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Protein

Acid phosphatase

Gene

phoA

Organism
Aspergillus niger
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei216 – 2161Proton donorBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acid phosphatase (EC:3.1.3.2)
Gene namesi
Name:phoA
OrganismiAspergillus niger
Taxonomic identifieri5061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 417398Acid phosphatasePRO_0000023978Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi333 – 3331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi383 – 3831N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP34724.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG11964.

Family and domain databases

InterProiIPR007312. Phosphoesterase.
[Graphical view]
PfamiPF04185. Phosphoesterase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34724-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTKQSLVTL LGGLSLAVAQ TTTEGYPSLA EIRAAQATVQ PYSPVSNVKG
60 70 80 90 100
LTFNRFVNIW LENTDFDAAA ATEHLPVLAK KGLLLNNFWA VTHPSEPNYC
110 120 130 140 150
RHLPLGDTFG MDNDDFHQIP SNVSTIADLF DTKNIAWGEY QEGLPYPGYQ
160 170 180 190 200
GYRYPESGAN DYVRNRNPLI LFDSVTEDAL RLRQIKNFSS FYDDLENHRL
210 220 230 240 250
PQYMFITPNM TNDGHDTNIT FSGDWTWGFL SELLENDYFT KDTLIMLTFD
260 270 280 290 300
ETGTYEIGNN IYTFLLGGAV PDDLLGTKDD TFYTHYSVIA SLSTNWGLPS
310 320 330 340 350
LGRWDCGANL FSWLAKKTGY VNYEVDTSNL YMNETHWGPL SDDDYSEYYA
360 370 380 390 400
GWPVPTTDAS CSAGNGILST VKKTYEGLTA TFNYTTPFPY DSRSGNNVGV
410
KYSRTLKNGK VESGTSE
Length:417
Mass (Da):46,736
Last modified:February 1, 1994 - v1
Checksum:i896FD2AF541C69C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20566 Genomic DNA. Translation: AAA62393.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20566 Genomic DNA. Translation: AAA62393.1.

3D structure databases

ProteinModelPortaliP34724.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiNOG11964.

Family and domain databases

InterProiIPR007312. Phosphoesterase.
[Graphical view]
PfamiPF04185. Phosphoesterase. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "An acid phosphatase from Aspergillus ficuum has homology to Penicillium chrysogenum PhoA."
    Ehrlich K.C., Montalbano B.G., Mullaney E.J., Dischinger H.C. Jr., Ullah A.H.J.
    Biochem. Biophys. Res. Commun. 204:63-68(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
    Strain: NRRL 3135 / Van Tieghem / Ficuum.

Entry informationi

Entry nameiPHOA_ASPNG
AccessioniPrimary (citable) accession number: P34724
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 27, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.