P34758 (SCD5_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein SCD5

Alternative name(s):
Protein FTB1

Gene names

Name:	SCD5
Synonyms:	FTB1
Ordered Locus Names:	YOR329C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	872 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in vesicular transport at a late stage of the secretory pathway.
Subunit structure	Putative 10-formyl-tetrahydrofolate binding protein.
Subcellular location	Membrane; Peripheral membrane protein.
Miscellaneous	Present with 704 molecules/cell in log phase SD medium.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Membrane
Domain	Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin filament organization Inferred from mutant phenotype PubMed 12356757. Source: SGD cortical actin cytoskeleton organization Inferred from mutant phenotype PubMed 12181333. Source: SGD endocytosis Inferred from mutant phenotype PubMed 16251346. Source: SGD protein secretion Inferred from genetic interaction Ref.1. Source: SGD
Cellular_component	actin cortical patch Inferred from direct assay PubMed 12181333. Source: SGD membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from mutant phenotype PubMed 16251346. Source: SGD
Molecular_function	protein phosphatase 1 binding Inferred from direct assay PubMed 12356757. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
GLC7	P32598	4	EBI-16685,EBI-13715

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 872	872	Protein SCD5		PRO_0000097621
Regions
	Repeat	405 – 424	20	1-1
	Repeat	439 – 458	20	1-2
	Repeat	479 – 498	20	1-3
	Repeat	534 – 545	12	2-1
	Repeat	564 – 575	12	2-2
	Repeat	593 – 604	12	2-3
	Repeat	608 – 619	12	2-4
	Repeat	623 – 634	12	2-5
	Repeat	636 – 647	12	2-5
	Repeat	650 – 661	12	2-7
	Repeat	683 – 694	12	2-8
	Repeat	717 – 728	12	2-9
	Region	405 – 448	44	3 X 20 AA approximate repeats
	Region	534 – 728	195	9 X 12 AA approximate repeats
Amino acid modifications
	Modified residue	57	1	Phosphoserine Ref.8 Ref.9
	Modified residue	564	1	Phosphoserine Ref.8 Ref.9

Sequences

	Sequence		Length	Mass (Da)
	P34758 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: C60F5BE8808E1D31	FASTA	872	97,305
	10 20 30 40 50 60 MSFDWLNVPG LDLSSGDQAE KRPSNGLGPP SVSFDFGINT AAPHDSSFWD QGSRSHSDTT 70 80 90 100 110 120 LSYRNNHSNT AADNATNVSS PQKDNPPNGE VRTLSGGDVY AESPEDMQVP LSLSQNQLTH 130 140 150 160 170 180 EEIRTYLRWY HYICLRTHGK LVRLNDVFRF LTNFNLSQKV KDRIVEIFRS CKNALNIGQF 190 200 210 220 230 240 FAVLRLVSRA IIYGILPLRR MILEKAPVPK PRPILSSENH EEVYEEVEDD DSSAKTGDQK 250 260 270 280 290 300 VDFDSFASLL LTGKTTRKRV RRRIKNLNFK SKKVRFSEHI TFQDPPNLNQ ESSNNSEARK 310 320 330 340 350 360 QDPDAEDEDQ DSNNDSPLDF TLPMDQLLKR LYKRRKNSGL VSSLPSEQQE TEEEKKVLED 370 380 390 400 410 420 MKDSLSHFKQ IQTVDSASLP ISSVFLQNGN TLPTSNVNNT TVPQQLPLEP LKPTATGSAN 430 440 450 460 470 480 HLVREEYNQG LHPSNGAIQT GLQPLKPTAT GSANYLMRSH MEQPQSIKPS STPETVTNSG 490 500 510 520 530 540 GLQPLKPTAT GSANYLMKQH ISPSVNNPVS SMFQAQFTNQ SSSPQSTGPA FLNSPNITLP 550 560 570 580 590 600 QSNQQQPYQE VNPTQAKIEP SNISPQHTYS NNVRINNGNI VSMPKVEITG AFPPQNTLPQ 610 620 630 640 650 660 HQQSHLLSPQ NTIPQHQRSQ LISPQNTFTQ NQPILSPQHT YSNNQATMIS PQNTYTNNQQ 670 680 690 700 710 720 QPQHLPPPPP PRAQQQQQGA IVPPQHMYSN VQKQNNLVPT QPSYTNSPSI QSPNFLSPQN 730 740 750 760 770 780 AANSYFQSLL SSSPSPNPTP SNASTVNGNN ASNGISSFQN TSAAMNNTQS HQTYIQQQQQ 790 800 810 820 830 840 QQTQQRIYGG QLSQMQQHPG QLHLNNSDIH SQPNKPNYGM LGQQVHQQQQ QQQQQFPFTA 850 860 870 DVNRSNSSDI LGNLQSLQQQ VDALQIQYNR RP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"SCD5, a suppressor of clathrin deficiency, encodes a novel protein with a late secretory function in yeast." Nelson K.K., Holmer M., Lemmon S.K. Mol. Biol. Cell 7:245-260(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ATCC 204508 / S288c.
[2]	Wang W., Zheng L., Chan C. Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC 204508 / S288c.
[3]	Song J.M., Cheung E., Rabinowitz J.C. Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: S288c / GRF88.
[4]	"Sequence of 29 kb around the PDR10 locus on the right arm of Saccharomyces cerevisiae chromosome XV: similarity to part of chromosome I." Parle-McDermott A.G., Hand N.J., Goulding S.E., Wolfe K.H. Yeast 12:999-1004(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K. Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[6]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[7]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]	"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-57 AND SER-564, MASS SPECTROMETRY.
[9]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-57 AND SER-564, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U03492 mRNA. Translation: AAB09719.1. U42227 Genomic DNA. Translation: AAA85443.1. Z49821 Genomic DNA. Translation: CAA89976.1. Z75237 Genomic DNA. Translation: CAA99650.1. BK006948 Genomic DNA. Translation: DAA11092.1.
PIR	S62061.
RefSeq	NP_014974.3. NM_001183749.3.
3D structure databases
ProteinModelPortal	P34758.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1341N.
IntAct	P34758. 3 interactions.
MINT	MINT-394108.
STRING	4932.YOR329C.
Proteomic databases
PaxDb	P34758.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YOR329C; YOR329C; YOR329C.
GeneID	854507.
KEGG	sce:YOR329C. sce:YOR332W.
Organism-specific databases
CYGD	YOR329c.
SGD	S000005856. SCD5.
Phylogenomic databases
eggNOG	NOG29165.
GeneTree	ENSGT00690000102560.
HOGENOM	HOG000000799.
KO	K02150.
OMA	FRSCKNA.
OrthoDB	EOG4TXG21.
Gene expression databases
Genevestigator	P34758.
GermOnline	YOR329C. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	976858.

Entry information

Entry name

SCD5_YEAST

Accession

Primary (citable) accession number: P34758
Secondary accession number(s): D6W326

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	May 1, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program