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Protein

Synaptotagmin-1

Gene

snt-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (By similarity).By similarity

Cofactori

Ca2+By similarityNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domains.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi190 – 1901Calcium 1By similarity
Metal bindingi190 – 1901Calcium 2By similarity
Metal bindingi196 – 1961Calcium 1By similarity
Metal bindingi248 – 2481Calcium 1By similarity
Metal bindingi248 – 2481Calcium 2By similarity
Metal bindingi249 – 2491Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi250 – 2501Calcium 1By similarity
Metal bindingi250 – 2501Calcium 2By similarity
Metal bindingi250 – 2501Calcium 3By similarity
Metal bindingi253 – 2531Calcium 3By similarity
Metal bindingi254 – 2541Calcium 3; via carbonyl oxygenBy similarity
Metal bindingi256 – 2561Calcium 2By similarity
Metal bindingi256 – 2561Calcium 3By similarity

GO - Molecular functioni

GO - Biological processi

  • calcium ion-regulated exocytosis of neurotransmitter Source: GO_Central
  • defecation Source: WormBase
  • locomotory behavior Source: WormBase
  • positive regulation of necrotic cell death Source: WormBase
  • regulation of calcium ion-dependent exocytosis Source: GO_Central
  • regulation of neurotransmitter secretion Source: WormBase
  • regulation of pharyngeal pumping Source: WormBase
  • synaptic vesicle endocytosis Source: WormBase
  • synaptic vesicle exocytosis Source: WormBase
  • vesicle fusion Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-210500. Glutamate Neurotransmitter Release Cycle.
R-CEL-264642. Acetylcholine Neurotransmitter Release Cycle.

Protein family/group databases

TCDBi1.F.1.1.3. the synaptosomal vesicle fusion pore (svf-pore) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-1
Alternative name(s):
Synaptotagmin I
Gene namesi
Name:snt-1
ORF Names:F31E8.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF31E8.2a; CE02711; WBGene00004921; snt-1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6969VesicularSequence analysisAdd
BLAST
Transmembranei70 – 9627HelicalSequence analysisAdd
BLAST
Topological domaini97 – 441345CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: GO_Central
  • synapse Source: WormBase
  • synaptic vesicle Source: WormBase
  • synaptic vesicle membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

Worms exhibit severe behavioral abnormalities that are characteristic of deficiencies in synaptic function, including severe locomotion, feeding, and defecation defects.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 441441Synaptotagmin-1PRO_0000183988Add
BLAST

Proteomic databases

EPDiP34693.
PaxDbiP34693.
PRIDEiP34693.

Expressioni

Tissue specificityi

Localized to regions known to be rich in synapses and appears to be associated with synaptic vesicles. Also found in some non-neuronal secretory structures.

Gene expression databases

BgeeiWBGene00004921.
ExpressionAtlasiP34693. baseline.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6239.F31E8.2b.

Structurei

3D structure databases

ProteinModelPortaliP34693.
SMRiP34693. Positions 159-435.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini175 – 26288C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini306 – 39792C2 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IT3Q. Eukaryota.
ENOG410Z15P. LUCA.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000232127.
InParanoidiP34693.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
[Graphical view]
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34693-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKLDFSSQD EENDEDLTKE FVRDEAPMEE TTSEAVKQIA TTTKETLKDV
60 70 80 90 100
VVNKVIDVKD VVKEKVMQQT GMPEWAFVFL GFVFILLVLA CAFCLIRKLF
110 120 130 140 150
GKKRHGEKNK KGGLKGFFGK GQDVVDGKNI QGMAQDLEEL GDAMEQNEKE
160 170 180 190 200
QAEEKEEVKL GRIQYKLDYD FQQGQLTVTV IQAEDLPGMD MSGTSDPYVK
210 220 230 240 250
LYLLPEKKKK VETKVHRKTL NPVFNETFIF KVAFNEITAK TLVFAIYDFD
260 270 280 290 300
RFSKHDQIGQ VLIPLGKIDL GAVIEEWKDI APPPDDKEAE KSLGDICFSL
310 320 330 340 350
RYVPTAGKLT VVILEAKNLK KMDVGGLSDP YVKIVLMQGG KRLKKKKTSI
360 370 380 390 400
KKCTLNPYYN ESFSFEVPFE QIQKVSLMIT VMDYDKLGSN DAIGRCLLGC
410 420 430 440
NGTGAELRHW MDMLASPRRP IAQWHTLGPV EEEGDKKDDK K
Length:441
Mass (Da):49,904
Last modified:February 1, 1994 - v1
Checksum:iF8D174337EB472DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15302 mRNA. Translation: AAA28145.1.
FO080321 Genomic DNA. Translation: CCD62852.1.
PIRiA40707.
RefSeqiNP_001022129.1. NM_001026958.3.
UniGeneiCel.18270.

Genome annotation databases

EnsemblMetazoaiF31E8.2a; F31E8.2a; WBGene00004921.
GeneIDi174120.
UCSCiF31E8.2a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15302 mRNA. Translation: AAA28145.1.
FO080321 Genomic DNA. Translation: CCD62852.1.
PIRiA40707.
RefSeqiNP_001022129.1. NM_001026958.3.
UniGeneiCel.18270.

3D structure databases

ProteinModelPortaliP34693.
SMRiP34693. Positions 159-435.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F31E8.2b.

Protein family/group databases

TCDBi1.F.1.1.3. the synaptosomal vesicle fusion pore (svf-pore) family.

Proteomic databases

EPDiP34693.
PaxDbiP34693.
PRIDEiP34693.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF31E8.2a; F31E8.2a; WBGene00004921.
GeneIDi174120.
UCSCiF31E8.2a. c. elegans.

Organism-specific databases

CTDi174120.
WormBaseiF31E8.2a; CE02711; WBGene00004921; snt-1.

Phylogenomic databases

eggNOGiENOG410IT3Q. Eukaryota.
ENOG410Z15P. LUCA.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000232127.
InParanoidiP34693.

Enzyme and pathway databases

ReactomeiR-CEL-210500. Glutamate Neurotransmitter Release Cycle.
R-CEL-264642. Acetylcholine Neurotransmitter Release Cycle.

Miscellaneous databases

PROiP34693.

Gene expression databases

BgeeiWBGene00004921.
ExpressionAtlasiP34693. baseline.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
[Graphical view]
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYT1_CAEEL
AccessioniPrimary (citable) accession number: P34693
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 7, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.