Reviewed,
UniProtKB/Swiss-Prot P34766 (PAL1_CAEEL)
Last modified
June 16, 2009.
Version 75.
History...
Clusters with 100%,
90%,
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Homeobox protein pal-1 Alternative name(s): Homeobox protein ceh-3 Posterior alae in males protein 1 | ||||||
| Gene names |
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| Organism | Caenorhabditis elegans [Complete proteome] | ||||||
| Taxonomic identifier | 6239 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 208 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Probable transcriptional activator. May activate the gene for mab-5. Is required for V6 cell to generate its characteristic ray lineage instead of alae lineages. |
| Subcellular location | Nucleus Probable. |
| Sequence similarities | Belongs to the Caudal homeobox family. Contains 1 homeobox DNA-binding domain. |
| Sequence caution | The sequence CAA86322.2 differs from that shown. Reason: Erroneous gene model prediction. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Domain | Homeobox |
| Ligand | DNA-binding |
| Molecular function | Activator Developmental protein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase positive regulation of growth rateInferred from mutant phenotype. Source: WormBase regulation of transcription, DNA-dependentInferred from electronic annotation. Source: UniProtKB-KW transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct sequence-specific DNA bindingInferred from electronic annotation. Source: InterPro transcription factor activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Binary interactions
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Regulation of cellular responsiveness to inductive signals in the developing C. elegans nervous system." Waring D.A., Kenyon C. Nature 350:712-715(1991) [PubMed: 2023634] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Bristol N2. |
| [2] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
| [3] | Buerglin T.R. Submitted (DEC-1990) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 136-206. Strain: Bristol N2. |
| [4] | "Caenorhabditis elegans has scores of homoeobox-containing genes." Buerglin T.R., Finney M., Coulson A., Ruvkun G. Nature 341:239-243(1989) [PubMed: 2571091] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 140-195. Strain: Bristol N2. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X62782 mRNA. Translation: CAA44619.1. Z46241 Genomic DNA. Translation: CAA86322.2. Sequence problems. X57140 mRNA. Translation: CAA40419.1. | |
| PIR | S15091. T19829. |
| UniGene | Cel.18383 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1B8I based on UniProtKB P02834. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P34766. 59 interactions. |
Genome annotation databases | |
| Ensembl | C38D4.6. Caenorhabditis elegans. [Contig view] |
Organism-specific databases | |
| WormBase | WBGene00003912. pal-1. |
| WormPep | C38D4.6. CE27837. [WorfDB] |
Gene expression databases | |
| ArrayExpress | P34766. |
Family and domain databases | |
| InterPro | IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR012287. Homeodomain-rel. [Graphical view] |
| Gene3D | G3DSA:1.10.10.60. Homeodomain-rel. 1 hit. |
| Pfam | PF00046. Homeobox. 1 hit. [Graphical view] |
| ProDom | PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00389. HOX. 1 hit. [Graphical view] |
| PROSITE | PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PAL1_CAEEL | ||||||||
| Accession | Primary (citable) accession number: P34766 Secondary accession number(s): Q18513 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| SIMILARITY comments Index of protein domains and families |
