DNA. Translation: CAB75681.1.
CCDSiCCDS444.1.
PIRiA45056.
RefSeqiNP_001711.2. NM_001720.3.
UniGeneiHs.734367.

Genome annotation databases

EnsembliENST00000372827; ENSP00000361915; ENSG00000116985.
GeneIDi656.
KEGGihsa:656.
UCSCiuc001cdz.1. human.

Polymorphism databases

DMDMi90110010.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Bone morphogenetic protein 8b entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M97016 mRNA. Translation: AAB01360.1 .
AY303955 mRNA. Translation: AAP74560.1 .
AL033527 Genomic DNA. Translation: CAB75681.1 .
CCDSi CCDS444.1.
PIRi A45056.
RefSeqi NP_001711.2. NM_001720.3.
UniGenei Hs.734367.

3D structure databases

ProteinModelPortali P34820.
SMRi P34820. Positions 162-402.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107124. 1 interaction.
IntActi P34820. 4 interactions.
MINTi MINT-7241133.
STRINGi 9606.ENSP00000361915.

PTM databases

PhosphoSitei P34820.

Polymorphism databases

DMDMi 90110010.

Proteomic databases

PaxDbi P34820.
PRIDEi P34820.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000372827 ; ENSP00000361915 ; ENSG00000116985 .
GeneIDi 656.
KEGGi hsa:656.
UCSCi uc001cdz.1. human.

Organism-specific databases

CTDi 656.
GeneCardsi GC01M040222.
HGNCi HGNC:1075. BMP8B.
HPAi HPA044883.
MIMi 602284. gene.
neXtProti NX_P34820.
PharmGKBi PA25385.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG323541.
HOGENOMi HOG000249476.
HOVERGENi HBG004860.
InParanoidi P34820.
KOi K16622.
OMAi GREKKEM.
OrthoDBi EOG7J9VPQ.
PhylomeDBi P34820.
TreeFami TF316134.

Enzyme and pathway databases

SignaLinki P34820.

Miscellaneous databases

GeneWikii Bone_morphogenetic_protein_8b.
GenomeRNAii 656.
NextBioi 2668.
PROi P34820.
SOURCEi Search...

Gene expression databases

ArrayExpressi P34820.
Bgeei P34820.
CleanExi HS_BMP8B.
Genevestigatori P34820.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
PRINTSi PR00669. INHIBINA.
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis."
    Oezkaynak E., Schnegelsberg P.N.J., Jin D.F., Clifford G.M., Warren F.D., Drier E.A., Oppermann H.
    J. Biol. Chem. 267:25220-25227(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hippocampus.
  2. "Evolution of testis specific Scot-t genes encoding succinyl-CoA:3-oxoacid CoA-transferase, functional retroposons generated from somatic tissue-type paralog."
    Onishi M., Yasunaga T., Tanaka H., Nishimune Y., Nozaki M.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiBMP8B_HUMAN
AccessioniPrimary (citable) accession number: P34820
Secondary accession number(s): Q53ZM7, Q9NUF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: March 21, 2006
Last modified: July 9, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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