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Protein

Protein her-1

Gene

her-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dictates male development. Probably plays a direct role in cell signaling during C.elegans sex determination. Inhibits the function of tra-2a.

GO - Molecular functioni

  • signaling receptor binding Source: WormBase

GO - Biological processi

  • male sex determination Source: WormBase

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Protein her-1
Alternative name(s):
Hermaphrodization of XO animals protein 1
Gene namesi
Name:her-1
ORF Names:ZK287.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiZK287.8a ; CE06617 ; WBGene00001842 ; her-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000002141219 – 175Protein her-1Add BLAST157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP34704
PRIDEiP34704

Expressioni

Gene expression databases

BgeeiWBGene00001842
ExpressionAtlasiP34704 baseline and differential

Interactioni

GO - Molecular functioni

  • signaling receptor binding Source: WormBase

Protein-protein interaction databases

BioGridi44396, 1 interactor
DIPiDIP-26672N
STRINGi6239.ZK287.8a

Structurei

Secondary structure

1175
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi22 – 32Combined sources11
Helixi35 – 37Combined sources3
Helixi38 – 47Combined sources10
Helixi61 – 73Combined sources13
Helixi78 – 80Combined sources3
Helixi84 – 95Combined sources12
Helixi99 – 111Combined sources13
Helixi119 – 129Combined sources11
Turni130 – 132Combined sources3
Helixi134 – 148Combined sources15
Helixi153 – 155Combined sources3
Helixi158 – 160Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SZHX-ray1.50A/B19-175[»]
ProteinModelPortaliP34704
SMRiP34704
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP34704

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JHTY Eukaryota
ENOG41113NR LUCA
HOGENOMiHOG000021640
InParanoidiP34704
OMAiCLTECIT
OrthoDBiEOG091G0X19

Family and domain databases

InterProiView protein in InterPro
IPR015313 Her-1
IPR036341 Her-1_sf
PANTHERiPTHR37979 PTHR37979, 1 hit
PfamiView protein in Pfam
PF09232 Caenor_Her-1, 1 hit
SUPFAMiSSF110014 SSF110014, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P34704-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRYLPIFVFL GSFGYTETTL TKELIKDAAE KCCTRNRQEC CIEIMKFGTP
60 70 80 90 100
IRCGYDRDPK LPGYVYKCLQ NVLFAKEPKK KINLDDSVCC SVFGNDQNDS
110 120 130 140 150
GRRCENRCKN LMTSPSIDAA TRLDSIKSCS LLDNVLYKCF EKCRSLRKDG
160 170
IKIEVLQFEE YCNATFIQKR TFRGV
Note: Active.
Length:175
Mass (Da):20,172
Last modified:February 1, 1994 - v1
Checksum:iC330DFE9BB3D869A
GO
Isoform Short (identifier: P34704-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.

Note: Inactive.
Show »
Length:64
Mass (Da):7,382
Checksum:iFE0ED85EE0B8786D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0042831 – 111Missing in isoform Short. CuratedAdd BLAST111

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19595 Genomic DNA Translation: CAA79650.1
Z19595 Genomic DNA Translation: CAA79651.1
Z70757 Genomic DNA Translation: CAA94804.1
PIRiA46388
RefSeqiNP_001024310.1, NM_001029139.1 [P34704-1]
NP_001024311.2, NM_001029140.2 [P34704-2]
UniGeneiCel.3209

Genome annotation databases

EnsemblMetazoaiZK287.8a; ZK287.8a; WBGene00001842 [P34704-1]
GeneIDi179360
KEGGicel:CELE_ZK287.8
UCSCiZK287.8a c. elegans [P34704-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHER1_CAEEL
AccessioniPrimary (citable) accession number: P34704
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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