P34741 (SDC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Syndecan-2
Short name=SYND2

Alternative name(s):
Fibroglycan
Heparan sulfate proteoglycan core protein
Short name=HSPG
CD_antigen=CD362

Gene names

Name:	SDC2
Synonyms:	HSPG1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	201 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis By similarity.
Subunit structure	Interacts (via cytoplasmic domain) with SARM1 By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Post-translational modification	O-glycosylated with core 1 or possibly core 8 glycans. Contains heparan sulfate. Ref.7
Sequence similarities	Belongs to the syndecan proteoglycan family.
Sequence caution	The sequence AAA52701.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein Heparan sulfate Phosphoprotein Proteoglycan
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Traceable author statement. Source: Reactome chondroitin sulfate metabolic process Traceable author statement. Source: Reactome dendrite morphogenesis Inferred from electronic annotation. Source: Compara glycosaminoglycan biosynthetic process Traceable author statement. Source: Reactome glycosaminoglycan catabolic process Traceable author statement. Source: Reactome regulation of dendrite morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB response to caffeine Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from electronic annotation. Source: Compara wound healing Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi lumen Traceable author statement. Source: Reactome integral to plasma membrane Non-traceable author statement. Source: UniProtKB lysosomal lumen Traceable author statement. Source: Reactome neuronal cell body Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CASK	O14936	2	EBI-1172957,EBI-1215506
NF1	P21359	4	EBI-1172957,EBI-1172917

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 201	183	Syndecan-2		PRO_0000033503
Regions
	Topological domain	19 – 144	126	Extracellular Potential
	Transmembrane	145 – 169	25	Helical; Potential
	Topological domain	170 – 201	32	Cytoplasmic Potential
Sites
	Site	142 – 143	2	Cleavage of ectodomain Potential
Amino acid modifications
	Modified residue	187	1	Phosphoserine Ref.8
	Glycosylation	41	1	O-linked (Xyl...) (heparan sulfate) Potential
	Glycosylation	55	1	O-linked (Xyl...) (heparan sulfate) Potential
	Glycosylation	57	1	O-linked (Xyl...) (heparan sulfate) Potential
	Glycosylation	101	1	O-linked (GalNAc...) Ref.7
Natural variations
	Natural variant	59	1	A → T. Ref.3 Corresponds to variant rs3816208 [ dbSNP | Ensembl ].		VAR_034675
	Natural variant	71	1	S → T. Ref.1 Ref.5 Corresponds to variant rs1042381 [ dbSNP | Ensembl ].		VAR_034676
Experimental info
	Sequence conflict	150	1	I → T in BAB15150. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P34741 [UniParc]. Last modified August 21, 2007. Version 2. Checksum: 7DA4159D54741054	FASTA	201	22,160
	10 20 30 40 50 60 MRRAWILLTL GLVACVSAES RAELTSDKDM YLDNSSIEEA SGVYPIDDDD YASASGSGAD 70 80 90 100 110 120 EDVESPELTT SRPLPKILLT SAAPKVETTT LNIQNKIPAQ TKSPEETDKE KVHLSDSERK 130 140 150 160 170 180 MDPAEEDTNV YTEKHSDSLF KRTEVLAAVI AGGVIGFLFA IFLILLLVYR MRKKDEGSYD 190 200 LGERKPSSAA YQKAPTKEFY A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Partial primary structure of the 48- and 90-kilodalton core proteins of cell surface-associated heparan sulfate proteoglycans of lung fibroblasts. Prediction of an integral membrane domain and evidence for multiple distinct core proteins at the cell surface of human lung fibroblasts." Marynen P., Zhang J., Cassiman J.-J., den Berghe H., David G. J. Biol. Chem. 264:7017-7024(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-71. Tissue: Lung fibroblast.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-59. Tissue: Embryo.
[4]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-71. Tissue: Brain and Muscle.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]	"Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD." Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G. Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION AT THR-101, STRUCTURE OF CARBOHYDRATES, MASS SPECTROMETRY.
[8]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-187, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J04621 mRNA. Translation: AAA52701.1. Different initiation. AK025488 mRNA. Translation: BAB15150.1. AK074530 mRNA. Translation: BAG51965.1. AK097839 mRNA. Translation: BAG53540.1. CH471060 Genomic DNA. Translation: EAW91755.1. BC030133 mRNA. Translation: AAH30133.1. BC049836 mRNA. Translation: AAH49836.1.
IPI	IPI00300407.
PIR	A33880.
RefSeq	NP_002989.2. NM_002998.3.
UniGene	Hs.1501. Hs.598247.
3D structure databases
ProteinModelPortal	P34741.
SMR	P34741. Positions 170-201.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-29943N.
IntAct	P34741. 10 interactions.
STRING	9606.ENSP00000307046.
PTM databases
PhosphoSite	P34741.
Polymorphism databases
DMDM	158962336.
Proteomic databases
PaxDb	P34741.
PRIDE	P34741.
Protocols and materials databases
DNASU	6383.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000302190; ENSP00000307046; ENSG00000169439. ENST00000545117; ENSP00000441453; ENSG00000169439.
GeneID	6383.
KEGG	hsa:6383.
UCSC	uc003yhv.1. human.
Organism-specific databases
CTD	6383.
GeneCards	GC08P097575.
HGNC	HGNC:10659. SDC2.
HPA	CAB025123.
MIM	142460. gene.
neXtProt	NX_P34741.
PharmGKB	PA35589.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG85596.
HOGENOM	HOG000263414.
HOVERGEN	HBG004501.
InParanoid	P34741.
KO	K16336.
OMA	KMPAQTK.
OrthoDB	EOG47PX75.
PhylomeDB	P34741.
Enzyme and pathway databases
Pathway_Interaction_DB	fgf_pathway. FGF signaling pathway. syndecan_pathway. Proteogylcan syndecan-mediated signaling events. syndecan_2_pathway. Syndecan-2-mediated signaling events.
Reactome	REACT_111217. Metabolism. REACT_116125. Disease.
Gene expression databases
ArrayExpress	P34741.
Bgee	P34741.
CleanEx	HS_SDC2.
Genevestigator	P34741.
GermOnline	ENSG00000169439. Homo sapiens.
Family and domain databases
InterPro	IPR003585. Neurexin-like. IPR001050. Syndecan. [Graphical view]
PANTHER	PTHR10915. PTHR10915. 1 hit.
Pfam	PF01034. Syndecan. 2 hits. [Graphical view]
SMART	SM00294. 4.1m. 1 hit. [Graphical view]
PROSITE	PS00964. SYNDECAN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00020. Sargramostim.
GenomeRNAi	6383.
NextBio	24788.
SOURCE	Search...

Entry information

Entry name

SDC2_HUMAN

Accession

Primary (citable) accession number: P34741
Secondary accession number(s): B3KQA3, Q6PIS6, Q9H6V1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	August 21, 2007
Last modified:	May 1, 2013
This is version 121 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.