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Protein

Bone morphogenetic protein 8B

Gene

BMP8B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Developmental protein, Growth factor
Biological processChondrogenesis, Differentiation, Osteogenesis

Enzyme and pathway databases

SignaLinkiP34820.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 8B
Short name:
BMP-8
Short name:
BMP-8B
Alternative name(s):
Osteogenic protein 2
Short name:
OP-2
Gene namesi
Name:BMP8B
Synonyms:BMP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116985.10.
HGNCiHGNC:1075. BMP8B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi656.
OpenTargetsiENSG00000116985.
PharmGKBiPA25385.

Polymorphism and mutation databases

BioMutaiBMP8B.
DMDMi90110010.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000003388220 – 263Sequence analysisAdd BLAST244
ChainiPRO_0000033883264 – 402Bone morphogenetic protein 8BAdd BLAST139

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi301 ↔ 367By similarity
Disulfide bondi330 ↔ 399By similarity
Disulfide bondi334 ↔ 401By similarity
Glycosylationi343N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi366InterchainBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP34820.
PeptideAtlasiP34820.
PRIDEiP34820.

PTM databases

iPTMnetiP34820.
PhosphoSitePlusiP34820.

Expressioni

Gene expression databases

BgeeiENSG00000116985.
CleanExiHS_BMP8B.
GenevisibleiP34820. HS.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107124. 7 interactors.
IntActiP34820. 4 interactors.
MINTiMINT-7241133.
STRINGi9606.ENSP00000361915.

Structurei

3D structure databases

ProteinModelPortaliP34820.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP34820.
KOiK16622.
OMAiMKPEAVP.
OrthoDBiEOG091G0K7Z.
PhylomeDBiP34820.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_propeptide.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiView protein in Pfam
PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
SMARTiView protein in SMART
SM00204. TGFB. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiView protein in PROSITE
PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P34820-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTALPGPLWL LGLALCALGG GGPGLRPPPG CPQRRLGARE RRDVQREILA
60 70 80 90 100
VLGLPGRPRP RAPPAASRLP ASAPLFMLDL YHAMAGDDDE DGAPAERRLG
110 120 130 140 150
RADLVMSFVN MVERDRALGH QEPHWKEFRF DLTQIPAGEA VTAAEFRIYK
160 170 180 190 200
VPSIHLLNRT LHVSMFQVVQ EQSNRESDLF FLDLQTLRAG DEGWLVLDVT
210 220 230 240 250
AASDCWLLKR HKDLGLRLYV ETEDGHSVDP GLAGLLGQRA PRSQQPFVVT
260 270 280 290 300
FFRASPSPIR TPRAVRPLRR RQPKKSNELP QANRLPGIFD DVHGSHGRQV
310 320 330 340 350
CRRHELYVSF QDLGWLDWVI APQGYSAYYC EGECSFPLDS CMNATNHAIL
360 370 380 390 400
QSLVHLMMPD AVPKACCAPT KLSATSVLYY DSSNNVILRK HRNMVVKACG

CH
Length:402
Mass (Da):44,768
Last modified:March 21, 2006 - v2
Checksum:iAE2330F1547E83A7
GO
Isoform 2 (identifier: P34820-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     226-253: HSVDPGLAGLLGQRAPRSQQPFVVTFFR → ETWTGWGWTK...LLCLLQGHCP
     317-402: DWVIAPQGYS...NMVVKACGCH → VIADSSCF

Note: No experimental confirmation available.Curated
Show »
Length:349
Mass (Da):39,151
Checksum:i3065C85AA8CF5020
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti358 – 360MPD → KPN in AAB01360 (PubMed:1460021).Curated3
Isoform 2 (identifier: P34820-2)
Sequence conflicti347S → P in AAI08679 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014474293H → R1 PublicationCorresponds to variant dbSNP:rs6525Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056842226 – 253HSVDP…VTFFR → ETWTGWGWTKDSRLQMWKLR LSRTPWVLSLHAPGPAQAPA ERPLLCLLQGHCP in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_056843317 – 402DWVIA…ACGCH → VIADSSCF in isoform 2. 1 PublicationAdd BLAST86

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97016 mRNA. Translation: AAB01360.1.
AY303955 mRNA. Translation: AAP74560.1.
AL033527 Genomic DNA. Translation: CAB75681.1.
AL049824 Genomic DNA. No translation available.
BC108678 mRNA. Translation: AAI08679.1.
CCDSiCCDS444.1. [P34820-1]
PIRiA45056.
RefSeqiNP_001711.2. NM_001720.4. [P34820-1]
UniGeneiHs.734367.

Genome annotation databases

EnsembliENST00000372827; ENSP00000361915; ENSG00000116985. [P34820-1]
GeneIDi656.
KEGGihsa:656.
UCSCiuc001cdz.2. human. [P34820-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBMP8B_HUMAN
AccessioniPrimary (citable) accession number: P34820
Secondary accession number(s): E7EMY8
, Q32NE5, Q53ZM7, Q9NUF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: March 21, 2006
Last modified: September 27, 2017
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families