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Protein

DNA utilization protein HofQ

Gene

hofQ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for the use of extracellular DNA as a nutrient (PubMed:11591672). Could be the porin responsible for transport of DNA across the outer membrane (PubMed:16707682).1 Publication1 Publication

GO - Molecular functioni

  • DNA binding Source: EcoliWiki
  • protein transporter activity Source: InterPro

GO - Biological processi

  • carbon utilization Source: EcoCyc
  • DNA catabolic process Source: EcoCyc
  • protein secretion Source: InterPro

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:EG12113-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA utilization protein HofQ
Gene namesi
Name:hofQ
Synonyms:hopQ
Ordered Locus Names:b3391, JW3354
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12113 hofQ

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutants show a stationary-phase competition defect during coculture with wild-type cells and an inability to utilize extracellular DNA as the sole source of carbon or energy. They have no defects in DNA uptake by electroporation or when made chemically competent (PubMed:11591672).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001310719 – 412DNA utilization protein HofQAdd BLAST394

Proteomic databases

PaxDbiP34749
PRIDEiP34749

Interactioni

Protein-protein interaction databases

BioGridi4261394, 17 interactors
IntActiP34749, 6 interactors
STRINGi316385.ECDH10B_3566

Structurei

3D structure databases

ProteinModelPortaliP34749
SMRiP34749
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GSP D family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105E4G Bacteria
COG4796 LUCA
HOGENOMiHOG000255072
InParanoidiP34749
KOiK02507
OMAiLGVNWGL
PhylomeDBiP34749

Family and domain databases

Gene3Di3.30.1370.120, 1 hit
InterProiView protein in InterPro
IPR001775 GspD/PilQ
IPR005644 NolW-like
IPR038591 NolW-like_sf
IPR013355 Pilus_4_PilQ
IPR011662 Secretin/TonB_short_N
IPR004846 T2SS/T3SS
IPR004845 T2SS_GspD_CS
PfamiView protein in Pfam
PF00263 Secretin, 1 hit
PF03958 Secretin_N, 1 hit
PRINTSiPR00811 BCTERIALGSPD
SMARTiView protein in SMART
SM00965 STN, 1 hit
TIGRFAMsiTIGR02515 IV_pilus_PilQ, 1 hit
PROSITEiView protein in PROSITE
PS00875 T2SP_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34749-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQWIAALLL MLIPGVQAAK PQKVTLMVDD VPVAQVLQAL AEQEKLNLVV
60 70 80 90 100
SPDVSGTVSL HLTDVPWKQA LQTVVKSAGL ITRQEGNILS VHSIAWQNNN
110 120 130 140 150
IARQEAEQAR AQANLPLENR SITLQYADAG ELAKAGEKLL SAKGSMTVDK
160 170 180 190 200
RTNRLLLRDN KTALSALEQW VAQMDLPVGQ VELSAHIVTI NEKSLRELGV
210 220 230 240 250
KWTLADAQHA GGVGQVTTLG SDLSVATATT HVGFNIGRIN GRLLDLELSA
260 270 280 290 300
LEQKQQLDII ASPRLLASHL QPASIKQGSE IPYQVSSGES GATSVEFKEA
310 320 330 340 350
VLGMEVTPTV LQKGRIRLKL HISQNVPGQV LQQADGEVLA IDKQEIETQV
360 370 380 390 400
EVKSGETLAL GGIFTRKNKS GQDSVPLLGD IPWFGQLFRH DGKEDERREL
410
VVFITPRLVS SE
Length:412
Mass (Da):44,716
Last modified:November 1, 1995 - v2
Checksum:i99FEAEE2606682E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19601 Genomic DNA No translation available.
U18997 Genomic DNA Translation: AAA58188.1
U00096 Genomic DNA Translation: AAC76416.1
AP009048 Genomic DNA Translation: BAE77900.1
PIRiB65134
RefSeqiNP_417850.1, NC_000913.3
WP_000815987.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76416; AAC76416; b3391
BAE77900; BAE77900; BAE77900
GeneIDi947901
KEGGiecj:JW3354
eco:b3391
PATRICifig|511145.12.peg.3484

Similar proteinsi

Entry informationi

Entry nameiHOFQ_ECOLI
AccessioniPrimary (citable) accession number: P34749
Secondary accession number(s): Q2M756
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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