ID   CD68_HUMAN              Reviewed;         354 AA.
AC   P34810; B4DVT4; Q53HR6; Q53XI3; Q96BI7;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 2.
DT   27-MAR-2024, entry version 193.
DE   RecName: Full=Macrosialin;
DE   AltName: Full=Gp110;
DE   AltName: CD_antigen=CD68;
DE   Flags: Precursor;
GN   Name=CD68;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT), AND VARIANT LYS-254.
RX   PubMed=7680921;
RA   Holness C.L., Simmons D.L.;
RT   "Molecular cloning of CD68, a human macrophage marker related to lysosomal
RT   glycoproteins.";
RL   Blood 81:1607-1613(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS LONG AND 3).
RC   TISSUE=Spleen, and Umbilical cord blood;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
RC   TISSUE=Adipose tissue;
RA   Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA   Tanaka A., Yokoyama S.;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
RC   TISSUE=Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28.
RX   PubMed=9790779; DOI=10.1006/geno.1998.5515;
RA   Jones E., Quinn C.M., See C.G., Montgomery D.S., Ford M.J., Koelble K.,
RA   Gordon S., Greaves D.R.;
RT   "The linked human elongation initiation factor 4A1 (EIF4A1) and CD68 genes
RT   map to chromosome 17p13.";
RL   Genomics 53:248-250(1998).
RN   [9]
RP   USE AS A MACROPHAGE MARKER.
RX   PubMed=15194571; DOI=10.1136/ard.2003.013029;
RA   Kunisch E., Fuhrmann R., Roth A., Winter R., Lungershausen W., Kinne R.W.;
RT   "Macrophage specificity of three anti-CD68 monoclonal antibodies (KP1,
RT   EBM11, and PGM1) widely used for immunohistochemistry and flow cytometry.";
RL   Ann. Rheum. Dis. 63:774-784(2004).
RN   [10]
RP   USE AS A MACROPHAGE MARKER.
RX   PubMed=15647451;
RA   Beranek J.T.;
RT   "CD68 is not a macrophage-specific antigen.";
RL   Ann. Rheum. Dis. 64:342-343(2005).
RN   [11]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-261.
RC   TISSUE=Platelet;
RX   PubMed=16263699; DOI=10.1074/mcp.m500324-mcp200;
RA   Lewandrowski U., Moebius J., Walter U., Sickmann A.;
RT   "Elucidation of N-glycosylation sites on human platelet proteins: a
RT   glycoproteomic approach.";
RL   Mol. Cell. Proteomics 5:226-233(2006).
RN   [12]
RP   TISSUE SPECIFICITY.
RX   PubMed=18405323; DOI=10.1111/j.1365-3083.2008.02091.x;
RA   Gottfried E., Kunz-Schughart L.A., Weber A., Rehli M., Peuker A.,
RA   Muller A., Kastenberger M., Brockhoff G., Andreesen R., Kreutz M.;
RT   "Expression of CD68 in non-myeloid cell types.";
RL   Scand. J. Immunol. 67:453-463(2008).
RN   [13]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-199; ASN-261 AND ASN-279.
RC   TISSUE=Liver;
RX   PubMed=19159218; DOI=10.1021/pr8008012;
RA   Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT   "Glycoproteomics analysis of human liver tissue by combination of multiple
RT   enzyme digestion and hydrazide chemistry.";
RL   J. Proteome Res. 8:651-661(2009).
RN   [14]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712; DOI=10.1002/pmic.201400617;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA   Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
CC   -!- FUNCTION: Could play a role in phagocytic activities of tissue
CC       macrophages, both in intracellular lysosomal metabolism and
CC       extracellular cell-cell and cell-pathogen interactions. Binds to
CC       tissue- and organ-specific lectins or selectins, allowing homing of
CC       macrophage subsets to particular sites. Rapid recirculation of CD68
CC       from endosomes and lysosomes to the plasma membrane may allow
CC       macrophages to crawl over selectin-bearing substrates or other cells.
CC   -!- INTERACTION:
CC       P34810; O95994: AGR2; NbExp=3; IntAct=EBI-2826276, EBI-712648;
CC       P34810; Q13520: AQP6; NbExp=3; IntAct=EBI-2826276, EBI-13059134;
CC       P34810; Q9UHP7-3: CLEC2D; NbExp=3; IntAct=EBI-2826276, EBI-11749983;
CC       P34810; Q86UP2-3: KTN1; NbExp=3; IntAct=EBI-2826276, EBI-12007212;
CC       P34810; Q969L2: MAL2; NbExp=3; IntAct=EBI-2826276, EBI-944295;
CC       P34810; P15941-11: MUC1; NbExp=3; IntAct=EBI-2826276, EBI-17263240;
CC       P34810; Q96CS7: PLEKHB2; NbExp=3; IntAct=EBI-2826276, EBI-373552;
CC       P34810; Q96EQ0: SGTB; NbExp=3; IntAct=EBI-2826276, EBI-744081;
CC       P34810; Q7Z7N9: TMEM179B; NbExp=3; IntAct=EBI-2826276, EBI-11724423;
CC       P34810; Q96B49: TOMM6; NbExp=6; IntAct=EBI-2826276, EBI-10826510;
CC   -!- SUBCELLULAR LOCATION: [Isoform Short]: Cell membrane; Single-pass type
CC       I membrane protein.
CC   -!- SUBCELLULAR LOCATION: [Isoform Long]: Endosome membrane; Single-pass
CC       type I membrane protein. Lysosome membrane; Single-pass type I membrane
CC       protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=Long; Synonyms=CD68.1;
CC         IsoId=P34810-1; Sequence=Displayed;
CC       Name=Short; Synonyms=CD68.2;
CC         IsoId=P34810-2; Sequence=VSP_003041, VSP_003042;
CC       Name=3;
CC         IsoId=P34810-3; Sequence=VSP_003041;
CC   -!- TISSUE SPECIFICITY: Highly expressed by blood monocytes and tissue
CC       macrophages. Also expressed in lymphocytes, fibroblasts and endothelial
CC       cells. Expressed in many tumor cell lines which could allow them to
CC       attach to selectins on vascular endothelium, facilitating their
CC       dissemination to secondary sites. {ECO:0000269|PubMed:18405323}.
CC   -!- PTM: N- and O-glycosylated. {ECO:0000269|PubMed:16263699,
CC       ECO:0000269|PubMed:19159218}.
CC   -!- SIMILARITY: Belongs to the LAMP family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00740}.
CC   -!- CAUTION: CD68 is a commonly used marker for macrophages. However, a
CC       number of studies (PubMed:15194571, PubMed:15647451, PubMed:18405323)
CC       have shown that CD68 antibodies react with other hematopoietic and non-
CC       hematopoietic cell types, suggesting that CD68 may not be a macrophage-
CC       specific antigen. {ECO:0000305}.
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DR   EMBL; S57235; AAB25811.1; -; mRNA.
DR   EMBL; BT009923; AAP88925.1; -; mRNA.
DR   EMBL; AK290238; BAF82927.1; -; mRNA.
DR   EMBL; AK222492; BAD96212.1; -; mRNA.
DR   EMBL; AK222514; BAD96234.1; -; mRNA.
DR   EMBL; AK301223; BAG62796.1; -; mRNA.
DR   EMBL; AC016876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471108; EAW90165.1; -; Genomic_DNA.
DR   EMBL; BC015557; AAH15557.1; -; mRNA.
DR   EMBL; AF060540; AAC70006.1; -; Genomic_DNA.
DR   CCDS; CCDS11114.1; -. [P34810-1]
DR   CCDS; CCDS58512.1; -. [P34810-3]
DR   PIR; A48931; A48931.
DR   RefSeq; NP_001035148.1; NM_001040059.1. [P34810-3]
DR   RefSeq; NP_001242.2; NM_001251.2. [P34810-1]
DR   AlphaFoldDB; P34810; -.
DR   SMR; P34810; -.
DR   BioGRID; 107406; 30.
DR   IntAct; P34810; 23.
DR   MINT; P34810; -.
DR   STRING; 9606.ENSP00000250092; -.
DR   GlyConnect; 1483; 17 N-Linked glycans (2 sites).
DR   GlyCosmos; P34810; 10 sites, 17 glycans.
DR   GlyGen; P34810; 12 sites, 16 N-linked glycans (2 sites), 2 O-linked glycans (3 sites).
DR   iPTMnet; P34810; -.
DR   PhosphoSitePlus; P34810; -.
DR   BioMuta; CD68; -.
DR   DMDM; 147744552; -.
DR   EPD; P34810; -.
DR   jPOST; P34810; -.
DR   MassIVE; P34810; -.
DR   MaxQB; P34810; -.
DR   PaxDb; 9606-ENSP00000250092; -.
DR   PeptideAtlas; P34810; -.
DR   ProteomicsDB; 54942; -. [P34810-1]
DR   ProteomicsDB; 54943; -. [P34810-2]
DR   Antibodypedia; 3511; 2691 antibodies from 55 providers.
DR   DNASU; 968; -.
DR   Ensembl; ENST00000250092.11; ENSP00000250092.6; ENSG00000129226.14. [P34810-1]
DR   Ensembl; ENST00000380498.10; ENSP00000369867.6; ENSG00000129226.14. [P34810-3]
DR   GeneID; 968; -.
DR   KEGG; hsa:968; -.
DR   MANE-Select; ENST00000250092.11; ENSP00000250092.6; NM_001251.3; NP_001242.2.
DR   UCSC; uc002ghu.4; human. [P34810-1]
DR   AGR; HGNC:1693; -.
DR   CTD; 968; -.
DR   DisGeNET; 968; -.
DR   GeneCards; CD68; -.
DR   HGNC; HGNC:1693; CD68.
DR   HPA; ENSG00000129226; Tissue enhanced (lung, lymphoid tissue).
DR   MIM; 153634; gene.
DR   neXtProt; NX_P34810; -.
DR   OpenTargets; ENSG00000129226; -.
DR   PharmGKB; PA26232; -.
DR   VEuPathDB; HostDB:ENSG00000129226; -.
DR   eggNOG; KOG4818; Eukaryota.
DR   GeneTree; ENSGT00950000182899; -.
DR   HOGENOM; CLU_071610_0_0_1; -.
DR   InParanoid; P34810; -.
DR   OMA; TTKHPNT; -.
DR   OrthoDB; 4338134at2759; -.
DR   PhylomeDB; P34810; -.
DR   TreeFam; TF316339; -.
DR   PathwayCommons; P34810; -.
DR   Reactome; R-HSA-6798695; Neutrophil degranulation.
DR   SignaLink; P34810; -.
DR   SIGNOR; P34810; -.
DR   BioGRID-ORCS; 968; 12 hits in 1159 CRISPR screens.
DR   ChiTaRS; CD68; human.
DR   GenomeRNAi; 968; -.
DR   Pharos; P34810; Tbio.
DR   PRO; PR:P34810; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; P34810; Protein.
DR   Bgee; ENSG00000129226; Expressed in leukocyte and 104 other cell types or tissues.
DR   ExpressionAtlas; P34810; baseline and differential.
DR   GO; GO:0035577; C:azurophil granule membrane; TAS:Reactome.
DR   GO; GO:0031902; C:late endosome membrane; IBA:GO_Central.
DR   GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR   GO; GO:0005764; C:lysosome; ISS:ARUK-UCL.
DR   GO; GO:0016020; C:membrane; TAS:ProtInc.
DR   GO; GO:0005886; C:plasma membrane; IDA:ARUK-UCL.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; ISS:ARUK-UCL.
DR   GO; GO:0031669; P:cellular response to nutrient levels; ISS:ARUK-UCL.
DR   GO; GO:0140052; P:cellular response to oxidised low-density lipoprotein particle stimulus; ISS:ARUK-UCL.
DR   GO; GO:0072594; P:establishment of protein localization to organelle; IBA:GO_Central.
DR   GO; GO:0002437; P:inflammatory response to antigenic stimulus; ISS:ARUK-UCL.
DR   GO; GO:0002605; P:negative regulation of dendritic cell antigen processing and presentation; ISS:ARUK-UCL.
DR   Gene3D; 2.40.160.110; -; 1.
DR   InterPro; IPR048528; Lamp2-like_luminal.
DR   InterPro; IPR018134; LAMP_CS.
DR   InterPro; IPR002000; Lysosome-assoc_membr_glycop.
DR   PANTHER; PTHR11506; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN; 1.
DR   PANTHER; PTHR11506:SF2; MACROSIALIN; 1.
DR   Pfam; PF01299; Lamp; 1.
DR   PRINTS; PR00336; LYSASSOCTDMP.
DR   PROSITE; PS00311; LAMP_2; 1.
DR   PROSITE; PS51407; LAMP_3; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell membrane; Disulfide bond; Endosome;
KW   Glycoprotein; Lysosome; Membrane; Reference proteome; Repeat; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..354
FT                   /note="Macrosialin"
FT                   /id="PRO_0000017102"
FT   TOPO_DOM        22..319
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..344
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00740"
FT   TOPO_DOM        345..354
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00740"
FT   REPEAT          70..99
FT                   /note="1"
FT   REPEAT          100..129
FT                   /note="2"
FT   REGION          23..140
FT                   /note="Mucin-like"
FT   REGION          40..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          70..129
FT                   /note="2 X 30 AA tandem repeats"
FT   COMPBIAS        40..136
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        137..151
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        88
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        96
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        118
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        126
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        164
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        199
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:19159218"
FT   CARBOHYD        246
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        261
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:16263699,
FT                   ECO:0000269|PubMed:19159218"
FT   CARBOHYD        279
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:19159218"
FT   DISULFID        169..207
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00740"
FT   DISULFID        277..314
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00740"
FT   VAR_SEQ         17..43
FT                   /note="Missing (in isoform Short and isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:7680921"
FT                   /id="VSP_003041"
FT   VAR_SEQ         83..112
FT                   /note="Missing (in isoform Short)"
FT                   /evidence="ECO:0000303|PubMed:7680921"
FT                   /id="VSP_003042"
FT   VARIANT         254
FT                   /note="Q -> K (in dbSNP:rs9901673)"
FT                   /evidence="ECO:0000269|PubMed:7680921"
FT                   /id="VAR_016144"
FT   VARIANT         329
FT                   /note="I -> T (in dbSNP:rs35452170)"
FT                   /id="VAR_049725"
FT   VARIANT         340
FT                   /note="A -> T (in dbSNP:rs17607)"
FT                   /id="VAR_016145"
FT   VARIANT         350
FT                   /note="A -> T (in dbSNP:rs9901675)"
FT                   /id="VAR_049726"
FT   CONFLICT        95
FT                   /note="S -> G (in Ref. 4; BAD96234)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   354 AA;  37408 MW;  69E68D69EDE8EFB0 CRC64;
     MRLAVLFSGA LLGLLAAQGT GNDCPHKKSA TLLPSFTVTP TVTESTGTTS HRTTKSHKTT
     THRTTTTGTT SHGPTTATHN PTTTSHGNVT VHPTSNSTAT SQGPSTATHS PATTSHGNAT
     VHPTSNSTAT SPGFTSSAHP EPPPPSPSPS PTSKETIGDY TWTNGSQPCV HLQAQIQIRV
     MYTTQGGGEA WGISVLNPNK TKVQGSCEGA HPHLLLSFPY GHLSFGFMQD LQQKVVYLSY
     MAVEYNVSFP HAAQWTFSAQ NASLRDLQAP LGQSFSCSNS SIILSPAVHL DLLSLRLQAA
     QLPHTGVFGQ SFSCPSDRSI LLPLIIGLIL LGLLALVLIA FCIIRRRPSA YQAL
//