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Protein

Suppressor of Ty 6 homolog

Gene

emb-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May regulate transcriptional elongation by RNA polymerase II. Required for several aspects of morphogenesis of C.elegans, including regulation of division in the germline and gut and specification of ventral-uterine precursor cell fate.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

SignaLinkiP34703.

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of Ty 6 homolog
Alternative name(s):
Abnormal embryogenesis protein 5
Gene namesi
Name:emb-5
ORF Names:T04A8.14
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiT04A8.14; CE13120; WBGene00001259; emb-5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi859 – 8591A → E in HC61; temperature-sensitive. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15211521Suppressor of Ty 6 homologPRO_0000072169Add
BLAST

Proteomic databases

EPDiP34703.
PaxDbiP34703.
PRIDEiP34703.

PTM databases

iPTMnetiP34703.

Expressioni

Tissue specificityi

Abundant in embryos, and less abundant in larvae.

Gene expression databases

BgeeiWBGene00001259.

Interactioni

Subunit structurei

Interacts with glp-1 and lin-12.1 Publication

Protein-protein interaction databases

BioGridi40856. 7 interactions.
STRINGi6239.T04A8.14.

Structurei

3D structure databases

ProteinModelPortaliP34703.
SMRiP34703. Positions 561-592, 853-1139, 1296-1482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1183 – 125270S1 motifPROSITE-ProRule annotationAdd
BLAST
Domaini1300 – 138990SH2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi26 – 4217Nuclear localization signalSequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi26 – 4015Lys-rich (basic)Add
BLAST
Compositional biasi46 – 240195Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the SPT6 family.Curated
Contains 1 S1 motif domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.Curated

Phylogenomic databases

eggNOGiKOG1856. Eukaryota.
COG2183. LUCA.
GeneTreeiENSGT00510000047446.
HOGENOMiHOG000001562.
InParanoidiP34703.
KOiK11292.
OMAiHEANEMD.
OrthoDBiEOG091G00SW.
PhylomeDBiP34703.

Family and domain databases

Gene3Di1.10.150.310. 1 hit.
1.10.3500.10. 2 hits.
2.40.50.140. 1 hit.
3.30.420.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR012337. RNaseH-like_dom.
IPR010994. RuvA_2-like.
IPR022967. S1_dom.
IPR003029. S1_domain.
IPR000980. SH2.
IPR028083. Spt6_acidic_N_dom.
IPR027999. Spt6_dom.
IPR032706. Spt6_HHH.
IPR028088. Spt6_HTH_DNA-bd_dom.
IPR028231. Spt6_YqgF.
IPR023323. Tex-like_dom.
IPR023097. Tex_RuvX-like_dom.
IPR017072. TF_Spt6.
IPR006641. YqgF/RNaseH-like_dom.
[Graphical view]
PANTHERiPTHR10145:SF6. PTHR10145:SF6. 1 hit.
PfamiPF14878. DLD. 1 hit.
PF14635. HHH_7. 1 hit.
PF14641. HTH_44. 1 hit.
PF00575. S1. 1 hit.
PF14633. SH2_2. 1 hit.
PF14632. SPT6_acidic. 1 hit.
PF14639. YqgF. 1 hit.
[Graphical view]
PIRSFiPIRSF036947. Spt6. 1 hit.
SMARTiSM00316. S1. 1 hit.
SM00252. SH2. 1 hit.
SM00732. YqgFc. 1 hit.
[Graphical view]
SUPFAMiSSF47781. SSF47781. 2 hits.
SSF50249. SSF50249. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34703-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFIDNQAEE SDASSGHSDD EEPQSKKMKM AKEKSKRKKK MVASSDEDED
60 70 80 90 100
DDDDEEENRK EMQGFIADDD DEEEDAKSEK SEKSRHSGED ELDDEDLDLI
110 120 130 140 150
NENYDIRETK KQNRVQLGDS SDEDEPIRRP NHEDDDLLSE RGSDDGDRRK
160 170 180 190 200
DRGRGDRGGY GSESERSEDD FIEDDGDAPR RHRKRHRGDE NLPEGAEDDA
210 220 230 240 250
RDVFGVEDFN LDEFYDDDDG EDGLEDEEEE IIEDDGEGGE IKIRRKKDTT
260 270 280 290 300
KKSTLLESIE PSEIDRGFLL PGDKKIAKED LPERFQLRRT PVTEADDDEL
310 320 330 340 350
ESEALWIIKY AFEEGTVTNQ ADLDQDDKLD CIMNLDPSVY EDRKKAVIKS
360 370 380 390 400
IKKVLQFIRV RSNSFEPTFI GFYRKEDIDN LLTMNNLWRV YDFDEKWCHL
410 420 430 440 450
SEKKNKIYDL MRRMREYQEL SDDLTAKRRP ISDADLMDTK YAETLEQLTD
460 470 480 490 500
IHANFQLLYG ALLDDMIRWE KGRLTGEEEE QEYRVKFKSS IRNDKYQMCV
510 520 530 540 550
ENGIGELAGR FGLTAKQFSE NLNWKKHDIE QDPMLPLEAA EEYVCPAFSD
560 570 580 590 600
SDMVLNGAKF MLAKEISRQP QVRHSVRQEF RQSAHFWIKP TKKGRDTIDQ
610 620 630 640 650
THPLYDKRYI KSKPVRSLTA EEFLFYHKAK EDGLVDVLIM YESEEDQDSN
660 670 680 690 700
NYLVNKYLSD SIFQKDEYTE NVEQWNSVRD ECVNMAITEM LVPYMRDELY
710 720 730 740 750
NTILEEAKTA VAKKCRKEFA SRISRSGYLP DFDNNDDDDD GMDQHGARRI
760 770 780 790 800
MAVCYPTERD EASFGVMVDE NGAIVDYLRM VHFTKRTFGG GNNGLRKAES
810 820 830 840 850
MDLFKKFVQR RKPHAIGLNI EDMECTRLKR DLEEAVADLF SQNLIYKPIP
860 870 880 890 900
VFLMDNEAAK VYMRSNVSLA ENPDHPPTLR QALSLARLLL DPIPEYAHLW
910 920 930 940 950
NIDEDIFCLS LHPLQRDIDQ EQLALVLSHE LVNKVNEEGV DINKCAEFPH
960 970 980 990 1000
YTNMLQFTCG LGPRKATDLL KSIKANDNLI ESRSKLVVGC KLGPKVFMNC
1010 1020 1030 1040 1050
AGFIKIDTIK VSEKTDAYVE VLDGSRVHPE TYEWARKMAV DALEVDDSAD
1060 1070 1080 1090 1100
PTAALQEIME SPDRLRDLDL DAFADELSRQ GFGEKKSTLY DISSELSARY
1110 1120 1130 1140 1150
KDLRQPFQEP TGELLYDLLA RSGKEIREGA KVLGTVQSVQ YRKVDKDAAD
1160 1170 1180 1190 1200
SMLPDVGEDG LFTCPCCKSF TSSAPGGIQE HMLGDSRQGG CPGTPVGIRV
1210 1220 1230 1240 1250
RFDNGMTGFC PNKNISSSHV DNPLTRVKIN QPYYFKVLKL DKERFSLFLS
1260 1270 1280 1290 1300
CKSSDLKEDD LSQRDQYWDE HQYQADLELM KSESKKKTEA NTRVKRVIAH
1310 1320 1330 1340 1350
PNFHNVSYEA ATKMLDEMDW SECIIRPSAN KDSGLSVTWK ICDRVYHNFF
1360 1370 1380 1390 1400
VKESAKDQVF SIGRQLSVGG EDFEDLDELI ARFVQPMIQI SHEITTHKYF
1410 1420 1430 1440 1450
FPNGTCEETE AVEQFVREKK RELGRSPYVF SASYRQPCQF CISYMFDNTE
1460 1470 1480 1490 1500
RIRHEYFKIV PHGVRFRHQN FDTLDRMMAW FKRHFHEPPI ELRRSAIPAP
1510 1520
QYRVGAPPAA PYYPPQFVGY H
Length:1,521
Mass (Da):175,816
Last modified:February 1, 1994 - v1
Checksum:i97855CAC28EE08F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14635 Genomic DNA. Translation: BAA03484.1.
Z35663, Z35719 Genomic DNA. Translation: CAA84737.1.
PIRiS35241.
RefSeqiNP_497969.1. NM_065568.3.
UniGeneiCel.23354.

Genome annotation databases

EnsemblMetazoaiT04A8.14; T04A8.14; WBGene00001259.
GeneIDi175621.
KEGGicel:CELE_T04A8.14.
UCSCiT04A8.14. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14635 Genomic DNA. Translation: BAA03484.1.
Z35663, Z35719 Genomic DNA. Translation: CAA84737.1.
PIRiS35241.
RefSeqiNP_497969.1. NM_065568.3.
UniGeneiCel.23354.

3D structure databases

ProteinModelPortaliP34703.
SMRiP34703. Positions 561-592, 853-1139, 1296-1482.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi40856. 7 interactions.
STRINGi6239.T04A8.14.

PTM databases

iPTMnetiP34703.

Proteomic databases

EPDiP34703.
PaxDbiP34703.
PRIDEiP34703.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT04A8.14; T04A8.14; WBGene00001259.
GeneIDi175621.
KEGGicel:CELE_T04A8.14.
UCSCiT04A8.14. c. elegans.

Organism-specific databases

CTDi175621.
WormBaseiT04A8.14; CE13120; WBGene00001259; emb-5.

Phylogenomic databases

eggNOGiKOG1856. Eukaryota.
COG2183. LUCA.
GeneTreeiENSGT00510000047446.
HOGENOMiHOG000001562.
InParanoidiP34703.
KOiK11292.
OMAiHEANEMD.
OrthoDBiEOG091G00SW.
PhylomeDBiP34703.

Enzyme and pathway databases

SignaLinkiP34703.

Miscellaneous databases

PROiP34703.

Gene expression databases

BgeeiWBGene00001259.

Family and domain databases

Gene3Di1.10.150.310. 1 hit.
1.10.3500.10. 2 hits.
2.40.50.140. 1 hit.
3.30.420.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR012337. RNaseH-like_dom.
IPR010994. RuvA_2-like.
IPR022967. S1_dom.
IPR003029. S1_domain.
IPR000980. SH2.
IPR028083. Spt6_acidic_N_dom.
IPR027999. Spt6_dom.
IPR032706. Spt6_HHH.
IPR028088. Spt6_HTH_DNA-bd_dom.
IPR028231. Spt6_YqgF.
IPR023323. Tex-like_dom.
IPR023097. Tex_RuvX-like_dom.
IPR017072. TF_Spt6.
IPR006641. YqgF/RNaseH-like_dom.
[Graphical view]
PANTHERiPTHR10145:SF6. PTHR10145:SF6. 1 hit.
PfamiPF14878. DLD. 1 hit.
PF14635. HHH_7. 1 hit.
PF14641. HTH_44. 1 hit.
PF00575. S1. 1 hit.
PF14633. SH2_2. 1 hit.
PF14632. SPT6_acidic. 1 hit.
PF14639. YqgF. 1 hit.
[Graphical view]
PIRSFiPIRSF036947. Spt6. 1 hit.
SMARTiSM00316. S1. 1 hit.
SM00252. SH2. 1 hit.
SM00732. YqgFc. 1 hit.
[Graphical view]
SUPFAMiSSF47781. SSF47781. 2 hits.
SSF50249. SSF50249. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50126. S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPT6H_CAEEL
AccessioniPrimary (citable) accession number: P34703
Secondary accession number(s): Q7JMP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 7, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.