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Reviewed, UniProtKB/Swiss-Prot P34713 (MDR3_CAEEL)

Last modified November 3, 2009. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Multidrug resistance protein 3
    EC=3.6.3.44
Alternative name(s):
    P-glycoprotein C
Gene names
Name: pgp-3
ORF Names: ZK455.7
OrganismCaenorhabditis elegans [Complete proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

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Protein attributes

Sequence length1268 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Mediates ATP-dependent export of organic anions and xenobiotics from the cytoplasm. Hydrolyzes ATP with low efficiency By similarity.

Catalytic activity

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Intestinal cells. Ref.3

Sequence similarities

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification]

Contains 2 ABC transmembrane type-1 domains.

Contains 2 ABC transporter domains.

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Ontologies

Keywords
   Biological processTransport
   Cellular componentCell membrane
Membrane
   DomainRepeat
Transmembrane
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtransport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

xenobiotic-transporting ATPase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12681268Multidrug resistance protein 3
PRO_0000093343

Regions

Topological domain1 – 3939Cytoplasmic By similarity
Transmembrane40 – 6223 By similarity
Topological domain63 – 10038Extracellular By similarity
Transmembrane101 – 12121 By similarity
Topological domain122 – 17049Cytoplasmic By similarity
Transmembrane171 – 19222 By similarity
Topological domain193 – 1997Extracellular By similarity
Transmembrane200 – 22021 By similarity
Topological domain221 – 27858Cytoplasmic By similarity
Transmembrane279 – 30022 By similarity
Topological domain301 – 31414Extracellular By similarity
Transmembrane315 – 33622 By similarity
Topological domain337 – 708372Cytoplasmic By similarity
Transmembrane709 – 72921 By similarity
Topological domain730 – 75122Extracellular By similarity
Transmembrane752 – 77221 By similarity
Topological domain773 – 82755Cytoplasmic By similarity
Transmembrane828 – 84821 By similarity
Topological domain8491Extracellular By similarity
Transmembrane850 – 86920 By similarity
Topological domain870 – 93162Cytoplasmic By similarity
Transmembrane932 – 95221 By similarity
Topological domain953 – 96816Extracellular By similarity
Transmembrane969 – 99022 By similarity
Topological domain991 – 1268278Cytoplasmic By similarity
Domain46 – 341296ABC transmembrane type-1 1
Domain376 – 612237ABC transporter 1
Domain708 – 995288ABC transmembrane type-1 2
Domain1029 – 1265237ABC transporter 2
Nucleotide binding411 – 4188ATP 1 Potential
Nucleotide binding1064 – 10718ATP 2 Potential

Amino acid modifications

Glycosylation831N-linked (GlcNAc...) Potential
Glycosylation9621N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict581 – 59414Missing in CAA46191. Ref.1
Sequence conflict8601A → E in CAA46191. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P34713-1 [UniParc].

Last modified March 28, 2003. Version 2.
Checksum: A26E2DED84CA8163

FASTA1,268140,291
        10         20         30         40         50         60 
MKKTKVNPED DITLGKFTPK PSPQDSYQGN FFDVFRDADY KDYILFSGGL ILSAVNGALV 

        70         80         90        100        110        120 
PFNSLIFEGI ANALMEGESQ YQNGTINMPW FSSEIKMFCL RYFYLGVALF LCSYFANSCL 

       130        140        150        160        170        180 
YTLCERRLHC IRKKYLKSVL RQDAKWFDET TIGGLTQKMS SGIEKIKDGI GDKVGVLVGG 

       190        200        210        220        230        240 
VATFISGVSI GFYMCWQLTL VMMITVPLQL GSMYLSAKHL NRATKNEMSA YSNAGGMANE 

       250        260        270        280        290        300 
VIAGIRTVMA FNAQPFEINR YAHQLNEARR MGIRKAIILA ICTAFPLMLM FTCMAVAFWY 

       310        320        330        340        350        360 
GATLAAAGAV SSGAVFAVFW AVLIGTRRLG EAAPHLGAIT GARLAIHDIF KVIDHEPEIK 

       370        380        390        400        410        420 
CTSSEGKIPE KIQGKLTFDG IEFTYPTRPE LKILKGVSFE VNPGETVALV GHSGCGKSTS 

       430        440        450        460        470        480 
IGLLMRFYNQ CAGMIKLDGI PIQEYNIRWL RSTIGIVQQE PIIFVATVAE NIRMGDVLIT 

       490        500        510        520        530        540 
DQDIEEACKM ANAHEFICKL SDRYDTVIGA GAVQLSGGQK QRVAIARAIV RKPQILLLDE 

       550        560        570        580        590        600 
ATSALDTESE RMVQTALDKA SEGRTTLCIA HRLSTIRNAS KILVFDQGLI AERGTHDELI 

       610        620        630        640        650        660 
SKDDGIYASM VKAQEIERAK EDTTLDDEED EKTHRSFHRD SVTSDEEREL QQSLARDSTR 

       670        680        690        700        710        720 
LRQSMISTTT QVPEWEIENA REEMIEEGAM EASLFDIFKY ASPEMRNIII SLVFTLIRGF 

       730        740        750        760        770        780 
TWPAFSIVYG QLFKILSAGG DDVSIKALLN SLWFILLAFT GGISTLISGS LLGKAGETMS 

       790        800        810        820        830        840 
GRLRMDVFRN IMQQDASYFD DSRHNVGSLT SRLATDAPNV QAAIDQRLAE VLTGIVSLFC 

       850        860        870        880        890        900 
GVGVAFYYGW NMAPIGLATA LLLVVVQSSV AQYLKFRGQR DMDSAIEASR LVTESISNWK 

       910        920        930        940        950        960 
TVQALTKQEY MYDAFTAASK SPHRRAIVRG LWQSLSFALA GSFVMWNFAI AYMFGLWLIS 

       970        980        990       1000       1010       1020 
NNWSTPYTVF QVIEALNMAS MSVMLAASYF PEYVRARISA GIMFTMIRQK SVIDNRGLTG 

      1030       1040       1050       1060       1070       1080 
DTPTIKGNIN MRGVYFAYPN RRRQLVLDGF NMSANFGQTV ALVGPSGCGK STTIQLIERY 

      1090       1100       1110       1120       1130       1140 
YDALCGSVKI DDSDIRDLSV KHLRDNIALV GQEPTLFNLT IRENITYGLE NITQDQVEKA 

      1150       1160       1170       1180       1190       1200 
ATLANIHTFV MGLPDGYDTS VGASGGRLSG GQKQRVAIAR AIVRDPKILL LDEATSALDT 

      1210       1220       1230       1240       1250       1260 
ESEKIVQEAL DKARLGRTCV VIAHRLSTIQ NADKIIVCRN GKAIEEGTHQ TLLARRGLYY 


RLVEKQSS

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References

« Hide 'large scale' references
[1]"The P-glycoprotein gene family of Caenorhabditis elegans. Cloning and characterization of genomic and complementary DNA sequences."
Lincke C.R., The I., van Groenigen M., Borst P.
J. Mol. Biol. 228:701-711(1992) [PubMed: 1360540] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Bristol N2.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[3]"The expression of two P-glycoprotein (pgp) genes in transgenic Caenorhabditis elegans is confined to intestinal cells."
Lincke C.R., Broeks A., The I., Plasterk H.A., Borst P.
EMBO J. 12:1615-1620(1993) [PubMed: 8096815] [Abstract]
Cited for: TISSUE SPECIFICITY.
Strain: Bristol N2.
+Additional computationally mapped references.

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Cross-references

Sequence databases

X65055 Genomic DNA. Translation: CAA46191.1.
Z66567, Z66562 Genomic DNA. Translation: CAA91495.1.
Z66562, Z66567 Genomic DNA. Translation: CAA91467.1.
PIRS27338.
T22094.
RefSeqNP_509901.1.
UniGeneCel.5916

3D structure databases

HSSPHSSP built from PDB template 1MT0 based on UniProtKB P08716.
ModBaseSearch...

Genome annotation databases

EnsemblZK455.7; ZK455.7; ZK455.7; Caenorhabditis elegans. [Genome view]
GeneID181326.
KEGGcel:ZK455.7.
NMPDRfig|6239.3.peg.24636.
UCSCZK455.7. c. elegans.

Organism-specific databases

CTD181326.
WormBaseWBGene00003997. pgp-3.
WormPepZK455.7. CE03818. [WorfDB]

Phylogenomic databases

OMALARDSTR.

Enzyme and pathway databases

BRENDA3.6.3.44. 672.

Gene expression databases

ArrayExpressP34713.

Family and domain databases

InterProIPR001140. ABC_TM_transpt.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017940. ABC_transporter_type1.
IPR003593. ATPase_AAA+_core.
[Graphical view]
PfamPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
ProDomPD000006. ABC_transporter. 2 hits.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00382. AAA. 2 hits.
[Graphical view]
PROSITEPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio913458.

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Entry information

Entry nameMDR3_CAEEL
AccessionPrimary (citable) accession number: P34713
Secondary accession number(s): Q20335
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: March 28, 2003
Last modified: November 3, 2009
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectCaenorhabditis annotation project

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Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents