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P34799

- URIC2_CANLI

UniProt

P34799 - URIC2_CANLI

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Protein

Uricase-2 isozyme 2

Gene
N/A
Organism
Canavalia lineata (Beach bean) (Dolichos lineatus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.By similarity

Catalytic activityi

Urate + O2 + H2O = 5-hydroxyisourate + H2O2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei182 – 1821Charge relay systemBy similarity
Binding sitei182 – 1821SubstrateBy similarity
Active sitei238 – 2381Charge relay systemBy similarity

GO - Molecular functioni

  1. urate oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. nodulation Source: UniProtKB-KW
  2. purine nucleobase metabolic process Source: UniProtKB-KW
  3. urate catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Nodulation, Purine metabolism

Enzyme and pathway databases

UniPathwayiUPA00394; UER00650.

Names & Taxonomyi

Protein namesi
Recommended name:
Uricase-2 isozyme 2 (EC:1.7.3.3)
Alternative name(s):
Urate oxidase
Uricase II clone pcClNUO-02
OrganismiCanavalia lineata (Beach bean) (Dolichos lineatus)
Taxonomic identifieri28957 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeCanavalia

Subcellular locationi

Peroxisome By similarity

GO - Cellular componenti

  1. peroxisome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Uricase-2 isozyme 2PRO_0000166001Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP34799.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni63 – 642Substrate bindingBy similarity
Regioni237 – 2382Substrate bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi299 – 3013Microbody targeting signalSequence Analysis

Sequence similaritiesi

Belongs to the uricase family.Curated

Family and domain databases

InterProiIPR002042. Uricase.
IPR019842. Uricase_CS.
[Graphical view]
PfamiPF01014. Uricase. 2 hits.
[Graphical view]
PIRSFiPIRSF000241. Urate_oxidase. 1 hit.
PRINTSiPR00093. URICASE.
TIGRFAMsiTIGR03383. urate_oxi. 1 hit.
PROSITEiPS00366. URICASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34799-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKEIVGGFK FDQRHGKERV RVARVWKTKK GGYFIVEWRV GISLLSDCVN
60 70 80 90 100
SYVRDDNSDI VATDTMKNTV YAKAKECSEI LSVEDFAILL AKHFISFYKQ
110 120 130 140 150
VTAAIVNIVE KPWERVSVDG QPHEHGFKLG SERHTAEAIV QKSGALQLTS
160 170 180 190 200
GIEGLSLLKT TKSGFEGFIR DKYTALPETH ERMLATEVTA LWRYSYESLY
210 220 230 240 250
SIPQKPLYFT DKYLEVKKVL ADTFFGPPNV GVYSPSVQNT LYLMAKAHSS
260 270 280 290 300
IQLKMPNIHF LPVNISNKDG PIVKFDDDVY FPTDEPHGSI QASLSRLWSK

L
Length:301
Mass (Da):34,035
Last modified:February 1, 1994 - v1
Checksum:iE90B96F7B5BD5294
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76287 mRNA. Translation: CAA53905.1.
PIRiS38910.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76287 mRNA. Translation: CAA53905.1 .
PIRi S38910.

3D structure databases

ProteinModelPortali P34799.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00394 ; UER00650 .

Family and domain databases

InterProi IPR002042. Uricase.
IPR019842. Uricase_CS.
[Graphical view ]
Pfami PF01014. Uricase. 2 hits.
[Graphical view ]
PIRSFi PIRSF000241. Urate_oxidase. 1 hit.
PRINTSi PR00093. URICASE.
TIGRFAMsi TIGR03383. urate_oxi. 1 hit.
PROSITEi PS00366. URICASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence and expression of cDNA clones encoding uricase II in Canavalia lineata."
    Bang K.H., An C.S.
    Singmul Hakhoe Chi 36:415-423(1993)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Root nodule.

Entry informationi

Entry nameiURIC2_CANLI
AccessioniPrimary (citable) accession number: P34799
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3