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Protein

F-actin-capping protein subunit beta

Gene

cap-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.

GO - Molecular functioni

  • actin filament binding Source: WormBase

GO - Biological processi

  • actin cytoskeleton organization Source: WormBase
  • barbed-end actin filament capping Source: GO_Central
  • cell morphogenesis Source: GO_Central
  • embryonic axis specification Source: WormBase
  • negative regulation of filopodium assembly Source: GO_Central
  • regulation of lamellipodium assembly Source: GO_Central

Keywordsi

Molecular functionActin capping, Actin-binding

Enzyme and pathway databases

ReactomeiR-CEL-6807878. COPI-mediated anterograde transport.
R-CEL-6811436. COPI-independent Golgi-to-ER retrograde traffic.
R-CEL-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
F-actin-capping protein subunit beta
Gene namesi
Name:cap-2
ORF Names:M106.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiM106.5; CE01608; WBGene00000293; cap-2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002046371 – 270F-actin-capping protein subunit betaAdd BLAST270

Proteomic databases

EPDiP34686.
PaxDbiP34686.
PRIDEiP34686.

Expressioni

Gene expression databases

BgeeiWBGene00000293.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.

GO - Molecular functioni

  • actin filament binding Source: WormBase

Protein-protein interaction databases

BioGridi39983. 4 interactors.
DIPiDIP-26957N.
IntActiP34686. 2 interactors.
MINTiMINT-1095007.
STRINGi6239.M106.5.1.

Structurei

3D structure databases

ProteinModelPortaliP34686.
SMRiP34686.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3174. Eukaryota.
ENOG410XQYD. LUCA.
GeneTreeiENSGT00390000017957.
HOGENOMiHOG000041208.
InParanoidiP34686.
KOiK10365.
OMAiACDYNRD.
OrthoDBiEOG091G0EH8.
PhylomeDBiP34686.

Family and domain databases

InterProiView protein in InterPro
IPR001698. CAPZB.
IPR019771. F-actin_capping_bsu_CS.
PANTHERiPTHR10619. PTHR10619. 1 hit.
PfamiView protein in Pfam
PF01115. F_actin_cap_B. 1 hit.
PRINTSiPR00192. FACTINCAPB.
PROSITEiView protein in PROSITE
PS00231. F_ACTIN_CAPPING_BETA. 1 hit.

Sequencei

Sequence statusi: Complete.

P34686-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEQQLDCAL DLMRRLPPQH CDKNLTDLID LCPHLVDDLL STIDQPLKIA
60 70 80 90 100
ADRETGKQYL LCDYNRDGDS YRSPWSNTYD PPLEDGQLPS EKRRKMEIEA
110 120 130 140 150
NAAFESYRDL YFEGGVSSVY FWDLDNGGFA GIVLIKKEGD GAKNITGCWD
160 170 180 190 200
SIHVIEITER ARQAHYKLTS TIMLWLQTNK SSSGVMNLGG SLTRQHEMDA
210 220 230 240 250
PINDQNTHLA NMGRMIEDQE SKMRLTINEI YFGKTKKVMS DLRSTEKQSE
260 270
LEKQDEIVRE LNNAMANRGN
Length:270
Mass (Da):30,786
Last modified:February 1, 1994 - v1
Checksum:i8EB7BC108233CDC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18806 Genomic DNA. Translation: CAA79270.1.
Z18854 mRNA. Translation: CAA79306.1.
Z46935 Genomic DNA. Translation: CAA87051.1.
PIRiB47734.
RefSeqiNP_496336.1. NM_063935.6.
UniGeneiCel.18252.

Genome annotation databases

EnsemblMetazoaiM106.5; M106.5; WBGene00000293.
GeneIDi174673.
KEGGicel:CELE_M106.5.
UCSCiM106.5.1. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiCAPZB_CAEEL
AccessioniPrimary (citable) accession number: P34686
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 27, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families