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P34810

- CD68_HUMAN

UniProt

P34810 - CD68_HUMAN

Protein

Macrosialin

Gene

CD68

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 2 (15 May 2007)
      Previous versions | rss
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    Functioni

    Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

    GO - Biological processi

    1. cellular response to organic substance Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Macrosialin
    Alternative name(s):
    Gp110
    CD_antigen: CD68
    Gene namesi
    Name:CD68
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Organism-specific databases

    HGNCiHGNC:1693. CD68.

    Subcellular locationi

    GO - Cellular componenti

    1. endosome membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: ProtInc
    3. lysosomal membrane Source: UniProtKB-SubCell
    4. membrane Source: ProtInc
    5. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Endosome, Lysosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26232.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 354333MacrosialinPRO_0000017102Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi169 ↔ 207PROSITE-ProRule annotations
    Glycosylationi199 – 1991N-linked (GlcNAc...)1 Publication
    Glycosylationi246 – 2461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi261 – 2611N-linked (GlcNAc...)2 Publications
    Disulfide bondi277 ↔ 314PROSITE-ProRule annotations
    Glycosylationi279 – 2791N-linked (GlcNAc...)1 Publication

    Post-translational modificationi

    N- and O-glycosylated.2 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP34810.
    PaxDbiP34810.
    PRIDEiP34810.

    PTM databases

    PhosphoSiteiP34810.

    Expressioni

    Tissue specificityi

    Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.1 Publication

    Gene expression databases

    BgeeiP34810.
    CleanExiHS_CD68.
    GenevestigatoriP34810.

    Organism-specific databases

    HPAiCAB000051.
    CAB000066.
    HPA048982.

    Interactioni

    Protein-protein interaction databases

    BioGridi107406. 2 interactions.
    IntActiP34810. 3 interactions.
    MINTiMINT-4824093.
    STRINGi9606.ENSP00000250092.

    Structurei

    3D structure databases

    ProteinModelPortaliP34810.
    SMRiP34810. Positions 156-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 319298ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini345 – 35410CytoplasmicPROSITE-ProRule annotations

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei320 – 34425HelicalPROSITE-ProRule annotationsAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati70 – 99301Add
    BLAST
    Repeati100 – 129302Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni23 – 140118Mucin-likeAdd
    BLAST
    Regioni70 – 129602 X 30 AA tandem repeatsAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi140 – 15213Pro-rich (hinge)Add
    BLAST

    Sequence similaritiesi

    Belongs to the LAMP family.PROSITE-ProRule annotations

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG244352.
    HOGENOMiHOG000070034.
    HOVERGENiHBG005287.
    InParanoidiP34810.
    KOiK06501.
    OMAiGNDCPHK.
    OrthoDBiEOG7ZD1VH.
    PhylomeDBiP34810.
    TreeFamiTF316339.

    Family and domain databases

    InterProiIPR018134. LAMP_CS.
    IPR002000. Lysosome-assoc_membr_glycop.
    [Graphical view]
    PANTHERiPTHR11506. PTHR11506. 1 hit.
    PfamiPF01299. Lamp. 1 hit.
    [Graphical view]
    PRINTSiPR00336. LYSASSOCTDMP.
    PROSITEiPS00311. LAMP_2. 1 hit.
    PS51407. LAMP_3. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: P34810-1) [UniParc]FASTAAdd to Basket

    Also known as: CD68.1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRLAVLFSGA LLGLLAAQGT GNDCPHKKSA TLLPSFTVTP TVTESTGTTS    50
    HRTTKSHKTT THRTTTTGTT SHGPTTATHN PTTTSHGNVT VHPTSNSTAT 100
    SQGPSTATHS PATTSHGNAT VHPTSNSTAT SPGFTSSAHP EPPPPSPSPS 150
    PTSKETIGDY TWTNGSQPCV HLQAQIQIRV MYTTQGGGEA WGISVLNPNK 200
    TKVQGSCEGA HPHLLLSFPY GHLSFGFMQD LQQKVVYLSY MAVEYNVSFP 250
    HAAQWTFSAQ NASLRDLQAP LGQSFSCSNS SIILSPAVHL DLLSLRLQAA 300
    QLPHTGVFGQ SFSCPSDRSI LLPLIIGLIL LGLLALVLIA FCIIRRRPSA 350
    YQAL 354
    Length:354
    Mass (Da):37,408
    Last modified:May 15, 2007 - v2
    Checksum:i69E68D69EDE8EFB0
    GO
    Isoform Short (identifier: P34810-2) [UniParc]FASTAAdd to Basket

    Also known as: CD68.2

    The sequence of this isoform differs from the canonical sequence as follows:
         17-43: Missing.
         83-112: Missing.

    Show »
    Length:297
    Mass (Da):31,738
    Checksum:iB0A78BF5F01BC0B0
    GO
    Isoform 3 (identifier: P34810-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         17-43: Missing.

    Show »
    Length:327
    Mass (Da):34,654
    Checksum:i8AD19346F7827330
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti254 – 2541Q → K.1 Publication
    Corresponds to variant rs25679 [ dbSNP | Ensembl ].
    VAR_016144
    Natural varianti329 – 3291I → T.
    Corresponds to variant rs35452170 [ dbSNP | Ensembl ].
    VAR_049725
    Natural varianti340 – 3401A → T.
    Corresponds to variant rs17607 [ dbSNP | Ensembl ].
    VAR_016145
    Natural varianti350 – 3501A → T.
    Corresponds to variant rs9901675 [ dbSNP | Ensembl ].
    VAR_049726

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei17 – 4327Missing in isoform Short and isoform 3. 2 PublicationsVSP_003041Add
    BLAST
    Alternative sequencei83 – 11230Missing in isoform Short. 1 PublicationVSP_003042Add
    BLAST

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti95 – 951S → G in BAD96234. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S57235 mRNA. Translation: AAB25811.1.
    BT009923 mRNA. Translation: AAP88925.1.
    AK290238 mRNA. Translation: BAF82927.1.
    AK222492 mRNA. Translation: BAD96212.1.
    AK222514 mRNA. Translation: BAD96234.1.
    AK301223 mRNA. Translation: BAG62796.1.
    AC016876 Genomic DNA. No translation available.
    CH471108 Genomic DNA. Translation: EAW90165.1.
    BC015557 mRNA. Translation: AAH15557.1.
    AF060540 Genomic DNA. Translation: AAC70006.1.
    CCDSiCCDS11114.1. [P34810-1]
    CCDS58512.1. [P34810-3]
    PIRiA48931.
    RefSeqiNP_001035148.1. NM_001040059.1. [P34810-3]
    NP_001242.2. NM_001251.2. [P34810-1]
    UniGeneiHs.647419.

    Genome annotation databases

    EnsembliENST00000250092; ENSP00000250092; ENSG00000129226. [P34810-1]
    ENST00000380498; ENSP00000369867; ENSG00000129226. [P34810-3]
    GeneIDi968.
    KEGGihsa:968.
    UCSCiuc002ghv.3. human. [P34810-1]

    Polymorphism databases

    DMDMi147744552.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S57235 mRNA. Translation: AAB25811.1 .
    BT009923 mRNA. Translation: AAP88925.1 .
    AK290238 mRNA. Translation: BAF82927.1 .
    AK222492 mRNA. Translation: BAD96212.1 .
    AK222514 mRNA. Translation: BAD96234.1 .
    AK301223 mRNA. Translation: BAG62796.1 .
    AC016876 Genomic DNA. No translation available.
    CH471108 Genomic DNA. Translation: EAW90165.1 .
    BC015557 mRNA. Translation: AAH15557.1 .
    AF060540 Genomic DNA. Translation: AAC70006.1 .
    CCDSi CCDS11114.1. [P34810-1 ]
    CCDS58512.1. [P34810-3 ]
    PIRi A48931.
    RefSeqi NP_001035148.1. NM_001040059.1. [P34810-3 ]
    NP_001242.2. NM_001251.2. [P34810-1 ]
    UniGenei Hs.647419.

    3D structure databases

    ProteinModelPortali P34810.
    SMRi P34810. Positions 156-316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107406. 2 interactions.
    IntActi P34810. 3 interactions.
    MINTi MINT-4824093.
    STRINGi 9606.ENSP00000250092.

    PTM databases

    PhosphoSitei P34810.

    Polymorphism databases

    DMDMi 147744552.

    Proteomic databases

    MaxQBi P34810.
    PaxDbi P34810.
    PRIDEi P34810.

    Protocols and materials databases

    DNASUi 968.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000250092 ; ENSP00000250092 ; ENSG00000129226 . [P34810-1 ]
    ENST00000380498 ; ENSP00000369867 ; ENSG00000129226 . [P34810-3 ]
    GeneIDi 968.
    KEGGi hsa:968.
    UCSCi uc002ghv.3. human. [P34810-1 ]

    Organism-specific databases

    CTDi 968.
    GeneCardsi GC17P007482.
    HGNCi HGNC:1693. CD68.
    HPAi CAB000051.
    CAB000066.
    HPA048982.
    MIMi 153634. gene.
    neXtProti NX_P34810.
    PharmGKBi PA26232.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG244352.
    HOGENOMi HOG000070034.
    HOVERGENi HBG005287.
    InParanoidi P34810.
    KOi K06501.
    OMAi GNDCPHK.
    OrthoDBi EOG7ZD1VH.
    PhylomeDBi P34810.
    TreeFami TF316339.

    Miscellaneous databases

    ChiTaRSi CD68. human.
    GenomeRNAii 968.
    NextBioi 4050.
    PROi P34810.
    SOURCEi Search...

    Gene expression databases

    Bgeei P34810.
    CleanExi HS_CD68.
    Genevestigatori P34810.

    Family and domain databases

    InterProi IPR018134. LAMP_CS.
    IPR002000. Lysosome-assoc_membr_glycop.
    [Graphical view ]
    PANTHERi PTHR11506. PTHR11506. 1 hit.
    Pfami PF01299. Lamp. 1 hit.
    [Graphical view ]
    PRINTSi PR00336. LYSASSOCTDMP.
    PROSITEi PS00311. LAMP_2. 1 hit.
    PS51407. LAMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins."
      Holness C.L., Simmons D.L.
      Blood 81:1607-1613(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT), VARIANT LYS-254.
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS LONG AND 3).
      Tissue: Spleen and Umbilical cord blood.
    4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
      Tissue: Adipose tissue.
    5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
      Tissue: Skin.
    8. "The linked human elongation initiation factor 4A1 (EIF4A1) and CD68 genes map to chromosome 17p13."
      Jones E., Quinn C.M., See C.G., Montgomery D.S., Ford M.J., Koelble K., Gordon S., Greaves D.R.
      Genomics 53:248-250(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28.
    9. "Macrophage specificity of three anti-CD68 monoclonal antibodies (KP1, EBM11, and PGM1) widely used for immunohistochemistry and flow cytometry."
      Kunisch E., Fuhrmann R., Roth A., Winter R., Lungershausen W., Kinne R.W.
      Ann. Rheum. Dis. 63:774-784(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: USE AS A MACROPHAGE MARKER.
    10. "CD68 is not a macrophage-specific antigen."
      Beranek J.T.
      Ann. Rheum. Dis. 64:342-343(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: USE AS A MACROPHAGE MARKER.
    11. "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
      Lewandrowski U., Moebius J., Walter U., Sickmann A.
      Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-261.
      Tissue: Platelet.
    12. Cited for: TISSUE SPECIFICITY.
    13. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-199; ASN-261 AND ASN-279.
      Tissue: Liver.

    Entry informationi

    Entry nameiCD68_HUMAN
    AccessioniPrimary (citable) accession number: P34810
    Secondary accession number(s): B4DVT4
    , Q53HR6, Q53XI3, Q96BI7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 132 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    CD68 is a commonly used marker for macrophages. However, a number of studies (PubMed:15194571, PubMed:15647451 and PubMed:18405323) have shown that CD68 antibodies react with other hematopoietic and non-hematopoietic cell types, suggesting that CD68 may not be a macrophage-specific antigen.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi