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Protein

Bone morphogenetic protein 8B

Gene

BMP8B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Enzyme and pathway databases

SignaLinkiP34820.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 8B
Short name:
BMP-8
Short name:
BMP-8B
Alternative name(s):
Osteogenic protein 2
Short name:
OP-2
Gene namesi
Name:BMP8B
Synonyms:BMP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:1075. BMP8B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25385.

Polymorphism and mutation databases

BioMutaiBMP8B.
DMDMi90110010.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 263244Sequence AnalysisPRO_0000033882Add
BLAST
Chaini264 – 402139Bone morphogenetic protein 8BPRO_0000033883Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi301 ↔ 367By similarity
Disulfide bondi330 ↔ 399By similarity
Disulfide bondi334 ↔ 401By similarity
Glycosylationi343 – 3431N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi366 – 366InterchainBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP34820.
PRIDEiP34820.

PTM databases

PhosphoSiteiP34820.

Expressioni

Gene expression databases

BgeeiP34820.
CleanExiHS_BMP8B.
GenevisibleiP34820. HS.

Organism-specific databases

HPAiHPA044883.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

BioGridi107124. 6 interactions.
IntActiP34820. 4 interactions.
MINTiMINT-7241133.
STRINGi9606.ENSP00000361915.

Structurei

3D structure databases

ProteinModelPortaliP34820.
SMRiP34820. Positions 162-402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG323541.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP34820.
KOiK16622.
OMAiRHREPEL.
OrthoDBiEOG7J9VPQ.
PhylomeDBiP34820.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P34820-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTALPGPLWL LGLALCALGG GGPGLRPPPG CPQRRLGARE RRDVQREILA
60 70 80 90 100
VLGLPGRPRP RAPPAASRLP ASAPLFMLDL YHAMAGDDDE DGAPAERRLG
110 120 130 140 150
RADLVMSFVN MVERDRALGH QEPHWKEFRF DLTQIPAGEA VTAAEFRIYK
160 170 180 190 200
VPSIHLLNRT LHVSMFQVVQ EQSNRESDLF FLDLQTLRAG DEGWLVLDVT
210 220 230 240 250
AASDCWLLKR HKDLGLRLYV ETEDGHSVDP GLAGLLGQRA PRSQQPFVVT
260 270 280 290 300
FFRASPSPIR TPRAVRPLRR RQPKKSNELP QANRLPGIFD DVHGSHGRQV
310 320 330 340 350
CRRHELYVSF QDLGWLDWVI APQGYSAYYC EGECSFPLDS CMNATNHAIL
360 370 380 390 400
QSLVHLMMPD AVPKACCAPT KLSATSVLYY DSSNNVILRK HRNMVVKACG

CH
Length:402
Mass (Da):44,768
Last modified:March 21, 2006 - v2
Checksum:iAE2330F1547E83A7
GO
Isoform 2 (identifier: P34820-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     226-253: HSVDPGLAGLLGQRAPRSQQPFVVTFFR → ETWTGWGWTK...LLCLLQGHCP
     317-402: DWVIAPQGYS...NMVVKACGCH → VIADSSCF

Note: No experimental confirmation available.Curated
Show »
Length:349
Mass (Da):39,151
Checksum:i3065C85AA8CF5020
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti358 – 3603MPD → KPN in AAB01360 (PubMed:1460021).Curated
Isoform 2 (identifier: P34820-2)
Sequence conflicti347 – 3471S → P in AAI08679 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti293 – 2931H → R.1 Publication
Corresponds to variant rs6525 [ dbSNP | Ensembl ].
VAR_014474

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei226 – 25328HSVDP…VTFFR → ETWTGWGWTKDSRLQMWKLR LSRTPWVLSLHAPGPAQAPA ERPLLCLLQGHCP in isoform 2. 1 PublicationVSP_056842Add
BLAST
Alternative sequencei317 – 40286DWVIA…ACGCH → VIADSSCF in isoform 2. 1 PublicationVSP_056843Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97016 mRNA. Translation: AAB01360.1.
AY303955 mRNA. Translation: AAP74560.1.
AL033527 Genomic DNA. Translation: CAB75681.1.
AL049824 Genomic DNA. No translation available.
BC108678 mRNA. Translation: AAI08679.1.
CCDSiCCDS444.1. [P34820-1]
PIRiA45056.
RefSeqiNP_001711.2. NM_001720.3. [P34820-1]
UniGeneiHs.734367.

Genome annotation databases

EnsembliENST00000372827; ENSP00000361915; ENSG00000116985. [P34820-1]
ENST00000397360; ENSP00000380518; ENSG00000116985. [P34820-2]
GeneIDi656.
KEGGihsa:656.
UCSCiuc001cdz.1. human. [P34820-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Bone morphogenetic protein 8b entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97016 mRNA. Translation: AAB01360.1.
AY303955 mRNA. Translation: AAP74560.1.
AL033527 Genomic DNA. Translation: CAB75681.1.
AL049824 Genomic DNA. No translation available.
BC108678 mRNA. Translation: AAI08679.1.
CCDSiCCDS444.1. [P34820-1]
PIRiA45056.
RefSeqiNP_001711.2. NM_001720.3. [P34820-1]
UniGeneiHs.734367.

3D structure databases

ProteinModelPortaliP34820.
SMRiP34820. Positions 162-402.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107124. 6 interactions.
IntActiP34820. 4 interactions.
MINTiMINT-7241133.
STRINGi9606.ENSP00000361915.

PTM databases

PhosphoSiteiP34820.

Polymorphism and mutation databases

BioMutaiBMP8B.
DMDMi90110010.

Proteomic databases

PaxDbiP34820.
PRIDEiP34820.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372827; ENSP00000361915; ENSG00000116985. [P34820-1]
ENST00000397360; ENSP00000380518; ENSG00000116985. [P34820-2]
GeneIDi656.
KEGGihsa:656.
UCSCiuc001cdz.1. human. [P34820-1]

Organism-specific databases

CTDi656.
GeneCardsiGC01M040222.
HGNCiHGNC:1075. BMP8B.
HPAiHPA044883.
MIMi602284. gene.
neXtProtiNX_P34820.
PharmGKBiPA25385.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG323541.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP34820.
KOiK16622.
OMAiRHREPEL.
OrthoDBiEOG7J9VPQ.
PhylomeDBiP34820.
TreeFamiTF316134.

Enzyme and pathway databases

SignaLinkiP34820.

Miscellaneous databases

GeneWikiiBone_morphogenetic_protein_8b.
GenomeRNAii656.
NextBioi2668.
PROiP34820.
SOURCEiSearch...

Gene expression databases

BgeeiP34820.
CleanExiHS_BMP8B.
GenevisibleiP34820. HS.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis."
    Oezkaynak E., Schnegelsberg P.N.J., Jin D.F., Clifford G.M., Warren F.D., Drier E.A., Oppermann H.
    J. Biol. Chem. 267:25220-25227(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Hippocampus.
  2. "Evolution of testis specific Scot-t genes encoding succinyl-CoA:3-oxoacid CoA-transferase, functional retroposons generated from somatic tissue-type paralog."
    Onishi M., Yasunaga T., Tanaka H., Nishimune Y., Nozaki M.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-293.
    Tissue: Testis.

Entry informationi

Entry nameiBMP8B_HUMAN
AccessioniPrimary (citable) accession number: P34820
Secondary accession number(s): E7EMY8
, Q32NE5, Q53ZM7, Q9NUF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: March 21, 2006
Last modified: June 24, 2015
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.