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P34799 (URIC2_CANLI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uricase-2 isozyme 2

EC=1.7.3.3
Alternative name(s):
Urate oxidase
Uricase II clone pcClNUO-02
OrganismCanavalia lineata (Beach bean) (Dolichos lineatus)
Taxonomic identifier28957 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeCanavalia

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin By similarity.

Catalytic activity

Urate + O2 + H2O = 5-hydroxyisourate + H2O2.

Pathway

Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.

Subcellular location

Peroxisome By similarity.

Sequence similarities

Belongs to the uricase family.

Ontologies

Keywords
   Biological processNodulation
Purine metabolism
   Cellular componentPeroxisome
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processnodulation

Inferred from electronic annotation. Source: UniProtKB-KW

purine nucleobase metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

urate catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentperoxisome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionurate oxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 301301Uricase-2 isozyme 2
PRO_0000166001

Regions

Region63 – 642Substrate binding By similarity
Region237 – 2382Substrate binding By similarity
Motif299 – 3013Microbody targeting signal Potential

Sites

Active site1821Charge relay system By similarity
Active site2381Charge relay system By similarity
Binding site1821Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P34799 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: E90B96F7B5BD5294

FASTA30134,035
        10         20         30         40         50         60 
MAKEIVGGFK FDQRHGKERV RVARVWKTKK GGYFIVEWRV GISLLSDCVN SYVRDDNSDI 

        70         80         90        100        110        120 
VATDTMKNTV YAKAKECSEI LSVEDFAILL AKHFISFYKQ VTAAIVNIVE KPWERVSVDG 

       130        140        150        160        170        180 
QPHEHGFKLG SERHTAEAIV QKSGALQLTS GIEGLSLLKT TKSGFEGFIR DKYTALPETH 

       190        200        210        220        230        240 
ERMLATEVTA LWRYSYESLY SIPQKPLYFT DKYLEVKKVL ADTFFGPPNV GVYSPSVQNT 

       250        260        270        280        290        300 
LYLMAKAHSS IQLKMPNIHF LPVNISNKDG PIVKFDDDVY FPTDEPHGSI QASLSRLWSK 


L 

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References

[1]"Nucleotide sequence and expression of cDNA clones encoding uricase II in Canavalia lineata."
Bang K.H., An C.S.
Singmul Hakhoe Chi 36:415-423(1993)
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Root nodule.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X76287 mRNA. Translation: CAA53905.1.
PIRS38910.

3D structure databases

ProteinModelPortalP34799.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00394; UER00650.

Family and domain databases

InterProIPR002042. Uricase.
IPR019842. Uricase_CS.
[Graphical view]
PANTHERPTHR10395:SF1. PTHR10395:SF1. 1 hit.
PfamPF01014. Uricase. 2 hits.
[Graphical view]
PIRSFPIRSF000241. Urate_oxidase. 1 hit.
PRINTSPR00093. URICASE.
TIGRFAMsTIGR03383. urate_oxi. 1 hit.
PROSITEPS00366. URICASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameURIC2_CANLI
AccessionPrimary (citable) accession number: P34799
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways