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Protein

Protein her-1

Gene

her-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Dictates male development. Probably plays a direct role in cell signaling during C.elegans sex determination. Inhibits the function of tra-2a.

GO - Molecular functioni

  • receptor binding Source: WormBase

GO - Biological processi

  • male sex determination Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Protein her-1
Alternative name(s):
Hermaphrodization of XO animals protein 1
Gene namesi
Name:her-1
ORF Names:ZK287.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiZK287.8a; CE06617; WBGene00001842; her-1.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 175157Protein her-1PRO_0000021412Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence analysis
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP34704.

Expressioni

Gene expression databases

BgeeiWBGene00001842.
ExpressionAtlasiP34704. baseline.

Interactioni

GO - Molecular functioni

  • receptor binding Source: WormBase

Protein-protein interaction databases

BioGridi44396. 1 interaction.
DIPiDIP-26672N.
MINTiMINT-1085312.
STRINGi6239.ZK287.8a.

Structurei

Secondary structure

1
175
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi22 – 3211Combined sources
Helixi35 – 373Combined sources
Helixi38 – 4710Combined sources
Helixi61 – 7313Combined sources
Helixi78 – 803Combined sources
Helixi84 – 9512Combined sources
Helixi99 – 11113Combined sources
Helixi119 – 12911Combined sources
Turni130 – 1323Combined sources
Helixi134 – 14815Combined sources
Helixi153 – 1553Combined sources
Helixi158 – 1603Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SZHX-ray1.50A/B19-175[»]
ProteinModelPortaliP34704.
SMRiP34704. Positions 18-164.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP34704.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JHTY. Eukaryota.
ENOG41113NR. LUCA.
HOGENOMiHOG000021640.
InParanoidiP34704.
OMAiCLTECIT.
OrthoDBiEOG091G0X19.

Family and domain databases

InterProiIPR015313. Her-1.
[Graphical view]
PfamiPF09232. Caenor_Her-1. 1 hit.
[Graphical view]
SUPFAMiSSF110014. SSF110014. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P34704-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRYLPIFVFL GSFGYTETTL TKELIKDAAE KCCTRNRQEC CIEIMKFGTP
60 70 80 90 100
IRCGYDRDPK LPGYVYKCLQ NVLFAKEPKK KINLDDSVCC SVFGNDQNDS
110 120 130 140 150
GRRCENRCKN LMTSPSIDAA TRLDSIKSCS LLDNVLYKCF EKCRSLRKDG
160 170
IKIEVLQFEE YCNATFIQKR TFRGV
Note: Active.
Length:175
Mass (Da):20,172
Last modified:February 1, 1994 - v1
Checksum:iC330DFE9BB3D869A
GO
Isoform Short (identifier: P34704-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.

Note: Inactive.
Show »
Length:64
Mass (Da):7,382
Checksum:iFE0ED85EE0B8786D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 111111Missing in isoform Short. CuratedVSP_004283Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19595 Genomic DNA. Translation: CAA79650.1.
Z19595 Genomic DNA. Translation: CAA79651.1.
Z70757 Genomic DNA. Translation: CAA94804.1.
PIRiA46388.
RefSeqiNP_001024310.1. NM_001029139.1. [P34704-1]
NP_001024311.2. NM_001029140.2. [P34704-2]
UniGeneiCel.3209.

Genome annotation databases

EnsemblMetazoaiZK287.8a; ZK287.8a; WBGene00001842. [P34704-1]
GeneIDi179360.
KEGGicel:CELE_ZK287.8.
UCSCiZK287.8a. c. elegans. [P34704-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19595 Genomic DNA. Translation: CAA79650.1.
Z19595 Genomic DNA. Translation: CAA79651.1.
Z70757 Genomic DNA. Translation: CAA94804.1.
PIRiA46388.
RefSeqiNP_001024310.1. NM_001029139.1. [P34704-1]
NP_001024311.2. NM_001029140.2. [P34704-2]
UniGeneiCel.3209.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SZHX-ray1.50A/B19-175[»]
ProteinModelPortaliP34704.
SMRiP34704. Positions 18-164.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi44396. 1 interaction.
DIPiDIP-26672N.
MINTiMINT-1085312.
STRINGi6239.ZK287.8a.

Proteomic databases

PaxDbiP34704.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK287.8a; ZK287.8a; WBGene00001842. [P34704-1]
GeneIDi179360.
KEGGicel:CELE_ZK287.8.
UCSCiZK287.8a. c. elegans. [P34704-1]

Organism-specific databases

CTDi179360.
WormBaseiZK287.8a; CE06617; WBGene00001842; her-1.

Phylogenomic databases

eggNOGiENOG410JHTY. Eukaryota.
ENOG41113NR. LUCA.
HOGENOMiHOG000021640.
InParanoidiP34704.
OMAiCLTECIT.
OrthoDBiEOG091G0X19.

Miscellaneous databases

EvolutionaryTraceiP34704.
PROiP34704.

Gene expression databases

BgeeiWBGene00001842.
ExpressionAtlasiP34704. baseline.

Family and domain databases

InterProiIPR015313. Her-1.
[Graphical view]
PfamiPF09232. Caenor_Her-1. 1 hit.
[Graphical view]
SUPFAMiSSF110014. SSF110014. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHER1_CAEEL
AccessioniPrimary (citable) accession number: P34704
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 7, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.