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Protein

Protein BMH2

Gene

BMH2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • DNA replication origin binding Source: SGD
  • phosphoserine binding Source: SGD

GO - Biological processi

  • ascospore formation Source: SGD
  • DNA damage checkpoint Source: SGD
  • DNA replication initiation Source: SGD
  • fungal-type cell wall chitin biosynthetic process Source: SGD
  • glycogen metabolic process Source: SGD
  • negative regulation of apoptotic process Source: SGD
  • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: SGD
  • pre-replicative complex assembly involved in nuclear cell cycle DNA replication Source: SGD
  • pseudohyphal growth Source: SGD
  • Ras protein signal transduction Source: SGD
  • signal transduction involved in filamentous growth Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-29702-MONOMER.
ReactomeiR-SCE-1445148. Translocation of GLUT4 to the plasma membrane.
R-SCE-3371453. Regulation of HSF1-mediated heat shock response.
R-SCE-3371511. HSF1 activation.
R-SCE-450385. Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.
R-SCE-5625740. RHO GTPases activate PKNs.
R-SCE-6804114. TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.
R-SCE-75035. Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BMH2
Gene namesi
Name:BMH2
Ordered Locus Names:YDR099W
ORF Names:YD8557.08
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR099W.
SGDiS000002506. BMH2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 273272Protein BMH2PRO_0000058716Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Cross-linki76 – 76Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei89 – 891PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP34730.
PRIDEiP34730.
TopDownProteomicsiP34730.

2D gel databases

SWISS-2DPAGEP34730.

PTM databases

iPTMnetiP34730.

Interactioni

Subunit structurei

Interacts with FIN1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NTH1P323568EBI-3672,EBI-19509

GO - Molecular functioni

  • phosphoserine binding Source: SGD

Protein-protein interaction databases

BioGridi32157. 182 interactions.
DIPiDIP-1212N.
IntActiP34730. 34 interactions.
MINTiMINT-397916.

Structurei

3D structure databases

ProteinModelPortaliP34730.
SMRiP34730. Positions 5-234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi245 – 26117Poly-GlnAdd
BLAST

Sequence similaritiesi

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

GeneTreeiENSGT00760000119116.
HOGENOMiHOG000240379.
InParanoidiP34730.
KOiK06630.
OMAiEKSEYQV.
OrthoDBiEOG092C46UY.

Family and domain databases

InterProiIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERiPTHR18860. PTHR18860. 1 hit.
PfamiPF00244. 14-3-3. 1 hit.
[Graphical view]
PIRSFiPIRSF000868. 14-3-3. 1 hit.
PRINTSiPR00305. 1433ZETA.
SMARTiSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMiSSF48445. SSF48445. 1 hit.
PROSITEiPS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34730-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQTREDSVY LAKLAEQAER YEEMVENMKA VASSGQELSV EERNLLSVAY
60 70 80 90 100
KNVIGARRAS WRIVSSIEQK EESKEKSEHQ VELIRSYRSK IETELTKISD
110 120 130 140 150
DILSVLDSHL IPSATTGESK VFYYKMKGDY HRYLAEFSSG DAREKATNSS
160 170 180 190 200
LEAYKTASEI ATTELPPTHP IRLGLALNFS VFYYEIQNSP DKACHLAKQA
210 220 230 240 250
FDDAIAELDT LSEESYKDST LIMQLLRDNL TLWTSDISES GQEDQQQQQQ
260 270
QQQQQQQQQQ QAPAEQTQGE PTK
Length:273
Mass (Da):31,061
Last modified:January 23, 2007 - v3
Checksum:i74788A9103F129FB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti119 – 1191S → C in CAA59275 (PubMed:7744048).Curated
Sequence conflicti174 – 1741G → F in CAA59275 (PubMed:7744048).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84817 Genomic DNA. Translation: CAA59275.1.
U01883 Unassigned DNA. Translation: AAA03336.1.
Z47746 Genomic DNA. Translation: CAA87675.1.
DQ881448 mRNA. Translation: ABI95875.1.
EF123145 mRNA. Translation: ABM97489.1.
BK006938 Genomic DNA. Translation: DAA11946.1.
PIRiS51250.
RefSeqiNP_010384.3. NM_001180407.3.

Genome annotation databases

EnsemblFungiiYDR099W; YDR099W; YDR099W.
GeneIDi851676.
KEGGisce:YDR099W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84817 Genomic DNA. Translation: CAA59275.1.
U01883 Unassigned DNA. Translation: AAA03336.1.
Z47746 Genomic DNA. Translation: CAA87675.1.
DQ881448 mRNA. Translation: ABI95875.1.
EF123145 mRNA. Translation: ABM97489.1.
BK006938 Genomic DNA. Translation: DAA11946.1.
PIRiS51250.
RefSeqiNP_010384.3. NM_001180407.3.

3D structure databases

ProteinModelPortaliP34730.
SMRiP34730. Positions 5-234.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32157. 182 interactions.
DIPiDIP-1212N.
IntActiP34730. 34 interactions.
MINTiMINT-397916.

PTM databases

iPTMnetiP34730.

2D gel databases

SWISS-2DPAGEP34730.

Proteomic databases

MaxQBiP34730.
PRIDEiP34730.
TopDownProteomicsiP34730.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR099W; YDR099W; YDR099W.
GeneIDi851676.
KEGGisce:YDR099W.

Organism-specific databases

EuPathDBiFungiDB:YDR099W.
SGDiS000002506. BMH2.

Phylogenomic databases

GeneTreeiENSGT00760000119116.
HOGENOMiHOG000240379.
InParanoidiP34730.
KOiK06630.
OMAiEKSEYQV.
OrthoDBiEOG092C46UY.

Enzyme and pathway databases

BioCyciYEAST:G3O-29702-MONOMER.
ReactomeiR-SCE-1445148. Translocation of GLUT4 to the plasma membrane.
R-SCE-3371453. Regulation of HSF1-mediated heat shock response.
R-SCE-3371511. HSF1 activation.
R-SCE-450385. Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.
R-SCE-5625740. RHO GTPases activate PKNs.
R-SCE-6804114. TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.
R-SCE-75035. Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.

Miscellaneous databases

PROiP34730.

Family and domain databases

InterProiIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERiPTHR18860. PTHR18860. 1 hit.
PfamiPF00244. 14-3-3. 1 hit.
[Graphical view]
PIRSFiPIRSF000868. 14-3-3. 1 hit.
PRINTSiPR00305. 1433ZETA.
SMARTiSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMiSSF48445. SSF48445. 1 hit.
PROSITEiPS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBMH2_YEAST
AccessioniPrimary (citable) accession number: P34730
Secondary accession number(s): A2TBP2, D6VS86, Q06HN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 156 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 47600 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.