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Protein

Glucose-6-phosphate isomerase, cytosolic 1A

Gene

PGIC1-A

Organism
Clarkia lewisii (Farewell-to-spring) (Clarkia bottae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathway:iglycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase, cytosolic 2A (PGIC2-A), Glucose-6-phosphate isomerase, cytosolic 1A (PGIC1-A), Glucose-6-phosphate isomerase, cytosolic 2B (PGIC2-B)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei360 – 3601Proton donorBy similarity
Active sitei391 – 3911By similarity
Active sitei516 – 5161By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase, cytosolic 1A (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
PGI2
Short name:
PGI
Phosphoglucose isomerase
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:PGIC1-A
OrganismiClarkia lewisii (Farewell-to-spring) (Clarkia bottae)
Taxonomic identifieri3936 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsMyrtalesOnagraceaeOnagroideaeOnagreaeClarkia

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 569569Glucose-6-phosphate isomerase, cytosolic 1APRO_0000180555Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP34796.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34796-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPALISET EAWKDLKAHL EGIKMTHLRE LMGDTERCQS MMVEFDNIFL
60 70 80 90 100
DYSRQQASPD TISKLYKLAD AAHLKQKIDR MYNGDHINTT ENRSVLHVAL
110 120 130 140 150
RAPRNSAICS DGKNVVPDVW NVLDKIKDFS DSVRNGSWIG ATGKELKDVI
160 170 180 190 200
AVGIGGSFLG PLFVHTALQT DPEASKNARG RELRFLANVD PIDVARNISG
210 220 230 240 250
LNPETTLVVV VSKTFTTAET MLNARTLREW ISSALGPSAV AKHMVAVSTN
260 270 280 290 300
LPLVEKFGID PNNAFAFWDW VGGRYSVCSA VGVLPLSLQY GFAVVEKFLQ
310 320 330 340 350
GAHSIDQHFS SAPFEKNIPV LLGLLSVWNV SFLGYPARAI LPYSQALEKL
360 370 380 390 400
APHIQQVSME SNGKGVSIDG LPLPFESGEI DFGEPGTNGQ HSFYQLIHQG
410 420 430 440 450
RVIPCDFIGV VKSQQPVYLK GEVVNNHDEL MSNFFAQPDA LAYGKTPEEL
460 470 480 490 500
KKENVSEHLI PHKTFTGNRP SISILLPTLD AYRIGQLLAI YEHRVAVQGF
510 520 530 540 550
VWGINSFDQW GVELGKSLAT QVRKQLHGSR VKGEPVEEGF NFSTKTLLTR
560
YLQATSDVPA DPSTLLPNI
Length:569
Mass (Da):62,689
Last modified:February 1, 1994 - v1
Checksum:i67E5E6D34B67BC07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71084 Genomic DNA. Translation: CAA50402.1.
X89384 Genomic DNA. Translation: CAA61564.1.
PIRiS41806.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71084 Genomic DNA. Translation: CAA50402.1.
X89384 Genomic DNA. Translation: CAA61564.1.
PIRiS41806.

3D structure databases

ProteinModelPortaliP34796.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular characterization of duplicate cytosolic phosphoglucose isomerase genes in Clarkia and comparison to the single gene in Arabidopsis."
    Thomas B.R., Ford V.S., Pichersky E., Gottlieb L.D.
    Genetics 135:895-905(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Phylogenetic relationships among the sections of Clarkia (Onagraceae) inferred from the nucleotide sequences of PgiC."
    Gottlieb L.D., Ford V.S.
    Syst. Bot. 21:1-18(1996)
    [AGRICOLA] [Europe PMC]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Population LDG 795.

Entry informationi

Entry nameiG6PI1_CLALE
AccessioniPrimary (citable) accession number: P34796
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 4, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.