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P34718 (NSP5_ROTBS) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Non-structural protein 5

Short name=NSP5
OrganismRotavirus C (isolate Cow/Japan/Shintoku/1991) (RV-C)
Taxonomic identifier33723 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostBos taurus (Bovine) [TaxID: 9913]

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in genome replication. Plays a crucial role, together with NSP2, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where core-like replication intermediates are assembled and RNA replication takes place By similarity.

Cofactor

Magnesium for ATPase activity By similarity.

Subunit structure

Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2; this interaction leads to formation of virus factories By similarity.

Subcellular location

Host cytoplasm. Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging By similarity.

Sequence similarities

Belongs to the rotavirus C NSP5 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 209209Non-structural protein 5
PRO_0000149642

Regions

Compositional bias2 – 8483Ser-rich

Sites

Metal binding861Magnesium Potential

Sequences

Sequence LengthMass (Da)Tools
P34718 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 820AC9B3C9DA1956

FASTA20923,438
        10         20         30         40         50         60 
MSDFGINLDA ICDNVRRNSS NSSIKSQVSN RSSRKMDFVD EDELSTYFNS KTSVTQSDSC 

        70         80         90        100        110        120 
SNDLNVKHSI IAEAVVCDES AHVSADAVQE KDVVVPKMDE SVMKWMMDSH DGICVNGGLN 

       130        140        150        160        170        180 
FSKLKNKSNE HETKVTSETN VSAHVSAGIN SQLGMFNPIQ HKIKKEAIPE MFEDEDTDEC 

       190        200 
TCRNCPYKEK YLKLRKKLKN VLVDIITEM 

« Hide

References

[1]"Nucleotide sequences of genes 6 and 10 of a bovine group C rotavirus."
Jiang B., Tsunemitsu H., Gentsch J.R., Saif L.J., Glass R.I.
Nucleic Acids Res. 21:2250-2250(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L12391 Genomic RNA. No translation available.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002512. Rotavirus_A/C_NSP5.
[Graphical view]
PfamPF01525. Rota_NS26. 1 hit.
[Graphical view]
PIRSFPIRSF004006. Rota_NS26. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNSP5_ROTBS
AccessionPrimary (citable) accession number: P34718
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 3, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families