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P34718

- NSP5_ROTBS

UniProt

P34718 - NSP5_ROTBS

Protein

Non-structural protein 5

Gene
N/A
Organism
Rotavirus C (isolate Cow/Japan/Shintoku/1991) (RV-C)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Involved in genome replication. Plays a crucial role, together with NSP2, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where core-like replication intermediates are assembled and RNA replication takes place By similarity.By similarity

    Cofactori

    Magnesium for ATPase activity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi86 – 861MagnesiumSequence Analysis

    GO - Molecular functioni

    1. ATPase activity Source: InterPro
    2. magnesium ion binding Source: InterPro
    3. nucleotide binding Source: UniProtKB-KW
    4. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. viral genome replication Source: InterPro

    Keywords - Ligandi

    Magnesium, Metal-binding, Nucleotide-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-structural protein 5
    Short name:
    NSP5
    OrganismiRotavirus C (isolate Cow/Japan/Shintoku/1991) (RV-C)
    Taxonomic identifieri33723 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
    Virus hostiBos taurus (Bovine) [TaxID: 9913]

    Subcellular locationi

    Host cytoplasm
    Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.By similarity

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 209209Non-structural protein 5PRO_0000149642Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2; this interaction leads to formation of virus factories By similarity.By similarity

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 8483Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the rotavirus C NSP5 family.Curated

    Family and domain databases

    InterProiIPR002512. Rotavirus_A/C_NSP5.
    [Graphical view]
    PfamiPF01525. Rota_NS26. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004006. Rota_NS26. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P34718-1 [UniParc]FASTAAdd to Basket

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    MSDFGINLDA ICDNVRRNSS NSSIKSQVSN RSSRKMDFVD EDELSTYFNS    50
    KTSVTQSDSC SNDLNVKHSI IAEAVVCDES AHVSADAVQE KDVVVPKMDE 100
    SVMKWMMDSH DGICVNGGLN FSKLKNKSNE HETKVTSETN VSAHVSAGIN 150
    SQLGMFNPIQ HKIKKEAIPE MFEDEDTDEC TCRNCPYKEK YLKLRKKLKN 200
    VLVDIITEM 209
    Length:209
    Mass (Da):23,438
    Last modified:February 1, 1994 - v1
    Checksum:i820AC9B3C9DA1956
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L12391 Genomic RNA. No translation available.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L12391 Genomic RNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR002512. Rotavirus_A/C_NSP5.
    [Graphical view ]
    Pfami PF01525. Rota_NS26. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004006. Rota_NS26. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequences of genes 6 and 10 of a bovine group C rotavirus."
      Jiang B., Tsunemitsu H., Gentsch J.R., Saif L.J., Glass R.I.
      Nucleic Acids Res. 21:2250-2250(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiNSP5_ROTBS
    AccessioniPrimary (citable) accession number: P34718
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3