ID   NSP3_ROTBS              Reviewed;         402 AA.
AC   P34717;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   08-NOV-2023, entry version 75.
DE   RecName: Full=Non-structural protein 3 {ECO:0000255|HAMAP-Rule:MF_04090};
DE            Short=NSP3 {ECO:0000255|HAMAP-Rule:MF_04090};
DE   AltName: Full=NCVP4 {ECO:0000255|HAMAP-Rule:MF_04090};
DE   AltName: Full=Non-structural RNA-binding protein 34 {ECO:0000255|HAMAP-Rule:MF_04090};
DE            Short=NS34 {ECO:0000255|HAMAP-Rule:MF_04090};
DE   Contains:
DE     RecName: Full=p38;
DE   Contains:
DE     RecName: Full=p8;
OS   Rotavirus C (isolate RVC/Cow/Japan/Shintoku/1991/G2P[3]) (RV-C).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Sedoreoviridae; Rotavirus; Rotavirus C.
OX   NCBI_TaxID=33723;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=8389040; DOI=10.1093/nar/21.9.2250;
RA   Jiang B., Tsunemitsu H., Gentsch J.R., Saif L.J., Glass R.I.;
RT   "Nucleotide sequences of genes 6 and 10 of a bovine group C rotavirus.";
RL   Nucleic Acids Res. 21:2250-2250(1993).
CC   -!- FUNCTION: May play a role in stimulating the translation of viral
CC       mRNAs. {ECO:0000255|HAMAP-Rule:MF_04090}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04090}.
CC   -!- SIMILARITY: Belongs to the rotavirus NSP3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_04090}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L12390; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   PIR; S35639; S35639.
DR   SMR; P34717; -.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-UniRule.
DR   CDD; cd20714; NSP3_rotavirus; 1.
DR   Gene3D; 3.30.160.20; -; 1.
DR   Gene3D; 3.30.70.1610; -; 1.
DR   Gene3D; 6.10.280.20; Rotavirus non-structural protein NSP3, N-terminal domain; 1.
DR   HAMAP; MF_04090; ROTA_NSP3; 1.
DR   InterPro; IPR014720; dsRBD_dom.
DR   InterPro; IPR042519; NSP3_N_rotavirus.
DR   InterPro; IPR036082; NSP3_sf.
DR   InterPro; IPR002873; Rotavirus_NSP3.
DR   Pfam; PF01665; Rota_NSP3; 1.
DR   SMART; SM00358; DSRM; 1.
DR   SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR   SUPFAM; SSF69903; NSP3 homodimer; 1.
DR   PROSITE; PS50137; DS_RBD; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Host cytoplasm; RNA-binding; Translation regulation.
FT   CHAIN           1..402
FT                   /note="Non-structural protein 3"
FT                   /id="PRO_0000149543"
FT   CHAIN           1..333
FT                   /note="p38"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000369883"
FT   CHAIN           334..402
FT                   /note="p8"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000369884"
FT   DOMAIN          334..402
FT                   /note="DRBM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT   COILED          87..113
FT                   /evidence="ECO:0000255"
FT   COILED          147..181
FT                   /evidence="ECO:0000255"
FT   SITE            333..334
FT                   /note="Cleavage; by autolysis"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   402 AA;  45081 MW;  EBF553E90D955D49 CRC64;
     MATQASVEWI FNVAGSAASA SLAKSIKDAG GSEDFAKYVV ARFYDNYKDS IDDSGIYNAC
     MGRARTVDKA LNDSRLAERN EEWHTNLATI RRLDLELAEL KLMLSNLGMK REERVLNSMF
     SVTREEGRSS NVVMLKQNAV KMIEEGKLKI KVEKNENYTE SLKNKIEELE CIIGAFEKGK
     EINIALDAMT GEVRLDGDSC SYNSTAAFVS TIMGTPIKMY DESNKPLFDV GKYINPKHVI
     DKMIESEIPI FKSDYRNNES PDFDAWNENS NLKIVSVNDC HAICVFKFEN EWWCFDDGRL
     RKYNGIGNPL IVANSKFQID RILISGDIEL NPGPNALVKL NDCITKYNLK IICTFDVNLD
     DDGSIMYICY LKVGSAEATG NGCSKKEAKR RAAVSILDQL GM
//