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Protein

Putative DNA transport protein HofQ

Gene

hofQ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Required for the use of extracellular DNA as a nutrient. Could be the porin responsible for transport of DNA across the outer membrane.1 Publication

GO - Molecular functioni

  • DNA binding Source: EcoliWiki
  • protein transporter activity Source: InterPro

GO - Biological processi

  • carbon utilization Source: EcoCyc
  • pilus assembly Source: InterPro
  • protein secretion Source: InterPro
  • transport Source: EcoliWiki
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG12113-MONOMER.
ECOL316407:JW3354-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative DNA transport protein HofQ
Gene namesi
Name:hofQ
Synonyms:hopQ
Ordered Locus Names:b3391, JW3354
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12113. hofQ.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutants show a stationary-phase competition defect during coculture with wild-type cells and an inability to utilize extracellular DNA as the sole source of carbon or energy.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 412394Putative DNA transport protein HofQPRO_0000013107Add
BLAST

Proteomic databases

PaxDbiP34749.

Interactioni

Protein-protein interaction databases

BioGridi4261394. 17 interactions.
IntActiP34749. 6 interactions.
STRINGi511145.b3391.

Structurei

3D structure databases

ProteinModelPortaliP34749.
SMRiP34749. Positions 15-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GSP D family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105E4G. Bacteria.
COG4796. LUCA.
HOGENOMiHOG000255072.
InParanoidiP34749.
KOiK02507.
OMAiYQVSSGA.
OrthoDBiEOG6423BN.
PhylomeDBiP34749.

Family and domain databases

InterProiIPR001775. GspD/PilQ.
IPR005644. NolW-like.
IPR013355. Pilus_4_PilQ.
IPR011662. Secretin/TonB_short_N.
IPR004846. T2SS/T3SS.
IPR004845. T2SS_GspD_CS.
[Graphical view]
PfamiPF00263. Secretin. 1 hit.
PF03958. Secretin_N. 1 hit.
[Graphical view]
PRINTSiPR00811. BCTERIALGSPD.
SMARTiSM00965. STN. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02515. IV_pilus_PilQ. 1 hit.
PROSITEiPS00875. T2SP_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34749-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQWIAALLL MLIPGVQAAK PQKVTLMVDD VPVAQVLQAL AEQEKLNLVV
60 70 80 90 100
SPDVSGTVSL HLTDVPWKQA LQTVVKSAGL ITRQEGNILS VHSIAWQNNN
110 120 130 140 150
IARQEAEQAR AQANLPLENR SITLQYADAG ELAKAGEKLL SAKGSMTVDK
160 170 180 190 200
RTNRLLLRDN KTALSALEQW VAQMDLPVGQ VELSAHIVTI NEKSLRELGV
210 220 230 240 250
KWTLADAQHA GGVGQVTTLG SDLSVATATT HVGFNIGRIN GRLLDLELSA
260 270 280 290 300
LEQKQQLDII ASPRLLASHL QPASIKQGSE IPYQVSSGES GATSVEFKEA
310 320 330 340 350
VLGMEVTPTV LQKGRIRLKL HISQNVPGQV LQQADGEVLA IDKQEIETQV
360 370 380 390 400
EVKSGETLAL GGIFTRKNKS GQDSVPLLGD IPWFGQLFRH DGKEDERREL
410
VVFITPRLVS SE
Length:412
Mass (Da):44,716
Last modified:November 1, 1995 - v2
Checksum:i99FEAEE2606682E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19601 Genomic DNA. No translation available.
U18997 Genomic DNA. Translation: AAA58188.1.
U00096 Genomic DNA. Translation: AAC76416.1.
AP009048 Genomic DNA. Translation: BAE77900.1.
PIRiB65134.
RefSeqiNP_417850.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC76416; AAC76416; b3391.
BAE77900; BAE77900; BAE77900.
GeneIDi947901.
KEGGiecj:JW3354.
eco:b3391.
PATRICi32122214. VBIEscCol129921_3484.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19601 Genomic DNA. No translation available.
U18997 Genomic DNA. Translation: AAA58188.1.
U00096 Genomic DNA. Translation: AAC76416.1.
AP009048 Genomic DNA. Translation: BAE77900.1.
PIRiB65134.
RefSeqiNP_417850.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP34749.
SMRiP34749. Positions 15-181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261394. 17 interactions.
IntActiP34749. 6 interactions.
STRINGi511145.b3391.

Proteomic databases

PaxDbiP34749.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76416; AAC76416; b3391.
BAE77900; BAE77900; BAE77900.
GeneIDi947901.
KEGGiecj:JW3354.
eco:b3391.
PATRICi32122214. VBIEscCol129921_3484.

Organism-specific databases

EchoBASEiEB2036.
EcoGeneiEG12113. hofQ.

Phylogenomic databases

eggNOGiENOG4105E4G. Bacteria.
COG4796. LUCA.
HOGENOMiHOG000255072.
InParanoidiP34749.
KOiK02507.
OMAiYQVSSGA.
OrthoDBiEOG6423BN.
PhylomeDBiP34749.

Enzyme and pathway databases

BioCyciEcoCyc:EG12113-MONOMER.
ECOL316407:JW3354-MONOMER.

Miscellaneous databases

PROiP34749.

Family and domain databases

InterProiIPR001775. GspD/PilQ.
IPR005644. NolW-like.
IPR013355. Pilus_4_PilQ.
IPR011662. Secretin/TonB_short_N.
IPR004846. T2SS/T3SS.
IPR004845. T2SS_GspD_CS.
[Graphical view]
PfamiPF00263. Secretin. 1 hit.
PF03958. Secretin_N. 1 hit.
[Graphical view]
PRINTSiPR00811. BCTERIALGSPD.
SMARTiSM00965. STN. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02515. IV_pilus_PilQ. 1 hit.
PROSITEiPS00875. T2SP_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the gene (aroK) encoding shikimic acid kinase I of Escherichia coli."
    Lobner-Olesen A., Boye E., Marinus M.G.
    J. Bacteriol. 174:525-529(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Characterization of pilQ, a new gene required for the biogenesis of type 4 fimbriae in Pseudomonas aeruginosa."
    Martin P.R., Hobbs M., Free P.D., Jeske Y., Mattick J.S.
    Mol. Microbiol. 9:857-868(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  5. "DNA as a nutrient: novel role for bacterial competence gene homologs."
    Finkel S.E., Kolter R.
    J. Bacteriol. 183:6288-6293(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
    Strain: K12 / W3110 / ZK126.
  6. "Escherichia coli competence gene homologs are essential for competitive fitness and the use of DNA as a nutrient."
    Palchevskiy V., Finkel S.E.
    J. Bacteriol. 188:3902-3910(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    Strain: K12 / W3110 / ZK126.

Entry informationi

Entry nameiHOFQ_ECOLI
AccessioniPrimary (citable) accession number: P34749
Secondary accession number(s): Q2M756
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1995
Last modified: January 20, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.