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Reviewed, UniProtKB/Swiss-Prot P34810 (CD68_HUMAN)

Last modified May 5, 2009. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Macrosialin
Alternative name(s):
    Gp110
    CD_antigen=CD68
Gene names
Name: CD68
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Bind to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes, lysosomes to the plasma membrane may allow macrophages to crawl over selectin bearing substrates or other cells.

Subcellular location

Isoform Short: Cell membrane; Single-pass type I membrane protein.

Isoform Long: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.

Tissue specificity

Highly expressed by blood monocytes and tissue macrophages. Also expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.

Post-translational modification

N- and O-glycosylated. Ref.4

Sequence similarities

Belongs to the LAMP family.

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Long (identifier: P34810-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: P34810-2)

The sequence of this isoform differs from the canonical sequence as follows:
     17-43: Missing.
     83-112: Missing.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 354333Macrosialin
PRO_0000017102

Regions

Topological domain22 – 319298Extracellular Potential
Transmembrane320 – 34425 Potential
Topological domain345 – 35410Cytoplasmic Potential
Repeat70 – 99301
Repeat100 – 129302
Region23 – 140118Mucin-like
Region70 – 129602 X 30 AA tandem repeats
Compositional bias140 – 15213Pro-rich (hinge)

Amino acid modifications

Glycosylation881N-linked (GlcNAc...) Potential
Glycosylation961N-linked (GlcNAc...) Potential
Glycosylation1181N-linked (GlcNAc...) Potential
Glycosylation1261N-linked (GlcNAc...) Potential
Glycosylation1641N-linked (GlcNAc...) Potential
Glycosylation1991N-linked (GlcNAc...)
Glycosylation2461N-linked (GlcNAc...) Potential
Glycosylation2611N-linked (GlcNAc...) Ref.4
Glycosylation2791N-linked (GlcNAc...)
Disulfide bond169 ↔ 207 By similarity
Disulfide bond277 ↔ 314 By similarity

Natural variations

Alternative sequence17 – 4327Missing in isoform Short.
VSP_003041
Alternative sequence83 – 11230Missing in isoform Short.
VSP_003042
Natural variant2541Q → K: dbSNP rs25679. Ref.1
VAR_016144
Natural variant3291I → T: dbSNP rs35452170.
VAR_049725
Natural variant3401A → T: dbSNP rs17607.
VAR_016145
Natural variant3501A → T: dbSNP rs9901675.
VAR_049726

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Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified May 15, 2007. Version 2.
Checksum: 69E68D69EDE8EFB0

FASTA35437,408
        10         20         30         40         50         60 
MRLAVLFSGA LLGLLAAQGT GNDCPHKKSA TLLPSFTVTP TVTESTGTTS HRTTKSHKTT 

        70         80         90        100        110        120 
THRTTTTGTT SHGPTTATHN PTTTSHGNVT VHPTSNSTAT SQGPSTATHS PATTSHGNAT 

       130        140        150        160        170        180 
VHPTSNSTAT SPGFTSSAHP EPPPPSPSPS PTSKETIGDY TWTNGSQPCV HLQAQIQIRV 

       190        200        210        220        230        240 
MYTTQGGGEA WGISVLNPNK TKVQGSCEGA HPHLLLSFPY GHLSFGFMQD LQQKVVYLSY 

       250        260        270        280        290        300 
MAVEYNVSFP HAAQWTFSAQ NASLRDLQAP LGQSFSCSNS SIILSPAVHL DLLSLRLQAA 

       310        320        330        340        350 
QLPHTGVFGQ SFSCPSDRSI LLPLIIGLIL LGLLALVLIA FCIIRRRPSA YQAL

« Hide

Isoform Short.

Checksum: B0A78BF5F01BC0B0
Show »

FASTA29731,738

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References

« Hide 'large scale' references
[1]"Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins."
Holness C.L., Simmons D.L.
Blood 81:1607-1613(1993) [PubMed: 7680921] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, VARIANT LYS-254.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[3]"The linked human elongation initiation factor 4A1 (EIF4A1) and CD68 genes map to chromosome 17p13."
Jones E., Quinn C.M., See C.G., Montgomery D.S., Ford M.J., Koelble K., Gordon S., Greaves D.R.
Genomics 53:248-250(1998) [PubMed: 9790779] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28.
[4]"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
Lewandrowski U., Moebius J., Walter U., Sickmann A.
Mol. Cell. Proteomics 5:226-233(2006) [PubMed: 16263699] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-261, MASS SPECTROMETRY.
Tissue: Platelet.
[5]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-199; ASN-261 AND ASN-279, MASS SPECTROMETRY.
Tissue: Liver.
+Additional computationally mapped references.

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Cross-references

Sequence databases

S57235 mRNA. Translation: AAB25811.1.
BC015557 mRNA. Translation: AAH15557.1.
AF060540 Genomic DNA. Translation: AAC70006.1.
IPIIPI00002252.
IPI00217167.
PIRA48931.
RefSeqNP_001035148.1.
NP_001242.2.
UniGeneHs.647419

3D structure databases

ModBaseSearch...

Proteomic databases

PRIDEP34810.

Genome annotation databases

EnsemblENSG00000129226. Homo sapiens. [Contig view]
GeneID968.
KEGGhsa:968.

Organism-specific databases

GeneCardsGC17P007423.
HGNCHGNC:1693. CD68.
HPACAB000051.
CAB000066.
MIM153634. gene.
PharmGKBPA26232.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP34810.
HOVERGENP34810.
OMAP34810. EYNVSFP.

Gene expression databases

BgeeP34810.
CleanExHS_CD68.

Family and domain databases

InterProIPR002000. Lamp.
IPR018133. LAMP/LAMP-like_membrane.
IPR018134. LAMP_CS.
[Graphical view]
PANTHERPTHR11506. Lamp. 1 hit.
PfamPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSPR00336. LYSASSOCTDMP.
PROSITEPS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio4050.
SOURCESearch...

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Entry information

Entry nameCD68_HUMAN
AccessionPrimary (citable) accession number: P34810
Secondary accession number(s): Q96BI7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 15, 2007
Last modified: May 5, 2009
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents