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P34820 (BMP8B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bone morphogenetic protein 8B

Short name=BMP-8
Short name=BMP-8B
Alternative name(s):
Osteogenic protein 2
Short name=OP-2
Gene names
Name:BMP8B
Synonyms:BMP8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length402 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis By similarity.

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the TGF-beta family.

Ontologies

Keywords
   Biological processChondrogenesis
Differentiation
Osteogenesis
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionCytokine
Developmental protein
Growth factor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcartilage development

Inferred from electronic annotation. Source: UniProtKB-KW

cell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

growth

Inferred from electronic annotation. Source: InterPro

ossification

Inferred from electronic annotation. Source: UniProtKB-KW

skeletal system development

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 263244 Potential
PRO_0000033882
Chain264 – 402139Bone morphogenetic protein 8B
PRO_0000033883

Amino acid modifications

Glycosylation1581N-linked (GlcNAc...) Potential
Glycosylation3431N-linked (GlcNAc...) Potential
Disulfide bond301 ↔ 367 By similarity
Disulfide bond330 ↔ 399 By similarity
Disulfide bond334 ↔ 401 By similarity
Disulfide bond366Interchain By similarity

Natural variations

Natural variant2931H → R.
Corresponds to variant rs6525 [ dbSNP | Ensembl ].
VAR_014474

Experimental info

Sequence conflict358 – 3603MPD → KPN in AAB01360. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P34820 [UniParc].

Last modified March 21, 2006. Version 2.
Checksum: AE2330F1547E83A7

FASTA40244,768
        10         20         30         40         50         60 
MTALPGPLWL LGLALCALGG GGPGLRPPPG CPQRRLGARE RRDVQREILA VLGLPGRPRP 

        70         80         90        100        110        120 
RAPPAASRLP ASAPLFMLDL YHAMAGDDDE DGAPAERRLG RADLVMSFVN MVERDRALGH 

       130        140        150        160        170        180 
QEPHWKEFRF DLTQIPAGEA VTAAEFRIYK VPSIHLLNRT LHVSMFQVVQ EQSNRESDLF 

       190        200        210        220        230        240 
FLDLQTLRAG DEGWLVLDVT AASDCWLLKR HKDLGLRLYV ETEDGHSVDP GLAGLLGQRA 

       250        260        270        280        290        300 
PRSQQPFVVT FFRASPSPIR TPRAVRPLRR RQPKKSNELP QANRLPGIFD DVHGSHGRQV 

       310        320        330        340        350        360 
CRRHELYVSF QDLGWLDWVI APQGYSAYYC EGECSFPLDS CMNATNHAIL QSLVHLMMPD 

       370        380        390        400 
AVPKACCAPT KLSATSVLYY DSSNNVILRK HRNMVVKACG CH 

« Hide

References

« Hide 'large scale' references
[1]"Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis."
Oezkaynak E., Schnegelsberg P.N.J., Jin D.F., Clifford G.M., Warren F.D., Drier E.A., Oppermann H.
J. Biol. Chem. 267:25220-25227(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Hippocampus.
[2]"Evolution of testis specific Scot-t genes encoding succinyl-CoA:3-oxoacid CoA-transferase, functional retroposons generated from somatic tissue-type paralog."
Onishi M., Yasunaga T., Tanaka H., Nishimune Y., Nozaki M.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Web resources

Wikipedia

Bone morphogenetic protein 8b entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M97016 mRNA. Translation: AAB01360.1.
AY303955 mRNA. Translation: AAP74560.1.
AL033527 Genomic DNA. Translation: CAB75681.1.
PIRA45056.
RefSeqNP_001711.2. NM_001720.3.
UniGeneHs.734367.

3D structure databases

ProteinModelPortalP34820.
SMRP34820. Positions 162-402.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107124. 1 interaction.
IntActP34820. 4 interactions.
MINTMINT-7241133.
STRING9606.ENSP00000361915.

PTM databases

PhosphoSiteP34820.

Polymorphism databases

DMDM90110010.

Proteomic databases

PaxDbP34820.
PRIDEP34820.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000372827; ENSP00000361915; ENSG00000116985.
GeneID656.
KEGGhsa:656.
UCSCuc001cdz.1. human.

Organism-specific databases

CTD656.
GeneCardsGC01M040222.
HGNCHGNC:1075. BMP8B.
HPAHPA044883.
MIM602284. gene.
neXtProtNX_P34820.
PharmGKBPA25385.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG323541.
HOGENOMHOG000249476.
HOVERGENHBG004860.
InParanoidP34820.
KOK16622.
OMAGREKKEM.
OrthoDBEOG7J9VPQ.
PhylomeDBP34820.
TreeFamTF316134.

Enzyme and pathway databases

SignaLinkP34820.

Gene expression databases

ArrayExpressP34820.
BgeeP34820.
CleanExHS_BMP8B.
GenevestigatorP34820.

Family and domain databases

InterProIPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSPR00669. INHIBINA.
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiBone_morphogenetic_protein_8b.
GenomeRNAi656.
NextBio2668.
PROP34820.
SOURCESearch...

Entry information

Entry nameBMP8B_HUMAN
AccessionPrimary (citable) accession number: P34820
Secondary accession number(s): Q53ZM7, Q9NUF0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: March 21, 2006
Last modified: February 19, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM