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P34799

- URIC2_CANLI

UniProt

P34799 - URIC2_CANLI

Protein

Uricase-2 isozyme 2

Gene
N/A
Organism
Canavalia lineata (Beach bean) (Dolichos lineatus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.By similarity

    Catalytic activityi

    Urate + O2 + H2O = 5-hydroxyisourate + H2O2.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei182 – 1821Charge relay systemBy similarity
    Binding sitei182 – 1821SubstrateBy similarity
    Active sitei238 – 2381Charge relay systemBy similarity

    GO - Molecular functioni

    1. urate oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. nodulation Source: UniProtKB-KW
    2. purine nucleobase metabolic process Source: UniProtKB-KW
    3. urate catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Nodulation, Purine metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00394; UER00650.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uricase-2 isozyme 2 (EC:1.7.3.3)
    Alternative name(s):
    Urate oxidase
    Uricase II clone pcClNUO-02
    OrganismiCanavalia lineata (Beach bean) (Dolichos lineatus)
    Taxonomic identifieri28957 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeCanavalia

    Subcellular locationi

    Peroxisome By similarity

    GO - Cellular componenti

    1. peroxisome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 301301Uricase-2 isozyme 2PRO_0000166001Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP34799.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni63 – 642Substrate bindingBy similarity
    Regioni237 – 2382Substrate bindingBy similarity

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi299 – 3013Microbody targeting signalSequence Analysis

    Sequence similaritiesi

    Belongs to the uricase family.Curated

    Family and domain databases

    InterProiIPR002042. Uricase.
    IPR019842. Uricase_CS.
    [Graphical view]
    PfamiPF01014. Uricase. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000241. Urate_oxidase. 1 hit.
    PRINTSiPR00093. URICASE.
    TIGRFAMsiTIGR03383. urate_oxi. 1 hit.
    PROSITEiPS00366. URICASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P34799-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKEIVGGFK FDQRHGKERV RVARVWKTKK GGYFIVEWRV GISLLSDCVN    50
    SYVRDDNSDI VATDTMKNTV YAKAKECSEI LSVEDFAILL AKHFISFYKQ 100
    VTAAIVNIVE KPWERVSVDG QPHEHGFKLG SERHTAEAIV QKSGALQLTS 150
    GIEGLSLLKT TKSGFEGFIR DKYTALPETH ERMLATEVTA LWRYSYESLY 200
    SIPQKPLYFT DKYLEVKKVL ADTFFGPPNV GVYSPSVQNT LYLMAKAHSS 250
    IQLKMPNIHF LPVNISNKDG PIVKFDDDVY FPTDEPHGSI QASLSRLWSK 300
    L 301
    Length:301
    Mass (Da):34,035
    Last modified:February 1, 1994 - v1
    Checksum:iE90B96F7B5BD5294
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76287 mRNA. Translation: CAA53905.1.
    PIRiS38910.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76287 mRNA. Translation: CAA53905.1 .
    PIRi S38910.

    3D structure databases

    ProteinModelPortali P34799.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00394 ; UER00650 .

    Family and domain databases

    InterProi IPR002042. Uricase.
    IPR019842. Uricase_CS.
    [Graphical view ]
    Pfami PF01014. Uricase. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000241. Urate_oxidase. 1 hit.
    PRINTSi PR00093. URICASE.
    TIGRFAMsi TIGR03383. urate_oxi. 1 hit.
    PROSITEi PS00366. URICASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence and expression of cDNA clones encoding uricase II in Canavalia lineata."
      Bang K.H., An C.S.
      Singmul Hakhoe Chi 36:415-423(1993)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Root nodule.

    Entry informationi

    Entry nameiURIC2_CANLI
    AccessioniPrimary (citable) accession number: P34799
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3