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Protein

Multidrug resistance protein pgp-1

Gene

pgp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

Catalytic activityi

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi451 – 458ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1112 – 1119ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • defense response to Gram-negative bacterium Source: WormBase
  • innate immune response Source: WormBase
  • response to metal ion Source: WormBase
  • response to nematicide Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Protein family/group databases

TCDBi3.A.1.201.14. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein pgp-1 (EC:3.6.3.44)
Alternative name(s):
P-glycoprotein A
P-glycoprotein-related protein 1
Gene namesi
Name:pgp-1
ORF Names:K08E7.9
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiK08E7.9; CE11932; WBGene00003995; pgp-1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 77CytoplasmicSequence analysisAdd BLAST77
Transmembranei78 – 98HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei144 – 164HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei213 – 233HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei240 – 260HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei321 – 341HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei350 – 370HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini371 – 753CytoplasmicSequence analysisAdd BLAST383
Transmembranei754 – 774HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei798 – 818HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei874 – 894HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei895 – 915HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei978 – 998HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1017 – 1037HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini1038 – 1321CytoplasmicSequence analysisAdd BLAST284

GO - Cellular componenti

  • apical plasma membrane Source: WormBase
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933421 – 1321Multidrug resistance protein pgp-1Add BLAST1321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi115N-linked (GlcNAc...)Sequence analysis1
Glycosylationi125N-linked (GlcNAc...)Sequence analysis1
Glycosylationi190N-linked (GlcNAc...)Sequence analysis1
Glycosylationi850N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP34712.
PaxDbiP34712.
PeptideAtlasiP34712.
PRIDEiP34712.

PTM databases

iPTMnetiP34712.

Expressioni

Tissue specificityi

Intestinal cells.1 Publication

Gene expression databases

BgeeiWBGene00003995.

Interactioni

Protein-protein interaction databases

STRINGi6239.K08E7.9.

Structurei

Secondary structure

11321
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 16Combined sources12
Helixi21 – 33Combined sources13
Turni37 – 39Combined sources3
Beta strandi42 – 44Combined sources3
Helixi62 – 65Combined sources4
Turni66 – 68Combined sources3
Helixi71 – 88Combined sources18
Helixi90 – 113Combined sources24
Helixi128 – 179Combined sources52
Helixi184 – 189Combined sources6
Helixi195 – 208Combined sources14
Helixi212 – 234Combined sources23
Helixi236 – 243Combined sources8
Helixi246 – 283Combined sources38
Helixi285 – 290Combined sources6
Helixi294 – 345Combined sources52
Turni346 – 348Combined sources3
Helixi352 – 392Combined sources41
Turni393 – 395Combined sources3
Beta strandi402 – 404Combined sources3
Beta strandi416 – 423Combined sources8
Beta strandi426 – 428Combined sources3
Beta strandi433 – 441Combined sources9
Beta strandi446 – 451Combined sources6
Beta strandi453 – 455Combined sources3
Helixi457 – 464Combined sources8
Beta strandi471 – 477Combined sources7
Turni482 – 484Combined sources3
Helixi487 – 493Combined sources7
Beta strandi494 – 497Combined sources4
Beta strandi505 – 507Combined sources3
Helixi508 – 513Combined sources6
Helixi521 – 530Combined sources10
Helixi534 – 539Combined sources6
Turni541 – 544Combined sources4
Beta strandi545 – 552Combined sources8
Helixi557 – 569Combined sources13
Beta strandi574 – 580Combined sources7
Turni581 – 584Combined sources4
Turni587 – 589Combined sources3
Helixi590 – 601Combined sources12
Beta strandi604 – 609Combined sources6
Turni613 – 618Combined sources6
Beta strandi620 – 626Combined sources7
Beta strandi629 – 634Combined sources6
Helixi636 – 640Combined sources5
Turni641 – 643Combined sources3
Helixi645 – 663Combined sources19
Helixi722 – 728Combined sources7
Turni729 – 732Combined sources4
Helixi740 – 746Combined sources7
Helixi747 – 750Combined sources4
Helixi751 – 763Combined sources13
Helixi764 – 766Combined sources3
Helixi767 – 781Combined sources15
Turni788 – 792Combined sources5
Helixi793 – 838Combined sources46
Beta strandi842 – 844Combined sources3
Helixi848 – 850Combined sources3
Helixi852 – 860Combined sources9
Helixi862 – 867Combined sources6
Turni868 – 870Combined sources3
Helixi872 – 894Combined sources23
Helixi896 – 916Combined sources21
Turni925 – 927Combined sources3
Helixi930 – 943Combined sources14
Helixi945 – 950Combined sources6
Turni951 – 953Combined sources3
Helixi954 – 986Combined sources33
Helixi989 – 1003Combined sources15
Beta strandi1006 – 1009Combined sources4
Helixi1014 – 1025Combined sources12
Turni1026 – 1028Combined sources3
Helixi1033 – 1036Combined sources4
Helixi1037 – 1056Combined sources20
Beta strandi1077 – 1084Combined sources8
Beta strandi1094 – 1102Combined sources9
Beta strandi1107 – 1111Combined sources5
Helixi1121 – 1125Combined sources5
Beta strandi1132 – 1138Combined sources7
Turni1143 – 1145Combined sources3
Helixi1148 – 1152Combined sources5
Beta strandi1155 – 1158Combined sources4
Beta strandi1166 – 1168Combined sources3
Helixi1169 – 1173Combined sources5
Beta strandi1174 – 1177Combined sources4
Turni1179 – 1181Combined sources3
Helixi1184 – 1193Combined sources10
Helixi1197 – 1201Combined sources5
Turni1204 – 1207Combined sources4
Beta strandi1209 – 1211Combined sources3
Turni1212 – 1214Combined sources3
Helixi1220 – 1233Combined sources14
Beta strandi1237 – 1243Combined sources7
Helixi1251 – 1260Combined sources10
Turni1261 – 1263Combined sources3
Beta strandi1264 – 1272Combined sources9
Beta strandi1274 – 1277Combined sources4
Turni1278 – 1281Combined sources4
Beta strandi1283 – 1297Combined sources15
Helixi1299 – 1304Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4F4CX-ray3.40A1-1321[»]
ProteinModelPortaliP34712.
SMRiP34712.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 381ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST305
Domaini416 – 652ABC transporter 1PROSITE-ProRule annotationAdd BLAST237
Domaini754 – 1043ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST290
Domaini1077 – 1315ABC transporter 2PROSITE-ProRule annotationAdd BLAST239

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00530000062896.
InParanoidiP34712.
KOiK05658.
OrthoDBiEOG091G0HVA.
PhylomeDBiP34712.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 3 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34712-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRNGSLRQS LRTLDSFSLA PEDVLKTAIK TVEDYEGDNI DSNGEIKITR
60 70 80 90 100
DAKEEVVNKV SIPQLYRYTT TLEKLLLFIG TLVAVITGAG LPLMSILQGK
110 120 130 140 150
VSQAFINEQI VINNNGSTFL PTGQNYTKTD FEHDVMNVVW SYAAMTVGMW
160 170 180 190 200
AAGQITVTCY LYVAEQMNNR LRREFVKSIL RQEISWFDTN HSGTLATKLF
210 220 230 240 250
DNLERVKEGT GDKIGMAFQY LSQFITGFIV AFTHSWQLTL VMLAVTPIQA
260 270 280 290 300
LCGFAIAKSM STFAIRETLR YAKAGKVVEE TISSIRTVVS LNGLRYELER
310 320 330 340 350
YSTAVEEAKK AGVLKGLFLG ISFGAMQASN FISFALAFYI GVGWVHDGSL
360 370 380 390 400
NFGDMLTTFS SVMMGSMALG LAGPQLAVLG TAQGAASGIY EVLDRKPVID
410 420 430 440 450
SSSKAGRKDM KIKGDITVEN VHFTYPSRPD VPILRGMNLR VNAGQTVALV
460 470 480 490 500
GSSGCGKSTI ISLLLRYYDV LKGKITIDGV DVRDINLEFL RKNVAVVSQE
510 520 530 540 550
PALFNCTIEE NISLGKEGIT REEMVAACKM ANAEKFIKTL PNGYNTLVGD
560 570 580 590 600
RGTQLSGGQK QRIAIARALV RNPKILLLDE ATSALDAESE GIVQQALDKA
610 620 630 640 650
AKGRTTIIIA HRLSTIRNAD LIISCKNGQV VEVGDHRALM AQQGLYYDLV
660 670 680 690 700
TAQTFTDAVD SAAEGKFSRE NSVARQTSEH EGLSRQASEM DDIMNRVRSS
710 720 730 740 750
TIGSITNGPV IDEKEERIGK DALSRLKQEL EENNAQKTNL FEILYHARPH
760 770 780 790 800
ALSLFIGMST ATIGGFIYPT YSVFFTSFMN VFAGNPADFL SQGHFWALMF
810 820 830 840 850
LVLAAAQGIC SFLMTFFMGI ASESLTRDLR NKLFRNVLSQ HIGFFDSPQN
860 870 880 890 900
ASGKISTRLA TDVPNLRTAI DFRFSTVITT LVSMVAGIGL AFFYGWQMAL
910 920 930 940 950
LIIAILPIVA FGQYLRGRRF TGKNVKSASE FADSGKIAIE AIENVRTVQA
960 970 980 990 1000
LAREDTFYEN FCEKLDIPHK EAIKEAFIQG LSYGCASSVL YLLNTCAYRM
1010 1020 1030 1040 1050
GLALIITDPP TMQPMRVLRV MYAITISTST LGFATSYFPE YAKATFAGGI
1060 1070 1080 1090 1100
IFGMLRKISK IDSLSLAGEK KKLYGKVIFK NVRFAYPERP EIEILKGLSF
1110 1120 1130 1140 1150
SVEPGQTLAL VGPSGCGKST VVALLERFYD TLGGEIFIDG SEIKTLNPEH
1160 1170 1180 1190 1200
TRSQIAIVSQ EPTLFDCSIA ENIIYGLDPS SVTMAQVEEA ARLANIHNFI
1210 1220 1230 1240 1250
AELPEGFETR VGDRGTQLSG GQKQRIAIAR ALVRNPKILL LDEATSALDT
1260 1270 1280 1290 1300
ESEKVVQEAL DRAREGRTCI VIAHRLNTVM NADCIAVVSN GTIIEKGTHT
1310 1320
QLMSEKGAYY KLTQKQMTEK K
Length:1,321
Mass (Da):145,063
Last modified:March 28, 2003 - v2
Checksum:i68094121B30E8746
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156T → I in CAA46190 (PubMed:1360540).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65054 Genomic DNA. Translation: CAA46190.1.
Z77666 Genomic DNA. Translation: CAB01232.1.
PIRiS27337.
T23476.
RefSeqiNP_502413.1. NM_070012.4.
UniGeneiCel.12537.

Genome annotation databases

EnsemblMetazoaiK08E7.9; K08E7.9; WBGene00003995.
GeneIDi178215.
KEGGicel:CELE_K08E7.9.
UCSCiK08E7.9. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65054 Genomic DNA. Translation: CAA46190.1.
Z77666 Genomic DNA. Translation: CAB01232.1.
PIRiS27337.
T23476.
RefSeqiNP_502413.1. NM_070012.4.
UniGeneiCel.12537.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4F4CX-ray3.40A1-1321[»]
ProteinModelPortaliP34712.
SMRiP34712.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.K08E7.9.

Protein family/group databases

TCDBi3.A.1.201.14. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetiP34712.

Proteomic databases

EPDiP34712.
PaxDbiP34712.
PeptideAtlasiP34712.
PRIDEiP34712.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK08E7.9; K08E7.9; WBGene00003995.
GeneIDi178215.
KEGGicel:CELE_K08E7.9.
UCSCiK08E7.9. c. elegans.

Organism-specific databases

CTDi178215.
WormBaseiK08E7.9; CE11932; WBGene00003995; pgp-1.

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00530000062896.
InParanoidiP34712.
KOiK05658.
OrthoDBiEOG091G0HVA.
PhylomeDBiP34712.

Miscellaneous databases

PROiP34712.

Gene expression databases

BgeeiWBGene00003995.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 3 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGP1_CAEEL
AccessioniPrimary (citable) accession number: P34712
Secondary accession number(s): Q21349
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: March 28, 2003
Last modified: November 2, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.