Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

F-actin-capping protein subunit beta

Gene

cap-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.

GO - Molecular functioni

  • actin filament binding Source: WormBase

GO - Biological processi

  • actin cytoskeleton organization Source: WormBase
  • barbed-end actin filament capping Source: GO_Central
  • cell morphogenesis Source: GO_Central
  • embryonic axis specification Source: WormBase
  • negative regulation of filopodium assembly Source: GO_Central
  • regulation of lamellipodium assembly Source: GO_Central

Keywordsi

Molecular functionActin capping, Actin-binding

Enzyme and pathway databases

ReactomeiR-CEL-6807878 COPI-mediated anterograde transport
R-CEL-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-CEL-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
F-actin-capping protein subunit beta
Gene namesi
Name:cap-2
ORF Names:M106.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiM106.5 ; CE01608 ; WBGene00000293 ; cap-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002046371 – 270F-actin-capping protein subunit betaAdd BLAST270

Proteomic databases

EPDiP34686
PaxDbiP34686
PRIDEiP34686

Expressioni

Gene expression databases

BgeeiWBGene00000293

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.

GO - Molecular functioni

  • actin filament binding Source: WormBase

Protein-protein interaction databases

BioGridi39983, 4 interactors
DIPiDIP-26957N
IntActiP34686, 1 interactor
STRINGi6239.M106.5.1

Structurei

3D structure databases

ProteinModelPortaliP34686
SMRiP34686
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3174 Eukaryota
ENOG410XQYD LUCA
GeneTreeiENSGT00390000017957
HOGENOMiHOG000041208
InParanoidiP34686
KOiK10365
OMAiACDYNRD
OrthoDBiEOG091G0EH8
PhylomeDBiP34686

Family and domain databases

InterProiView protein in InterPro
IPR037282 CapZ_alpha/beta
IPR001698 CAPZB
IPR019771 F-actin_capping_bsu_CS
PANTHERiPTHR10619 PTHR10619, 1 hit
PfamiView protein in Pfam
PF01115 F_actin_cap_B, 1 hit
PRINTSiPR00192 FACTINCAPB
SUPFAMiSSF90096 SSF90096, 1 hit
PROSITEiView protein in PROSITE
PS00231 F_ACTIN_CAPPING_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

P34686-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEQQLDCAL DLMRRLPPQH CDKNLTDLID LCPHLVDDLL STIDQPLKIA
60 70 80 90 100
ADRETGKQYL LCDYNRDGDS YRSPWSNTYD PPLEDGQLPS EKRRKMEIEA
110 120 130 140 150
NAAFESYRDL YFEGGVSSVY FWDLDNGGFA GIVLIKKEGD GAKNITGCWD
160 170 180 190 200
SIHVIEITER ARQAHYKLTS TIMLWLQTNK SSSGVMNLGG SLTRQHEMDA
210 220 230 240 250
PINDQNTHLA NMGRMIEDQE SKMRLTINEI YFGKTKKVMS DLRSTEKQSE
260 270
LEKQDEIVRE LNNAMANRGN
Length:270
Mass (Da):30,786
Last modified:February 1, 1994 - v1
Checksum:i8EB7BC108233CDC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18806 Genomic DNA Translation: CAA79270.1
Z18854 mRNA Translation: CAA79306.1
Z46935 Genomic DNA Translation: CAA87051.1
PIRiB47734
RefSeqiNP_496336.1, NM_063935.6
UniGeneiCel.18252

Genome annotation databases

EnsemblMetazoaiM106.5; M106.5; WBGene00000293
GeneIDi174673
KEGGicel:CELE_M106.5
UCSCiM106.5.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiCAPZB_CAEEL
AccessioniPrimary (citable) accession number: P34686
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health